#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
ensembl:ENSG00000112115	uniprotkb:Q03060	intact:EBI-10047571	intact:EBI-3907794|uniprotkb:Q9NZ98|uniprotkb:Q5W1A9|uniprotkb:Q16114|uniprotkb:Q14505|uniprotkb:Q5W1A6|uniprotkb:Q9NZ99|uniprotkb:Q15731|uniprotkb:Q14506|uniprotkb:Q5W1A8|uniprotkb:Q8IVD4|uniprotkb:Q5T9H7|uniprotkb:B4DXC1|uniprotkb:O75519|uniprotkb:Q16116|uniprotkb:Q14503|uniprotkb:Q9NZB9|uniprotkb:Q7Z2Q6|uniprotkb:Q14504|uniprotkb:A8MPQ2|uniprotkb:C9J785|uniprotkb:C9JZ10|uniprotkb:E9PAR4|uniprotkb:E9PHM1|uniprotkb:Q5W1A7|uniprotkb:A8K014|uniprotkb:A8K6A1|uniprotkb:Q5W1B2|uniprotkb:A8K3J7|uniprotkb:Q96AG7|uniprotkb:Q14501|uniprotkb:Q5W1B0|ensembl:ENSP00000393538	uniprotkb:IL17A(gene name)|psi-mi:IL17A(display_short)|uniprotkb:CTLA8(gene name synonym)|uniprotkb:IL17(gene name synonym)|ensembl:il17_human_gene(shortlabel)|psi-mi:ENSG00000112115(display_long)	psi-mi:crem_human(display_long)|uniprotkb:CREM(gene name)|psi-mi:CREM(display_short)|uniprotkb:Inducible cAMP early repressor(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Rauen et al. (2011)	pubmed:22025620|imex:IM-23618	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10047584|imex:IM-23618-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_002181.1	refseq:XP_011517626.1|refseq:XP_011517627.1|refseq:XP_006717441.1|refseq:XP_006717442.1|refseq:XP_006717445.1|refseq:XP_006717446.1|refseq:NP_001872.3|refseq:NP_877572.1|refseq:NP_874389.1|refseq:NP_853549.1|refseq:NP_874387.1|refseq:NP_877570.1|refseq:NP_877571.1|refseq:NP_877573.1|refseq:NP_874386.1|refseq:NP_874390.1|refseq:NP_874392.1|refseq:NP_874393.1|refseq:NP_001254491.1|refseq:NP_001254493.1|refseq:NP_001254499.1|refseq:NP_874388.1|refseq:NP_898829.1|refseq:NP_898830.1|refseq:NP_898831.1|refseq:NP_001254496.1|refseq:NP_898883.1|ensembl:ENSG00000095794(gene)|ensembl:ENST00000429130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0048511"(rhythmic process)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|reactome:R-HSA-400253|refseq:XP_016871211.1	-	-	-	figure legend:Fig. 2c, 2d|comment:"The interaction was significantly increased in activated CD4+ T cells.  Binding was increased in Th17 helper cells (which express IL17)  as compared to Th1 and 2 cells (Fig. 3)."|agonist:anti-CD3 and anti-CD28 antibodies|causality statement:Q03060 increases expression at RNA level of ENSG00000112115|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t cells cd 4+)|taxid:9606(Homo sapiens)	-	2014/12/19	2019/01/30	-	rogid:qZeS07Fyrw2lTZ6t5kgxUy11kpA9606	intact-crc:ED29B07F71274C65	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000112115	uniprotkb:Q13547	intact:EBI-10047571	intact:EBI-301834|uniprotkb:Q92534|ensembl:ENSP00000362649	uniprotkb:IL17A(gene name)|psi-mi:IL17A(display_short)|uniprotkb:CTLA8(gene name synonym)|uniprotkb:IL17(gene name synonym)|ensembl:il17_human_gene(shortlabel)|psi-mi:ENSG00000112115(display_long)	psi-mi:hdac1_human(display_long)|uniprotkb:HDAC1(gene name)|psi-mi:HDAC1(display_short)|uniprotkb:RPD3L1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Rauen et al. (2011)	pubmed:22025620|imex:IM-23618	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10047739|imex:IM-23618-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_002181.1	ensembl:ENSG00000116478(gene)|ensembl:ENST00000373548(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002039"(p53 binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031000"(response to