#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16602	uniprotkb:O60895	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9635707|imex:IM-22908-1|wwpdb:3aqf	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	-	-	-	3d-r-factors:Rwork = 0.22, Rfree = 0.28|3d-resolution:2.6 A|figure legend:Fig.s 1b-d, 3,  Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2014/10/16	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	intact-crc:D31BE5A5BC2E6958|rigid:bh0ZoryN/bSIarXWyUw/boOw3Ek	false	sufficient binding region:23-136(IPR001879)|L-selenomethionine:?-?	sufficient binding region:56-139|L-selenomethionine:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60895	uniprotkb:O60895	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9635757|imex:IM-22908-2|wwpdb:3aqe	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	-	-	-	3d-r-factors:R = 0.23, Rwork = 0.23, Rfree = 0.28|3d-resolution:2.0 A|figure legend:Fig. 2c, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2014/10/16	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	intact-crc:E321283C7EFD86BE|rigid:T4TmDkClL4egj7u+t+uM97xjmmc	false	sufficient binding region:56-139|L-selenomethionine:?-?	sufficient binding region:56-139|L-selenomethionine:?-?	6	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16602	uniprotkb:O60895	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9635809|imex:IM-22908-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	-	-	-	figure legend:Fig. 4b|comment:arg97 and glu117 mutations to p-benzoyl-L-phenylalanine were much weaker than such mutants at ser94 and phe121.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/03	2014/11/03	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	intact-crc:655C65F0E3B355B4|rigid:bh0ZoryN/bSIarXWyUw/boOw3Ek	false	myc tag:c-c	mutation:94-94|flag tag:c-c|mutation:97-97|mutation:121-121|mutation:117-117|mutation disrupting interaction:93-93|mutation disrupting interaction:120-120|mutation disrupting interaction:124-124|mutation disrupting interaction:128-128	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16602	uniprotkb:O60895	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9678532|imex:IM-22908-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	-	-	-	figure legend:Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/07/03	2014/11/03	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	intact-crc:C3C141BD45944537|rigid:bh0ZoryN/bSIarXWyUw/boOw3Ek	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P06881-PRO_0000004054	reactome:R-HSA-419782	intact:EBI-962972	intact:EBI-9009008|wwpdb:3n7p|wwpdb:3n7r|wwpdb:3n7s|chembl target:CHEMBL2107838	psi-mi:p06881-pro_0000004054(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)	psi-mi:cgrp-receptor_human(display_short)|psi-mi:R-HSA-419782(display_long)|intact:calcitonin-gene-related peptide receptor, CALCRL/RAMP1(complex synonym)|intact:CGRP receptor complex(complex recommended name)|intact:CGRP-R complex(complex synonym)|intact:calrl-ramp1 complex(complex synonym)|intact:"CALCRL:RAMP1"(complex systematic name)|intact:calcitonin-gene-related polypeptide receptor complex(complex synonym)|intact:calcitonin-gene-related peptide receptor complex(complex synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9639463|imex:IM-22908-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:1302"(stable complex)	intact:EBI-962928(chain-parent)	efo:"EFO:0003821"(see-also)|intact:EBI-15876252(exp-evidence)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:1990407"(calcitonin gene-related peptide binding)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|pubmed:24115156(see-also)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|pubmed:18687416(see-also)|pubmed:21649645(see-also)|evidence ontology:"ECO:0000353"|complex portal:CPX-2189(complex-primary)	-	chain-seq-start:83|chain-seq-end:119	curated-complex:"A transmembrane, G-protein-coupled signalling receptor complex that serves as receptor for calcitonin gene-related peptides (CGRP). CGRPs are produced in both peripheral and central neurons and are one of the most potent peptide vasodilators known. Expressed at trigeminal nerve endings that innervate cerebral blood vessels. RAMP1 is responsible for transporting CALCRL to the plasma membrane."