#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9699865|imex:IM-22986-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 1B, 1F, 4A, 4B, 4C, 5F, S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:848F824856171237|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	flag tag:?-?	ha tag:?-?|necessary binding region:251-352	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817380|imex:IM-22986-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig.  S4B|comment:CIP treatment didn't have any effect in this interaction|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:526517E8978EE3B1|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?|mutation:157-157	sufficient binding region:167-433|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817380|imex:IM-22986-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig.  S4B|comment:CIP treatment didn't have any effect in this interaction|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:526517E8978EE3B1|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?|mutation:157-157	ha tag:?-?|mutation:222-222,226-226	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9869145|imex:IM-22986-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig. 4C|comment:Figure 4C has a very weak band showing interaction between Pin1 and Mek2-K dead mutant.   Figure 3E, doesn't show interaction between the mutant Mek2-K and Pin1.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/21	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:DADE1C3E58079A21|rigid:Yq9ojrNy4gomeyL0eylsxf2ZKoc	false	flag tag:?-?	ha tag:?-?|mutation:101-101	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9699898|imex:IM-22986-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig.3A|comment:"HA-MeK2-K (dead mutant K101A) reduces the interaction between Flag Pin 1 and HA-PC."|comment:"HA-active c-Raf (mutant Y340D) increases interaction between  Flag -Pin1 and HA-PC"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:409EBBF530646E58|rigid:qIur15JRrrdP9sG+s5yjg8CEayY	false	flag tag:?-?	sufficient binding region:167-433|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P04049	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9699898|imex:IM-22986-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N	-	-	-	figure legend:Fig.3A|comment:"HA-MeK2-K (dead mutant K101A) reduces the interaction between Flag Pin 1 and HA-PC."|comment:"HA-active c-Raf (mutant Y340D) increases interaction between  Flag -Pin1 and HA-PC"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606	intact-crc:409EBBF530646E58|rigid:qIur15JRrrdP9sG+s5yjg8CEayY	false	flag tag:?-?	mutation:340-340|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9775966|imex:IM-22986-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig.  3E, 4A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/21	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:351A30BE6BD27A69|rigid:Yq9ojrNy4gomeyL0eylsxf2ZKoc	false	flag tag:?-?	mutation:222-222,226-226|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817203|imex:IM-22986-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:C5191A937B92ABCE|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	ha tag:?-?|sufficient binding region:167-433|mutation increasing interaction:186-186,187-187,188-188,189-189|mutation increasing interaction:186-186,184-184	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9521505|imex:IM-22986-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig.  3A, 3E, 4A, 4B, 4C, 5E, S4A, 5F, 5G|comment:"Mek2-SD (mutant S222D-S226D) enhances the interaction between Flag-Pin 1 and HA-PC.  As the expressed amount of Mek2-SD increases, the interaction between PC and Pin1 (in the triple complex) decreases (Fig. 4A)"|comment:"As the expressed amount of Mek2-K (mutant K101A) increases, the interaction between PC and Pin1 is disrupted."|comment:"As the expressed amount of Mek2 WT increases the interaction of Mek2WT with the complex PC-Pin1 appears (1.5ug of plasmid) (Fig. 4B)"|comment:"CIAP treatment improved the interaction between Mek2-SD and the PC-PIN1 complex (Fig. S4A)"|comment:"The loss of the following PC fragment: 256-260aa prevents Mek2-SD from binding to Pin1 and reduces the binding between Pin1 and BPGAP1 PC fragment"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/21	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:CDDBBE94BB923C0A|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	ha tag:?-?|sufficient binding region:167-433|necessary binding region:256-260	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9521505|imex:IM-22986-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig.  3A, 3E, 4A, 4B, 4C, 5E, S4A, 5F, 5G|comment:"Mek2-SD (mutant S222D-S226D) enhances the interaction between Flag-Pin 1 and HA-PC.  As the expressed amount of Mek2-SD increases, the interaction between PC and Pin1 (in the triple complex) decreases (Fig. 4A)"|comment:"As the expressed amount of Mek2-K (mutant K101A) increases, the interaction between PC and Pin1 is disrupted."|comment:"As the expressed amount of Mek2 WT increases the interaction of Mek2WT with the complex PC-Pin1 appears (1.5ug of plasmid) (Fig. 4B)"|comment:"CIAP treatment improved the interaction between Mek2-SD and the PC-PIN1 complex (Fig. S4A)"|comment:"The loss of the following PC fragment: 256-260aa prevents Mek2-SD from binding to Pin1 and reduces the binding between Pin1 and BPGAP1 PC fragment"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/21	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:CDDBBE94BB923C0A|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	ha tag:?