#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P15387 uniprotkb:P63142 intact:EBI-7511254|intact:MINT-8283237 intact:EBI-631446|uniprotkb:P15386|uniprotkb:Q02010|ensembl:ENSRNOP00000042653|ensembl:ENSRNOP00000075841|ensembl:ENSRNOP00000075852 psi-mi:kcnb1_rat(display_long)|uniprotkb:Kcnb1(gene name)|psi-mi:Kcnb1(display_short)|uniprotkb:Delayed rectifier potassium channel 1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv2.1(gene name synonym) psi-mi:kcna2_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.2(gene name synonym)|uniprotkb:RBK2(gene name synonym)|uniprotkb:RCK5(gene name synonym)|uniprotkb:RAK(gene name synonym)|uniprotkb:Kcna2(gene name)|psi-mi:Kcna2(display_short) psi-mi:"MI:0813"(proximity ligation assay) Zhong et al. (2010) imex:IM-22506|pubmed:20876197 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9315565|imex:IM-22506-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027359|rcsb pdb:2R9R|rcsb pdb:4JTA|interpro:IPR000210(BTB/POZ-like)|interpro:IPR005821(Ion transport)|interpro:IPR004350(Potassium channel, voltage dependent, Kv2.1)|rcsb pdb:4JTD|rcsb pdb:3LNM|rgd:2954|rcsb pdb:4JTC|interpro:IPR011333(BTB/POZ fold)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|refseq:NP_037318.1|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003973(Potassium channel, voltage dependent, Kv2)|interpro:IPR028325|go:"GO:0000149"(SNARE binding)|go:"GO:0001508"(action potential)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:2000671"(regulation of motor neuron apoptotic process)|reactome:R-RNO-1296072|reactome:R-RNO-381676 rgd:2950|refseq:NP_037102.1|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|rcsb pdb:1DSX|rcsb pdb:1QDV|rcsb pdb:1QDW|rcsb pdb:2A79|rcsb pdb:2R9R|rcsb pdb:3LNM|rcsb pdb:3LUT|rcsb pdb:4JTA|rcsb pdb:4JTC|rcsb pdb:4JTD|rcsb pdb:5WIE|rcsb pdb:6EBK|rcsb pdb:6EBL|rcsb pdb:6EBM|interpro:IPR005821(Ion transport)|reactome:R-RNO-1296072|ensembl:ENSRNOG00000018285(gene)|ensembl:ENSRNOT00000050149(transcript)|ensembl:ENSRNOT00000092365(transcript)|ensembl:ENSRNOT00000092450(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019894"(kinesin binding)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033010"(paranodal junction)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004049(Potassium channel, voltage dependent, Kv1.2)|go:"GO:0014059"(regulation of dopamine secretion)|refseq:XP_008759593.1|refseq:XP_006233194.1|refseq:XP_006233195.1|refseq:XP_006233196.1|refseq:XP_006233197.1 go:"GO:0071944"(cell periphery) comment:mint - figure legend:10F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus) - 2014/03/25 2015/03/24 rogid:XskxHGYDpeOX7fADwIzU0n2gT4810116 rogid:AimFojHr+yjzzdtmfxUCRBTvJyc10116 intact-crc:4C61BB1E72B8A345|rigid:5tYznCotuLUayRvvz4I7EqoJTGg false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P15387 uniprotkb:O88759 intact:EBI-7511254|intact:MINT-8283237 intact:EBI-9304022|uniprotkb:O54900|ensembl:ENSRNOP00000006499 psi-mi:kcnb1_rat(display_long)|uniprotkb:Kcnb1(gene name)|psi-mi:Kcnb1(display_short)|uniprotkb:Delayed rectifier potassium channel 1(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv2.1(gene name synonym) psi-mi:kcns3_rat(display_long)|uniprotkb:Kcns3(gene name)|psi-mi:Kcns3(display_short)|uniprotkb:"Delayed-rectifier K(+) channel alpha subunit 3"(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv9.3(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Zhong et al. (2010) imex:IM-22506|pubmed:20876197 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9302446|imex:IM-22506-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027359|rcsb pdb:2R9R|rcsb pdb:4JTA|interpro:IPR000210(BTB/POZ-like)|interpro:IPR005821(Ion transport)|interpro:IPR004350(Potassium channel, voltage dependent, Kv2.1)|rcsb pdb:4JTD|rcsb pdb:3LNM|rgd:2954|rcsb pdb:4JTC|interpro:IPR011333(BTB/POZ fold)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|refseq:NP_037318.1|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003973(Potassium channel, voltage dependent, Kv2)|interpro:IPR028325|go:"GO:0000149"(SNARE binding)|go:"GO:0001508"(action potential)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:2000671"(regulation of motor neuron apoptotic process)|reactome:R-RNO-1296072|reactome:R-RNO-381676 refseq:NP_113966.2|rgd:621527|ensembl:ENSRNOG00000004899(gene)|ensembl:ENSRNOT00000006499(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003971(Potassium channel, voltage dependent, Kv9)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|reactome:R-RNO-1296072|reactome:R-RNO-381676 go:"GO:0005886"(plasma membrane) comment:mint - figure legend:9C-F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus) - 2014/03/25 2014/10/16 rogid:XskxHGYDpeOX7fADwIzU0n2gT4810116 rogid:DFwXLOPZh7KYTWuBkhwgWX1WTRI10116 intact-crc:7404F709E8638214|rigid:M3I0ELeg9ta1unE0TeuiwVkXa6I false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P19024 uniprotkb:P63142 intact:EBI-7051888|ensembl:ENSRNOP00000026691|uniprotkb:Q6LEB7|intact:MINT-3973915 intact:EBI-631446|uniprotkb:P15386|uniprotkb:Q02010|ensembl:ENSRNOP00000042653|ensembl:ENSRNOP00000075841|ensembl:ENSRNOP00000075852 psi-mi:kcna5_rat(display_long)|uniprotkb:Kcna5(gene name)|psi-mi:Kcna5(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.5(gene name synonym)|uniprotkb:RCK7(gene name synonym)|uniprotkb:RK4(gene name