|complex-assembly:Heterodimer|complex-properties:"Consisting of the calcitonin receptor-like receptor (CALCRL), a class B G-protein-coupled receptor, and RAMP1, a receptor activity-modifying protein. The ligand binding site resides in the dimerization-interface of the extracellular domains.    Buried surface: 1010 A^2    Complex may also exist with CALCRL as dimer."|ligand:"Calcitonin gene-related peptide 1 (CGRP1, CALCA, alpha-type CGRP) (P06881- PRO_0000004045)"|ligand:"Calcitonin gene-related peptide 2 (CGRP2, CALCB, beta-type CGRP) (P10092-PRO_0000004087)"|disease:Trigeminal nerve ending location, vasodilatory effect, and other evidence suggest a direct role of CGRPs in migraine.	comment:"The complex participants have the following lengths:  CALCRL: 23-136 aa, and RAMP1: 27–112."|figure legend:Table II, Fig. 6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.11x-6^0(molar)	2014/07/03	2016/06/28	rogid:I325+5UFSlBI9a/kg2RBtHheFwM9606	-	intact-crc:FE5D43421FEE379F	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chembl target:CHEMBL2109232	uniprotkb:P06881-PRO_0000004054	intact:EBI-9009036|wwpdb:3aqf|reactome:R-HSA-420232	intact:EBI-962972	psi-mi:am1-receptor_human(display_short)|psi-mi:CHEMBL2109232(display_long)|intact:Adrenomedullin receptor AM1 complex(complex recommended name)|intact:AM1 complex(complex synonym)|intact:CALRL-RAMP2 complex(complex synonym)|intact:"CALCRL:RAMP2"(complex systematic name)|intact:ADM1 receptor(complex synonym)|intact:Adrenomedullin receptor AM1; CALCRL/RAMP2(complex synonym)	psi-mi:p06881-pro_0000004054(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9636341|imex:IM-22908-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0327"(peptide)	go:"GO:1990409"(adrenomedullin binding)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|pubmed:18687416(see-also)|pubmed:21649645(see-also)|pubmed:24115156(see-also)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|evidence ontology:"ECO:0000353"|complex portal:CPX-2191(complex-primary)	intact:EBI-962928(chain-parent)	-	curated-complex:"A transmembrane, G-protein-coupled signalling receptor complex that serves as the adrenomedullin (AM) receptor to control neovascularization and the stabilization of vascular integrity. AM, a polypeptide, belongs to the calcitonin family of peptides. It is produced by vascular smooth muscle cells and endothelial cells and has strong hypotensive and vasodilation activity. RAMP2 is responsible for transporting CALCRL to the plasma membrane."|complex-properties:"Consisting of the calcitonin receptor-like receptor (CALCRL), a class B G-protein-coupled receptor, and RAMP2, a receptor activity-modifying protein. The ligand binding site resides in the dimerization-interface of the extracellular domains.    MW ~80 kD  buried surface: 924 A^2    Complex may also exist with CALCRL as dimer."|complex-assembly:Heterodimer|ligand:"Adrenomedullin (AM, ADM) (P35318, PRO_0000000963)"	chain-seq-start:83|chain-seq-end:119	comment:"The complex participants have the following lengths:  CALCRL: 23-136 aa, and RAMP2: 56-139.     Mutations decreasing:   CALCRL WT / RAMP2 Glu101Ala,   CALCRL WT / RAMP2 Phe111Ala,   CALCRL Trp72Ala / RAMP2 WT,   CALCRL Phe92Ala / RAMP2 WT,   CALCRL Trp121Ala / RAMP2 WT,     Mutation increasing:  CALCRL WT / RAMP2 Ser94Arg/Arg97Ala/Glu101Trp/Phe111Trp"|figure legend:Table II, Fig. 6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.34x-4^0(molar)	2014/07/03	2019/09/03	-	rogid:I325+5UFSlBI9a/kg2RBtHheFwM9606	intact-crc:CA046724341464EE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35318-PRO_0000000963	uniprotkb:Q16602	intact:EBI-9635999	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	psi-mi:p35318-pro_0000000963(display_long)|uniprotkb:ADM(gene name)|psi-mi:ADM(display_short)|uniprotkb:AM(gene name synonym)	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9636239|imex:IM-22908-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-9635935(chain-parent)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	