#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:C0H519 uniprotkb:Q8IJK2 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0114"(x-ray crystallography) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9544766|wwpdb:4EOY|imex:IM-22714-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Table 1|3d-resolution:2.2A|3d-r-factors:working 20.5%, free 27.9%|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:FA0D411AE6CD8FBA|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false sufficient binding region:103-110(LIG_LIR_Apic_2) sufficient binding region:1-124(IPR029071)|mutation:32-32,119-119,122-122|tag:n-n 3 3 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IJK2 uniprotkb:C0H519 intact:EBI-9544757|ensemblprotists:CZT98454 intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9544819|imex:IM-22714-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - - - figure legend:Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(562-rosetta ii de3)|taxid:562(Escherichia coli) - 2014/06/03 2014/10/16 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:B939DD699F0CD4A6|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false mutation:32-32,119-119,122-122|his tag:n-n maltose binding protein tag:n-n|mutation decreasing interaction:105-105 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:C0H519 uniprotkb:Q8IJK2 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9544863|imex:IM-22714-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Fig. 1d, Fig 5c, Fig. 5d, Fig. 5e|kinetic_conditions:Temp = 25C|kinetics:"PfAtg3 (C0H519) binds to wild-type PfAtg8 (Q8IJK2) with Kd = 290 x 10e-9 molar, k-on = 54.3 x 10e+5 per molar per second, and k-off = 0.13 per second. PfAtg3 (C0H519) binds to the triple cys mutant of PfAtg8 (Q8IJK2) (cys32ile-cys119ser-cys122ser) with Kd = 326 x 10e-9 molar, k-on = 5.1 x 10e+5 per molar per second, and k-off = 0.17 per second."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.9x10^-7(molar)|kon:5.43x10^6(per mole per second)|koff:0.13(second -1) 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:ED996BC80687D3D0|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false maltose binding protein tag:n-n his tag:n-n|mutation:32-32,119-119,122-122 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:C0H519 uniprotkb:C0H519 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9544908|imex:IM-22714-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - - - figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:9340D50AE1D6BAB7|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false maltose binding protein tag:n-n sufficient binding region:103-110(LIG_LIR_Apic_2) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:C0H519 uniprotkb:Q8IJK2 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9544908|imex:IM-22714-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:9340D50AE1D6BAB7|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false maltose binding protein tag:n-n his tag:n-n|mutation:32-32,119-119,122-122 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16971" uniprotkb:C0H519 intact:EBI-9545777|chebi:"CHEBI:11136"|chebi:"CHEBI:13877"|chebi:"CHEBI:3026"|chebi:"CHEBI:22709" intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:benzene-1,2,4-triol(display_short)|psi-mi:"CHEBI:16971"(display_long)|intact:1,2,4-benzenetriol(synonym)|intact:1,2,4-Benzenetriol(synonym)|intact:1,2,4-Trihydroxybenzene(synonym)|intact:Benzene-1,2,4-triol(synonym)|intact:Hydroxyhydroquinone(synonym)|intact:Hydroxyquinol(synonym)|intact:benzene-1,2,4-triol(iupac name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9545793|imex:IM-22714-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - inchi key:GGNQRNBDZQJCCN-UHFFFAOYSA-N - figure legend:Fig. 7b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) ic50:1.0x10^-3(molar) 2014/06/03 2014/10/16 - rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:BFEFC69BAC80FD01 false - maltose binding protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:C0H519 uniprotkb:Q8IJK2 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9545793|imex:IM-22714-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Fig. 7b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) ic50:1.0x10^-3(molar) 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:BFEFC69BAC80FD01 false maltose binding protein tag:n-n his tag:n-n|mutation:32-32,119-119,122-122 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:C0H519 