#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q03111 uniprotkb:P63208 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351592|imex:IM-22311-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Eii|comment:The amount of AF9 and TRRAP found is vanishingly small.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:10C1FD7073D5859D|rigid:VWzpHAy7/SkSGQCGyl/0uVObqwE false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q03111 uniprotkb:Q8TEK3 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351592|imex:IM-22311-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Eii|comment:The amount of AF9 and TRRAP found is vanishingly small.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 intact-crc:10C1FD7073D5859D|rigid:VWzpHAy7/SkSGQCGyl/0uVObqwE false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q03111 uniprotkb:P55198 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 intact:EBI-740216|uniprotkb:Q9UF49|intact:EBI-945884|intact:EBI-28966978|ensembl:ENSP00000477969|ensembl:ENSP00000479910|uniprotkb:Q59F28|uniprotkb:Q9H5F6|uniprotkb:Q96IU3 psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:af17_human(display_long)|uniprotkb:MLLT6(gene name)|psi-mi:MLLT6(display_short)|uniprotkb:AF17(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 17 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351592|imex:IM-22311-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 ensembl:ENSP00000477969|ensembl:ENSP00000479910|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0035812"(renal sodium excretion)|go:"GO:0036359"(renal potassium excretion)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2001161"(negative regulation of histone H3-K79 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|ensembl:ENSG00000275023(gene)|ensembl:ENSG00000275851(gene)|ensembl:ENST00000618876(transcript)|ensembl:ENST00000621332(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0031491"(nucleosome binding)|refseq:NP_005928.2 go:"GO:0005634"(nucleus) - - figure legend:Figure 3Eii|comment:The amount of AF9 and TRRAP found is vanishingly small.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 rogid:VcJKH3p3r1+7OGgwYfeR5plOfz49606 intact-crc:10C1FD7073D5859D|rigid:VWzpHAy7/SkSGQCGyl/0uVObqwE false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q03111 uniprotkb:P55197 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351592|imex:IM-22311-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Eii|comment:The amount of AF9 and TRRAP found is vanishingly small.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 intact-crc:10C1FD7073D5859D|rigid:VWzpHAy7/SkSGQCGyl/0uVObqwE false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P42568 uniprotkb:P55197 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351577|imex:IM-22311-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Ei|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 intact-crc:93514FFABF088569|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P42568 uniprotkb:P55198 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 intact:EBI-740216|uniprotkb:Q9UF49|intact:EBI-945884|intact:EBI-28966978|ensembl:ENSP00000477969|ensembl:ENSP00000479910|uniprotkb:Q59F28|uniprotkb:Q9H5F6|uniprotkb:Q96IU3 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:af17_human(display_long)|uniprotkb:MLLT6(gene name)|psi-mi:MLLT6(display_short)|uniprotkb:AF17(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 17 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351577|imex:IM-22311-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N ensembl:ENSP00000477969|ensembl:ENSP00000479910|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0035812"(renal sodium excretion)|go:"GO:0036359"(renal potassium excretion)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2001161"(negative regulation of histone H3-K79 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|ensembl:ENSG00000275023(gene)|ensembl:ENSG00000275851(gene)|ensembl:ENST00000618876(transcript)|ensembl:ENST00000621332(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0031491"(nucleosome binding)|refseq:NP_005928.2 go:"GO:0005634"(nucleus) - - figure legend:Figure 3Ei|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:VcJKH3p3r1+7OGgwYfeR5plOfz49606 intact-crc:93514FFABF088569|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P42568 uniprotkb:Q8TEK3 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351577|imex:IM-22311-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Ei|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 intact-crc:93514FFABF088569|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P42568 uniprotkb:Q03111 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351577|imex:IM-22311-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 