#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19157	uniprotkb:O08709	intact:EBI-2309446|uniprotkb:Q8BNY4|ensembl:ENSMUSP00000129565	intact:EBI-444895|uniprotkb:Q91WT2|uniprotkb:Q9QWP4|uniprotkb:Q9QWW0	psi-mi:gstp1_mouse(display_long)|uniprotkb:Gstp1(gene name)|psi-mi:Gstp1(display_short)|uniprotkb:Gstpib(gene name synonym)|uniprotkb:GST YF-YF(gene name synonym)|uniprotkb:GST-piB(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:Preadipocyte growth factor(gene name synonym)	psi-mi:prdx6_mouse(display_long)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:Prdx6(gene name)|psi-mi:Prdx6(display_short)|uniprotkb:Aop2(gene name synonym)|uniprotkb:Ltw4(gene name synonym)|uniprotkb:Prdx5(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Zhou et al. (2013)	imex:IM-22636|pubmed:23164639	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9545575|imex:IM-22636-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038569.1|ensembl:ENSMUSG00000060803(gene)|ensembl:ENSMUST00000169613(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:2000429"(negative regulation of neutrophil aggregation)|go:"GO:2000469"(negative regulation of peroxidase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|mint:P19157|rcsb pdb:1BAY|rcsb pdb:1GLP|rcsb pdb:1GLQ|rcsb pdb:1GSY|rcsb pdb:1GTI|rcsb pdb:2GLR|rcsb pdb:2OA7|rcsb pdb:2OAC|rcsb pdb:2OAD|rcsb pdb:3O76|reactome:R-MMU-156590|reactome:R-MMU-3299685|reactome:R-MMU-6798695	refseq:NP_031479.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032060"(bleb assembly)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|reactome:R-MMU-3299685|reactome:R-MMU-6798695|interpro:IPR013766(Thioredoxin domain)|mint:O08709|interpro:IPR036249	-	-	-	figure legend:4|agonist:"t-BOOH  (tert-butylhydroperoxide) - an organic peroxide and oxidising agent."|comment:The association of endogenous Prdx6 and πGST occurred only in the presence of oxidative stress.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2014/06/04	2014/10/16	rogid:hJoMh/r+TgFJqQL95dBmcBsAVn810090	rogid:3Hnse2vkowtSGEobI2LJX6WrNl410090	intact-crc:825464513CEB166E|rigid:8QlouZn0v+mxXeQBiGaylWLuibM	false	-	mutation disrupting interaction:47-47|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O08709	uniprotkb:P19157	intact:EBI-444895|uniprotkb:Q91WT2|uniprotkb:Q9QWP4|uniprotkb:Q9QWW0	intact:EBI-2309446|uniprotkb:Q8BNY4|ensembl:ENSMUSP00000129565	psi-mi:prdx6_mouse(display_long)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:Prdx6(gene name)|psi-mi:Prdx6(display_short)|uniprotkb:Aop2(gene name synonym)|uniprotkb:Ltw4(gene name synonym)|uniprotkb:Prdx5(gene name synonym)	psi-mi:gstp1_mouse(display_long)|uniprotkb:Gstp1(gene name)|psi-mi:Gstp1(display_short)|uniprotkb:Gstpib(gene name synonym)|uniprotkb:GST YF-YF(gene name synonym)|uniprotkb:GST-piB(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:Preadipocyte growth factor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Zhou et al. (2013)	imex:IM-22636|pubmed:23164639	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9545598|imex:IM-22636-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031479.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032060"(bleb assembly)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|reactome:R-MMU-3299685|reactome:R-MMU-6798695|interpro:IPR013766(Thioredoxin domain)|mint:O08709|interpro:IPR036249	refseq:NP_038569.1|ensembl:ENSMUSG00000060803(gene)|ensembl:ENSMUST00000169613(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:2000429"(negative regulation of neutrophil aggregation)|go:"GO:2000469"(negative regulation of peroxidase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|mint:P19157|rcsb pdb:1BAY|rcsb pdb:1GLP|rcsb pdb:1GLQ|rcsb pdb:1GSY|rcsb pdb:1GTI|rcsb pdb:2GLR|rcsb pdb:2OA7|rcsb pdb:2OAC|rcsb pdb:2OAD|rcsb pdb:3O76|reactome:R-MMU-156590|reactome:R-MMU-3299685|reactome:R-MMU-6798695	-	-	-	figure legend:3, 5B|agonist:"t-BOOH  (tert-butylhydroperoxide) - an organic peroxide and oxidising agent."