#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q06697 uniprotkb:P49573 intact:EBI-29913|uniprotkb:D6VZ54|ensemblfungi:YLR418C intact:EBI-5261|uniprotkb:D6W4C2|ensemblfungi:YPR124W psi-mi:cdc73_yeast(display_long)|uniprotkb:RNA polymerase-associated protein CDC73(gene name synonym)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:YLR418C(locus name) psi-mi:ctr1_yeast(display_long)|uniprotkb:CTR1(gene name)|psi-mi:CTR1(display_short)|uniprotkb:P9642.3(orf name)|uniprotkb:YPR124W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9102163|imex:IM-22048-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013522.1|sgd:S000004410|dip:DIP-1148N|mint:Q06697|ensemblfungi:YLR418C(gene)|ensemblfungi:YLR418C_mRNA(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016570"(histone modification)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0090262"(regulation of transcription-coupled nucleotide-excision repair)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|go:"GO:2001209"(positive regulation of transcription elongation from RNA polymerase I promoter)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR038103|rcsb pdb:3V46|rcsb pdb:4DM4|reactome:R-SCE-674695|reactome:R-SCE-75955 refseq:NP_015449.1|sgd:S000006328|dip:DIP-6447N|mint:P49573|ensemblfungi:YPR124W(gene)|ensemblfungi:YPR124W_mRNA(transcript)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016021"(integral component of membrane)|interpro:IPR007274(Ctr copper transporter) - crc64:9580B53EEFB75345 crc64:569C9CB19C1117E8 figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2014/01/28 2014/10/16 rogid:9d/PessN2v7cZ2ZuQW1vjTnjcaQ559292 rogid:ZBHA8DsRaWE20ANtlw2JSfjD8uQ559292 intact-crc:ED2E1750AE709BC0|rigid:dfQqfUU2Hiuzi8szspp7GKBZX2A false flag tag:?-? - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q06697 uniprotkb:P53064 intact:EBI-29913|uniprotkb:D6VZ54|ensemblfungi:YLR418C intact:EBI-16303|uniprotkb:P89115|ensemblfungi:YGL244W|uniprotkb:D6VV91 psi-mi:cdc73_yeast(display_long)|uniprotkb:RNA polymerase-associated protein CDC73(gene name synonym)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:YLR418C(locus name) psi-mi:rtf1_yeast(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:YGL244W(locus name)|uniprotkb:HRA458(orf name)|uniprotkb:CSL3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9102163|imex:IM-22048-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013522.1|sgd:S000004410|dip:DIP-1148N|mint:Q06697|ensemblfungi:YLR418C(gene)|ensemblfungi:YLR418C_mRNA(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016570"(histone modification)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0090262"(regulation of transcription-coupled nucleotide-excision repair)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|go:"GO:2001209"(positive regulation of transcription elongation from RNA polymerase I promoter)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR038103|rcsb pdb:3V46|rcsb pdb:4DM4|reactome:R-SCE-674695|reactome:R-SCE-75955 go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070911"(global genome nucleotide-excision repair)|go:"GO:0090262"(regulation of transcription-coupled nucleotide-excision repair)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2001160"(regulation of histone H3-K79 methylation)|go:"GO:2001163"(regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001166"(regulation of histone H2B ubiquitination)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|go:"GO:2001209"(positive regulation of transcription elongation from RNA polymerase I promoter)|interpro:IPR004343(Plus-3)|interpro:IPR036128|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0031126"("sno(s)RNA 3'-end processing")|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|rcsb pdb:5E8B|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0035327"|go:"GO:0042138"(meiotic DNA double-strand break formation)|rcsb pdb:5EMX|ensemblfungi:YGL244W(gene)|ensemblfungi:YGL244W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001015"(snoRNA transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-SCE-674695|reactome:R-SCE-75955|refseq:NP_011270.1|sgd:S000003213|dip:DIP-4065N|mint:P53064 - crc64:9580B53EEFB75345 crc64:13AECCEC6D63CED4 figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2014/01/28 2014/10/16 rogid:9d/PessN2v7cZ2ZuQW1vjTnjcaQ559292 rogid:jPawNxTgh9wPA5Uxbn5QCUeDw9Q559292 intact-crc:ED2E1750AE709BC0|rigid:dfQqfUU2Hiuzi8szspp7GKBZX2A false flag tag:?-? - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q06697 uniprotkb:P38439 intact:EBI-29913|uniprotkb:D6VZ54|ensemblfungi:YLR418C intact:EBI-10108|uniprotkb:D6W2I1|ensemblfungi:YOR123C psi-mi:cdc73_yeast(display_long)|uniprotkb:RNA polymerase-associated protein CDC73(gene name synonym)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:YLR418C(locus name) psi-mi:leo1_yeast(display_long)|uniprotkb:O3278(orf name)|uniprotkb:YOR3278C(orf name)|uniprotkb:YOR123C(locus name)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9102163|imex:IM-22048-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013522.1|sgd:S000004410|dip:DIP-1148N|mint:Q06697|ensemblfungi:YLR418C(gene)|ensemblfungi:YLR418C_mRNA(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016570"(histone modification)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0090262"(regulation of transcription-coupled nucleotide-excision repair)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|go:"GO:2001209"(positive regulation of transcription elongation from RNA polymerase I