-	chain-seq-start:95|chain-seq-end:146	-	figure legend:Fig. 5a, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x-5^0(molar)	2014/07/03	2014/10/16	rogid:u113h2dRItswthFZ0IgrhFtvQe89606	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	intact-crc:71E89D8BEA4FC42D|rigid:yk5nL7wo50H0H2PTQShxyBqts0k	false	-	sufficient binding region:23-136(IPR001879)|L-selenomethionine:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35318-PRO_0000000963	chembl target:CHEMBL2109232	intact:EBI-9635999	intact:EBI-9009036|wwpdb:3aqf|reactome:R-HSA-420232	psi-mi:p35318-pro_0000000963(display_long)|uniprotkb:ADM(gene name)|psi-mi:ADM(display_short)|uniprotkb:AM(gene name synonym)	psi-mi:am1-receptor_human(display_short)|psi-mi:CHEMBL2109232(display_long)|intact:Adrenomedullin receptor AM1 complex(complex recommended name)|intact:AM1 complex(complex synonym)|intact:CALRL-RAMP2 complex(complex synonym)|intact:"CALCRL:RAMP2"(complex systematic name)|intact:ADM1 receptor(complex synonym)|intact:Adrenomedullin receptor AM1; CALCRL/RAMP2(complex synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9635913|imex:IM-22908-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	intact:EBI-9635935(chain-parent)	go:"GO:1990409"(adrenomedullin binding)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|pubmed:18687416(see-also)|pubmed:21649645(see-also)|pubmed:24115156(see-also)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|evidence ontology:"ECO:0000353"|complex portal:CPX-2191(complex-primary)	-	chain-seq-start:95|chain-seq-end:146	curated-complex:"A transmembrane, G-protein-coupled signalling receptor complex that serves as the adrenomedullin (AM) receptor to control neovascularization and the stabilization of vascular integrity. AM, a polypeptide, belongs to the calcitonin family of peptides. It is produced by vascular smooth muscle cells and endothelial cells and has strong hypotensive and vasodilation activity. RAMP2 is responsible for transporting CALCRL to the plasma membrane."|complex-properties:"Consisting of the calcitonin receptor-like receptor (CALCRL), a class B G-protein-coupled receptor, and RAMP2, a receptor activity-modifying protein. The ligand binding site resides in the dimerization-interface of the extracellular domains.    MW ~80 kD  buried surface: 924 A^2    Complex may also exist with CALCRL as dimer."|complex-assembly:Heterodimer|ligand:"Adrenomedullin (AM, ADM) (P35318, PRO_0000000963)"	comment:"The complex participants have the following lengths:  CALCRL: 23-136 aa, and RAMP2: 56-139.     Mutations decreasing:   CALCRL WT / RAMP2 Glu101Ala,   CALCRL WT / RAMP2 Phe111Ala,   CALCRL Trp72Ala / RAMP2 WT,   CALCRL Phe92Ala / RAMP2 WT,   CALCRL Trp121Ala / RAMP2 WT,   CALCRL WT / RAMP2 Ser94Arg/Arg97Ala/Glu101Trp/Phe111Trp"|figure legend:Fig.s 5a, 5e, 6c, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.96x-8^0(molar)	2014/07/03	2019/09/03	rogid:u113h2dRItswthFZ0IgrhFtvQe89606	-	intact-crc:FF8D34B1D17A5FBC	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-419782	uniprotkb:P35318-PRO_0000000963	intact:EBI-9009008|wwpdb:3n7p|wwpdb:3n7r|wwpdb:3n7s|chembl target:CHEMBL2107838	intact:EBI-9635999	psi-mi:cgrp-receptor_human(display_short)|psi-mi:R-HSA-419782(display_long)|intact:calcitonin-gene-related peptide receptor, CALCRL/RAMP1(complex synonym)|intact:CGRP receptor complex(complex recommended name)|intact:CGRP-R complex(complex synonym)|intact:calrl-ramp1 complex(complex synonym)|intact:"CALCRL:RAMP1"(complex systematic name)|intact:calcitonin-gene-related polypeptide receptor complex(complex synonym)|intact:calcitonin-gene-related peptide receptor complex(complex synonym)	psi-mi:p35318-pro_0000000963(display_long)|uniprotkb:ADM(gene name)|psi-mi:ADM(display_short)|uniprotkb:AM(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9639413|imex:IM-22908-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	efo:"EFO:0003821"(see-also)|intact:EBI-15876252(exp-evidence)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:1990407"(calcitonin gene-related peptide