go:"GO:0005634"(nucleus) - - figure legend:Figure 3Ei|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 intact-crc:93514FFABF088569|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P42568 uniprotkb:Q9Y4A5 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 intact:EBI-399128|uniprotkb:O75218|uniprotkb:Q9Y631|uniprotkb:Q9Y6H4|uniprotkb:A4D265|ensembl:ENSP00000352925 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:trrap_human(display_long)|uniprotkb:TRRAP(gene name)|psi-mi:TRRAP(display_short)|uniprotkb:PAF400(gene name synonym)|uniprotkb:350/400 kDa PCAF-associated factor(gene name synonym)|uniprotkb:STAF40(gene name synonym)|uniprotkb:Tra1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351577|imex:IM-22311-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N refseq:NP_003487.1|ensembl:ENSG00000196367(gene)|ensembl:ENST00000359863(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q9Y4A5|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689880|refseq:NP_001231509.1|dip:DIP-28149N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Ei|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:bGoQLXxMT0zZ0jVW+2s4hUwnBA49606 intact-crc:93514FFABF088569|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P42568 uniprotkb:P63208 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351577|imex:IM-22311-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Ei|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:93514FFABF088569|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q8TEK3 uniprotkb:Q9Y4A5 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-399128|uniprotkb:O75218|uniprotkb:Q9Y631|uniprotkb:Q9Y6H4|uniprotkb:A4D265|ensembl:ENSP00000352925 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:trrap_human(display_long)|uniprotkb:TRRAP(gene name)|psi-mi:TRRAP(display_short)|uniprotkb:PAF400(gene name synonym)|uniprotkb:350/400 kDa PCAF-associated factor(gene name synonym)|uniprotkb:STAF40(gene name synonym)|uniprotkb:Tra1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351352|imex:IM-22311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N refseq:NP_003487.1|ensembl:ENSG00000196367(gene)|ensembl:ENST00000359863(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q9Y4A5|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689880|refseq:NP_001231509.1|dip:DIP-28149N go:"GO:0005634"(nucleus) - - figure legend:Figure 1D, 3D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:bGoQLXxMT0zZ0jVW+2s4hUwnBA49606 intact-crc:D06872C90C0C3551|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q8TEK3 uniprotkb:P55198 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-740216|uniprotkb:Q9UF49|intact:EBI-945884|intact:EBI-28966978|ensembl:ENSP00000477969|ensembl:ENSP00000479910|uniprotkb:Q59F28|uniprotkb:Q9H5F6|uniprotkb:Q96IU3 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:af17_human(display_long)|uniprotkb:MLLT6(gene name)|psi-mi:MLLT6(display_short)|uniprotkb:AF17(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 17 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351352|imex:IM-22311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N ensembl:ENSP00000477969|ensembl:ENSP00000479910|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0035812"(renal sodium excretion)|go:"GO:0036359"(renal potassium excretion)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2001161"(negative regulation of histone H3-K79 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|ensembl:ENSG00000275023(gene)|ensembl:ENSG00000275851(gene)|ensembl:ENST00000618876(transcript)|ensembl:ENST00000621332(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0031491"(nucleosome binding)|refseq:NP_005928.2 go:"GO:0005634"(nucleus) - - figure legend:Figure 1D, 3D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:VcJKH3p3r1+7OGgwYfeR5plOfz49606 intact-crc:D06872C90C0C3551|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q8TEK3 uniprotkb:P63208 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351352|imex:IM-22311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N go:"GO:0005634"(nucleus) - - figure legend:Figure 1D, 3D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:D06872C90C0C3551|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q8TEK3 uniprotkb:P55197 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351352|imex:IM-22311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N go:"GO:0005634"(nucleus) - - figure legend:Figure 1D, 3D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 intact-crc:D06872C90C0C3551|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q8TEK3 uniprotkb:P42568 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351352|imex:IM-22311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N go:"GO:0005634"(nucleus) - - figure