#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0052"(fluorescence correlation spectroscopy)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117393|imex:IM-22200-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:3A/B/C/D|kinetics:"Kd values for mutants (uM):-   A519N = 1.0   V523N =1.1   K524A = 1.1   K527A =1.1  a-Syn65 D2A = 1.8"|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.31x10^-6(molar)	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:A0940865A12B6F85|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	mutation decreasing interaction:519-519|tag:n-n|his tag:c-c|sufficient binding region:487-557(IPR020683)|mutation decreasing interaction:523-523|mutation decreasing interaction:524-524|mutation decreasing interaction:527-527	sufficient binding region:1-65|dansyl label:n-n|mutation decreasing interaction:2-2|mutation disrupting interaction:3-4|necessary binding region:1-4	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0052"(fluorescence correlation spectroscopy)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117432|imex:IM-22200-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:3B|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:0C7EDBB7292769C3|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	sufficient binding region:487-557(IPR020683)|his tag:c-c|tag:n-n	sufficient binding region:1-65|dansyl label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0052"(fluorescence correlation spectroscopy)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117432|imex:IM-22200-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:3B|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:0C7EDBB7292769C3|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	sufficient binding region:487-557(IPR020683)|his tag:c-c|tag:n-n	sufficient binding region:1-12	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:Q9Y6H5	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0096"(pull down)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117323|imex:IM-22200-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:1B, 2D.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:B09FF40C7F38D6A4|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	necessary binding region:1-65|glutathione s tranferase tag:n-n	his tag:c-c|sufficient binding region:349-557(IPR020683)|tag:n-n	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P37840	uniprotkb:Q9Y6H5	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0096"(pull down)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210860|imex:IM-22200-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:1B, 2D. i|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:661FA70989AB7C3D|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	necessary binding region:1-65|glutathione s tranferase tag:n-n	tag:n-n|his tag:c-c|sufficient binding region:349-557(IPR020683)	1	2	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9Y6H5	uniprotkb:Q9Y6H5	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0071"(molecular sieving)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117781|imex:IM-22200-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:7B|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:8E3206B21A02E0D6|rigid:FbqEXSVYsfi0rT3gLOZ+n5txCbo	false	mutation decreasing interaction:529-529|mutation decreasing interaction:525-525|tag:n-n|mutation decreasing interaction:518-518|his tag:c-c|sufficient binding region:512-557(IPR020683)	mutation decreasing interaction:529-529|mutation decreasing interaction:525-525|tag:n-n|mutation decreasing interaction:518-518|his tag:c-c|sufficient binding region:512-557(IPR020683)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117925|imex:IM-22200-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:supp 6|comment:When a-Syn12 binds to GB1-Sph1M, its NOESY spectrum exhibits a number of transferred NOE peaks, wheras  few NOEs are seen for a-Syn alone.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:AC250808444C1EA6|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	sufficient binding region:349-557(IPR020683)|tag:n-n|his tag:c-c	sufficient binding region:1-12	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6H5	uniprotkb:Q9Y6H5	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9211031|imex:IM-22200-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:Supp 5|comment:It is not clear if the His-tags have been removed from the 15N labeled  SphCC  proteins, or not.|comment:"MTSSL (MTSL) - (1-Oxyl-2,2,5,5-tetramethylpyrroline-3- methyl)methanethiosulfonate.  Paramagnetic spin labels  affect nuclei  near to the label, which show peak broadening and loss of signal intensity.  Results here suggest an antiparallel dimer forms."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:9FC2DD5D40449D57|rigid:FbqEXSVYsfi0rT3gLOZ+n5txCbo	false	15n label:?-?|tag:?-?|sufficient binding region:512-557(IPR020683)|his tag:?-?	15n label:?-?|tag:?-?|sufficient binding region:512-557(IPR020683)|his tag:?-?	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117275|imex:IM-22200-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:2B,  Supp Fig 1.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:10604CEFA51816F2|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	sufficient binding region:512-557(IPR020683)|his tag:?-?