#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04206	uniprotkb:O60885	intact:EBI-73886|ensembl:ENSP00000384273|uniprotkb:Q6GTV1|uniprotkb:Q6SLK1	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:tf65_human(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9870709|rcsb pdb:2LSP|imex:IM-23230-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_001138610.1|refseq:NP_068810.3|refseq:NP_001230913.1|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0070301"(cellular response to hydrogen peroxide)|dip:DIP-24238N|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0051607"(defense response to virus)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|mint:Q04206|rcsb pdb:1NFI|rcsb pdb:2LSP|rcsb pdb:2O61|rcsb pdb:3GUT|rcsb pdb:3QXY|rcsb pdb:3RC0|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:5U4K|rcsb pdb:5URN|rcsb pdb:6NV2|rcsb pdb:6QHL|rcsb pdb:6QHM|rcsb pdb:6YOW|rcsb pdb:6YOX|rcsb pdb:6YOY|rcsb pdb:6YP2|rcsb pdb:6YP3|rcsb pdb:6YP8|rcsb pdb:6YPL|rcsb pdb:6YPY|rcsb pdb:6YQ2|rcsb pdb:7BI3|rcsb pdb:7BIQ|rcsb pdb:7BIY|rcsb pdb:7BJF|rcsb pdb:7BJL|rcsb pdb:7BJW|rcsb pdb:7BKH|rcsb pdb:7NJ9|rcsb pdb:7NJB|rcsb pdb:7NK3|rcsb pdb:7NK5|rcsb pdb:7NLA|rcsb pdb:7NLE|rcsb pdb:7NM1|rcsb pdb:7NM3|rcsb pdb:7NM9|rcsb pdb:7NQP|rcsb pdb:7NR7|rcsb pdb:7NSV|rcsb pdb:7NV4|rcsb pdb:7NVI|rcsb pdb:7NWS|rcsb pdb:7NXS|rcsb pdb:7NXT|rcsb pdb:7NXW|rcsb pdb:7NXY|rcsb pdb:7NY4|rcsb pdb:7NYE|rcsb pdb:7NYF|rcsb pdb:7NYG|rcsb pdb:7NZ6|rcsb pdb:7NZG|rcsb pdb:7NZK|rcsb pdb:7NZV|rcsb pdb:7O34|rcsb pdb:7O3A|rcsb pdb:7O3F|rcsb pdb:7O3P|rcsb pdb:7O3Q|rcsb pdb:7O3R|rcsb pdb:7O3S|rcsb pdb:7O57|rcsb pdb:7O59|rcsb pdb:7O5A|rcsb pdb:7O5C|rcsb pdb:7O5D|rcsb pdb:7O5F|rcsb pdb:7O5G|rcsb pdb:7O5O|rcsb pdb:7O5P|rcsb pdb:7O5S|rcsb pdb:7O5U|rcsb pdb:7O5X|rcsb pdb:7O6F|rcsb pdb:7O6G|rcsb pdb:7O6I|rcsb pdb:7O6J|rcsb pdb:7O6K|rcsb pdb:7O6M|rcsb pdb:7O6O|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|reactome:R-HSA-448706|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9660826	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:Suppl. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/23	2014/12/23	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:C1056058E6F1A23C|rigid:xlpdNgamIYFonUS2GH9vgiubMy0	false	sufficient binding region:304-316|N6-acetyl-L-lysine:310-310	13c label:?-?|sufficient binding region:333-460(IPR001487)|15n label:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:O60885	intact:EBI-10107976	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10107983|imex:IM-23230-2|rcsb pdb:4F3I	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Suppl. Table 2|3d-resolution:1.40A|3d-r-factors:working 13.6%, free 18.3%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/23	2015/02/17	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:B8769C517C8F34B8	false	-	sufficient binding region:42-168(IPR001487)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:O60885	intact:EBI-10107976	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10636523|imex:IM-23230-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Fig. 2b|comment:"The second bromodomain of Brd4 (BRD4-BD2) bound MS417 with similar affinity (Kd = 25.4 +/- 3.4 nM) as measured by ITC; however, this result is not shown."|kinetic_conditions:Temp = 15C, pH = 7.4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:36.1x10^-9 ~7.8(molar)	2014/10/23	2015/02/18	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:D113E29DCF56DC67	false	-	sufficient binding region:42-168(IPR001487)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:O60885	intact:EBI-10107976	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10636544|imex:IM-23230-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.03x10^-6 ~0.004(molar)	2014/10/23	2015/02/17	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:1545CAC572B6BB27	false	fluorescein isothiocyanate label:?-?	