caffeine)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043044"|go:"GO:0019213"(deacetylase activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q13547|rcsb pdb:1TYI|rcsb pdb:4BKX|rcsb pdb:5ICN|rcsb pdb:6Z2J|rcsb pdb:6Z2K|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-193670|reactome:R-HSA-201722|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-3769402|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-4641265|reactome:R-HSA-6804758|reactome:R-HSA-69205|reactome:R-HSA-73762|reactome:R-HSA-8936459|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9022538|reactome:R-HSA-9022692|go:"GO:0017053"(transcription repressor complex)|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9615017|reactome:R-HSA-9679191|reactome:R-HSA-983231|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_004955.2|dip:DIP-24184N	-	-	-	figure legend:Fig. 5a, 5b|comment:The interaction was significantly decreased in activated CD4+ T cells.|caution:Although the figure legend is titled 'Increased HDAC1 recruitment to the CRE site after T cell activation', both the figure and the main text clearly indicate less HDAC1 binding to this site in activated cells.|antagonist:anti-CD3 and anti-CD28 antibodies|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t cells cd 4+)|taxid:9606(Homo sapiens)	-	2014/12/19	2019/01/30	-	rogid:RP+yIBWH55NgoPTY1nKXqeJL/xY9606	intact-crc:79EF0FA1D5C23BD4	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q03060	ensembl:ENSG00000112115	intact:EBI-3907794|uniprotkb:Q9NZ98|uniprotkb:Q5W1A9|uniprotkb:Q16114|uniprotkb:Q14505|uniprotkb:Q5W1A6|uniprotkb:Q9NZ99|uniprotkb:Q15731|uniprotkb:Q14506|uniprotkb:Q5W1A8|uniprotkb:Q8IVD4|uniprotkb:Q5T9H7|uniprotkb:B4DXC1|uniprotkb:O75519|uniprotkb:Q16116|uniprotkb:Q14503|uniprotkb:Q9NZB9|uniprotkb:Q7Z2Q6|uniprotkb:Q14504|uniprotkb:A8MPQ2|uniprotkb:C9J785|uniprotkb:C9JZ10|uniprotkb:E9PAR4|uniprotkb:E9PHM1|uniprotkb:Q5W1A7|uniprotkb:A8K014|uniprotkb:A8K6A1|uniprotkb:Q5W1B2|uniprotkb:A8K3J7|uniprotkb:Q96AG7|uniprotkb:Q14501|uniprotkb:Q5W1B0|ensembl:ENSP00000393538	intact:EBI-10047571	psi-mi:crem_human(display_long)|uniprotkb:CREM(gene name)|psi-mi:CREM(display_short)|uniprotkb:Inducible cAMP early repressor(gene name synonym)	uniprotkb:IL17A(gene name)|psi-mi:IL17A(display_short)|uniprotkb:CTLA8(gene name synonym)|uniprotkb:IL17(gene name synonym)|ensembl:il17_human_gene(shortlabel)|psi-mi:ENSG00000112115(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Rauen et al. (2011)	pubmed:22025620|imex:IM-23618	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10047604|imex:IM-23618-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:XP_011517626.1|refseq:XP_011517627.1|refseq:XP_006717441.1|refseq:XP_006717442.1|refseq:XP_006717445.1|refseq:XP_006717446.1|refseq:NP_001872.3|refseq:NP_877572.1|refseq:NP_874389.1|refseq:NP_853549.1|refseq:NP_874387.1|refseq:NP_877570.1|refseq:NP_877571.1|refseq:NP_877573.1|refseq:NP_874386.1|refseq:NP_874390.1|refseq:NP_874392.1|refseq:NP_874393.1|refseq:NP_001254491.1|refseq:NP_001254493.1|refseq:NP_001254499.1|refseq:NP_874388.1|refseq:NP_898829.1|refseq:NP_898830.1|refseq:NP_898831.1|refseq:NP_001254496.1|refseq:NP_898883.1|ensembl:ENSG00000095794(gene)|ensembl:ENST00000429130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0048511"(rhythmic process)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|reactome:R-HSA-400253|refseq:XP_016871211.1	refseq:NP_002181.1	-	-	-	figure legend:Fig. 2e, 2f|comment:Chromatin immunoprecipitation was performed with T cells from healthy individuals and T cells from SLE patients. A trend was observed towards increased binding in SLE T cells; however, the difference was not statistically significant.