#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q05127	uniprotkb:Q12906	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9822751|imex:IM-23233-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	-	-	-	figure legend:1B|comment:"Prey proteins specifically detected in presence of polyI:C  ."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/22	2014/10/16	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	intact-crc:F1B1C1286D43B49D|rigid:eIQeYZDQ7XTreyOGVxegon3gxYw	false	mutation disrupting interaction:312-312|sufficient binding region:215-340|maltose binding protein tag:?-?|mutation disrupting interaction:339-339	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q05127	uniprotkb:P19338	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9822751|imex:IM-23233-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226	-	-	-	figure legend:1B|comment:"Prey proteins specifically detected in presence of polyI:C  ."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/22	2014/10/16	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606	intact-crc:F1B1C1286D43B49D|rigid:eIQeYZDQ7XTreyOGVxegon3gxYw	false	mutation disrupting interaction:312-312|sufficient binding region:215-340|maltose binding protein tag:?-?|mutation disrupting interaction:339-339	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q05127	uniprotkb:Q08211	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	intact:EBI-352022|intact:EBI-1058470|uniprotkb:Q5VY62|uniprotkb:Q6PD69|uniprotkb:Q99556|uniprotkb:B2RNV4|uniprotkb:Q05CI5|uniprotkb:Q12803|uniprotkb:Q32Q22|ensembl:ENSP00000356520	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:dhx9_human(display_long)|uniprotkb:DHX9(gene name)|psi-mi:DHX9(display_short)|uniprotkb:DDX9(gene name synonym)|uniprotkb:NDH2(gene name synonym)|uniprotkb:DExH-box helicase 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)|uniprotkb:LKP(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:Leukophysin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9822751|imex:IM-23233-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	refseq:NP_001348.2|dip:DIP-31504N|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447|mint:Q08211|rcsb pdb:3LLM|rcsb pdb:3VYX|rcsb pdb:3VYY|reactome:R-HSA-1810476|reactome:R-HSA-3134963|reactome:R-HSA-72163|go:"GO:1904973"(positive regulation of viral translation)|ensembl:ENSG00000135829(gene)|ensembl:ENST00000367549(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006260"(DNA replication)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)	-	-	-	figure legend:1B|comment:"Prey proteins specifically detected in presence of polyI:C  ."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/22	2014/10/16	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	rogid:b0VP2Frtvwa9WbYVMwB6TbV2uGU9606	intact-crc:F1B1C1286D43B49D|rigid:eIQeYZDQ7XTreyOGVxegon3gxYw	false	mutation disrupting interaction:312-312|sufficient binding region:215-340|maltose binding protein tag:?-?|mutation disrupting interaction:339-339	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q05127	uniprotkb:Q12906	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825674|imex:IM-23233-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	-	comment:"Association detected in absence of dsRNA (pI:C)"	-	figure legend:2C|comment:"Interaction specifically detected in absence of polyI:C ."|comment:Interaction is weaker compared to that full length VP35 carrying a arg312ala mutation. Mutations VP35 lys248ala and lys251ala do not change the association|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/22	2014/10/16	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	intact-crc:42494D6D3FE353E6|rigid:oUYb0lKC5jUOXgqkWLO+6dnMKp0	false	mutation disrupting interaction:339-339|maltose binding protein tag:?-?|sufficient binding region:58-340|mutation decreasing interaction:322-322	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05127	uniprotkb:Q12906	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825660|imex:IM-23233-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	-	comment:"Association detected in absence of dsRNA (pI:C)"	-	figure legend:2C|comment:"Interaction specifically detected in absence of polyI:C ."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/22	2014/10/16	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	intact-crc:D90F8F0251494659|rigid:oUYb0lKC5jUOXgqkWLO+6dnMKp0	false	maltose binding protein tag:?