promoter)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR038103|rcsb pdb:3V46|rcsb pdb:4DM4|reactome:R-SCE-674695|reactome:R-SCE-75955 refseq:NP_014766.1|sgd:S000005649|ensemblfungi:YOR123C(gene)|ensemblfungi:YOR123C_mRNA(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0006325"(chromatin organization)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0090262"(regulation of transcription-coupled nucleotide-excision repair)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|go:"GO:2001209"(positive regulation of transcription elongation from RNA polymerase I promoter)|interpro:IPR007149(Leo1-like protein)|go:"GO:0005634"(nucleus)|reactome:R-SCE-674695|reactome:R-SCE-75955|dip:DIP-4143N|mint:P38439 - crc64:9580B53EEFB75345 crc64:ABDE3D7D5A2C78A5 figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2014/01/28 2014/10/16 rogid:9d/PessN2v7cZ2ZuQW1vjTnjcaQ559292 rogid:qhB5pVP3l4WqXtp3JhmPsxEVHE0559292 intact-crc:ED2E1750AE709BC0|rigid:dfQqfUU2Hiuzi8szspp7GKBZX2A false flag tag:?-? - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q06697 uniprotkb:P38351 intact:EBI-29913|uniprotkb:D6VZ54|ensemblfungi:YLR418C intact:EBI-12855|uniprotkb:Q9URC9|uniprotkb:D6VQS4|ensemblfungi:YBR279W psi-mi:cdc73_yeast(display_long)|uniprotkb:RNA polymerase-associated protein CDC73(gene name synonym)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:YLR418C(locus name) psi-mi:paf1_yeast(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:YBR279W(locus name)|uniprotkb:YBR2016(orf name)|uniprotkb:Protein PAF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9102163|imex:IM-22048-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013522.1|sgd:S000004410|dip:DIP-1148N|mint:Q06697|ensemblfungi:YLR418C(gene)|ensemblfungi:YLR418C_mRNA(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016570"(histone modification)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0090262"(regulation of transcription-coupled nucleotide-excision repair)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|go:"GO:2001209"(positive regulation of transcription elongation from RNA polymerase I promoter)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR038103|rcsb pdb:3V46|rcsb pdb:4DM4|reactome:R-SCE-674695|reactome:R-SCE-75955 ensemblfungi:YBR279W(gene)|ensemblfungi:YBR279W_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001015"(snoRNA transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006364"(rRNA processing)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0016570"(histone modification)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0031126"("sno(s)RNA 3'-end processing")|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070911"(global genome nucleotide-excision repair)|go:"GO:0090262"(regulation of transcription-coupled nucleotide-excision repair)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2001163"(regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|go:"GO:2001166"(regulation of histone H2B ubiquitination)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|go:"GO:2001209"(positive regulation of transcription elongation from RNA polymerase I promoter)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|rcsb pdb:5ZYP|reactome:R-SCE-674695|reactome:R-SCE-75955|refseq:NP_009838.1|sgd:S000000483|mint:P38351|dip:DIP-1149N - crc64:9580B53EEFB75345 - figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2014/01/28 2014/10/16 rogid:9d/PessN2v7cZ2ZuQW1vjTnjcaQ559292 rogid:k4kVCyYuA4w4+4OEroTkwhbxs6Q559292 intact-crc:ED2E1750AE709BC0|rigid:dfQqfUU2Hiuzi8szspp7GKBZX2A false flag tag:?-? his tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P06104 uniprotkb:Q07457 intact:EBI-19722|uniprotkb:D6VU83|ensemblfungi:YGL058W intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C psi-mi:ubc2_yeast(display_long)|uniprotkb:RAD6(gene name)|psi-mi:RAD6(display_short)|uniprotkb:UBC2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase UBC2(gene name synonym)|uniprotkb:Ubiquitin carrier protein UBC2(gene name synonym)|uniprotkb:Radiation sensitivity protein 6(gene name synonym)|uniprotkb:YGL058W(locus name)|uniprotkb:E2 ubiquitin-conjugating enzyme 2(gene name synonym) psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name) psi-mi:"MI:0096"(pull down) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9102068|imex:IM-22048-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011457.1|sgd:S000003026|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033503"(HULC complex)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042275"(error-free postreplication DNA repair)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0090089"(regulation of dipeptide transport)|go:"GO:0097505"(Rad6-Rad18 complex)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:1990303"(UBR1-RAD6 ubiquitin ligase complex)|go:"GO:1990304"(MUB1-RAD6-UBR2 ubiquitin ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1AYZ|rcsb pdb:4R62|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-983168|ensemblfungi:YGL058W(gene)|ensemblfungi:YGL058W_mRNA(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-1555N|mint:P06104 refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E - crc64:5F568DC28ABBD60F crc64:FC6B32825970D36F figure legend:Fig. 5A, 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/28 2014/10/16 rogid:NHteg3G6/ga0Apqc/vkqrJJURwg559292 rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292 intact-crc:AC71511922FBE8D2|rigid:3akK/HrG99GtdGfukUQJLmMMp8w false glutathione s tranferase tag:?-? flag tag:?-?