binding)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|pubmed:24115156(see-also)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|pubmed:18687416(see-also)|pubmed:21649645(see-also)|evidence ontology:"ECO:0000353"|complex portal:CPX-2189(complex-primary)	intact:EBI-9635935(chain-parent)	-	curated-complex:"A transmembrane, G-protein-coupled signalling receptor complex that serves as receptor for calcitonin gene-related peptides (CGRP). CGRPs are produced in both peripheral and central neurons and are one of the most potent peptide vasodilators known. Expressed at trigeminal nerve endings that innervate cerebral blood vessels. RAMP1 is responsible for transporting CALCRL to the plasma membrane."|complex-assembly:Heterodimer|complex-properties:"Consisting of the calcitonin receptor-like receptor (CALCRL), a class B G-protein-coupled receptor, and RAMP1, a receptor activity-modifying protein. The ligand binding site resides in the dimerization-interface of the extracellular domains.    Buried surface: 1010 A^2    Complex may also exist with CALCRL as dimer."|ligand:"Calcitonin gene-related peptide 1 (CGRP1, CALCA, alpha-type CGRP) (P06881- PRO_0000004045)"|ligand:"Calcitonin gene-related peptide 2 (CGRP2, CALCB, beta-type CGRP) (P10092-PRO_0000004087)"|disease:Trigeminal nerve ending location, vasodilatory effect, and other evidence suggest a direct role of CGRPs in migraine.	chain-seq-start:95|chain-seq-end:146	comment:"The complex participants have the following lengths:  CALCRL: 23-136 aa, and RAMP1: 27–112."|figure legend:Table II, Fig. 6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.48x-3^0(molar)	2014/07/03	2016/06/28	-	rogid:u113h2dRItswthFZ0IgrhFtvQe89606	intact-crc:FC499F10A72B4F14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16602	uniprotkb:O60895	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9636049|imex:IM-22908-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	-	-	-	figure legend:Fig.s S1A, S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2014/10/16	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	intact-crc:753AAFB045029A23|rigid:bh0ZoryN/bSIarXWyUw/boOw3Ek	false	sufficient binding region:23-136(IPR001879)	sufficient binding region:56-139	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16602	uniprotkb:O60895	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9636078|imex:IM-22908-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	-	-	-	figure legend:Fig.s S1A, S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2014/10/16	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	intact-crc:F71D4FBA44C07BEB|rigid:bh0ZoryN/bSIarXWyUw/boOw3Ek	false	sufficient binding region:23-136(IPR001879)	sufficient binding region:56-139	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16602	uniprotkb:O60895	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-9009040|uniprotkb:Q8N1F2|uniprotkb:A7L9S6|uniprotkb:K7EMD3|ensembl:ENSP00000253796	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:ramp2_human(display_long)|uniprotkb:RAMP2(gene name)|psi-mi:RAMP2(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 2(gene name synonym)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Kusano et al. (2012)	pubmed:22102369|imex:IM-22908	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9636126|imex:IM-22908-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	refseq:NP_005845.2|ensembl:ENSG00000131477(gene)|ensembl:ENST00000253796(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150057"(amylin receptor complex 2)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR006985(Receptor activity modifying protein)|interpro:IPR038126|rcsb pdb:2XVT|rcsb pdb:3AQE|rcsb pdb:3AQF|rcsb pdb:4RWF|rcsb pdb:6UUN|rcsb pdb:6V2E|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821	-	-	-	figure legend:Fig.s S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/03	2014/10/16	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:K9iq6MBq+OEIjmL+K755zHhCTNE9606	intact-crc:681C16E4DE36C6BB|rigid:bh0ZoryN/bSIarXWyUw/boOw3Ek	false	sufficient binding region:23-136(IPR001879)	sufficient binding region:56-139	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)