-?|mutation:312-312	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12906	uniprotkb:Q05127	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9822836|imex:IM-23233-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	-	-	comment:"Association detected in absence of dsRNA (pI:C)"	figure legend:1D and 2B|comment:"Interaction specifically detected in presence of polyI:C . VP35 mutant arg312ala does not interact neither in presence or absence of  polyI:C."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/22	2014/10/16	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	intact-crc:D0CA43989DB9D7A9|rigid:oUYb0lKC5jUOXgqkWLO+6dnMKp0	false	-	mutation disrupting interaction:339-339|sufficient binding region:221-340|mutation disrupting interaction:312-312|maltose binding protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12906	uniprotkb:Q05127	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9825644|imex:IM-23233-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	-	-	comment:"Association detected in absence of dsRNA (pI:C)"	figure legend:2B|comment:"Interaction specifically detected in absence of polyI:C ."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/22	2014/10/16	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	intact-crc:EB511D9330898C06|rigid:oUYb0lKC5jUOXgqkWLO+6dnMKp0	false	-	maltose binding protein tag:?-?|sufficient binding region:56-340	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12906	uniprotkb:Q05127	intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym)	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9822878|imex:IM-23233-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	-	-	-	figure legend:2D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/22	2014/10/16	rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	intact-crc:EB9BF3DB78F7AFCB|rigid:oUYb0lKC5jUOXgqkWLO+6dnMKp0	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05127	uniprotkb:P18272	intact:EBI-6148294|uniprotkb:Q8JS63|uniprotkb:Q77LU7	intact:EBI-9820219|uniprotkb:Q773N6|uniprotkb:Q8JS64|uniprotkb:Q9DQD3|uniprotkb:Q9YMG4	psi-mi:vp35_ebozm(display_long)|uniprotkb:VP35(gene name)|psi-mi:VP35(display_short)|uniprotkb:Ebola VP35(gene name synonym)	psi-mi:ncap_ebozm(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)|uniprotkb:Ebola NP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shabman et al. (2011)	imex:IM-23233|pubmed:21987769	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	taxid:128952(ebozm)|taxid:128952("Zaire ebolavirus (strain Mayinga-76)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9822891|imex:IM-23233-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066244.1|dip:DIP-48771N|go:"GO:0003723"(RNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039613"(suppression by virus of host protein phosphorylation)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0039724"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity)|go:"GO:0044414"(suppression of host defenses by symbiont)|go:"GO:0046775"(suppression by virus of host cytokine production)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|interpro:IPR002953(Filoviridae VP35 protein)|interpro:IPR031163|interpro:IPR043060|interpro:IPR043061|rcsb pdb:3FKE|rcsb pdb:3L25|rcsb pdb:3L26|rcsb pdb:3L27|rcsb pdb:3L28|rcsb pdb:3L29|rcsb pdb:4IBB|rcsb pdb:4IBC|rcsb pdb:4IBD|rcsb pdb:4IBE|rcsb pdb:4IBF|rcsb pdb:4IBG|rcsb pdb:4IBI|rcsb pdb:4IBJ|rcsb pdb:4IBK|rcsb pdb:4IJE|rcsb pdb:4IJF|rcsb pdb:4YPI|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:6GBO|rcsb pdb:6GBP	rcsb pdb:4QAZ|rcsb pdb:4QB0|interpro:IPR008609(Ebola nucleoprotein)|refseq:NP_066243.1|rcsb pdb:4YPI|rcsb pdb:4Z9P|rcsb pdb:4ZTA|rcsb pdb:4ZTG|rcsb pdb:4ZTI|rcsb pdb:5T3T|rcsb pdb:5Z9W|rcsb pdb:6NUT|rcsb pdb:6EHL|rcsb pdb:6EHM|rcsb pdb:6C54|go:"GO:0003723"(RNA binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0030430"(host cell cytoplasm)	-	-	-	figure legend:6B|comment:"Presence of overexpressed host Flag-ILF3/DRBP76 (UniProt Ac Q12906) disrupts the association."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/09/22	2014/10/16	rogid:dNxhJ6s484zTGfDLnmoGqE+MlMc128952	rogid:3gzyp+qys0/sPa2AahEeyMFElIo128952	intact-crc:ADD6B3584E631887|rigid:CTz1puQJPNv9osqk0n+nEjV+964	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)