#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62469	matrixdb:MULT_51_mouse	intact:EBI-8400688|intact:MINT-1866744|uniprotkb:Q6P1C7|uniprotkb:Q62163|ensembl:ENSMUSP00000053891	intact:EBI-9248941	psi-mi:ita2_mouse(display_long)|uniprotkb:Itga2(gene name)|psi-mi:Itga2(display_short)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:"MI:0416"(fluorescence microscopy)	Veit et al. (2011)	pubmed:21652699	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9976312	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_032422.2|ensembl:ENSMUSG00000015533(gene)|ensembl:ENSMUST00000056117(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030424"(axon)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:Q62469|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|reactome:R-MMU-8874081	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	-	comment:mint|function:Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	figure legend:Figure 1A|curation depth:imex curation	taxid:10090(mouse-embryonic_skin)|taxid:10090(Mouse embryonic skin)	-	2014/11/10	2016/06/23	rogid:fiMqFnebmgHpvaT50Pv0hRw+BEI10090	-	intact-crc:67151F7BDE2766B6	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:P17301	matrixdb:MULT_51_mouse	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	intact:EBI-9248941	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:"MI:0892"(solid phase assay)	Veit et al. (2011)	pubmed:21652699	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9974211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	-	-	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	figure legend:Figure 6A|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.8x10^-8 ~0.16(molar)	2014/11/10	2019/09/10	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	-	intact-crc:12F55E493A00FA7A	false	glutathione s tranferase tag:n-n|mutation:347-347|sufficient binding region:154-368	sufficient binding region:46-532|flag tag:c-c|his tag:c-c	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_51_mouse	uniprotkb:P17301	intact:EBI-9248941	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Veit et al. (2011)	pubmed:21652699	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9974222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	-	figure legend:Figure 6B|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-9 ~0.78(molar)	2014/11/10	2014/11/18	-	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:1500E295A6AD32FC	false	sufficient binding region:46-532|flag tag:c-c|his tag:c-c	glutathione s tranferase tag:n-n|sufficient binding region:154-368|mutation:347-347	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_51_mouse	reactome:R-HSA-114561	intact:EBI-9248941	intact:EBI-2565102|matrixdb:MULT_25_human|signor:SIGNOR-C160	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:intg_a2_b1_human(display_short)|psi-mi:R-HSA-114561(display_long)|intact:alpha-2/beta-1 integrin complex(complex synonym)|intact:"ITGA2:ITGB1"(complex systematic name)|intact:Integrin alpha2-beta1 complex(complex recommended name)|intact:alpha2-beta1 integrin complex(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Veit et al. (2011)	pubmed:21652699	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9974282	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:1302"(stable complex)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	intact:EBI-703266(exp-evidence)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030198"(extracellular matrix organization)|complex portal:CPX-1801(complex-primary)|evidence ontology:"ECO:0000353"	-	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the sequence G-F-P-G-E-R in a wide array of ligands. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer|comment:"Interaction of collagen XXIII with the heterodimeric integrin alpha2beta1 ectodomain (alpha2: mature ectodomain fused to dimerizing motif of the transcription factor Fos, beta1: 21-728 fused to dimerizing Jun alpha helix)"	figure legend:Figure 7A, Figure 7D|comment:The absence of binding after addition of  EDTA revealed the dependence on bivalent cations commonly  seen in integrin-collagen interactions and furthermore  indicated the specificity of the observed interaction|comment:"A prerequisite for the interaction of collagen to collagen-  binding integrins is the presence of an intact collagen  triple helix folding.Disruption of the native folding strongly reduced  binding to soluble integrin alpha2beta1 (Figure 7D)."|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.9x10^-8 ~0.23(molar)	2014/11/10	2014/11/19	-	-	intact-crc:BF13B868B043B4E1	false	flag tag:c-c|his tag:c-c|sufficient binding region:46-532	-	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
reactome:R-HSA-114561	matrixdb:MULT_51_mouse	intact:EBI-2565102|matrixdb:MULT_25_human|signor:SIGNOR-C160	intact:EBI-9248941	psi-mi:intg_a2_b1_human(display_short)|psi-mi:R-HSA-114561(display_long)|intact:alpha-2/beta-1 integrin complex(complex synonym)|intact:"ITGA2:ITGB1"(complex systematic name)|intact:Integrin alpha2-beta1 complex(complex recommended name)|intact:alpha2-beta1 integrin complex(complex synonym)	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:"MI:0892"(solid phase assay)	Veit et al. (2011)	pubmed:21652699	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9974297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:1302"(stable complex)	intact:EBI-703266(exp-evidence)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030198"(extracellular matrix organization)|complex portal:CPX-1801(complex-primary)|evidence ontology:"ECO:0000353"	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the sequence G-F-P-G-E-R in a wide array of ligands. