#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17362	uniprotkb:A7MCY6	intact:EBI-9519257|uniprotkb:Q76ZY6	intact:EBI-359969|uniprotkb:Q14DW3|uniprotkb:O94873|uniprotkb:B2RZG6|ensembl:ENSP00000354777	psi-mi:c6_vaccw(display_long)|uniprotkb:C6L(orf name)|uniprotkb:VACWR022(locus name)	psi-mi:tbkb1_human(display_long)|uniprotkb:TBKBP1(gene name)|psi-mi:TBKBP1(display_short)|uniprotkb:SINTBAD(gene name synonym)|uniprotkb:KIAA0775(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519273|imex:IM-24038-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR022819|refseq:YP_232904.1|interpro:IPR043018|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)	refseq:NP_055541.1|ensembl:ENSG00000198933(gene)|ensembl:ENST00000361722(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|interpro:IPR024581|interpro:IPR041641|mint:A7MCY6|refseq:XP_005257916.1|refseq:XP_005257917.1|refseq:XP_005257918.1|refseq:XP_005257919.1|dip:DIP-27604N	-	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2014/10/16	rogid:7IctjFx75aaYSblYFtD/T3+XFvU10254	rogid:Hf7hEVRztbT681BKO7sMjh1EwX09606	intact-crc:A00D804DA7702CBD|rigid:EeYoKpWdm6AoZNtUrEIPe/1EdGc	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H6S1	uniprotkb:P17362	intact:EBI-359973|intact:EBI-1384309|uniprotkb:Q86W99|uniprotkb:Q9BQF1|uniprotkb:A8K3M2|ensembl:ENSP00000419371|uniprotkb:C9JB40|uniprotkb:H7BXU6	intact:EBI-9519257|uniprotkb:Q76ZY6	psi-mi:azi2_human(display_long)|uniprotkb:AZI2(gene name)|psi-mi:AZI2(display_short)|uniprotkb:NAP1(gene name synonym)|uniprotkb:TBKBP2(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase-associated protein 1(gene name synonym)|uniprotkb:TILP(gene name synonym)	psi-mi:c6_vaccw(display_long)|uniprotkb:C6L(orf name)|uniprotkb:VACWR022(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519265|imex:IM-24038-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127904.1|refseq:NP_001127905.1|refseq:NP_071906.1|ensembl:ENSG00000163512(gene)|ensembl:ENST00000479665(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042110"(T cell activation)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR024581|rcsb pdb:5EP6|rcsb pdb:5Z7G|rcsb pdb:5Z7L|refseq:XP_005265449.1|dip:DIP-27605N	interpro:IPR022819|refseq:YP_232904.1|interpro:IPR043018|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)	-	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2015/03/31	rogid:lfjd4cD2rm6NOjdh3XTTuFxnK9A9606	rogid:7IctjFx75aaYSblYFtD/T3+XFvU10254	intact-crc:8A22EDCCF7F9DEDE|rigid:Qw8IEsotA7yh88AcSo/b+axZgGU	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17362	uniprotkb:Q92844	intact:EBI-9519257|uniprotkb:Q76ZY6	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:c6_vaccw(display_long)|uniprotkb:C6L(orf name)|uniprotkb:VACWR022(locus name)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519279|imex:IM-24038-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR022819|refseq:YP_232904.1|interpro:IPR043018|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2015/03/31	rogid:7IctjFx75aaYSblYFtD/T3+XFvU10254	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	intact-crc:B347E2715B68BBDF|rigid:5TI26vqQ0vMYh0E6SRCb3UTYFG4	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A7MCY6	uniprotkb:P17362	intact:EBI-359969|uniprotkb:Q14DW3|uniprotkb:O94873|uniprotkb:B2RZG6|ensembl:ENSP00000354777	intact:EBI-9519257|uniprotkb:Q76ZY6	psi-mi:tbkb1_human(display_long)|uniprotkb:TBKBP1(gene name)|psi-mi:TBKBP1(display_short)|uniprotkb:SINTBAD(gene name synonym)|uniprotkb:KIAA0775(gene name synonym)	psi-mi:c6_vaccw(display_long)|uniprotkb:C6L(orf name)|uniprotkb:VACWR022(locus name)	psi-mi:"MI:0400"(affinity technology)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519297|imex:IM-24038-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055541.1|ensembl:ENSG00000198933(gene)|ensembl:ENST00000361722(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|interpro:IPR024581|interpro:IPR041641|mint:A7MCY6|refseq:XP_005257916.1|refseq:XP_005257917.1|refseq:XP_005257918.1|refseq:XP_005257919.1|dip:DIP-27604N	interpro:IPR022819|refseq:YP_232904.1|interpro:IPR043018|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2015/03/31	rogid:Hf7hEVRztbT681BKO7sMjh1EwX09606	rogid:7IctjFx75aaYSblYFtD/T3+XFvU10254	intact-crc:FCC32F4FB5F2D952|rigid:EeYoKpWdm6AoZNtUrEIPe/1EdGc	false	flag tag:?-?	