legend:Figure 1D, 3D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 intact-crc:D06872C90C0C3551|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:Q8TEK3 uniprotkb:Q03111 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351352|imex:IM-22311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 go:"GO:0005634"(nucleus) - - figure legend:Figure 1D, 3D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 intact-crc:D06872C90C0C3551|rigid:t+QjGzCbr6rjA33bfpX5OY3FdEY false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P55197 uniprotkb:Q8TEK3 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351560|imex:IM-22311-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N go:"GO:0005634"(nucleus) - - figure legend:Figure 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 intact-crc:95203E6BFF49E261|rigid:k5usImO65So8LCRbGxB1+f6Xnbo false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P55197 uniprotkb:P55198 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 intact:EBI-740216|uniprotkb:Q9UF49|intact:EBI-945884|intact:EBI-28966978|ensembl:ENSP00000477969|ensembl:ENSP00000479910|uniprotkb:Q59F28|uniprotkb:Q9H5F6|uniprotkb:Q96IU3 psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:af17_human(display_long)|uniprotkb:MLLT6(gene name)|psi-mi:MLLT6(display_short)|uniprotkb:AF17(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 17 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351560|imex:IM-22311-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N ensembl:ENSP00000477969|ensembl:ENSP00000479910|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0035812"(renal sodium excretion)|go:"GO:0036359"(renal potassium excretion)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2001161"(negative regulation of histone H3-K79 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|ensembl:ENSG00000275023(gene)|ensembl:ENSG00000275851(gene)|ensembl:ENST00000618876(transcript)|ensembl:ENST00000621332(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0031491"(nucleosome binding)|refseq:NP_005928.2 go:"GO:0005634"(nucleus) - - figure legend:Figure 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 rogid:VcJKH3p3r1+7OGgwYfeR5plOfz49606 intact-crc:95203E6BFF49E261|rigid:k5usImO65So8LCRbGxB1+f6Xnbo false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P55197 uniprotkb:P42568 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351560|imex:IM-22311-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N go:"GO:0005634"(nucleus) - - figure legend:Figure 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 intact-crc:95203E6BFF49E261|rigid:k5usImO65So8LCRbGxB1+f6Xnbo false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P55197 uniprotkb:P63208 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351560|imex:IM-22311-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N go:"GO:0005634"(nucleus) - - figure legend:Figure 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:95203E6BFF49E261|rigid:k5usImO65So8LCRbGxB1+f6Xnbo false flag tag:n-n - - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology) uniprotkb:P35222 uniprotkb:Q8TEK3 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351610|imex:IM-22311-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N go:"GO:0005634"(nucleus) - - figure legend:Figure 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 intact-crc:B244F47F092A7037|rigid:KcRlrA+XPk57k0veOJ9VYgrheyI false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35222 uniprotkb:P55197 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351642|imex:IM-22311-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N go:"GO:0005634"(nucleus) - - figure legend:Figure 4Ci|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2014/10/16 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 intact-crc:3EAE556A8E3F2BD4|rigid:jy2biJYF60hBhCXsISqTUA7FEq0 false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TEK3 uniprotkb:Q03111 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351371|imex:IM-22311-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 go:"GO:0005634"(nucleus) - - figure legend:Figure 1Di|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 intact-crc:23FE964668C24ACD|rigid:togL55jGAjMrhI7ayImQT45Skho false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03111 uniprotkb:Q8TEK3 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351446|imex:IM-22311-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N go:"GO:0005634"(nucleus) - - figure legend:Figure 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 intact-crc:CE88449264466D8A|rigid:togL55jGAjMrhI7ayImQT45Skho false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42568 uniprotkb:Q8TEK3 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351458|imex:IM-22311-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Bi|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 