|sufficient binding region:1-210 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P06104 uniprotkb:Q07457 intact:EBI-19722|uniprotkb:D6VU83|ensemblfungi:YGL058W intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C psi-mi:ubc2_yeast(display_long)|uniprotkb:RAD6(gene name)|psi-mi:RAD6(display_short)|uniprotkb:UBC2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase UBC2(gene name synonym)|uniprotkb:Ubiquitin carrier protein UBC2(gene name synonym)|uniprotkb:Radiation sensitivity protein 6(gene name synonym)|uniprotkb:YGL058W(locus name)|uniprotkb:E2 ubiquitin-conjugating enzyme 2(gene name synonym) psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name) psi-mi:"MI:0096"(pull down) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-9101968|imex:IM-22048-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011457.1|sgd:S000003026|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033503"(HULC complex)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042275"(error-free postreplication DNA repair)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0090089"(regulation of dipeptide transport)|go:"GO:0097505"(Rad6-Rad18 complex)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:1990303"(UBR1-RAD6 ubiquitin ligase complex)|go:"GO:1990304"(MUB1-RAD6-UBR2 ubiquitin ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1AYZ|rcsb pdb:4R62|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-983168|ensemblfungi:YGL058W(gene)|ensemblfungi:YGL058W_mRNA(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-1555N|mint:P06104 refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E - crc64:5F568DC28ABBD60F crc64:FC6B32825970D36F figure legend:Fig. 1B, 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/28 2014/10/16 rogid:NHteg3G6/ga0Apqc/vkqrJJURwg559292 rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292 intact-crc:9B1A44CBF2DECFCE|rigid:3akK/HrG99GtdGfukUQJLmMMp8w false glutathione s tranferase tag:?-?|sufficient binding region:1-152 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q07457 intact:EBI-2461489 intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C - psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name) psi-mi:pafc_yeast(display_short)|psi-mi:EBI-2461489(display_long)|intact:PAF1 complex(complex recommended name)|intact:PAF1C(complex synonym)|intact:Cdc73/Paf1 complex(complex synonym)|intact:"CDC73:CTR9:LEO1:PAF1:RTF1"(complex systematic name)|intact:Polymerase Associated Factor 1(complex synonym) psi-mi:"MI:0096"(pull down) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9102217|imex:IM-22048-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:1302"(stable complex) refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E intact:EBI-2436762(exp-evidence)|go:"GO:0016571"(histone methylation)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|complex portal:CPX-1726(complex-primary)|evidence ontology:"ECO:0000353" - crc64:FC6B32825970D36F complex-properties:None of the PAF1 complex components are essential for the viability of S. cerevisiae, but functional loss of the complex causes diverse phenotypes including sensitivity to cellular stresses, which is linked to defects in chromatin and transcriptional regulation.|curated-complex:"A multifunctional complex involved in many aspects of RNA polymerase II (Pol II) transcriptional regulation, including transcriptional elongation, 3-prime-terminal end processing, and histone modification. Role in 3-prime end formation of mRNAs, required for the recruitment of cleavage and polyadenylation factors CFT1 and PCF11 to RNA polymerase II. Required for activation of the RAD6/UBC2-BRE1 ubiquitin ligase complex, which ubiquitinates histone H2B to form H2BK123ub1. Also required for the methylation of histone H3 by the COMPASS complex (CPX-1039) to form H3K4me, by SET2 to form H3K36me, and by DOT1 to form H3K79me." figure legend:Fig 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/28 2016/06/28 rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292 - intact-crc:30BB15E4F03FC883 false flag tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q07457 uniprotkb:Q07457 intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name) psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9102106|imex:IM-22048-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E - crc64:FC6B32825970D36F crc64:FC6B32825970D36F figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2014/01/28 2014/10/16 rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292 rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292 intact-crc:D892560D8C59D7AF|rigid:ekHZLvfswn97XS4SSDsnLu2ibpk false sufficient binding region:450-700|flag tag:?-?|sufficient binding region:1-110 his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q07457 uniprotkb:Q07457 intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name) psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2009) pubmed:19531475|imex:IM-22048 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9101986|imex:IM-22048-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E - crc64:FC6B32825970D36F crc64:FC6B32825970D36F figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2014/01/28 2014/10/16 rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292 rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292 intact-crc:1B8176A329CCEC4F|rigid:ekHZLvfswn97XS4SSDsnLu2ibpk false sufficient binding region:210-700|flag tag:?-?|sufficient binding region:1-210 sufficient binding region:1-210|sufficient binding region:210-700|his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)