#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P56703	uniprotkb:O75084	intact:EBI-3644922|uniprotkb:Q2M237|uniprotkb:Q9H1J9|ensembl:ENSP00000225512|ensembl:ENSP00000478327|ensembl:ENSP00000480990	intact:EBI-746917|uniprotkb:Q53S59|uniprotkb:O94816|uniprotkb:Q96B74|ensembl:ENSP00000286201	psi-mi:wnt3_human(display_long)|uniprotkb:WNT3(gene name)|psi-mi:WNT3(display_short)|uniprotkb:INT4(gene name synonym)|uniprotkb:Proto-oncogene Int-4 homolog(gene name synonym)	psi-mi:fzd7_human(display_long)|uniprotkb:FzE3(gene name synonym)|uniprotkb:FZD7(gene name)|psi-mi:FZD7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2008)	imex:IM-22114|pubmed:18313787	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9087394|imex:IM-22114-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110380.1|ensembl:ENSG00000108379(gene)|ensembl:ENSG00000277626(gene)|ensembl:ENSG00000277641(gene)|ensembl:ENST00000225512(transcript)|ensembl:ENST00000611547(transcript)|ensembl:ENST00000616347(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007276"(gamete generation)|go:"GO:0007411"(axon guidance)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060064"(Spemann organizer formation at the anterior end of the primitive streak)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060323"(head morphogenesis)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072089"(stem cell proliferation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905474"(canonical Wnt signaling pathway involved in stem cell proliferation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:6AHY|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080	refseq:NP_003498.1|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-9673324|ensembl:ENSG00000155760(gene)|ensembl:ENST00000286201(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042666"(negative regulation of ectodermal cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026552|interpro:IPR036790|interpro:IPR042742|mint:O75084|rcsb pdb:4Z33|rcsb pdb:5T44|rcsb pdb:5URV|rcsb pdb:5WBS|rcsb pdb:6NE2|rcsb pdb:6NE4|rcsb pdb:6O3A|rcsb pdb:6O3B|reactome:R-HSA-373080	-	-	-	figure legend:Fig. 6A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2014/01/17	2014/10/16	rogid:kf9z2nF0k139zqLaC8Ue5+qNBvs9606	rogid:jvopJlAyREkQnaICXFPbufHIv5E9606	intact-crc:E818C9AFFB9D0558|rigid:H/L37OprhifhTzxFyEBWvVYArDs	false	myc tag:c-c	glu tag:c-c|necessary binding region:49-152(IPR020067)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56703	uniprotkb:O75084	intact:EBI-3644922|uniprotkb:Q2M237|uniprotkb:Q9H1J9|ensembl:ENSP00000225512|ensembl:ENSP00000478327|ensembl:ENSP00000480990	intact:EBI-746917|uniprotkb:Q53S59|uniprotkb:O94816|uniprotkb:Q96B74|ensembl:ENSP00000286201	psi-mi:wnt3_human(display_long)|uniprotkb:WNT3(gene name)|psi-mi:WNT3(display_short)|uniprotkb:INT4(gene name synonym)|uniprotkb:Proto-oncogene Int-4 homolog(gene name synonym)	psi-mi:fzd7_human(display_long)|uniprotkb:FzE3(gene name synonym)|uniprotkb:FZD7(gene name)|psi-mi:FZD7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2008)	imex:IM-22114|pubmed:18313787	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9087419|imex:IM-22114-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110380.1|ensembl:ENSG00000108379(gene)|ensembl:ENSG00000277626(gene)|ensembl:ENSG00000277641(gene)|ensembl:ENST00000225512(transcript)|ensembl:ENST00000611547(transcript)|ensembl:ENST00000616347(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007276"(gamete generation)|go:"GO:0007411"(axon guidance)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060064"(Spemann organizer formation at the anterior end of the primitive streak)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060323"(head morphogenesis)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072089"(stem cell proliferation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905474"(canonical Wnt signaling pathway involved in stem cell proliferation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:6AHY|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080	refseq:NP_003498.1|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-9673324|ensembl:ENSG00000155760(gene)|ensembl:ENST00000286201(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042666"(negative regulation of ectodermal cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026552|interpro:IPR036790|interpro:IPR042742|mint:O75084|rcsb pdb:4Z33|rcsb pdb:5T44|rcsb pdb:5URV|rcsb pdb:5WBS|rcsb pdb:6NE2|rcsb pdb:6NE4|rcsb pdb:6O3A|rcsb pdb:6O3B|reactome:R-HSA-373080	-	-	-	figure legend:Fig. 6A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-focus hcc)|taxid:9606(Human-Focus hepatocellular carcinoma cell line)	-	2014/01/17	2014/10/16	rogid:kf9z2nF0k139zqLaC8Ue5+qNBvs9606	rogid:jvopJlAyREkQnaICXFPbufHIv5E9606	intact-crc:3EBF9ADA6E2DBD06|rigid:H/L37OprhifhTzxFyEBWvVYArDs	false	myc tag:c-c	necessary binding region:49-152(IPR020067)|glu tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)