#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BUZ4	uniprotkb:Q9HCE7-2	intact:EBI-3650647|uniprotkb:O75615|uniprotkb:Q14848|uniprotkb:Q2KJU4|uniprotkb:Q2PJN8|ensembl:ENSP00000262395	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:traf4_human(display_long)|uniprotkb:TRAF4(gene name)|psi-mi:TRAF4(display_short)|uniprotkb:CART1(gene name synonym)|uniprotkb:MLN62(gene name synonym)|uniprotkb:RNF83(gene name synonym)|uniprotkb:Cysteine-rich domain associated with RING and Traf domains protein 1(gene name synonym)|uniprotkb:Metastatic lymph node gene 62 protein(gene name synonym)|uniprotkb:RING finger protein 83(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2010)	pubmed:19937093|imex:IM-23210	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846435|imex:IM-23210-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004286.2|dip:DIP-40910N|ensembl:ENSG00000076604(gene)|ensembl:ENST00000262395(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030323"(respiratory tube development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027138|interpro:IPR037307|interpro:IPR043211|mint:Q9BUZ4|rcsb pdb:2EOD|rcsb pdb:2YUC|rcsb pdb:3ZJB|rcsb pdb:4K8U|rcsb pdb:4M4E|rcsb pdb:5YC1	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 1a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(baker's yeast-mav203)|taxid:4932(Saccharomyces cerevisiae)	-	2014/10/14	2014/10/20	rogid:9Bjl/NCcleyKgZb7suHw3AVWpG09606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:A0803F5A2585CD30|rigid:VyoOj9BObxx4Gz0w9Tg0PZxBfSk	false	sufficient binding region:1-363	sufficient binding region:236-340(IPR001202)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BUZ4	uniprotkb:Q9HCE7-2	intact:EBI-3650647|uniprotkb:O75615|uniprotkb:Q14848|uniprotkb:Q2KJU4|uniprotkb:Q2PJN8|ensembl:ENSP00000262395	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:traf4_human(display_long)|uniprotkb:TRAF4(gene name)|psi-mi:TRAF4(display_short)|uniprotkb:CART1(gene name synonym)|uniprotkb:MLN62(gene name synonym)|uniprotkb:RNF83(gene name synonym)|uniprotkb:Cysteine-rich domain associated with RING and Traf domains protein 1(gene name synonym)|uniprotkb:Metastatic lymph node gene 62 protein(gene name synonym)|uniprotkb:RING finger protein 83(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2010)	pubmed:19937093|imex:IM-23210	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846454|imex:IM-23210-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004286.2|dip:DIP-40910N|ensembl:ENSG00000076604(gene)|ensembl:ENST00000262395(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030323"(respiratory tube development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027138|interpro:IPR037307|interpro:IPR043211|mint:Q9BUZ4|rcsb pdb:2EOD|rcsb pdb:2YUC|rcsb pdb:3ZJB|rcsb pdb:4K8U|rcsb pdb:4M4E|rcsb pdb:5YC1	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 1b, 2b, 2e|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/10/14	2014/10/16	rogid:9Bjl/NCcleyKgZb7suHw3AVWpG09606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:619AC46374B4D3D7|rigid:VyoOj9BObxx4Gz0w9Tg0PZxBfSk	false	sufficient binding region:307..307-470(IPR002083)|myc tag:?-?|mutation disrupting interaction:335-335,60-63,337-338,194-197|sufficient binding region:18..18-58..58(IPR001841)|sufficient binding region:102..102-266..266(IPR001293)	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BUZ4	uniprotkb:Q9HCE7-2	intact:EBI-3650647|uniprotkb:O75615|uniprotkb:Q14848|uniprotkb:Q2KJU4|uniprotkb:Q2PJN8|ensembl:ENSP00000262395	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:traf4_human(display_long)|uniprotkb:TRAF4(gene name)|psi-mi:TRAF4(display_short)|uniprotkb:CART1(gene name synonym)|uniprotkb:MLN62(gene name synonym)|uniprotkb:RNF83(gene name synonym)|uniprotkb:Cysteine-rich domain associated with RING and Traf domains protein 1(gene name synonym)|uniprotkb:Metastatic lymph node gene 62 protein(gene name synonym)|uniprotkb:RING finger protein 83(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2010)	pubmed:19937093|imex:IM-23210	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846462|imex:IM-23210-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004286.2|dip:DIP-40910N|ensembl:ENSG00000076604(gene)|ensembl:ENST00000262395(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030323"(respiratory tube development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027138|interpro:IPR037307|interpro:IPR043211|mint:Q9BUZ4|rcsb pdb:2EOD|rcsb pdb:2YUC|rcsb pdb:3ZJB|rcsb pdb:4K8U|rcsb pdb:4M4E|rcsb pdb:5YC1	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 1b, 2a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/10/14	2014/10/16	rogid:9Bjl/NCcleyKgZb7suHw3AVWpG09606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:E73E2E6ED1EF00F7|rigid:VyoOj9BObxx4Gz0w9Tg0PZxBfSk	false	myc tag:?-?	flag tag:?-?|necessary binding region:280..280-313..313(IPR001202)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BUZ4	uniprotkb:Q9HCE7-2	intact:EBI-3650647|uniprotkb:O75615|uniprotkb:Q14848|uniprotkb:Q2KJU4|uniprotkb:Q2PJN8|ensembl:ENSP00000262395	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:traf4_human(display_long)|uniprotkb:TRAF4(gene name)|psi-mi:TRAF4(display_short)|uniprotkb:CART1(gene name synonym)|uniprotkb:MLN62(gene name synonym)|uniprotkb:RNF83(gene name synonym)|uniprotkb:Cysteine-rich domain associated with RING and Traf domains protein 1(gene name synonym)|uniprotkb:Metastatic lymph node gene 62 protein(gene name synonym)|uniprotkb:RING finger protein 83(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2010)	pubmed:19937093|imex:IM-23210	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846480|imex:IM-23210-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004286.2|dip:DIP-40910N|ensembl:ENSG00000076604(gene)|ensembl:ENST00000262395(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030323"(respiratory tube development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027138|interpro:IPR037307|interpro:IPR043211|mint:Q9BUZ4|rcsb pdb:2EOD|rcsb pdb:2YUC|rcsb pdb:3ZJB|rcsb pdb:4K8U|rcsb pdb:4M4E|rcsb pdb:5YC1	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 1c|causality statement:Q9HCE7-2 increases degradation at protein level of Q9BUZ4|causality statement:Q9HCE7-2 is required for ubiquitination of Q9BUZ4|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/14	2014/10/16	rogid:9Bjl/NCcleyKgZb7suHw3AVWpG09606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:7954A8FD8B071AC9|rigid:VyoOj9BObxx4Gz0w9Tg0PZxBfSk	false	glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)