-?|mutation increasing interaction:222-222,226-226|mutation decreasing interaction:101-101	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9700069|imex:IM-22986-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 1G|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:CDA2792477730C58|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	mutation:113-113|sufficient binding region:60-163|flag tag:?-?	ha tag:?-?|sufficient binding region:251-433	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9700046|imex:IM-22986-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 1J|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:A11FBE17B124426A|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	ha tag:?-?|necessary binding region:256-260	mutation:157-157|flag tag:?-?|sufficient binding region:60-163	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q63932	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9522678|imex:IM-22986-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 3D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:EE99387E4A7D2D1C|rigid:H2rNdZySgkQ5ObiKY7SfKgviDGM	false	flag tag:?-?|sufficient binding region:167-433	ha tag:?-?|mutation decreasing interaction:222-222,226-226|mutation decreasing interaction:101-101	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63932	uniprotkb:P85298-4	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817260|imex:IM-22986-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 5H|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:F008A90747928BF7|rigid:H2rNdZySgkQ5ObiKY7SfKgviDGM	false	mutation decreasing interaction:101-101|mutation decreasing interaction:222-222,226-226|ha tag:?-?|mutation increasing interaction:222-222,226-226	sufficient binding region:167-255,261-433|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q63932	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9700115|imex:IM-22986-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:B69F2E99C9870ABF|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	sufficient binding region:167-433|flag tag:?-?	ha tag:?-?|mutation:222-222,226-226	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9700115|imex:IM-22986-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:B69F2E99C9870ABF|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	sufficient binding region:167-433|flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P31938	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-298860|ensembl:ENSMUSP00000005066	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9772403|imex:IM-22986-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	-	-	-	figure legend:Fig.S3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	intact-crc:8A93556C6E59C499|rigid:OplLqMEt8eLGn1lbumKi95IdSVY	false	flag tag:?-?	mutation increasing interaction:218-218,222-222|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9772403|imex:IM-22986-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig.S3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:8A93556C6E59C499|rigid:OplLqMEt8eLGn1lbumKi95IdSVY	false	flag tag:?-?	ha tag:?-?|sufficient binding region:167-433	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31938	uniprotkb:Q13526	intact:EBI-298860|ensembl:ENSMUSP00000005066	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9523366|imex:IM-22986-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:Fig.S3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:031EFFA4E2ED199A|rigid:RvYoT29kluDZHyxrSGCPULuYnxk	false	ha tag:?-?|mutation increasing interaction:218-218,222-222	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9774277|imex:IM-22986-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig.S3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:E2FDED40BEC18B31|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	flag tag:?-?	ha tag:?-?|sufficient binding region:167-433	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817139|imex:IM-22986-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig. 5E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:36199FA3CF1F6601|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	ha tag:?-?|mutation:222-222,226-226	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817139|imex:IM-22986-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 5E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:36199FA3CF1F6601|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	sufficient binding region:167-175,190-433|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817128|imex:IM-22986-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 5E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:207385FA851260C3|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	flag tag:?-?	ha tag:?-?|sufficient binding region:167-179,190-433	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817117|imex:IM-22986-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:17744E04B7DD78D0|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	ha tag:?-?|sufficient binding region:167-175,190-433	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9869047|imex:IM-22986-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig. S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/21	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:33EA3AF50FBE2D86|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	mutation:222-222,226-226|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9869047|imex:IM-22986-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/21	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:33EA3AF50FBE2D86|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	sufficient binding region:251-433|ha tag:?