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2014/12/19	2018/09/18	rogid:qZeS07Fyrw2lTZ6t5kgxUy11kpA9606	-	intact-crc:8D43DBEA8FFBD9D8	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000112115	uniprotkb:Q13547	intact:EBI-10047571	intact:EBI-301834|uniprotkb:Q92534|ensembl:ENSP00000362649	uniprotkb:IL17A(gene name)|psi-mi:IL17A(display_short)|uniprotkb:CTLA8(gene name synonym)|uniprotkb:IL17(gene name synonym)|ensembl:il17_human_gene(shortlabel)|psi-mi:ENSG00000112115(display_long)	psi-mi:hdac1_human(display_long)|uniprotkb:HDAC1(gene name)|psi-mi:HDAC1(display_short)|uniprotkb:RPD3L1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Rauen et al. (2011)	pubmed:22025620|imex:IM-23618	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10047777|imex:IM-23618-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_002181.1	ensembl:ENSG00000116478(gene)|ensembl:ENST00000373548(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002039"(p53 binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007492"(endoderm development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031000"(response to caffeine)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043044"|go:"GO:0019213"(deacetylase activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q13547|rcsb pdb:1TYI|rcsb pdb:4BKX|rcsb pdb:5ICN|rcsb pdb:6Z2J|rcsb pdb:6Z2K|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-193670|reactome:R-HSA-201722|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-3769402|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-4641265|reactome:R-HSA-6804758|reactome:R-HSA-69205|reactome:R-HSA-73762|reactome:R-HSA-8936459|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9022538|reactome:R-HSA-9022692|go:"GO:0017053"(transcription repressor complex)|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9615017|reactome:R-HSA-9679191|reactome:R-HSA-983231|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_004955.2|dip:DIP-24184N	-	-	-	figure legend:Fig. 5c, 5d|comment:Chromatin immunoprecipitation was performed with T cells from healthy individuals and T cells from SLE patients. The interaction was significantly decreased in the latter.|caution:Although the figure legend is titled 'Increased HDAC1 recruitment to the CRE site in SLE T cells', both the figure and the main text clearly indicate less HDAC1 binding to this site in these cells.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2014/12/19	2014/12/19	-	rogid:RP+yIBWH55NgoPTY1nKXqeJL/xY9606	intact-crc:9752D6718C6B40D0	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000112115	uniprotkb:Q9Y6K1	intact:EBI-10047571	intact:EBI-923653|uniprotkb:Q8WXU9|uniprotkb:Q86XF5|uniprotkb:Q8IZV0|uniprotkb:Q86TE8|uniprotkb:E9PEB8|ensembl:ENSP00000264709|ensembl:ENSP00000324375	uniprotkb:IL17A(gene name)|psi-mi:IL17A(display_short)|uniprotkb:CTLA8(gene name synonym)|uniprotkb:IL17(gene name synonym)|ensembl:il17_human_gene(shortlabel)|psi-mi:ENSG00000112115(display_long)	psi-mi:dnm3a_human(display_long)|uniprotkb:DNMT3A(gene name)|psi-mi:DNMT3A(display_short)|uniprotkb:DNA methyltransferase HsaIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Rauen et al. (2011)	pubmed:22025620|imex:IM-23618	