|tag:n-n	sufficient binding region:1-65|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:Q9Y6H5	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117662|imex:IM-22200-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:7A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:9D146BE665780C23|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	glutathione s tranferase tag:n-n	15n label:?-?|his tag:c-c|tag:n-n|sufficient binding region:512-557(IPR020683)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6H5	uniprotkb:Q9Y6H5	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117954|imex:IM-22200-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:Supp 7|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:055B0B1AF8AF9915|rigid:FbqEXSVYsfi0rT3gLOZ+n5txCbo	false	sufficient binding region:512-557(IPR020683)|mutation decreasing interaction:529-529|tag:n-n|mutation decreasing interaction:525-525|mutation decreasing interaction:518-518|his tag:c-c	sufficient binding region:512-557(IPR020683)|mutation decreasing interaction:529-529|tag:n-n|mutation decreasing interaction:525-525|mutation decreasing interaction:518-518|his tag:c-c	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117170|imex:IM-22200-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:1C|comment:The synphilin dimer  was also detected.  However a-Syn can be cross-linked with  monomeric GB1-Sph1M, indicating that the dimerization of Sph1M is likely to be irrelevant to its interaction with a-Syn.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:6CF5297618BFFC21|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	his tag:c-c|tag:n-n|sufficient binding region:349-557(IPR020683)	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q9Y6H5	uniprotkb:Q9Y6H5	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0030"(cross-linking study)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210901|imex:IM-22200-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:1Ci|comment:The synphilin dimer  was also detected.  However a-Syn can be cross-linked with  monomeric GB1-Sph1M, indicating that the dimerization of Sph1M is likely to be irrelevant to its interaction with a-Syn.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:ECE00286E546C6A7|rigid:FbqEXSVYsfi0rT3gLOZ+n5txCbo	false	tag:n-n|his tag:c-c|sufficient binding region:349-557(IPR020683)	tag:n-n|his tag:c-c|sufficient binding region:349-557(IPR020683)	2	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q9Y6H5	uniprotkb:Q9Y6H5	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:"MI:0096"(pull down)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9210964|imex:IM-22200-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	-	-	-	figure legend:2A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	intact-crc:722E6CF1A0413902|rigid:FbqEXSVYsfi0rT3gLOZ+n5txCbo	false	sufficient binding region:349-557(IPR020683)|his tag:c-c|tag:n-n	sufficient binding region:349-557(IPR020683)|his tag:c-c|tag:n-n	2	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9211012|imex:IM-22200-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:2A, 2E.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:EA4C815A6C4F5940|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	sufficient binding region:349-557(IPR020683)|tag:n-n|his tag:c-c	glutathione s tranferase tag:n-n|necessary binding region:1-65	2	1	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117239|imex:IM-22200-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:2A, 2E.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:CEDCB2AA93B06683|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	his tag:c-c|tag:n-n|sufficient binding region:349-557(IPR020683)	necessary binding region:1-65|glutathione s tranferase tag:n-n	1	1	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y6H5	uniprotkb:P37840	intact:EBI-717182|uniprotkb:Q9HC59|uniprotkb:Q05BS1|uniprotkb:Q1PSC2|uniprotkb:Q49AC6|uniprotkb:Q504U9|uniprotkb:Q6L984|uniprotkb:Q6L985|uniprotkb:Q6L986|uniprotkb:D3DSZ1|ensembl:ENSP00000261368	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:sncap_human(display_long)|uniprotkb:Alpha-synuclein-interacting protein(gene name synonym)|uniprotkb:SNCAIP(gene name)|psi-mi:SNCAIP(display_short)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Xie et al. (2010)	imex:IM-22200|pubmed:19762560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9117626|imex:IM-22200-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229864.1|refseq:NP_005451.2|refseq:NP_001295029.1|refseq:NP_001295034.1|refseq:NP_001295035.1|refseq:NP_001295036.1|refseq:NP_001295037.1|refseq:NP_001295038.1|refseq:XP_011542039.1|refseq:XP_011542040.1|refseq:XP_011542041.1|refseq:XP_011542043.1|refseq:XP_011542045.1|refseq:XP_016865567.1|refseq:XP_016865571.1|ensembl:ENSG00000064692(gene)|ensembl:ENST00000261368(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008219"(cell death)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0090083"(regulation of inclusion body assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR032027|interpro:IPR036770|interpro:IPR040133|rcsb pdb:2KES|reactome:R-HSA-977225|dip:DIP-61155N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	go:"GO:0097413"(Lewy body)	-	-	figure legend:4/5|comment:"Sph1MDelta CC (residues 349–515) mainly forms nuclear bodies with no s-syn present."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/31	2014/10/16	rogid:IfOPQ/2MEuaMVQAzM/SWajUQ1cE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:D786565A8AE5A132|rigid:E7B+lPX/QU9ffwfd5FIZOi9tlnk	false	necessary binding region:516-557|flag tag:?-?	necessary binding region:1-12|his tag:c-c|myc tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)