intact-crc:0873665DCBF45CE6|rigid:3S4ueTEQ1DD/q/uOSiYepeT/8aY false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P55197 uniprotkb:Q8TEK3 intact:EBI-1104952|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENSP00000488569|uniprotkb:Q5JT37|uniprotkb:Q66K63|uniprotkb:B1ANA8|uniprotkb:Q5VX90|intact:EBI-11060398 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 psi-mi:af10_human(display_long)|uniprotkb:MLLT10(gene name)|psi-mi:MLLT10(display_short)|uniprotkb:AF10(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 10 protein(gene name synonym) psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9351466|imex:IM-22311-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078403(gene)|ensembl:ENSP00000307411|ensembl:ENSP00000366258|ensembl:ENST00000377072|ensembl:ENSP00000366272|ensembl:ENST00000377091|ensembl:ENSP00000366295|ensembl:ENST00000377100|ensembl:ENSP00000366304|ensembl:ENST00000621220|ensembl:ENSP00000484335|ensembl:ENSP00000488569|ensembl:ENST00000652497|ensembl:ENSP00000498595|refseq:NP_001182556.1|refseq:NP_004632.1|ensembl:ENST00000307729(transcript)|ensembl:ENST00000377059(transcript)|ensembl:ENST00000631589(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|mint:P55197|rcsb pdb:5DAG|rcsb pdb:5DAH|rcsb pdb:6CKN|rcsb pdb:6CKO|rcsb pdb:6JN2|refseq:NP_001182557.1|refseq:NP_001182559.1|refseq:NP_001182555.1|refseq:NP_001311225.1|dip:DIP-37633N refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N go:"GO:0005634"(nucleus) - - figure legend:Figure 3Bii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/21 2018/09/18 rogid:7jWr9+kJgTFVbZvq+BndUhHQstA9606 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 intact-crc:5A1E5D387CFD4B6C|rigid:hkijaXNBVZS8fZT0Po15O22moOM false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TEK3 uniprotkb:Q71DI3 intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657 intact:EBI-750650|uniprotkb:A2BDF6|uniprotkb:A6NFS4|uniprotkb:Q6B053|ensembl:ENSP00000333277|ensembl:ENSP00000358154|ensembl:ENSP00000385479 psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym) psi-mi:h32_human(display_long)|uniprotkb:H3C13(gene name)|psi-mi:H3C13(display_short)|uniprotkb:H3C14(gene name)|psi-mi:H3C14(display_short)|uniprotkb:H3C15(gene name)|psi-mi:H3C15(display_short)|uniprotkb:H3-clustered histone 13(gene name synonym)|uniprotkb:H3-clustered histone 14(gene name synonym)|uniprotkb:H3-clustered histone 15(gene name synonym)|uniprotkb:H3F2(gene name synonym)|uniprotkb:H3FM(gene name synonym)|uniprotkb:HIST2H3A(gene name synonym)|uniprotkb:HIST2H3C(gene name synonym)|uniprotkb:HIST2H3D(gene name synonym)|uniprotkb:Histone H3/m(gene name synonym)|uniprotkb:Histone H3/o(gene name synonym) psi-mi:"MI:0515"(methyltransferase assay) Mohan et al. (2010) imex:IM-22311|pubmed:20203130 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0213"(methylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9351390|imex:IM-22311-3 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N refseq:NP_001005464.1|refseq:NP_001116847.1|refseq:NP_066403.2|dip:DIP-48606N|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|rcsb pdb:7BU9|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214858|reactome:R-HSA-3247509|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-983231|rcsb pdb:7JZV|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|ensembl:ENSG00000183598(gene)|ensembl:ENSG00000203811(gene)|ensembl:ENSG00000203852(gene)|ensembl:ENST00000331491(transcript)|ensembl:ENST00000369158(transcript)|ensembl:ENST00000403683(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q71DI3|rcsb pdb:2IIJ|rcsb pdb:2X4W|rcsb pdb:2X4X|rcsb pdb:2X4Y|rcsb pdb:3AV1|rcsb pdb:3DB3|rcsb pdb:3MO8|rcsb pdb:3QO2|rcsb pdb:3R93|rcsb pdb:4MZF|rcsb pdb:4MZG|rcsb pdb:4MZH|rcsb pdb:4OUC|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B40|rcsb pdb:5BO0|rcsb pdb:5CIU|rcsb pdb:5VAC|rcsb pdb:6ACE|rcsb pdb:6FML|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6Y5E|rcsb pdb:7BQZ go:"GO:0034729"(histone H3-K79 methylation) - - figure legend:2C-E|comment:Mostly trimethylated histone H3 peptides were observed, but also some di and mono methylated peptides.|resulting-ptm:Q71DI3 lys-80 N6Me3Lys Q71DI3 lys-80 N6Me2Lys Q71DI3 lys-80 N6Me1Lys|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/03/21 2018/09/18 rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606 rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o9606 intact-crc:8A140A89B5995F4F|rigid:nGy/frtIzbFP2nJ5kIDQ2MQI52k false sufficient binding region:1-416 sufficient binding region:71-85 - - psi-mi:"MI:0658"(multidimensional protein identification technology) psi-mi:"MI:0658"(multidimensional protein identification technology)