#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y5W3	uniprotkb:Q9HCE7	intact:EBI-9846663|uniprotkb:Q6IPC4|uniprotkb:Q9UJS5|uniprotkb:Q9UKR6|ensembl:ENSP00000248071	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:klf2_human(display_long)|uniprotkb:KLF2(gene name)|psi-mi:KLF2(display_short)|uniprotkb:LKLF(gene name synonym)|uniprotkb:Lung krueppel-like factor(gene name synonym)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Xie et al. (2011)	pubmed:21382345|imex:IM-23208	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846662|imex:IM-23208-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057354.1|dip:DIP-41973N|ensembl:ENSG00000127528(gene)|ensembl:ENST00000248071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	-	-	-	dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-mav203)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/10/20	rogid:lUfWW/Fi/LdaO0zwI8QIbi405Xg9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:B9DA343F91B4766D|rigid:PtX2TG+BHYrVnCUen8v/v6H2Lis	false	-	sufficient binding region:236-340(IPR001202)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9HCE7-2	uniprotkb:Q9Y5W3	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	intact:EBI-9846663|uniprotkb:Q6IPC4|uniprotkb:Q9UJS5|uniprotkb:Q9UKR6|ensembl:ENSP00000248071	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:klf2_human(display_long)|uniprotkb:KLF2(gene name)|psi-mi:KLF2(display_short)|uniprotkb:LKLF(gene name synonym)|uniprotkb:Lung krueppel-like factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xie et al. (2011)	pubmed:21382345|imex:IM-23208	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846712|imex:IM-23208-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	refseq:NP_057354.1|dip:DIP-41973N|ensembl:ENSG00000127528(gene)|ensembl:ENST00000248071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	figure legend:Fig. 1a|causality statement:Q9HCE7-2 increases degradation at protein level of Q9Y5W3|causality statement:Q9HCE7-2 is required for ubiquitination of Q9Y5W3|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/14	2014/10/16	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	rogid:lUfWW/Fi/LdaO0zwI8QIbi405Xg9606	intact-crc:0908EB1EEB2EFF4B|rigid:ieTtJ29meffv1XI31b3EijBrOBM	false	his tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y5W3	uniprotkb:Q9HCE7-2	intact:EBI-9846663|uniprotkb:Q6IPC4|uniprotkb:Q9UJS5|uniprotkb:Q9UKR6|ensembl:ENSP00000248071	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:klf2_human(display_long)|uniprotkb:KLF2(gene name)|psi-mi:KLF2(display_short)|uniprotkb:LKLF(gene name synonym)|uniprotkb:Lung krueppel-like factor(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xie et al. (2011)	pubmed:21382345|imex:IM-23208	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846746|imex:IM-23208-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057354.1|dip:DIP-41973N|ensembl:ENSG00000127528(gene)|ensembl:ENST00000248071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 1b, 2b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2014/10/14	2014/10/20	rogid:lUfWW/Fi/LdaO0zwI8QIbi405Xg9606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:9A409635565D8C0D|rigid:ieTtJ29meffv1XI31b3EijBrOBM	false	sufficient binding region:111-267|sufficient binding region:268-354(IPR007087)|myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HCE7-2	uniprotkb:Q53GL0	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	intact:EBI-949945|ensembl:ENSP00000358120|uniprotkb:Q336K5|uniprotkb:Q8IZ51|uniprotkb:Q9UL48|uniprotkb:Q9NRV3	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:pkho1_human(display_long)|uniprotkb:HQ0024c(orf name)|uniprotkb:PLEKHO1(gene name)|psi-mi:PLEKHO1(display_short)|uniprotkb:CKIP1(gene name synonym)|uniprotkb:Casein kinase 2-interacting protein 1(gene name synonym)|uniprotkb:Osteoclast maturation-associated gene 120 protein(gene name synonym)|uniprotkb:C-Jun-binding protein(gene name synonym)|uniprotkb:OC120(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xie et al. (2011)	pubmed:21382345|imex:IM-23208	