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer|comment:"Interaction of collagen XXIII with the heterodimeric integrin alpha2beta1 ectodomain (alpha2: mature ectodomain fused to dimerizing motif of the transcription factor Fos, beta1: 21-728 fused to dimerizing Jun alpha helix)"	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	figure legend:Figure 7B|comment:"1:1 interaction"|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.3x10^-8 ~0.7(molar)	2014/11/10	2014/11/18	-	-	intact-crc:8ACE4DEE8A87C988	false	-	his tag:c-c|sufficient binding region:46-532|flag tag:c-c	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_51_mouse	uniprotkb:P17301	intact:EBI-9248941	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Veit et al. (2011)	pubmed:21652699	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9974244	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	-	figure legend:Figure 6C|comment:"Langmuir 1:1 binding model"|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.0x10^-8(molar)	2014/11/10	2014/11/18	-	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:503CF41B5854D2E0	false	sufficient binding region:46-532|flag tag:c-c|his tag:c-c	mutation:347-347|glutathione s tranferase tag:n-n|sufficient binding region:154-368	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-114561	matrixdb:MULT_51_mouse	intact:EBI-2565102|matrixdb:MULT_25_human|signor:SIGNOR-C160	intact:EBI-9248941	psi-mi:intg_a2_b1_human(display_short)|psi-mi:R-HSA-114561(display_long)|intact:alpha-2/beta-1 integrin complex(complex synonym)|intact:"ITGA2:ITGB1"(complex systematic name)|intact:Integrin alpha2-beta1 complex(complex recommended name)|intact:alpha2-beta1 integrin complex(complex synonym)	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Veit et al. (2011)	pubmed:21652699	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9974270	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:1302"(stable complex)	intact:EBI-703266(exp-evidence)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030198"(extracellular matrix organization)|complex portal:CPX-1801(complex-primary)|evidence ontology:"ECO:0000353"	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the sequence G-F-P-G-E-R in a wide array of ligands. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	figure legend:Figure 7C|comment:"Interaction of collagen XXIII with the heterodimeric integrin alpha2beta1 ectodomain (alpha2: mature ectodomain fused to dimerizing motif of the transcription factor Fos, beta1: 21-728 fused to dimerizing Jun alpha helix)"|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-8(molar)	2014/11/10	2014/11/18	-	-	intact-crc:A98C374CAA4E2B8C	false	-	sufficient binding region:46-532|his tag:c-c|flag tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62469	matrixdb:MULT_51_mouse	intact:EBI-8400688|intact:MINT-1866744|uniprotkb:Q6P1C7|uniprotkb:Q62163|ensembl:ENSMUSP00000053891	intact:EBI-9248941	psi-mi:ita2_mouse(display_long)|uniprotkb:Itga2(gene name)|psi-mi:Itga2(display_short)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:"MI:0416"(fluorescence microscopy)	Veit et al. (2011)	pubmed:21652699	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9982595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_032422.2|ensembl:ENSMUSG00000015533(gene)|ensembl:ENSMUST00000056117(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030424"(axon)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:Q62469|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|reactome:R-MMU-8874081	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	-	comment:mint|function:Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	figure legend:Figure 1B|curation depth:imex curation	taxid:10090(mouse-skin)|taxid:10090(Mus musculus skin cells)	-	2014/11/10	2014/11/21	rogid:fiMqFnebmgHpvaT50Pv0hRw+BEI10090	-	intact-crc:91E62BC1A826B407	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q62469	matrixdb:MULT_51_mouse	intact:EBI-8400688|intact:MINT-1866744|uniprotkb:Q6P1C7|uniprotkb:Q62163|ensembl:ENSMUSP00000053891	intact:EBI-9248941	psi-mi:ita2_mouse(display_long)|uniprotkb:Itga2(gene name)|psi-mi:Itga2(display_short)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)	psi-mi:collagen_xxiii_mouse(display_short)|psi-mi:MULT_51_mouse(display_long)|intact:Collagen type XXIII trimer(complex recommended name)|intact:Type XXIII collagen(complex synonym)|intact:Col23a1 trimer(complex systematic name)	psi-mi:"MI:0416"(fluorescence microscopy)	Veit et al. (2011)	pubmed:21652699	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9982610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_032422.2|ensembl:ENSMUSG00000015533(gene)|ensembl:ENSMUST00000056117(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030424"(axon)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:Q62469|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|reactome:R-MMU-8874081	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990322"(collagen type XXIII trimer)|complex portal:CPX-3005(complex-primary)|evidence ontology:"ECO:0005547"	-	comment:mint|function:Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis	curated-complex:Type II orientated transmembrane collagen.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.	figure legend:Figure 1C|curation depth:imex curation	taxid:10090(mouse_tongue)|taxid:10090(Mouse-tongue)	-	2014/11/10	2014/11/21	rogid:fiMqFnebmgHpvaT50Pv0hRw+BEI10090	-	intact-crc:16E6566EE1EACA4D	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)