-?|sufficient binding region:167-352	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9869034|imex:IM-22986-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/21	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:4DA2800BAE214590|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	flag tag:?-?	ha tag:?-?|sufficient binding region:251-433|necessary binding region:352-433	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0096"(pull down)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9521523|imex:IM-22986-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 1D, 1I, 5A|comment:"256-260aa PC deletion (PC3D)  decreases its interaction with WW as shown in Fig. 1I"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:9FDFF99F69E8E836|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	ha tag:?-?|necessary binding region:167-433|mutation decreasing interaction:256-256,257-257	glutathione s tranferase tag:?-?|sufficient binding region:1-39	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817417|imex:IM-22986-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 1D, 1I, 5A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:9E2E225144AA6F60|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	glutathione s tranferase tag:?-?|sufficient binding region:60-163	sufficient binding region:167-433|mutation decreasing interaction:256-256,257-257|ha tag:?-?|necessary binding region:256-260	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9525098|imex:IM-22986-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig. 5A, 5C, 5D, S4C|comment:"Interaction between ww domain (of Pin1) and Mek2-SD is abolished when the PC domain of BPGAP1 deletes specific region: 176-189 (see constructions P1, P2, P3)"|comment:CIAP treatment doesn't have any effect in the interaction among Mek2-SD, PC, and WW|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:4C884D25334D663F|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	glutathione s tranferase tag:?-?|sufficient binding region:1-39	ha tag:?-?|mutation:222-222,226-226	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9525098|imex:IM-22986-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 5A, 5C, 5D, S4C|comment:"Interaction between ww domain (of Pin1) and Mek2-SD is abolished when the PC domain of BPGAP1 deletes specific region: 176-189 (see constructions P1, P2, P3)"|comment:CIAP treatment doesn't have any effect in the interaction among Mek2-SD, PC, and WW|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:4C884D25334D663F|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	glutathione s tranferase tag:?-?|sufficient binding region:1-39	ha tag:?-?|sufficient binding region:167-433|necessary binding region:176-189	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0096"(pull down)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9818419|imex:IM-22986-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5C|comment:"Interaction between ww domain (of Pin1) and Mek2-SD is abolished when the PC domain of BPGAP1 deletes specific region: 176-189 (see constructions P1, P2, P3)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:FD98249F7C179FFF|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	ha tag:?-?|sufficient binding region:167-433|necessary binding region:180-189	sufficient binding region:1-39|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63932	uniprotkb:Q13526	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0096"(pull down)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9818440|imex:IM-22986-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:Fig. 5D|comment:The PPLP mutant  doesn't bind to WW and Mek2-SD|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/16	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:AEED0FD3C6531BDE|rigid:Yq9ojrNy4gomeyL0eylsxf2ZKoc	false	mutation:222-222,226-226|ha tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-39	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9868539|imex:IM-22986-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig. 3B|comment:"When NNP (from BPGAP1) is expressed in the cell, Pin1is able to precipitate Mek2-SD but not NNP."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:F5D17A112E330D9D|rigid:Yq9ojrNy4gomeyL0eylsxf2ZKoc	false	flag tag:?-?	ha tag:?-?|mutation:222-222,226-226	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9868505|imex:IM-22986-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:91574C4CD99873E1|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	flag tag:?-?	ha tag:?-?|sufficient binding region:167-433	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9522699|imex:IM-22986-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 3C|comment:Interaction between PC and endogenous Pin1increases when Mek2-SD is expressed.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:1880CA7950BA5DAF|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	sufficient binding region:167-433|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:Q63932	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9868515|imex:IM-22986-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	figure legend:Fig. 3B|comment:"Mek2-SD increases the interaction between BPGAP1 (FL and PC) and Pin1."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:15BC9AEE5A075F1E|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	ha tag:?-?