#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q0D2K0 uniprotkb:Q6P1M0 intact:EBI-9550165|uniprotkb:A8S6F1|uniprotkb:A8S6F5|uniprotkb:A8S6F8|uniprotkb:B4DLF3|uniprotkb:Q0D2J8|uniprotkb:Q0D2J9|ensembl:ENSP00000311687|ensembl:ENSP00000406456 intact:EBI-1052237|uniprotkb:O95186|uniprotkb:A8K2F7|uniprotkb:Q96G53|ensembl:ENSP00000300456 psi-mi:nipa4_human(display_long)|uniprotkb:NIPAL4(gene name)|psi-mi:NIPAL4(display_short)|uniprotkb:ICHN(gene name synonym)|uniprotkb:Ichthyin(gene name synonym)|uniprotkb:NIPA-like protein 4(gene name synonym)|uniprotkb:NIPA4(gene name synonym)|uniprotkb:Non-imprinted in Prader-Willi/Angelman syndrome region protein 4(gene name synonym) psi-mi:s27a4_human(display_long)|uniprotkb:Solute carrier family 27 member 4(gene name synonym)|uniprotkb:SLC27A4(gene name)|psi-mi:SLC27A4(display_short)|uniprotkb:ACSVL4(gene name synonym)|uniprotkb:FATP4(gene name synonym)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase(gene name synonym)|uniprotkb:Very long-chain acyl-CoA synthetase 4(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Li et al. (2013) pubmed:23290633|imex:IM-22647 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9550162|imex:IM-22647-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001092757.1|refseq:NP_001165763.1|ensembl:ENSG00000172548(gene)|ensembl:ENST00000311946(transcript)|ensembl:ENST00000435489(transcript)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008521(Protein of unknown function DUF803)|reactome:R-HSA-5223345 refseq:NP_005085.2|ensembl:ENSG00000167114(gene)|ensembl:ENST00000300456(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001579"(medium-chain fatty acid transport)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0015245"(fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031957"(very long-chain fatty acid-CoA ligase activity)|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0062003"(negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity)|go:"GO:0090433"(palmitoyl-CoA ligase activity)|go:"GO:0090434"(oleoyl-CoA ligase activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1990379"(lipid transport across blood-brain barrier)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR022272|interpro:IPR025110|interpro:IPR030304|interpro:IPR042099|reactome:R-HSA-5619108|reactome:R-HSA-804914|refseq:XP_016869711.1 - - - figure legend:3/4, Supp Fig 3|comment:FATP4 and ichthyin colocalize in the stratum granulosum in healthy skin. Colocalisation was decreased in patients with NIPAL4, SLC27A4, and TGM1 mutations but unchanged in patients with ALOX12B and ALOXE3 mutations.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-skin)|taxid:9606(Homo sapiens skin) - 2014/06/11 2014/10/16 rogid:5eKez6N9+7syo8EGU+EXf0o8gKw9606 rogid:0HD2kZ5IbnIpfLwEK1aFQesLQ289606 intact-crc:1A402B3F24B6C72D|rigid:X6jXkDokTcurnWZbarGLxGs6syE false mutation decreasing interaction:176-176 sufficient binding region:1-168 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)