|comment:The association of endogenous Prdx6 and πGST occurred only in the presence of oxidative stress.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2014/06/04	2014/10/16	rogid:3Hnse2vkowtSGEobI2LJX6WrNl410090	rogid:hJoMh/r+TgFJqQL95dBmcBsAVn810090	intact-crc:F1B6E77F3A7CAC95|rigid:8QlouZn0v+mxXeQBiGaylWLuibM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30041	uniprotkb:P09211	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Zhou et al. (2013)	imex:IM-22636|pubmed:23164639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9545625|imex:IM-22636-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:Supp 3A|agonist:hydrogen peroxide - an inorganic oxidising agent|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2014/06/04	2014/10/16	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:B5DB2A4A197077DC|rigid:p+5K3x6cax6q+tccOvgYQs3JGso	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30041	uniprotkb:P09211	intact:EBI-2255129|uniprotkb:A8JZY7|uniprotkb:P32077|uniprotkb:Q5TAH4|uniprotkb:Q5ZEZ8|ensembl:ENSP00000342026	intact:EBI-353467|uniprotkb:O00460|uniprotkb:Q15690|ensembl:ENSP00000381607|uniprotkb:Q5TZY3	psi-mi:prdx6_human(display_long)|uniprotkb:PRDX6(gene name)|psi-mi:PRDX6(display_short)|uniprotkb:AOP2(gene name synonym)|uniprotkb:KIAA0106(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:24 kDa protein(gene name synonym)|uniprotkb:Liver 2D page spot 40(gene name synonym)|uniprotkb:Red blood cells page spot 12(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:gstp1_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short)|uniprotkb:GST3(gene name synonym)|uniprotkb:FAEES3(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:GSTP1-1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Zhou et al. (2013)	imex:IM-22636|pubmed:23164639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9545647|imex:IM-22636-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004896.1|ensembl:ENSG00000117592(gene)|ensembl:ENST00000340385(transcript)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:1PRX|rcsb pdb:5B6M|rcsb pdb:5B6N|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0042744"(hydrogen peroxide catabolic process)	refseq:NP_000843.1|ensembl:ENSG00000084207(gene)|go:"GO:0000302"(response to reactive oxygen species)|ensembl:ENST00000398606(transcript)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0035732"(nitric oxide storage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P09211|rcsb pdb:10GS|rcsb pdb:11GS|rcsb pdb:12GS|rcsb pdb:13GS|rcsb pdb:14GS|rcsb pdb:16GS|rcsb pdb:17GS|rcsb pdb:18GS|rcsb pdb:19GS|rcsb pdb:1AQV|rcsb pdb:1AQW|rcsb pdb:1AQX|rcsb pdb:1EOG|rcsb pdb:1EOH|rcsb pdb:1GSS|rcsb pdb:1KBN|rcsb pdb:1LBK|rcsb pdb:1MD3|rcsb pdb:1MD4|rcsb pdb:1PGT|rcsb pdb:1PX6|rcsb pdb:1PX7|rcsb pdb:1ZGN|rcsb pdb:20GS|rcsb pdb:22GS|rcsb pdb:2A2R|rcsb pdb:2A2S|rcsb pdb:2GSS|rcsb pdb:2J9H|rcsb pdb:2PGT|rcsb pdb:3CSH|rcsb pdb:3CSI|rcsb pdb:3CSJ|rcsb pdb:3DD3|rcsb pdb:3DGQ|rcsb pdb:3GSS|rcsb pdb:3GUS|rcsb pdb:3HJM|rcsb pdb:3HJO|rcsb pdb:3HKR|rcsb pdb:3IE3|rcsb pdb:3KM6|rcsb pdb:3KMN|rcsb pdb:3KMO|rcsb pdb:3N9J|rcsb pdb:3PGT|rcsb pdb:4GSS|rcsb pdb:4PGT|rcsb pdb:5DAK|rcsb pdb:5DAL|rcsb pdb:5DCG|rcsb pdb:5DDL|rcsb pdb:5DJL|rcsb pdb:5DJM|rcsb pdb:5GSS|rcsb pdb:5J41|rcsb pdb:5JCW|rcsb pdb:5L6X|rcsb pdb:5X79|rcsb pdb:6AP9|rcsb pdb:6GSS|rcsb pdb:6LLX|rcsb pdb:6Y1E|rcsb pdb:7GSS|rcsb pdb:8GSS|rcsb pdb:9GSS|reactome:R-HSA-156590|reactome:R-HSA-3299685|reactome:R-HSA-6798695|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)	-	-	-	figure legend:Supp 3B|agonist:"t-BOOH - (tert-butylhydroperoxide)  an organic oxidising agent"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2014/06/04	2014/10/16	rogid:ZMsHgrAJf0VJiCELzo+zSi8Ji+49606	rogid:JxqbNusNIvkTg3Cq+7pmygP/EIA9606	intact-crc:B3B1EB284E369DB8|rigid:p+5K3x6cax6q+tccOvgYQs3JGso	false	-	tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)