#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HA65	uniprotkb:Q96CV9	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636165|imex:IM-22998-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	go:"GO:0031410"(cytoplasmic vesicle)	-	-	figure legend:1G, H, S5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2018/04/06	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:44FAE00C3A35BB9F|rigid:OqzG6rpnIbBXQPtQo69BcPAQxcQ	false	green fluorescent protein tag:?-?|sufficient binding region:218-648	ha tag:?-?|mutation increasing interaction:50-50	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9HA65	uniprotkb:P02786	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636200|imex:IM-22998-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	go:"GO:0031410"(cytoplasmic vesicle)	-	-	figure legend:S1A|comment:"Optineurin (HA-tagged optineurin transfected, UniProt AC Q96CV9) enhanced colocalization."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2014/10/16	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	intact-crc:E3D67F4A50109486|rigid:jPrV/J2kk4cdwSGFkRXFbwMdatE	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P61006	uniprotkb:Q9HA65	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636258|imex:IM-22998-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	-	-	comment:Knock down of optineurin decreases interaction.	figure legend:2B and S1C|comment:"Optineurin (HA-tagged optineurin Uniprot AC  Q96CV9 transfected) enhanced the innteraction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2014/10/16	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	intact-crc:7D451E548E9E9A21|rigid:Pcvku8iFPfhaNopGZAM3COiYU7w	false	-	ha tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02786	uniprotkb:P61006	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636384|imex:IM-22998-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:S3A|comment:"TBC1D17 (GFP-tagged TBC1D17 Uniprot AC  Q9HA65 transfected) with a arg381ala mutation enhanced the innteraction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2014/10/16	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:69B8C5CD083EA09D|rigid:1x2IKqEgGQCCYgyik6wSKIwGgcA	false	-	mutation decreasing interaction:22-22|green fluorescent protein tag:?-?|mutation:67-67	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02786	uniprotkb:P61006	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636333|imex:IM-22998-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:6D|comment:"In cells coexpressing TBC1D17 and Rab8, the amount of Rab8 colocalising with TFRC was significantly reduced. Catalitically inactive TBC1D17 (GFP-tagged TBC1D17 Uniprot AC  Q9HA65 transfected with a arg381ala mutation) had no effect on the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2014/10/16	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:71015084867AD9AD|rigid:1x2IKqEgGQCCYgyik6wSKIwGgcA	false	-	ha tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q96CV9	uniprotkb:P61006	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636359|imex:IM-22998-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:8C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2018/04/06	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:0D465861349A5B46|rigid:kubdsvSXhuv4ySJ7+baZLwayrhc	false	green fluorescent protein tag:?-?|mutation decreasing interaction:50-50	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P61006	uniprotkb:Q96CV9	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636420|imex:IM-22998-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	omim:137760(see-also)	-	comment:OPTN glu50lys also interacted	figure legend:S6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/03	2018/04/06	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:975B74CBCF444F7B|rigid:kubdsvSXhuv4ySJ7+baZLwayrhc	false	-	mutation disrupting interaction:50-50	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HA65	uniprotkb:Q96CV9	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636025|imex:IM-22998-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	comment:OPTN glu50lys also interacted	figure legend:1A, S3C, S4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/03	2018/04/06	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:C88AE58C71BA4ADB|rigid:OqzG6rpnIbBXQPtQo69BcPAQxcQ	false	-	necessary binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HA65	uniprotkb:Q96CV9	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636072|imex:IM-22998-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/03	2018/04/06	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:152FB8E256753901|rigid:OqzG6rpnIbBXQPtQo69BcPAQxcQ	false	necessary binding region:1-309|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HA65	uniprotkb:Q96CV9	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636218|imex:IM-22998-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	-	figure legend:2A|comment:Knock down of optineurin abolishes the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2018/04/06	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:B3580A4F17D7A6EF|rigid:RG+WtF7YHAI8l83Y3LprlDW78AM	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HA65	uniprotkb:P61006	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636218|imex:IM-22998-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:2A|comment:Knock down of optineurin abolishes the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2018/04/06	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:B3580A4F17D7A6EF|rigid:RG+WtF7YHAI8l83Y3LprlDW78AM	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HA65	uniprotkb:Q96CV9	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636405|imex:IM-22998-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	comment:OPTN glu50lys also interacted	figure legend:2A|comment:Knock down of optineurin abolishes the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/03	2018/04/06	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:9F514F4DE815557D|rigid:OqzG6rpnIbBXQPtQo69BcPAQxcQ	false	green fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96CV9	uniprotkb:Q9HA65	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	intact:EBI-714625|ensembl:ENSP00000221543|ensembl:ENSP00000446323|uniprotkb:B9A6L8|uniprotkb:B4DT12|uniprotkb:F5H1W7	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:tbc17_human(display_long)|uniprotkb:TBC1D17(gene name)|psi-mi:TBC1D17(display_short)	psi-mi:"MI:0096"(pull down)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636102|imex:IM-22998-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	refseq:NP_001161694.1|ensembl:ENSG00000104946(gene)|ensembl:ENST00000221543(transcript)|ensembl:ENST00000535102(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214|go:"GO:0090630"(activation of GTPase activity)|refseq:NP_078958.2|go:"GO:0055037"(recycling endosome)	-	-	-	figure legend:1E and F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2018/04/06	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	rogid:/FUNCWD2xK94tfYIyhG5trPsFMs9606	intact-crc:B23448DFF2577859|rigid:OqzG6rpnIbBXQPtQo69BcPAQxcQ	false	glutathione s tranferase tag:?-?	green fluorescent protein tag:?-?|necessary binding region:218-309|sufficient binding region:218-648	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P02786	uniprotkb:P61006	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vaibhava et al. (2012)	imex:IM-22998|pubmed:22854040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9636267|imex:IM-22998-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:6B and C|comment:"Co-transfection of  GFP-tagged TBC1D17 (UniProt AC Q9HA65) with arg381ala mutation enhanced interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2014/10/16	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:CDB6C5CACE29C6A4|rigid:1x2IKqEgGQCCYgyik6wSKIwGgcA	false	sufficient binding region:1-67|glutathione s tranferase tag:n-n	green fluorescent protein tag:?-?|mutation:67-67|mutation decreasing interaction:22-22	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)