#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10451	uniprotkb:P16070	intact:EBI-723648|ensembl:ENSP00000378517|ensembl:ENSP00000477824|uniprotkb:Q15681|uniprotkb:Q15682|uniprotkb:Q15683|uniprotkb:Q8NBK2|uniprotkb:Q96IZ1|uniprotkb:B2RDA1|uniprotkb:Q4W597|uniprotkb:Q567T5	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	psi-mi:ostp_human(display_long)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:OPN(gene name synonym)|uniprotkb:PSEC0156(orf name)|uniprotkb:BNSP(gene name synonym)	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Hsu et al. (2010)	imex:IM-22278|pubmed:20549562	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9293654|imex:IM-22278-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000573.1|refseq:NP_001035147.1|ensembl:ENSG00000118785(gene)|ensembl:ENST00000395080(transcript)|ensembl:ENST00000614857(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042995"(cell projection)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048685"(negative regulation of collateral sprouting of intact axon in response to injury)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|mint:P10451|rcsb pdb:3CXD|rcsb pdb:3DSF|reactome:R-HSA-1474228|reactome:R-HSA-186797|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8949275|reactome:R-HSA-8957275|go:"GO:0046697"(decidualization)|refseq:NP_001035149.1|refseq:NP_001238758.1|refseq:NP_001238759.1|dip:DIP-49933N	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	-	-	-	figure legend:Figure 1 n-p|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-gist_tissue)|taxid:9606(Human Gist_tissue)	-	2014/03/24	2014/10/16	rogid:a1xqyCMAIQpBwLFBbfKN7R+7K3M9606	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	intact-crc:BFC881AA9121CCAE|rigid:+DolgP4A7i7Y60ozZE2Y6epI39Q	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P16070	uniprotkb:P10451	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	intact:EBI-723648|ensembl:ENSP00000378517|ensembl:ENSP00000477824|uniprotkb:Q15681|uniprotkb:Q15682|uniprotkb:Q15683|uniprotkb:Q8NBK2|uniprotkb:Q96IZ1|uniprotkb:B2RDA1|uniprotkb:Q4W597|uniprotkb:Q567T5	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:ostp_human(display_long)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:OPN(gene name synonym)|uniprotkb:PSEC0156(orf name)|uniprotkb:BNSP(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Hsu et al. (2010)	imex:IM-22278|pubmed:20549562	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9293672|imex:IM-22278-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	refseq:NP_000573.1|refseq:NP_001035147.1|ensembl:ENSG00000118785(gene)|ensembl:ENST00000395080(transcript)|ensembl:ENST00000614857(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042995"(cell projection)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048685"(negative regulation of collateral sprouting of intact axon in response to injury)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|mint:P10451|rcsb pdb:3CXD|rcsb pdb:3DSF|reactome:R-HSA-1474228|reactome:R-HSA-186797|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8949275|reactome:R-HSA-8957275|go:"GO:0046697"(decidualization)|refseq:NP_001035149.1|refseq:NP_001238758.1|refseq:NP_001238759.1|dip:DIP-49933N	-	-	-	figure legend:Figure 2B|comment:Increased PLA signals were observed after CD44 transfection.|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-gist882)|taxid:9606("Human GIST882 -with activating Kit mutation (K642E)")	-	2014/03/24	2014/10/16	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	rogid:a1xqyCMAIQpBwLFBbfKN7R+7K3M9606	intact-crc:160C5746CA30BD5B|rigid:+DolgP4A7i7Y60ozZE2Y6epI39Q	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)