uniprotkb:Q8IJK2 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9545814|imex:IM-22714-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Fig. 7b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) ic50:150.0x10^-6(molar) 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:2CACBF567F5B3729 false maltose binding protein tag:n-n his tag:n-n|mutation:32-32,119-119,122-122 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16164" uniprotkb:C0H519 intact:EBI-9545816|chebi:"CHEBI:45264"|chebi:"CHEBI:11135"|chebi:"CHEBI:14985"|chebi:"CHEBI:22708"|chebi:"CHEBI:482" intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:pyrogallol(display_short)|psi-mi:"CHEBI:16164"(display_long)|intact:1,2,3-Benzenetriol(synonym)|intact:1,2,3-Trihydroxybenzene(synonym)|intact:benzene-1,2,3-triol(synonym)|intact:Pyrogallic acid(synonym)|intact:Pyrogallol(synonym)|intact:benzene-1,2,3-triol(iupac name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9545814|imex:IM-22714-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - inchi key:WQGWDDDVZFFDIG-UHFFFAOYSA-N - figure legend:Fig. 7b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) ic50:150.0x10^-6(molar) 2014/06/03 2014/10/16 - rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:2CACBF567F5B3729 false - maltose binding protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16971" uniprotkb:Q8IJK2 intact:EBI-9545777|chebi:"CHEBI:11136"|chebi:"CHEBI:13877"|chebi:"CHEBI:3026"|chebi:"CHEBI:22709" intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:benzene-1,2,4-triol(display_short)|psi-mi:"CHEBI:16971"(display_long)|intact:1,2,4-benzenetriol(synonym)|intact:1,2,4-Benzenetriol(synonym)|intact:1,2,4-Trihydroxybenzene(synonym)|intact:Benzene-1,2,4-triol(synonym)|intact:Hydroxyhydroquinone(synonym)|intact:Hydroxyquinol(synonym)|intact:benzene-1,2,4-triol(iupac name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551691|imex:IM-22714-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - inchi key:GGNQRNBDZQJCCN-UHFFFAOYSA-N - figure legend:Suppl. Fig. S9, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:1BDEDF6B3EC567F1 false - mutation decreasing interaction:19-19,47-47|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16164" uniprotkb:Q8IJK2 intact:EBI-9545816|chebi:"CHEBI:45264"|chebi:"CHEBI:11135"|chebi:"CHEBI:14985"|chebi:"CHEBI:22708"|chebi:"CHEBI:482" intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:pyrogallol(display_short)|psi-mi:"CHEBI:16164"(display_long)|intact:1,2,3-Benzenetriol(synonym)|intact:1,2,3-Trihydroxybenzene(synonym)|intact:benzene-1,2,3-triol(synonym)|intact:Pyrogallic acid(synonym)|intact:Pyrogallol(synonym)|intact:benzene-1,2,3-triol(iupac name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551760|imex:IM-22714-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - inchi key:WQGWDDDVZFFDIG-UHFFFAOYSA-N - figure legend:Suppl. Fig. S9, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:93F6DF6B3FB30EFA false - his tag:n-n|mutation decreasing interaction:19-19,47-47 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16318" uniprotkb:Q8IJK2 intact:EBI-9551775|chebi:"CHEBI:12033"|chebi:"CHEBI:20456"|chebi:"CHEBI:40103"|chebi:"CHEBI:1912" intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:4-nitrocatechol(display_short)|psi-mi:"CHEBI:16318"(display_long)|intact:1,2-Dihydroxy-4-nitrobenzene(synonym)|intact:4-Nitrocatechol(synonym)|intact:4-nitrocatechol OK(synonym)|intact:4-Nitropyrocatechol(synonym)|intact:4-nitrobenzene-1,2-diol(iupac name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551773|imex:IM-22714-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - inchi key:XJNPNXSISMKQEX-UHFFFAOYSA-N - figure legend:Suppl. Fig. S9, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:97BCDF6B3CFA9714 false - his tag:n-n|mutation decreasing interaction:19-19,47-47 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:78877" uniprotkb:Q8IJK2 intact:EBI-9551676 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:1,3-indandione(display_short)|psi-mi:"CHEBI:78877"(display_long) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551815|imex:IM-22714-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Suppl. Fig. S9, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:55CF6047B022C28F false - his tag:n-n|mutation decreasing interaction:19-19,47-47 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:490095" uniprotkb:Q8IJK2 