|mutation:222-222,226-226	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9868515|imex:IM-22986-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 3B|comment:"Mek2-SD increases the interaction between BPGAP1 (FL and PC) and Pin1."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/05/09	2014/10/20	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:15BC9AEE5A075F1E|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?	ha tag:?-?|sufficient binding region:167-433	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817337|imex:IM-22986-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig S3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/05/09	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:B9221B6C48F6AB17|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	flag tag:?-?	sufficient binding region:167-433|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P85298-4	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9522735|imex:IM-22986-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig S3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:112F47917CB24CA2|rigid:OplLqMEt8eLGn1lbumKi95IdSVY	false	flag tag:?-?	ha tag:?-?|sufficient binding region:167-433	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P31938	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-298860|ensembl:ENSMUSP00000005066	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9522735|imex:IM-22986-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	-	-	-	figure legend:Fig S3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/05/09	2014/10/17	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	intact-crc:112F47917CB24CA2|rigid:OplLqMEt8eLGn1lbumKi95IdSVY	false	flag tag:?-?	ha tag:?-?|mutation:222-222,226-226	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63932	uniprotkb:P85298-4	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9524951|imex:IM-22986-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	go:"GO:0005829"(cytosol)	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 4E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2014/05/09	2014/10/16	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:3251E0A99F20E7A0|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?|mutation:226-226,222-222	sufficient binding region:167-433|ha tag:?-?|sufficient binding region:1-206	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q63932	uniprotkb:Q13526	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9524951|imex:IM-22986-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0005829"(cytosol)	-	-	figure legend:Fig. 4E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2014/05/09	2014/10/16	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:3251E0A99F20E7A0|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?|mutation:226-226,222-222	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q63932	uniprotkb:P85298-4	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	intact:EBI-9523517|ensembl:ENSP00000348407	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9818682|imex:IM-22986-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	go:"GO:0005829"(cytosol)	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 4E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2014/05/09	2014/10/20	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	intact-crc:DFB1E23D29FC2A4C|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?|mutation:226-226,222-222	ha tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q63932	uniprotkb:Q13526	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9818682|imex:IM-22986-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0005829"(cytosol)	-	-	figure legend:Fig. 4E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2014/05/09	2014/10/20	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:DFB1E23D29FC2A4C|rigid:QHKFJ1QVjTVRR17sPZF60cDhVbo	false	flag tag:?-?|mutation:226-226,222-222	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P85298-4	uniprotkb:Q13526	intact:EBI-9523517|ensembl:ENSP00000348407	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:p85298-4(display_long)|uniprotkb:ARHGAP8(gene name)|psi-mi:ARHGAP8(display_short)|uniprotkb:Rho-type GTPase-activating protein 8(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9523761|imex:IM-22986-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000241484(gene)|ensembl:ENST00000356099(transcript)|intact:EBI-4289876(isoform-parent)|uniprotkb:P85298-4(isoform-parent)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0005634"(nucleus)	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 4F|comment:Full length HA-BPGAP1 doesn't colocalize in the nucleus with Pin 1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2014/05/09	2014/10/16	rogid:5yQbcVoVLdM/ON0kWpyL9wgfNtc9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:B0D480BE63814162|rigid:NespWXdrAkv/AtbV+FNCygY18zg	false	sufficient binding region:167-433|ha tag:?-?|sufficient binding region:167-255,261-433|sufficient binding region:1-206	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P31938	uniprotkb:Q13526	intact:EBI-298860|ensembl:ENSMUSP00000005066	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pan et al. (2010)	imex:IM-22986|pubmed:20179103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9817366|imex:IM-22986-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:Fig. S3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/05/09	2014/10/16	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:1EFB73D8ABB2EC8A|rigid:RvYoT29kluDZHyxrSGCPULuYnxk	false	ha tag:?-?|mutation:226-226,222-222	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)