#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O54784	uniprotkb:P61079	intact:EBI-77359|ensembl:ENSMUSP00000035962|ensembl:ENSMUSP00000137333|ensembl:ENSMUSP00000151577	intact:EBI-9682701|ensembl:ENSMUSP00000101898|ensembl:ENSMUSP00000130096|ensembl:ENSMUSP00000142974|ensembl:ENSMUSP00000143065|ensembl:ENSMUSP00000143301|ensembl:ENSMUSP00000143608	psi-mi:dapk3_mouse(display_long)|uniprotkb:Dapk3(gene name)|psi-mi:Dapk3(display_short)|uniprotkb:Zipk(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:ZIP-kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:ub2d3_mouse(display_long)|uniprotkb:Ube2d3(gene name)|psi-mi:Ube2d3(display_short)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ohbayashi et al. (2008)	imex:IM-23027|pubmed:18515077	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9682735|imex:IM-23027-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177402.1|refseq:NP_031854.1|refseq:XP_006513258.1|ensembl:ENSMUSG00000034974(gene)|ensembl:ENSMUST00000047665(transcript)|ensembl:ENSMUST00000178422(transcript)|ensembl:ENSMUST00000219850(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016301"(kinase activity)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870	refseq:NP_079632.1|refseq:XP_006501936.1|refseq:XP_006501937.1|refseq:XP_006501938.1|ensembl:ENSMUSG00000078578(gene)|ensembl:ENSMUST00000106291(transcript)|ensembl:ENSMUST00000166033(transcript)|ensembl:ENSMUST00000196446(transcript)|ensembl:ENSMUST00000197539(transcript)|ensembl:ENSMUST00000197859(transcript)|ensembl:ENSMUST00000199613(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-MMU-1234176|reactome:R-MMU-201451|reactome:R-MMU-2173795|reactome:R-MMU-8866654|reactome:R-MMU-8951664|reactome:R-MMU-9033241|reactome:R-MMU-937041|reactome:R-MMU-9705462|reactome:R-MMU-983168	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/30	2014/10/16	rogid:LOZoxWuCRZi1kVZyrtoEijElfC810090	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs10090	intact-crc:F4C5AA757A7C3114|rigid:OFu9NbzvV2xGJLwhdkcDBY+q2bQ	false	sufficient binding region:1-275	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54784	uniprotkb:P61077	intact:EBI-77359|ensembl:ENSMUSP00000035962|ensembl:ENSMUSP00000137333|ensembl:ENSMUSP00000151577	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	psi-mi:dapk3_mouse(display_long)|uniprotkb:Dapk3(gene name)|psi-mi:Dapk3(display_short)|uniprotkb:Zipk(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:ZIP-kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ohbayashi et al. (2008)	imex:IM-23027|pubmed:18515077	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9682750|imex:IM-23027-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177402.1|refseq:NP_031854.1|refseq:XP_006513258.1|ensembl:ENSMUSG00000034974(gene)|ensembl:ENSMUST00000047665(transcript)|ensembl:ENSMUST00000178422(transcript)|ensembl:ENSMUST00000219850(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016301"(kinase activity)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/30	2014/10/16	rogid:LOZoxWuCRZi1kVZyrtoEijElfC810090	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	intact-crc:5799F10DBA98FC95|rigid:3YcBTnaUw8i74X0j1ebQYNCywGU	false	sufficient binding region:1-275|myc tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61077	uniprotkb:O54784	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	intact:EBI-77359|ensembl:ENSMUSP00000035962|ensembl:ENSMUSP00000137333|ensembl:ENSMUSP00000151577	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:dapk3_mouse(display_long)|uniprotkb:Dapk3(gene name)|psi-mi:Dapk3(display_short)|uniprotkb:Zipk(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:ZIP-kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ohbayashi et al. (2008)	imex:IM-23027|pubmed:18515077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9682761|imex:IM-23027-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	refseq:NP_001177402.1|refseq:NP_031854.1|refseq:XP_006513258.1|ensembl:ENSMUSG00000034974(gene)|ensembl:ENSMUST00000047665(transcript)|ensembl:ENSMUST00000178422(transcript)|ensembl:ENSMUST00000219850(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016301"(kinase activity)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870	-	comment:UBE2D3/UBCH5C ubiquitin-deficient mutant also interacts	-	