#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O43520 uniprotkb:Q9NV96 intact:EBI-9524729|uniprotkb:Q9BTP8|intact:EBI-28976955|ensembl:ENSP00000497896 intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461 psi-mi:at8b1_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B1(gene name synonym)|uniprotkb:ATP8B1(gene name)|psi-mi:ATP8B1(display_short)|uniprotkb:ATPIC(gene name synonym)|uniprotkb:FIC1(gene name synonym)|uniprotkb:PFIC(gene name synonym)|uniprotkb:ATPase class I type 8B member 1(gene name synonym)|uniprotkb:Familial intrahepatic cholestasis type 1(gene name synonym) psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Folmer et al. (2009) pubmed:19731236|imex:IM-22577 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-9524765|imex:IM-22577-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000497896|refseq:XP_011524324.1|refseq:XP_006722544.1|refseq:NP_005594.1|ensembl:ENSG00000081923(gene)|ensembl:ENST00000648908(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031526"(brush border membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045176"(apical protein localization)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1903729"(regulation of plasma membrane organization)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030346|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837 refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L omim:243300(see-also)|omim:147480(see-also)|omim:211600(see-also) - - figure legend:3A and B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS) - 2014/05/14 2014/10/16 rogid:etMCmFj6oGhBGan/RrxU5eUdWCM9606 rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606 intact-crc:82D69EB987E4A46D|rigid:2yvSqj7gC2sM/lIgVP3rtz0JSjg false enhanced green fluorescent protein tag:c-c|mutation disrupting interaction:308-308|mutation disrupting interaction:554-554|mutation decreasing interaction:1040-1040|mutation disrupting interaction:454-454|mutation decreasing interaction:661-661|mutation decreasing interaction:70-70|mutation decreasing interaction:867-867 ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)