#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P54257	uniprotkb:P54252-1	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	intact:EBI-946068|ensembl:ENSP00000437157	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Takeshita et al. (2011)	pubmed:21386698|imex:IM-23009	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9648144|imex:IM-23009-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)	go:"GO:0016234"(inclusion body)	-	isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."	figure legend:3f|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2014/07/10	2018/01/16	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606	intact-crc:63F9C1A23E35966A|rigid:yB+ta/d9WAx8ReXy8BgZY3qOcLU	false	-	flag tag:n-n|mutation:296..296-305..305	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P54257	uniprotkb:P54252-1	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	intact:EBI-946068|ensembl:ENSP00000437157	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Takeshita et al. (2011)	pubmed:21386698|imex:IM-23009	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9644194|imex:IM-23009-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)	go:"GO:0016234"(inclusion body)	-	isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."	figure legend:1i|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2014/07/10	2018/01/16	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606	intact-crc:48E312DE3BA6B051|rigid:yB+ta/d9WAx8ReXy8BgZY3qOcLU	false	-	flag tag:n-n|mutation:296..296-305..305	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P54257	uniprotkb:P54252-1	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	intact:EBI-946068|ensembl:ENSP00000437157	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Takeshita et al. (2011)	pubmed:21386698|imex:IM-23009	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9648133|imex:IM-23009-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)	go:"GO:0016234"(inclusion body)	-	isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."	figure legend:2n|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2014/07/10	2018/01/16	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606	intact-crc:48E7000E3BA6B051|rigid:yB+ta/d9WAx8ReXy8BgZY3qOcLU	false	-	sufficient binding region:1-170..170(IPR006155)|flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P54257	uniprotkb:P54252-1	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	intact:EBI-946068|ensembl:ENSP00000437157	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takeshita et al. (2011)	pubmed:21386698|imex:IM-23009	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9648173|imex:IM-23009-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)	-	-	isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."	figure legend:2o and 3h|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2014/07/10	2018/01/16	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606	intact-crc:7E6F0E9764834FC3|rigid:yB+ta/d9WAx8ReXy8BgZY3qOcLU	false	-	flag tag:n-n|mutation:296..296-305..305	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54252-1	uniprotkb:P54257	intact:EBI-946068|ensembl:ENSP00000437157	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym)	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takeshita et al. (2011)	pubmed:21386698|imex:IM-23009	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9644215|imex:IM-23009-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	-	isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."	-	figure legend:2o|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2014/07/10	2018/01/16	rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	intact-crc:9B262ACCB017D77C|rigid:yB+ta/d9WAx8ReXy8BgZY3qOcLU	false	sufficient binding region:1-170..170(IPR006155)|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54252-1	uniprotkb:P54257	intact:EBI-946068|ensembl:ENSP00000437157	intact:EBI-712814|intact:EBI-28977941|ensembl:ENSP00000309392|uniprotkb:O75358|uniprotkb:Q9H4G3|uniprotkb:Q9HA98|uniprotkb:Q9NY90|uniprotkb:A8MQB5|uniprotkb:Q59GK4	psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym)	psi-mi:hap1_human(display_long)|uniprotkb:Neuroan 1(gene name synonym)|uniprotkb:HAP1(gene name)|psi-mi:HAP1(display_short)|uniprotkb:HLP1(gene name synonym)|uniprotkb:HAP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Takeshita et al. (2011)	pubmed:21386698|imex:IM-23009	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9648161|imex:IM-23009-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)	ensembl:ENSG00000173805(gene)|ensembl:ENST00000310778(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_001073339.1|refseq:NP_001073340.1|refseq:NP_817084.2|ensembl:ENSP00000309392|ensembl:ENST00000341193|ensembl:ENSP00000343170|ensembl:ENST00000347901|ensembl:ENSP00000334002|ensembl:ENST00000393939|ensembl:ENSP00000377513	-	isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."	-	figure legend:3h|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2014/07/10	2018/01/16	rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606	rogid:jzDnFZfhnAmyNHvrXcotECiMOc49606	intact-crc:8C46A53BED613076|rigid:yB+ta/d9WAx8ReXy8BgZY3qOcLU	false	flag tag:n-n|mutation:296..296-305..305	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)