sufficient binding region:42-168(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:O60885	intact:EBI-10107976	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10636544|imex:IM-23230-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.03x10^-6 ~0.004(molar)	2014/10/23	2015/02/17	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:1545CAC572B6BB27	false	-	sufficient binding region:42-168(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:O60885	intact:EBI-10107976	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10636555|imex:IM-23230-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.046x10^-6 ~0.004(molar)	2014/10/23	2015/02/17	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:F8C4CEDE4F70F520	false	fluorescein isothiocyanate label:?-?	sufficient binding region:333-460(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:O60885	intact:EBI-10107976	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10636555|imex:IM-23230-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.046x10^-6 ~0.004(molar)	2014/10/23	2015/02/17	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:F8C4CEDE4F70F520	false	-	sufficient binding region:333-460(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:Q92793	intact:EBI-10107976	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637511|imex:IM-23230-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:32.7x10^-6 ~0.9(molar)	2014/10/23	2015/03/04	-	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	intact-crc:52E9E0F5F56147F8	false	-	sufficient binding region:1082-1197(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:Q92793	intact:EBI-10107976	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637511|imex:IM-23230-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:32.7x10^-6 ~0.9(molar)	2014/10/23	2015/03/04	-	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	intact-crc:52E9E0F5F56147F8	false	fluorescein isothiocyanate label:?-?	sufficient binding region:1082-1197(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:Q92793	intact:EBI-10107976	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637522|imex:IM-23230-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Suppl. Fig. 3b, 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:18.0x10^-6 ~0.9(molar)	2014/10/23	2015/02/18	-	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	intact-crc:9F69F00DB8658D44	false	fluorescein isothiocyanate label:?-?	sufficient binding region:1082-1197(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:O60885	intact:EBI-10107976	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637532|imex:IM-23230-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Suppl. Fig. 3b, 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.085x10^-6 ~0.009(molar)	2014/10/23	2015/02/18	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:2A42B1D09AE12EDE	false	fluorescein isothiocyanate label:?-?	sufficient binding region:42-168(IPR001487)|sufficient binding region:333-460	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:Q15059	intact:EBI-10107976	intact:EBI-1383460|uniprotkb:Q5T1R7|uniprotkb:Q8N5M3|uniprotkb:Q92645|uniprotkb:Q4G5Y3|uniprotkb:B1APD9|ensembl:ENSP00000305918	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd3_human(display_long)|uniprotkb:BRD3(gene name)|psi-mi:BRD3(display_short)|uniprotkb:KIAA0043(gene name synonym)|uniprotkb:RING3L(gene name synonym)|uniprotkb:RING3-like protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637552|imex:IM-23230-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006717354.1|refseq:NP_031397.1|refseq:XP_011517354.1|dip:DIP-39755N|ensembl:ENSG00000169925(gene)|ensembl:ENST00000303407(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0070577"(lysine-acetylated histone binding)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|rcsb pdb:2E7N|rcsb pdb:2NXB|rcsb pdb:2OO1|rcsb pdb:2YW5|rcsb pdb:3S91|rcsb pdb:3S92|rcsb pdb:5A7C|rcsb pdb:5HFR|rcsb pdb:5HJC|rcsb pdb:6BGG|rcsb pdb:6BGH|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6U4A|rcsb pdb:6ULP|rcsb pdb:6I7A|rcsb pdb:6QJU|rcsb pdb:7JQ8|rcsb pdb:7JYN|rcsb pdb:7JYZ|rcsb pdb:7JMY	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Suppl. Fig. 3b, 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.11x10^-6 ~0.01(molar)	2014/10/23	2015/03/04	-	rogid:RIwhmbGQ4NziOcjy4M80p+TY1OQ9606	intact-crc:87367D8BFDB4B5B0	false	fluorescein isothiocyanate label:?