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846761|imex:IM-23208-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	refseq:NP_057358.2|go:"GO:0008360"(regulation of cell shape)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0051451"(myoblast migration)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028452|interpro:IPR043448|mint:Q53GL0|rcsb pdb:3AA1|ensembl:ENSG00000023902(gene)|ensembl:ENST00000369124(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007520"(myoblast fusion)|refseq:NP_001291651.1|refseq:NP_001291652.1|refseq:NP_001291653.1|ensembl:ENSP00000358120|refseq:XP_016856909.1|dip:DIP-46903N	-	-	-	figure legend:Fig. 1b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2014/10/14	2014/10/16	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	rogid:f+fuKzDy9VwrKcC9fJMo3JqRenM9606	intact-crc:86E3713060D63D0E|rigid:GDiyNfCTNaNygoemnMK+CBWjjik	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HCE7-2	uniprotkb:Q9Y5W3	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	intact:EBI-9846663|uniprotkb:Q6IPC4|uniprotkb:Q9UJS5|uniprotkb:Q9UKR6|ensembl:ENSP00000248071	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:klf2_human(display_long)|uniprotkb:KLF2(gene name)|psi-mi:KLF2(display_short)|uniprotkb:LKLF(gene name synonym)|uniprotkb:Lung krueppel-like factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xie et al. (2011)	pubmed:21382345|imex:IM-23208	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9868490|imex:IM-23208-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	refseq:NP_057354.1|dip:DIP-41973N|ensembl:ENSG00000127528(gene)|ensembl:ENST00000248071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	figure legend:Fig. 2a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2014/10/14	2014/10/20	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	rogid:lUfWW/Fi/LdaO0zwI8QIbi405Xg9606	intact-crc:B66D75454776F11C|rigid:ieTtJ29meffv1XI31b3EijBrOBM	false	myc tag:?-?|necessary binding region:208..208-313..313(IPR001202)	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y5W3	uniprotkb:Q9HCE7	intact:EBI-9846663|uniprotkb:Q6IPC4|uniprotkb:Q9UJS5|uniprotkb:Q9UKR6|ensembl:ENSP00000248071	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:klf2_human(display_long)|uniprotkb:KLF2(gene name)|psi-mi:KLF2(display_short)|uniprotkb:LKLF(gene name synonym)|uniprotkb:Lung krueppel-like factor(gene name synonym)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xie et al. (2011)	pubmed:21382345|imex:IM-23208	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846779|imex:IM-23208-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057354.1|dip:DIP-41973N|ensembl:ENSG00000127528(gene)|ensembl:ENST00000248071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	-	-	-	figure legend:Fig. 1c|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2014/10/14	2014/10/16	rogid:lUfWW/Fi/LdaO0zwI8QIbi405Xg9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:10C4914476ED40E5|rigid:PtX2TG+BHYrVnCUen8v/v6H2Lis	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y5W3	uniprotkb:Q9HCE7-2	intact:EBI-9846663|uniprotkb:Q6IPC4|uniprotkb:Q9UJS5|uniprotkb:Q9UKR6|ensembl:ENSP00000248071	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:klf2_human(display_long)|uniprotkb:KLF2(gene name)|psi-mi:KLF2(display_short)|uniprotkb:LKLF(gene name synonym)|uniprotkb:Lung krueppel-like factor(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Xie et al. (2011)	pubmed:21382345|imex:IM-23208	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846795|imex:IM-23208-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057354.1|dip:DIP-41973N|ensembl:ENSG00000127528(gene)|ensembl:ENST00000248071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1d|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2014/10/14	2014/10/16	rogid:lUfWW/Fi/LdaO0zwI8QIbi405Xg9606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:92EE188F980F1362|rigid:ieTtJ29meffv1XI31b3EijBrOBM	false	green fluorescent protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:1200"(immunocytochemistry)