intact:EBI-9551827|chebi:"CHEBI:4852"|chebi:"CHEBI:605090" intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:esculetin(display_short)|psi-mi:"CHEBI:490095"(display_long)|intact:6,7-dihydroxy-2H-1-benzopyran-2-one(synonym)|intact:6,7-dihydroxycoumarin(synonym)|intact:aesculetin(synonym)|intact:cichorigenin(synonym)|intact:cichoriin aglucon(synonym)|intact:cichoriin aglycon(synonym)|intact:esculetin(synonym)|intact:Esculetin(synonym)|intact:esculin aglucon(synonym)|intact:esculin aglycon(synonym)|intact:6,7-dihydroxy-2H-chromen-2-one(iupac name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551845|imex:IM-22714-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - inchi key:ILEDWLMCKZNDJK-UHFFFAOYSA-N - figure legend:Suppl. Fig. S9, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:9CD1F3A926324065 false - his tag:n-n|mutation decreasing interaction:19-19,47-47 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:78878" uniprotkb:Q8IJK2 intact:EBI-9551679 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:nbd-chloride(display_short)|psi-mi:"CHEBI:78878"(display_long) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551856|imex:IM-22714-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Suppl. Fig. S9, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:55CF6047B3B8AD1F false - his tag:n-n|mutation decreasing interaction:19-19,47-47 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16164" uniprotkb:C0H519 intact:EBI-9545816|chebi:"CHEBI:45264"|chebi:"CHEBI:11135"|chebi:"CHEBI:14985"|chebi:"CHEBI:22708"|chebi:"CHEBI:482" intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:pyrogallol(display_short)|psi-mi:"CHEBI:16164"(display_long)|intact:1,2,3-Benzenetriol(synonym)|intact:1,2,3-Trihydroxybenzene(synonym)|intact:benzene-1,2,3-triol(synonym)|intact:Pyrogallic acid(synonym)|intact:Pyrogallol(synonym)|intact:benzene-1,2,3-triol(iupac name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551920|imex:IM-22714-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - inchi key:WQGWDDDVZFFDIG-UHFFFAOYSA-N - figure legend:Suppl. Fig. S11|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:682A93BCA9FF3256 false - maltose binding protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IJK2 uniprotkb:C0H519 intact:EBI-9544757|ensemblprotists:CZT98454 intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:1235"(thermal shift binding) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9544935|imex:IM-22714-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - - - figure legend:Fig. 1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:4C6D8C51525D4D05|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false mutation:119-119,122-122,32-32|his tag:n-n sufficient binding region:103-110(LIG_LIR_Apic_2) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:490095" uniprotkb:Q8IJK2 intact:EBI-9551827|chebi:"CHEBI:4852"|chebi:"CHEBI:605090" intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:esculetin(display_short)|psi-mi:"CHEBI:490095"(display_long)|intact:6,7-dihydroxy-2H-1-benzopyran-2-one(synonym)|intact:6,7-dihydroxycoumarin(synonym)|intact:aesculetin(synonym)|intact:cichorigenin(synonym)|intact:cichoriin aglucon(synonym)|intact:cichoriin aglycon(synonym)|intact:esculetin(synonym)|intact:Esculetin(synonym)|intact:esculin aglucon(synonym)|intact:esculin aglycon(synonym)|intact:6,7-dihydroxy-2H-chromen-2-one(iupac name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:1235"(thermal shift binding) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551867|imex:IM-22714-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - inchi key:ILEDWLMCKZNDJK-UHFFFAOYSA-N - figure legend:Fig. 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:C30EADDB40EA110F false - his tag:n-n|mutation:32-32,119-119,122-122 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16318" uniprotkb:Q8IJK2 intact:EBI-9551775|chebi:"CHEBI:12033"|chebi:"CHEBI:20456"|chebi:"CHEBI:40103"|chebi:"CHEBI:1912" intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:4-nitrocatechol(display_short)|psi-mi:"CHEBI:16318"(display_long)|intact:1,2-Dihydroxy-4-nitrobenzene(synonym)|intact:4-Nitrocatechol(synonym)|intact:4-nitrocatechol OK(synonym)|intact:4-Nitropyrocatechol(synonym)|intact:4-nitrobenzene-1,2-diol(iupac name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:1235"(thermal shift binding) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551879|imex:IM-22714-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - inchi key:XJNPNXSISMKQEX-UHFFFAOYSA-N - figure legend:Fig. 