#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8NBP7	uniprotkb:P07355	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9258147|imex:IM-22274-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	figure legend:Fig. 3A, 4B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:956921FFF7C85F2C|rigid:UhcaeuCGUmgA6aqOnHu9AxfdDs4	false	v5 tag:c-c|mutation increasing interaction:554-554	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8NBP7	uniprotkb:P07355	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9258475|imex:IM-22274-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	figure legend:Fig. 3D|comment:Purified AnxA2 was submitted to electrophoresis under reducing and non-reducing conditions. PCSK9 binds in a dose-dependent  manner AnxA2 in both situations.|antagonist:Under reducing conditions only binding of the monomeric form of Anxa-His to Pcsk9 was observed.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:795B11D7DDE5B4D1|rigid:UhcaeuCGUmgA6aqOnHu9AxfdDs4	false	v5 tag:c-c	his tag:n-n|s tag:n-n	-	2	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8NBP7	uniprotkb:P07355	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9635368|imex:IM-22274-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	figure legend:Fig. 3D|comment:Purified AnxA2 was submitted to electrophoresis under reducing and non-reducing conditions. PCSK9 binds in a dose-dependent  manner AnxA2 in both situations.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:76ADE00B5DB2DBD5|rigid:UhcaeuCGUmgA6aqOnHu9AxfdDs4	false	v5 tag:c-c	s tag:n-n|his tag:n-n	-	1	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8NBP7	uniprotkb:P07355	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9259037|imex:IM-22274-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	figure legend:Fig. 9 B, C|comment:Individual deletions of R2, R3 and R4 reduce the ability to bind to PCSK9|comment:"Exchanging the 49-75aa fragment in AnxA2 with the 58-84aa fragment of AnxA1 significantly reduces the AnxA2 ability to bind PCSK9. (Fig. 9C)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:885CA4205BF18E0D|rigid:UhcaeuCGUmgA6aqOnHu9AxfdDs4	false	v5 tag:c-c	ha tag:c-c|necessary binding region:37-102|mutation decreasing interaction:78-78,80-80,77-77|mutation decreasing interaction:88-88,77-77,78-78,80-80,81-81|mutation decreasing interaction:77-77,78-78,80-80,81-81	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8NBP7	uniprotkb:P07355	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9258167|imex:IM-22274-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	figure legend:Fg. 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:476CDA2569F631BD|rigid:UhcaeuCGUmgA6aqOnHu9AxfdDs4	false	v5 tag:c-c	his tag:n-n|s tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NBP7	uniprotkb:P07355	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9258189|imex:IM-22274-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	figure legend:Fig. 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:E9C84F86EBE749E5|rigid:UhcaeuCGUmgA6aqOnHu9AxfdDs4	false	v5 tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8NBP7	intact:EBI-8785901	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	-	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_chlae_protein(display_short)|psi-mi:EBI-8785901(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9258465|imex:IM-22274-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	-	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	comment:similar to P07355	figure legend:Fig. 2 A,E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	-	intact-crc:D0DE338B9305596F	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P07355	uniprotkb:P07355	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9258505|imex:IM-22274-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	-	-	figure legend:Fig. 3D|antagonist:reducing conditions|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/14	2014/10/16	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:27B56BBA2D384519|rigid:Qum3LcM2VfQVdZ28N72HgGEaHKE	false	his tag:n-n|s tag:n-n	his tag:n-n|s tag:n-n	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBP7	intact:EBI-8785901	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	-	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_chlae_protein(display_short)|psi-mi:EBI-8785901(display_long)	psi-mi:"MI:0047"(far western blotting)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9258674|imex:IM-22274-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	-	-	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	comment:similar to P07355	figure legend:Fig. 2C, D, E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	-	intact-crc:FD4A147215CB097D	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBP7	uniprotkb:P07355	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Mayer et al. (2008)	pubmed:18799458|imex:IM-22274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9259018|imex:IM-22274-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	go:"GO:0005886"(plasma membrane)	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	-	figure legend:Fig. 5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2014/03/14	2014/10/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	intact-crc:108D27450742B856|rigid:UhcaeuCGUmgA6aqOnHu9AxfdDs4	false	v5 tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)