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10047824|imex:IM-23618-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_002181.1	refseq:NP_001307821.1|refseq:NP_072046.2|refseq:NP_783328.1|refseq:NP_783329.1|refseq:XP_016859015.1|refseq:XP_016859016.1|refseq:XP_011530969.1|refseq:NP_001307822.1|refseq:NP_715640.2|refseq:XP_005264232.1|dip:DIP-38004N|refseq:XP_005264234.1|ensembl:ENSG00000119772(gene)|ensembl:ENST00000264709(transcript)|ensembl:ENST00000321117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:Q9Y6K1|rcsb pdb:2QRV|rcsb pdb:3A1A|rcsb pdb:3A1B|rcsb pdb:3LLR|rcsb pdb:3SVM|rcsb pdb:4QBQ|rcsb pdb:4QBR|rcsb pdb:4QBS|rcsb pdb:4U7P|rcsb pdb:4U7T|rcsb pdb:5YX2|rcsb pdb:6BRR|rcsb pdb:6F57|rcsb pdb:6PA7|rcsb pdb:6W89|rcsb pdb:6W8B|rcsb pdb:6W8D|rcsb pdb:6W8J|reactome:R-HSA-212300|reactome:R-HSA-3214858|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421	-	-	-	figure legend:Fig. 7a, 7b|comment:Chromatin immunoprecipitation was performed with T cells from healthy individuals and T cells from SLE patients. The interaction was significantly decreased in the latter.|causality statement:Q9Y6K1 decreases expression at RNA level of ENSG00000112115|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2014/12/19	2019/01/30	-	rogid:rnq1Yv4tlQ1t9JXS3CfMmTlcPKE9606	intact-crc:DFFB515AD144E7CC	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
intact:EBI-10047904	uniprotkb:Q03060	-	intact:EBI-3907794|uniprotkb:Q9NZ98|uniprotkb:Q5W1A9|uniprotkb:Q16114|uniprotkb:Q14505|uniprotkb:Q5W1A6|uniprotkb:Q9NZ99|uniprotkb:Q15731|uniprotkb:Q14506|uniprotkb:Q5W1A8|uniprotkb:Q8IVD4|uniprotkb:Q5T9H7|uniprotkb:B4DXC1|uniprotkb:O75519|uniprotkb:Q16116|uniprotkb:Q14503|uniprotkb:Q9NZB9|uniprotkb:Q7Z2Q6|uniprotkb:Q14504|uniprotkb:A8MPQ2|uniprotkb:C9J785|uniprotkb:C9JZ10|uniprotkb:E9PAR4|uniprotkb:E9PHM1|uniprotkb:Q5W1A7|uniprotkb:A8K014|uniprotkb:A8K6A1|uniprotkb:Q5W1B2|uniprotkb:A8K3J7|uniprotkb:Q96AG7|uniprotkb:Q14501|uniprotkb:Q5W1B0|ensembl:ENSP00000393538	psi-mi:il17_human_cre-site_dna-probe(display_short)|psi-mi:EBI-10047904(display_long)	psi-mi:crem_human(display_long)|uniprotkb:CREM(gene name)|psi-mi:CREM(display_short)|uniprotkb:Inducible cAMP early repressor(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Rauen et al. (2011)	pubmed:22025620|imex:IM-23618	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10047935|imex:IM-23618-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112115(see-also)	refseq:XP_011517626.1|refseq:XP_011517627.1|refseq:XP_006717441.1|refseq:XP_006717442.1|refseq:XP_006717445.1|refseq:XP_006717446.1|refseq:NP_001872.3|refseq:NP_877572.1|refseq:NP_874389.1|refseq:NP_853549.1|refseq:NP_874387.1|refseq:NP_877570.1|refseq:NP_877571.1|refseq:NP_877573.1|refseq:NP_874386.1|refseq:NP_874390.1|refseq:NP_874392.1|refseq:NP_874393.1|refseq:NP_001254491.1|refseq:NP_001254493.1|refseq:NP_001254499.1|refseq:NP_874388.1|refseq:NP_898829.1|refseq:NP_898830.1|refseq:NP_898831.1|refseq:NP_001254496.1|refseq:NP_898883.1|ensembl:ENSG00000095794(gene)|ensembl:ENST00000429130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0048511"(rhythmic process)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|reactome:R-HSA-400253|refseq:XP_016871211.1	-	-	-	figure legend:Fig. 2a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/12/19	2019/01/30	-	rogid:qZeS07Fyrw2lTZ6t5kgxUy11kpA9606	intact-crc:6FBDC89965CE4486	false	32p radiolabel:?-?	his tag:c-c	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)