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:4FDF2227CE66EC07 false - his tag:n-n|mutation:32-32,119-119,122-122 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16971" uniprotkb:Q8IJK2 intact:EBI-9545777|chebi:"CHEBI:11136"|chebi:"CHEBI:13877"|chebi:"CHEBI:3026"|chebi:"CHEBI:22709" intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:benzene-1,2,4-triol(display_short)|psi-mi:"CHEBI:16971"(display_long)|intact:1,2,4-benzenetriol(synonym)|intact:1,2,4-Benzenetriol(synonym)|intact:1,2,4-Trihydroxybenzene(synonym)|intact:Benzene-1,2,4-triol(synonym)|intact:Hydroxyhydroquinone(synonym)|intact:Hydroxyquinol(synonym)|intact:benzene-1,2,4-triol(iupac name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:1235"(thermal shift binding) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9551891|imex:IM-22714-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - inchi key:GGNQRNBDZQJCCN-UHFFFAOYSA-N - figure legend:Fig. 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 - rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:BE7338E5FABB222E false - mutation:32-32,119-119,122-122|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:C0H519 uniprotkb:Q8IJK2 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0096"(pull down) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9545570|imex:IM-22714-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Fig. 4b, Fig. S7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:16A0910360B9B8AF|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false - his tag:n-n|mutation:32-32,119-119,122-122 - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q8IJK2 uniprotkb:C0H519 intact:EBI-9544757|ensemblprotists:CZT98454 intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:0038"(dynamic light scattering) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9545652|imex:IM-22714-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - - - figure legend:Fig. 5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:72406A062245407B|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false his tag:n-n his tag:n-n 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IJK2 uniprotkb:C0H519 intact:EBI-9544757|ensemblprotists:CZT98454 intact:EBI-9544745|ensemblprotists:CAX64196 psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:"MI:0071"(molecular sieving) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9545701|imex:IM-22714-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) - - - figure legend:Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 intact-crc:7241FB315242D5CE|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false his tag:n-n his tag:n-n 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:C0H519 uniprotkb:Q8IJK2 intact:EBI-9544745|ensemblprotists:CAX64196 intact:EBI-9544757|ensemblprotists:CZT98454 psi-mi:c0h519_plaf7(display_long)|uniprotkb:PF3D7_0905700.2(orf name) psi-mi:q8ijk2_plaf7(display_long)|uniprotkb:PF3D7_1019900(orf name) psi-mi:"MI:0096"(pull down) Hain et al. (2012) imex:IM-22714|pubmed:22982544 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9545735|imex:IM-22714-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-PFA-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|rcsb pdb:4EOY|refseq:XP_002808915.1|ensemblprotists:CAX64196(transcript)|ensemblprotists:PF3D7_0905700.2(gene)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000153"(cytoplasmic ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019776"(Atg8 ligase activity)|go:"GO:0044804"(autophagy of nucleus) reactome:R-PFA-1632852|interpro:IPR004241("Light chain 3 (LC3)")|rcsb pdb:4EOY|refseq:XP_001347478.1|interpro:IPR029071|ensemblprotists:CZT98454(transcript)|ensemblprotists:PF3D7_1019900(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0016020"(membrane)|go:"GO:0020011"(apicoplast)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding) - - - figure legend:Fig. 6c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/03 2014/10/16 rogid:atX/D2YLWq64BKpxJkbKr2i048s36329 rogid:r0DPopBJ35mDXyatUUIda1Agkv436329 intact-crc:C128BE468B1A4637|rigid:rzGV+APRYfP5+lbL5IT/Og+ahXo false maltose binding protein tag:n-n mutation decreasing interaction:49-49|mutation disrupting interaction:27-27|mutation decreasing interaction:44-46|mutation disrupting interaction:47-47|mutation disrupting interaction:19-19,47-47|his tag:n-n|necessary binding region:68-76 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)