-?	sufficient binding region:51..51-123..123(IPR001487)|sufficient binding region:326..326-398..398	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:Q9NPI1	intact:EBI-10107976	intact:EBI-711221|uniprotkb:Q4VC09|uniprotkb:Q8N2L9|uniprotkb:Q96KA4|uniprotkb:Q9BV48|uniprotkb:Q9UH59|intact:EBI-2560548|ensembl:ENSP00000378180	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:brd7_human(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Protein CELTIX-1(gene name synonym)|uniprotkb:BRD7(gene name)|psi-mi:BRD7(display_short)|uniprotkb:BP75(gene name synonym)|uniprotkb:CELTIX1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637571|imex:IM-23230-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001167455.1|refseq:NP_037395.2|dip:DIP-32509N|ensembl:ENSG00000166164(gene)|ensembl:ENST00000394688(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:Q9NPI1|rcsb pdb:2I7K|rcsb pdb:5MQ1|rcsb pdb:6PPA|rcsb pdb:6V0Q|rcsb pdb:6V16|rcsb pdb:6V17|rcsb pdb:6V1E|rcsb pdb:6V1F|rcsb pdb:6V1H|reactome:R-HSA-6804758	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Suppl. Fig. 3b, 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.8x10^-6 ~1.0(molar)	2014/10/23	2015/03/04	-	rogid:F1N3XsdbpPy8TgHdMLSmnhdKNYs9606	intact-crc:9F0790EDD061D5D1	false	fluorescein isothiocyanate label:?-?	sufficient binding region:148..148-218..218(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:83406"	uniprotkb:Q12830	intact:EBI-10107976	intact:EBI-1560273|uniprotkb:Q6NX67|uniprotkb:Q7Z7D6|uniprotkb:Q9UIG2|ensembl:ENSP00000315454	psi-mi:ms-417(display_short)|psi-mi:"CHEBI:83406"(display_long)|intact:MS417(synonym)|intact:"methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)	psi-mi:bptf_human(display_long)|uniprotkb:Bromodomain and PHD finger-containing transcription factor(gene name synonym)|uniprotkb:Fetal Alzheimer antigen(gene name synonym)|uniprotkb:Fetal Alz-50 clone 1 protein(gene name synonym)|uniprotkb:BPTF(gene name)|psi-mi:BPTF(display_short)|uniprotkb:FAC1(gene name synonym)|uniprotkb:FALZ(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10637581|imex:IM-23230-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004450.3|refseq:NP_872579.2|dip:DIP-38919N|ensembl:ENSG00000171634(gene)|ensembl:ENST00000321892(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007492"(endoderm development)|go:"GO:0009611"(response to wounding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016589"(NURF complex)|go:"GO:0030425"(dendrite)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR036427|interpro:IPR038028|mint:Q12830|rcsb pdb:2F6J|rcsb pdb:2F6N|rcsb pdb:2FSA|rcsb pdb:2FUI|rcsb pdb:2FUU|rcsb pdb:2RI7|rcsb pdb:3QZS|rcsb pdb:3QZT|rcsb pdb:3QZV|rcsb pdb:3UV2|rcsb pdb:5H6Y|rcsb pdb:5R4G|rcsb pdb:5R4H|rcsb pdb:5R4I|rcsb pdb:5R4J|rcsb pdb:5R4K|rcsb pdb:5R4L|rcsb pdb:5R4M|rcsb pdb:5R4N|rcsb pdb:5R4O|rcsb pdb:6AZE|rcsb pdb:7K6R|rcsb pdb:7K6S|rcsb pdb:7KDW|rcsb pdb:7KDZ	-	inchi key:GGRCIHACOIMRKY-HNNXBMFYSA-N	-	figure legend:Suppl. Fig. 3b, 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:11.8x10^-6 ~0.7(molar)	2014/10/23	2015/03/04	-	rogid:QQehqJ6NUFT7JEUOto64C73imBY9606	intact-crc:F9918F735E6BF110	false	fluorescein isothiocyanate label:?-?	sufficient binding region:2944..2944-3014..3014(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:84982"	uniprotkb:O60885	intact:EBI-10684404	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-566(display_short)|psi-mi:"CHEBI:84982"(display_long)|intact:"methyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)|intact:MS566(synonym)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10684402|imex:IM-23230-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-OAHLLOKOSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:18.5x10^-6 ~1.3(molar)	2014/10/23	2015/03/04	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:FAE849FBCC260878	false	fluorescein isothiocyanate label:?