synonym) psi-mi:kcna2_rat(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.2(gene name synonym)|uniprotkb:RBK2(gene name synonym)|uniprotkb:RCK5(gene name synonym)|uniprotkb:RAK(gene name synonym)|uniprotkb:Kcna2(gene name)|psi-mi:Kcna2(display_short) psi-mi:"MI:0813"(proximity ligation assay) Zhong et al. (2010) imex:IM-22506|pubmed:20876197 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9302440|imex:IM-22506-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000019719(gene)|go:"GO:0086052"(membrane repolarization during SA node cell action potential)|go:"GO:0086087"(voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization)|go:"GO:0086089"(voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization)|go:"GO:0086090"(voltage-gated potassium channel activity involved in SA node cell action potential repolarization)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098914"(membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000288"(positive regulation of myoblast proliferation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004052(Potassium channel, voltage dependent, Kv1.5)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P19024|reactome:R-RNO-1296072|ensembl:ENSRNOT00000026691(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0045121"(membrane raft)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086050"(membrane repolarization during bundle of His cell action potential)|refseq:NP_037104.1|rgd:2953 rgd:2950|refseq:NP_037102.1|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|rcsb pdb:1DSX|rcsb pdb:1QDV|rcsb pdb:1QDW|rcsb pdb:2A79|rcsb pdb:2R9R|rcsb pdb:3LNM|rcsb pdb:3LUT|rcsb pdb:4JTA|rcsb pdb:4JTC|rcsb pdb:4JTD|rcsb pdb:5WIE|rcsb pdb:6EBK|rcsb pdb:6EBL|rcsb pdb:6EBM|interpro:IPR005821(Ion transport)|reactome:R-RNO-1296072|ensembl:ENSRNOG00000018285(gene)|ensembl:ENSRNOT00000050149(transcript)|ensembl:ENSRNOT00000092365(transcript)|ensembl:ENSRNOT00000092450(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019894"(kinesin binding)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033010"(paranodal junction)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004049(Potassium channel, voltage dependent, Kv1.2)|go:"GO:0014059"(regulation of dopamine secretion)|refseq:XP_008759593.1|refseq:XP_006233194.1|refseq:XP_006233195.1|refseq:XP_006233196.1|refseq:XP_006233197.1 go:"GO:0005886"(plasma membrane) comment:mint|function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient - figure legend:9A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus) - 2014/03/25 2015/03/24 rogid:Qcb1z+hiv2D2bn7GN5TRJZIwxtE10116 rogid:AimFojHr+yjzzdtmfxUCRBTvJyc10116 intact-crc:FD9B46DD07A1AF84|rigid:eEr6Dwp8Lsd+HQRKwqAop/aYNCc false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P19024 uniprotkb:O88759 intact:EBI-7051888|ensembl:ENSRNOP00000026691|uniprotkb:Q6LEB7|intact:MINT-3973915 intact:EBI-9304022|uniprotkb:O54900|ensembl:ENSRNOP00000006499 psi-mi:kcna5_rat(display_long)|uniprotkb:Kcna5(gene name)|psi-mi:Kcna5(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv1.5(gene name synonym)|uniprotkb:RCK7(gene name synonym)|uniprotkb:RK4(gene name synonym) psi-mi:kcns3_rat(display_long)|uniprotkb:Kcns3(gene name)|psi-mi:Kcns3(display_short)|uniprotkb:"Delayed-rectifier K(+) channel alpha subunit 3"(gene name synonym)|uniprotkb:Voltage-gated potassium channel subunit Kv9.3(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Zhong et al. (2010) imex:IM-22506|pubmed:20876197 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9315523|imex:IM-22506-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000019719(gene)|go:"GO:0086052"(membrane repolarization during SA node cell action potential)|go:"GO:0086087"(voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization)|go:"GO:0086089"(voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization)|go:"GO:0086090"(voltage-gated potassium channel activity involved in SA node cell action potential repolarization)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098914"(membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000288"(positive regulation of myoblast proliferation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004052(Potassium channel, voltage dependent, Kv1.5)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|mint:P19024|reactome:R-RNO-1296072|ensembl:ENSRNOT00000026691(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0034705"(potassium channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0045121"(membrane raft)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086050"(membrane repolarization during bundle of His cell action potential)|refseq:NP_037104.1|rgd:2953 refseq:NP_113966.2|rgd:621527|ensembl:ENSRNOG00000004899(gene)|ensembl:ENSRNOT00000006499(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003971(Potassium channel, voltage dependent, Kv9)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|reactome:R-RNO-1296072|reactome:R-RNO-381676 go:"GO:0071944"(cell periphery) comment:mint|function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient - figure legend:10E|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus) - 2014/03/25 2014/10/16 rogid:Qcb1z+hiv2D2bn7GN5TRJZIwxtE10116 rogid:DFwXLOPZh7KYTWuBkhwgWX1WTRI10116 intact-crc:4C636B1E72B8A345|rigid:xhZyyYTIIWfH0VqpscVEu3YqMDw false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)