figure legend:1A and D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/30	2014/10/16	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	rogid:LOZoxWuCRZi1kVZyrtoEijElfC810090	intact-crc:91DD55BE1FF7CDC1|rigid:3YcBTnaUw8i74X0j1ebQYNCywGU	false	his tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51668	uniprotkb:O54784	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	intact:EBI-77359|ensembl:ENSMUSP00000035962|ensembl:ENSMUSP00000137333|ensembl:ENSMUSP00000151577	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:dapk3_mouse(display_long)|uniprotkb:Dapk3(gene name)|psi-mi:Dapk3(display_short)|uniprotkb:Zipk(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:ZIP-kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ohbayashi et al. (2008)	imex:IM-23027|pubmed:18515077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9682772|imex:IM-23027-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	refseq:NP_001177402.1|refseq:NP_031854.1|refseq:XP_006513258.1|ensembl:ENSMUSG00000034974(gene)|ensembl:ENSMUST00000047665(transcript)|ensembl:ENSMUST00000178422(transcript)|ensembl:ENSMUST00000219850(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016301"(kinase activity)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/30	2014/10/16	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	rogid:LOZoxWuCRZi1kVZyrtoEijElfC810090	intact-crc:48FDDA4E580ADB08|rigid:Y698E7XfoTYJ+0bygU9fxZtEfZs	false	his tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O54784	uniprotkb:P62837	intact:EBI-77359|ensembl:ENSMUSP00000035962|ensembl:ENSMUSP00000137333|ensembl:ENSMUSP00000151577	intact:EBI-347677|uniprotkb:P51669|uniprotkb:Q3MN78|uniprotkb:D3DQC9|uniprotkb:Q96RP6|ensembl:ENSP00000381717|ensembl:ENSP00000381718	psi-mi:dapk3_mouse(display_long)|uniprotkb:Dapk3(gene name)|psi-mi:Dapk3(display_short)|uniprotkb:Zipk(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:ZIP-kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym)	psi-mi:ub2d2_human(display_long)|uniprotkb:UBC5B(gene name synonym)|uniprotkb:UBCH4(gene name synonym)|uniprotkb:UBE2D2(gene name)|psi-mi:UBE2D2(display_short)|uniprotkb:UBC4(gene name synonym)|uniprotkb:UBCH5B(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D2(gene name synonym)|uniprotkb:Ubiquitin carrier protein D2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 2(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 2"(gene name synonym)|uniprotkb:PUBC1(gene name synonym)|uniprotkb:p53-regulated ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D2"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ohbayashi et al. (2008)	imex:IM-23027|pubmed:18515077	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9682784|imex:IM-23027-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177402.1|refseq:NP_031854.1|refseq:XP_006513258.1|ensembl:ENSMUSG00000034974(gene)|ensembl:ENSMUST00000047665(transcript)|ensembl:ENSMUST00000178422(transcript)|ensembl:ENSMUST00000219850(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016301"(kinase activity)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870	refseq:NP_003330.1|refseq:NP_862821.1|dip:DIP-29267N|ensembl:ENSG00000131508(gene)|ensembl:ENST00000398733(transcript)|ensembl:ENST00000398734(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P62837|rcsb pdb:1UR6|rcsb pdb:1W4U|rcsb pdb:2CLW|rcsb pdb:2ESK|rcsb pdb:2ESO|rcsb pdb:2ESP|rcsb pdb:2ESQ|rcsb pdb:3A33|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3L1Y|rcsb pdb:3TGD|rcsb pdb:3ZNI|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4AUQ|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4LDT|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZ3|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5D1K|rcsb pdb:5D1L|rcsb pdb:5D1M|rcsb pdb:5EDV|rcsb pdb:5MNJ|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5VZW|rcsb pdb:5ZBU|rcsb pdb:6HPR|rcsb pdb:6M2C|rcsb pdb:6SQO|rcsb pdb:6SQR|rcsb pdb:6SQS|rcsb pdb:6TTU|rcsb pdb:6W7Z|rcsb pdb:6W9D|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BOL|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/30	2014/10/16	rogid:LOZoxWuCRZi1kVZyrtoEijElfC810090	rogid:vVGrEi0osU/WG0Y9qRCFMT4lgvg9606	intact-crc:11E15D79B7A98983|rigid:hPldXdokMRYIX9PSosq4Rk5Ko/A	false	myc tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)