calmodulin binding peptide plus protein a tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P17362	uniprotkb:Q9H6S1	intact:EBI-9519257|uniprotkb:Q76ZY6	intact:EBI-359973|intact:EBI-1384309|uniprotkb:Q86W99|uniprotkb:Q9BQF1|uniprotkb:A8K3M2|ensembl:ENSP00000419371|uniprotkb:C9JB40|uniprotkb:H7BXU6	psi-mi:c6_vaccw(display_long)|uniprotkb:C6L(orf name)|uniprotkb:VACWR022(locus name)	psi-mi:azi2_human(display_long)|uniprotkb:AZI2(gene name)|psi-mi:AZI2(display_short)|uniprotkb:NAP1(gene name synonym)|uniprotkb:TBKBP2(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase-associated protein 1(gene name synonym)|uniprotkb:TILP(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519295|imex:IM-24038-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR022819|refseq:YP_232904.1|interpro:IPR043018|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)	refseq:NP_001127904.1|refseq:NP_001127905.1|refseq:NP_071906.1|ensembl:ENSG00000163512(gene)|ensembl:ENST00000479665(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042110"(T cell activation)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR024581|rcsb pdb:5EP6|rcsb pdb:5Z7G|rcsb pdb:5Z7L|refseq:XP_005265449.1|dip:DIP-27605N	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2015/03/31	rogid:7IctjFx75aaYSblYFtD/T3+XFvU10254	rogid:lfjd4cD2rm6NOjdh3XTTuFxnK9A9606	intact-crc:3B658F458A668E09|rigid:Qw8IEsotA7yh88AcSo/b+axZgGU	false	calmodulin binding peptide plus protein a tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92844	uniprotkb:P17362	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	intact:EBI-9519257|uniprotkb:Q76ZY6	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:c6_vaccw(display_long)|uniprotkb:C6L(orf name)|uniprotkb:VACWR022(locus name)	psi-mi:"MI:0400"(affinity technology)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519299|imex:IM-24038-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	interpro:IPR022819|refseq:YP_232904.1|interpro:IPR043018|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2015/03/31	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	rogid:7IctjFx75aaYSblYFtD/T3+XFvU10254	intact-crc:5886C775D6D5DD7B|rigid:5TI26vqQ0vMYh0E6SRCb3UTYFG4	false	flag tag:?-?	calmodulin binding peptide plus protein a tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UHD2	uniprotkb:A7MCY6	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	intact:EBI-359969|uniprotkb:Q14DW3|uniprotkb:O94873|uniprotkb:B2RZG6|ensembl:ENSP00000354777	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:tbkb1_human(display_long)|uniprotkb:TBKBP1(gene name)|psi-mi:TBKBP1(display_short)|uniprotkb:SINTBAD(gene name synonym)|uniprotkb:KIAA0775(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519349|imex:IM-24038-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	refseq:NP_055541.1|ensembl:ENSG00000198933(gene)|ensembl:ENST00000361722(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|interpro:IPR024581|interpro:IPR041641|mint:A7MCY6|refseq:XP_005257916.1|refseq:XP_005257917.1|refseq:XP_005257918.1|refseq:XP_005257919.1|dip:DIP-27604N	-	-	-	figure legend:5E, 5F|comment:Coexpression of Vaccinia virus protein C6 did not change the interaction. Truncated SINTBAD construct containing  only the TBD inhibited the  the scaffold-kinase interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2014/10/16	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rogid:Hf7hEVRztbT681BKO7sMjh1EwX09606	intact-crc:DE10B10FBC6FDB0D|rigid:2fh8RtG++2Jgc9AtefvB1r0FZn4	false	renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q9UHD2	uniprotkb:Q9H6S1	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	intact:EBI-359973|intact:EBI-1384309|uniprotkb:Q86W99|uniprotkb:Q9BQF1|uniprotkb:A8K3M2|ensembl:ENSP00000419371|uniprotkb:C9JB40|uniprotkb:H7BXU6	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:azi2_human(display_long)|uniprotkb:AZI2(gene name)|psi-mi:AZI2(display_short)|uniprotkb:NAP1(gene name synonym)|uniprotkb:TBKBP2(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase-associated protein 1(gene name synonym)|uniprotkb:TILP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519345|imex:IM-24038-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	refseq:NP_001127904.1|refseq:NP_001127905.1|refseq:NP_071906.1|ensembl:ENSG00000163512(gene)|ensembl:ENST00000479665(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042110"(T cell