#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31240	uniprotkb:P05622	intact:EBI-9101509|uniprotkb:Q6P3C4	intact:EBI-1554855|uniprotkb:E9QPE2	psi-mi:pdgfb_mouse(display_long)|uniprotkb:Pdgfb(gene name)|psi-mi:Pdgfb(display_short)|uniprotkb:Sis(gene name synonym)|uniprotkb:PDGF-2(gene name synonym)|uniprotkb:Platelet-derived growth factor B chain(gene name synonym)|uniprotkb:Platelet-derived growth factor beta polypeptide(gene name synonym)|uniprotkb:Proto-oncogene c-Sis(gene name synonym)	psi-mi:pgfrb_mouse(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:Pdgfrb(gene name)|psi-mi:Pdgfrb(display_short)|uniprotkb:Pdgfr(gene name synonym)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Pdgfr1(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Winkler et al. (2010)	pubmed:20738866|imex:IM-22306	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9348139|imex:IM-22306-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001568"(blood vessel development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|reactome:R-MMU-114608|reactome:R-MMU-1257604|reactome:R-MMU-186763|reactome:R-MMU-186797|reactome:R-MMU-3000171|reactome:R-MMU-5673001|reactome:R-MMU-6811558|refseq:XP_017171991.1|refseq:NP_035187.2|interpro:IPR023581|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR006782(Platelet-derived growth factor, N-terminal)|rcsb pdb:2DZ4|rcsb pdb:2DZ5|interpro:IPR029034|interpro:IPR015583(Platelet-Derived Growth Factor B Chain)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010512"(negative regulation of phosphatidylinositol biosynthetic process)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021782"(glial cell development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071506"(cellular response to mycophenolic acid)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072255"(metanephric glomerular mesangial cell development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072264"(metanephric glomerular endothelium development)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904899"(positive regulation of hepatic stellate cell proliferation)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905176"(positive regulation of vascular associated smooth muscle cell dedifferentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000591"(positive regulation of metanephric mesenchymal cell migration)	refseq:NP_001139740.1|refseq:NP_032835.2|mint:P05622|dip:DIP-39669N|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001822"(kidney development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072223"(metanephric glomerular mesangium development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0097178"(ruffle assembly)|go:"GO:0106096"(response to ceramide)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|rcsb pdb:1AYA|rcsb pdb:1AYC|reactome:R-MMU-1257604|reactome:R-MMU-186763|reactome:R-MMU-186797|reactome:R-MMU-5673001|reactome:R-MMU-6811558	-	-	-	figure legend:3 A/B|comment:PDGF-B/PDGFRbeta  interactions occur only on PDGFRbeta-positive pericytes located on lectin-positive brain capillaries in layer III of the parietal cortex and CA1 subfield of the hippocampus, in the adult 129S1/SvlmJ mouse brain.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-pericyte)|taxid:10090(Mouse Pericyte)	-	2014/04/02	2019/07/08	rogid:lrlYYCAz6rPFJ+asPYJLprnPuPI10090	rogid:Z5QKa7DWFevufdsXMCQhd2ui/U810090	intact-crc:58899FC67A3D683A|rigid:qUkvWhF0NBtQ3ZiEatgQiKLXv3s	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)