#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-9994533	uniprotkb:P19838-PRO_0000030311	-	intact:EBI-697771	psi-mi:ucp4_human_nfkb-site_dna-probe(display_short)|psi-mi:EBI-9994533(display_long)	psi-mi:p19838-pro_0000030311(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Ho et al. (2012)	imex:IM-23509|pubmed:22580300	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9994536|imex:IM-23509-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000153291(see-also)	intact:EBI-300010(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:433	figure legend:Fig. 3b|comment:Increased binding of p50 to UCP4 probe was observed when the probe was incubated with nuclear extracts from SH-SY5Y cells overexpressing human c-Rel.|comment:"Increased binding of NF-kappaB proteins to UCP4 probe was observed when SH-SY5Y cells were treated with hydrogen peroxide (H2O2) (CHEBI:16240). Binding was decreased when unlabeled UCP4 probe was added as a competitor."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/12/02	2019/01/30	-	rogid:ZgJEP6sTCusv6e6HxIkMJ5Yuv1E9606	intact-crc:84491FE439F2159F	false	biotin tag:1-1	-	-	-	psi-mi:"MI:0981"(tag visualisation by peroxidase activity)	psi-mi:"MI:0981"(tag visualisation by peroxidase activity)
intact:EBI-9994533	uniprotkb:Q04864	-	intact:EBI-307352|uniprotkb:Q2PNZ7|uniprotkb:Q6LDY0|ensembl:ENSP00000295025|intact:EBI-11133860|uniprotkb:Q17RU2	psi-mi:ucp4_human_nfkb-site_dna-probe(display_short)|psi-mi:EBI-9994533(display_long)	psi-mi:rel_human(display_long)|uniprotkb:REL(gene name)|psi-mi:REL(display_short)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Ho et al. (2012)	imex:IM-23509|pubmed:22580300	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9994543|imex:IM-23509-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000153291(see-also)	refseq:NP_002899.1|ensembl:ENSG00000162924(gene)|ensembl:ENST00000295025(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034097"(response to cytokine)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030505|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|interpro:IPR042845|mint:Q04864|reactome:R-HSA-1169091|ensembl:ENSP00000295025|ensembl:ENST00000394479|ensembl:ENSP00000377989|refseq:NP_001278675.1|dip:DIP-301N	-	-	-	figure legend:Fig. 3b|comment:Binding of c-Rel to UCP4 probe was only observed when the probe was incubated with nuclear extracts from SH-SY5Y cells overexpressing human c-Rel.|comment:"Increased binding of NF-kappaB proteins to UCP4 probe was observed when SH-SY5Y cells were treated with hydrogen peroxide (H2O2) (CHEBI:16240). Binding was decreased when unlabeled UCP4 probe was added as a competitor."|causality statement:Q04864 increases expression at RNA level of ENSG00000153291|causality statement:Q04864 increases expression at protein level of ENSG00000153291|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/12/02	2019/01/30	-	rogid:pcMbZU8647eKKyub9wOL93NK6VE9606	intact-crc:ED2BB61C608FF761	false	biotin tag:1-1	-	-	-	psi-mi:"MI:0981"(tag visualisation by peroxidase activity)	psi-mi:"MI:0981"(tag visualisation by peroxidase activity)