-?	sufficient binding region:42-168(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:84982"	uniprotkb:O60885	intact:EBI-10684404	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-566(display_short)|psi-mi:"CHEBI:84982"(display_long)|intact:"methyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)|intact:MS566(synonym)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10684402|imex:IM-23230-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-OAHLLOKOSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:18.5x10^-6 ~1.3(molar)	2014/10/23	2015/03/04	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:FAE849FBCC260878	false	-	sufficient binding region:42-168(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:84982"	uniprotkb:O60885	intact:EBI-10684404	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-566(display_short)|psi-mi:"CHEBI:84982"(display_long)|intact:"methyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)|intact:MS566(synonym)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10684420|imex:IM-23230-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-OAHLLOKOSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:14.9x10^-6 ~1.1(molar)	2014/10/23	2015/02/24	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:0F6AB173CC4E4BB0	false	fluorescein isothiocyanate label:?-?	sufficient binding region:333-460(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:84982"	uniprotkb:O60885	intact:EBI-10684404	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ms-566(display_short)|psi-mi:"CHEBI:84982"(display_long)|intact:"methyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)|intact:MS566(synonym)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10684420|imex:IM-23230-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	inchi key:GGRCIHACOIMRKY-OAHLLOKOSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:14.9x10^-6 ~1.1(molar)	2014/10/23	2015/02/24	-	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	intact-crc:0F6AB173CC4E4BB0	false	-	sufficient binding region:333-460(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:84982"	uniprotkb:Q92793	intact:EBI-10684404	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	psi-mi:ms-566(display_short)|psi-mi:"CHEBI:84982"(display_long)|intact:"methyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)|intact:MS566(synonym)	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10684431|imex:IM-23230-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	-	inchi key:GGRCIHACOIMRKY-OAHLLOKOSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:120.7x10^-6 ~7.3(molar)	2014/10/23	2015/03/04	-	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	intact-crc:881C3D1602CF3855	false	fluorescein isothiocyanate label:?-?	sufficient binding region:1082-1197(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:84982"	uniprotkb:Q92793	intact:EBI-10684404	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	psi-mi:ms-566(display_short)|psi-mi:"CHEBI:84982"(display_long)|intact:"methyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate"(iupac name)|intact:MS566(synonym)	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Zhang et al. (2012)	pubmed:22645123|imex:IM-23230	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10684431|imex:IM-23230-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	-	inchi key:GGRCIHACOIMRKY-OAHLLOKOSA-N	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:120.7x10^-6 ~7.3(molar)	2014/10/23	2015/03/04	-	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	intact-crc:881C3D1602CF3855	false	-	sufficient binding region:1082-1197(IPR001487)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)