#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16531	uniprotkb:P05928	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	intact:EBI-9210238	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Le et al. (2007)	imex:IM-23287|pubmed:17314515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9915420|imex:IM-23287-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	-	-	-	figure legend:2B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/11/03	2014/11/03	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	intact-crc:8E834E97C92832B1|rigid:+pt8CFRuvrmhAGcrbYU4GzTfnGU	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q16531	uniprotkb:Q9Y4B6-3	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	intact:EBI-9915372|ensembl:ENSP00000338857	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:q9y4b6-3(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Le et al. (2007)	imex:IM-23287|pubmed:17314515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9915420|imex:IM-23287-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	ensembl:ENSG00000145041(gene)|ensembl:ENST00000335891(transcript)|intact:EBI-1996353(isoform-parent)|uniprotkb:Q9Y4B6-3(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:2B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/11/03	2014/11/03	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	rogid:yz0csb8EiV6wMTLLkE30rPR/IEA9606	intact-crc:8E834E97C92832B1|rigid:+pt8CFRuvrmhAGcrbYU4GzTfnGU	false	flag tag:c-c	myc tag:?-?|sufficient binding region:592-928(IPR017986)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P05928	uniprotkb:Q9Y4B6-3	intact:EBI-9210238	intact:EBI-9915372|ensembl:ENSP00000338857	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:q9y4b6-3(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Le et al. (2007)	imex:IM-23287|pubmed:17314515	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9915735|imex:IM-23287-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	ensembl:ENSG00000145041(gene)|ensembl:ENST00000335891(transcript)|intact:EBI-1996353(isoform-parent)|uniprotkb:Q9Y4B6-3(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/11/03	2014/11/04	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:yz0csb8EiV6wMTLLkE30rPR/IEA9606	intact-crc:D33A85E4FAC31C3C|rigid:FO4DzIMFH2SKD2GUMIszTH6aB+0	false	ha tag:?-?|mutation disrupting interaction:65-65	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y4B6-3	uniprotkb:Q16531	intact:EBI-9915372|ensembl:ENSP00000338857	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	psi-mi:q9y4b6-3(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Le et al. (2007)	imex:IM-23287|pubmed:17314515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9915408|imex:IM-23287-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145041(gene)|ensembl:ENST00000335891(transcript)|intact:EBI-1996353(isoform-parent)|uniprotkb:Q9Y4B6-3(isoform-parent)	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	-	isoform-comment:No experimental confirmation available.	-	figure legend:2A|comment:"Detected in presence of HA-tagged HIV-1 Vpr  (UniProt AC P05928)  wildtype and gln65arg mutant"|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/11/03	2014/11/03	rogid:yz0csb8EiV6wMTLLkE30rPR/IEA9606	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	intact-crc:978069021A19EC44|rigid:ag+dxekBAp3U+W5nNHiRB8kD/TY	false	flag tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P13051	uniprotkb:P05928	intact:EBI-1025947|uniprotkb:O00637|uniprotkb:O00719|uniprotkb:Q93028|uniprotkb:A8K5M6|uniprotkb:B2R8Y1|ensembl:ENSP00000242576	intact:EBI-9210238	psi-mi:ung_human(display_long)|uniprotkb:UNG(gene name)|psi-mi:UNG(display_short)|uniprotkb:DGU(gene name synonym)|uniprotkb:UNG15(gene name synonym)|uniprotkb:UNG1(gene name synonym)	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Le et al. (2007)	imex:IM-23287|pubmed:17314515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9915647|imex:IM-23287-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003353.1|refseq:NP_550433.1|ensembl:ENSG00000076248(gene)|ensembl:ENST00000242576(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045008"(depyrimidination)|go:"GO:0045190"(isotype switching)|go:"GO:0097510"(base-excision repair, AP site formation via deaminated base removal)|interpro:IPR002043(Uracil-DNA glycosylase)|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR018085|interpro:IPR036895|rcsb pdb:1AKZ|rcsb pdb:1DPU|rcsb pdb:1EMH|rcsb pdb:1EMJ|rcsb pdb:1Q3F|rcsb pdb:1SSP|rcsb pdb:1UGH|rcsb pdb:1YUO|rcsb pdb:2HXM|rcsb pdb:2OXM|rcsb pdb:2OYT|rcsb pdb:2SSP|rcsb pdb:3FCF|rcsb pdb:3FCI|rcsb pdb:3FCK|rcsb pdb:3FCL|rcsb pdb:3TKB|rcsb pdb:4SKN|rcsb pdb:5AYR|rcsb pdb:5JK7|rcsb pdb:6VBA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|dip:DIP-24194N	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	-	-	-	figure legend:S1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/11/03	2014/11/04	rogid:pjzUi17Vpmhp1JddThFwPvNhZCE9606	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	intact-crc:B8E8E79843D93F5D|rigid:HWIHtYdxJOYU81km9Rq2GCLt0B4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05928	uniprotkb:Q9Y4B6-3	intact:EBI-9210238	intact:EBI-9915372|ensembl:ENSP00000338857	psi-mi:vpr_hv1br(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym)	psi-mi:q9y4b6-3(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Le et al. (2007)	imex:IM-23287|pubmed:17314515	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9915370|imex:IM-23287-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000012(Retroviral VpR/VpX protein)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)	ensembl:ENSG00000145041(gene)|ensembl:ENST00000335891(transcript)|intact:EBI-1996353(isoform-parent)|uniprotkb:Q9Y4B6-3(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:4A, S1A and B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/11/03	2014/11/11	rogid:+hinnBUvYp/EWY/a/PMagBXixQ811686	rogid:yz0csb8EiV6wMTLLkE30rPR/IEA9606	intact-crc:9C0D68727844D952|rigid:FO4DzIMFH2SKD2GUMIszTH6aB+0	false	mutation disrupting interaction:65-65|sufficient binding region:1-78|mutation disrupting interaction:65-65	sufficient binding region:592-928(IPR017986)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19508	uniprotkb:Q9Y4B6-3	intact:EBI-6558117	intact:EBI-9915372|ensembl:ENSP00000338857	psi-mi:vpx_sivsp(display_long)|uniprotkb:vpx(gene name)|psi-mi:vpx(display_short)|uniprotkb:Viral protein X(gene name synonym)|uniprotkb:X ORF protein(gene name synonym)	psi-mi:q9y4b6-3(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Le et al. (2007)	imex:IM-23287|pubmed:17314515	taxid:11738(sivsp)|taxid:11738("Simian immunodeficiency virus (isolate PBj14/BCL-3)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9915686|imex:IM-23287-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019058"(viral life cycle)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:4CC9|dip:DIP-60689N	ensembl:ENSG00000145041(gene)|ensembl:ENST00000335891(transcript)|intact:EBI-1996353(isoform-parent)|uniprotkb:Q9Y4B6-3(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:4A and B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/11/03	2014/11/04	rogid:jDDas6ALg67KZEtqvT/ca8Ogytk11738	rogid:yz0csb8EiV6wMTLLkE30rPR/IEA9606	intact-crc:8B5C37EA765C9868|rigid:jZbRz2pOI7MkEroe2IEQjkcqkgk	false	mutation disrupting interaction:76-76	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)