activation)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR024581|rcsb pdb:5EP6|rcsb pdb:5Z7G|rcsb pdb:5Z7L|refseq:XP_005265449.1|dip:DIP-27605N	-	-	-	figure legend:5C, 5D|comment:Coexpression of Vaccinia virus protein C6 did not change the interaction. Truncated NAP1 construct containing  only the TBD inhibited the  the scaffold-kinase interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2015/03/31	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rogid:lfjd4cD2rm6NOjdh3XTTuFxnK9A9606	intact-crc:22CBABE1D6C9C6BD|rigid:I63vZdrXfOp3fvRkOOOnmVJdGpw	false	renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q14164	uniprotkb:Q9H6S1	intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754	intact:EBI-359973|intact:EBI-1384309|uniprotkb:Q86W99|uniprotkb:Q9BQF1|uniprotkb:A8K3M2|ensembl:ENSP00000419371|uniprotkb:C9JB40|uniprotkb:H7BXU6	psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:azi2_human(display_long)|uniprotkb:AZI2(gene name)|psi-mi:AZI2(display_short)|uniprotkb:NAP1(gene name synonym)|uniprotkb:TBKBP2(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase-associated protein 1(gene name synonym)|uniprotkb:TILP(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519394|imex:IM-24038-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N	refseq:NP_001127904.1|refseq:NP_001127905.1|refseq:NP_071906.1|ensembl:ENSG00000163512(gene)|ensembl:ENST00000479665(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042110"(T cell activation)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR024581|rcsb pdb:5EP6|rcsb pdb:5Z7G|rcsb pdb:5Z7L|refseq:XP_005265449.1|dip:DIP-27605N	-	-	-	figure legend:S2A|comment:Coexpression of Vaccinia virus protein C6 did not change the interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2015/03/31	rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606	rogid:lfjd4cD2rm6NOjdh3XTTuFxnK9A9606	intact-crc:CE4F2D4178DEE65D|rigid:clplQ73qURsrnm9YlELce77v5Ac	false	renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q92844	uniprotkb:Q14164	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519403|imex:IM-24038-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N	-	-	-	figure legend:S2C|comment:Coexpression of Vaccinia virus protein C6 did not change the interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2014/10/16	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606	intact-crc:D8AF0B619BAF1A64|rigid:jLSbmBuMC59ZwSYjBDtpTCd/ktQ	false	flag tag:?-?	renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q14164	uniprotkb:A7MCY6	intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754	intact:EBI-359969|uniprotkb:Q14DW3|uniprotkb:O94873|uniprotkb:B2RZG6|ensembl:ENSP00000354777	psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:tbkb1_human(display_long)|uniprotkb:TBKBP1(gene name)|psi-mi:TBKBP1(display_short)|uniprotkb:SINTBAD(gene name synonym)|uniprotkb:KIAA0775(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519412|imex:IM-24038-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N	refseq:NP_055541.1|ensembl:ENSG00000198933(gene)|ensembl:ENST00000361722(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|interpro:IPR024581|interpro:IPR041641|mint:A7MCY6|refseq:XP_005257916.1|refseq:XP_005257917.1|refseq:XP_005257918.1|refseq:XP_005257919.1|dip:DIP-27604N	-	-	-	figure legend:S2B|comment:Coexpression of Vaccinia virus protein C6 did not change the interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2014/10/16	rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606	rogid:Hf7hEVRztbT681BKO7sMjh1EwX09606	intact-crc:BC4A43AE5E721DA5|rigid:2meybvD4etrOVnS9P7XE6ytntHk	false	renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q9UHD2	uniprotkb:Q92844	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Unterholzner et al. (2011)	imex:IM-24038|pubmed:21931555	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9519347|imex:IM-24038-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:5G, 5H|comment:Coexpression of Vaccinia virus protein C6 did not change the interaction. Truncated TANK construct containing  only the TBD inhibited the  the scaffold-kinase interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/05/08	2014/10/16	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	intact-crc:1A56F2C0BA186164|rigid:90DB6awis7/KyACvA35KjPkVrPw	false	renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)