#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03132	uniprotkb:Q9NXV2	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1056857|uniprotkb:D3DU96|ensembl:ENSP00000301738	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:kctd5_human(display_long)|uniprotkb:KCTD5(gene name)|psi-mi:KCTD5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Weger et al. (2007)	pubmed:17239418|imex:IM-22583	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9514905|imex:IM-22583-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1	refseq:NP_061865.1|interpro:IPR011333(BTB/POZ fold)|mint:Q9NXV2|rcsb pdb:3DRX|rcsb pdb:3DRY|rcsb pdb:3DRZ|ensembl:ENSG00000167977(gene)|ensembl:ENST00000301738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	-	function:Essential for DNA replication|comment:mint|comment:Rep68 NLS mutant also interacted.	-	figure legend:4 A/B , 7, 8|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/04/30	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:KzXA4jgTKUY/EE1ORX+nMLCPfro9606	intact-crc:B8AF4BF1924E5845|rigid:w1W8H5AxOu23miNkyj935O9UJ4c	false	necessary binding region:482-514|necessary binding region:1-171	sufficient binding region:21-234|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NXV2	uniprotkb:Q89268	intact:EBI-1056857|uniprotkb:D3DU96|ensembl:ENSP00000301738	intact:EBI-9485551|uniprotkb:O56651	psi-mi:kctd5_human(display_long)|uniprotkb:KCTD5(gene name)|psi-mi:KCTD5(display_short)	psi-mi:rep78_aav2s(display_long)|uniprotkb:Rep78(gene name)|psi-mi:Rep78(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Weger et al. (2007)	pubmed:17239418|imex:IM-22583	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9514934|imex:IM-22583-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061865.1|interpro:IPR011333(BTB/POZ fold)|mint:Q9NXV2|rcsb pdb:3DRX|rcsb pdb:3DRY|rcsb pdb:3DRZ|ensembl:ENSG00000167977(gene)|ensembl:ENST00000301738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|interpro:IPR014835(Rep protein catalytic  like)|rcsb pdb:5BYG|refseq:YP_680423.1|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)	-	-	comment:Rep78 NLS mutant also interacted.	figure legend:4A and 7|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/04/30	2014/10/16	rogid:KzXA4jgTKUY/EE1ORX+nMLCPfro9606	rogid:CRl4VPCCbv4a09MrPhwOddP9gG8648242	intact-crc:190506401E49ACDD|rigid:KubWua1JWNXtvNjkRdnk1OpifQ8	false	sufficient binding region:21-234|flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q89268	uniprotkb:Q9NXV2	intact:EBI-9485551|uniprotkb:O56651	intact:EBI-1056857|uniprotkb:D3DU96|ensembl:ENSP00000301738	psi-mi:rep78_aav2s(display_long)|uniprotkb:Rep78(gene name)|psi-mi:Rep78(display_short)	psi-mi:kctd5_human(display_long)|uniprotkb:KCTD5(gene name)|psi-mi:KCTD5(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Weger et al. (2007)	pubmed:17239418|imex:IM-22583	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9515008|imex:IM-22583-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|interpro:IPR014835(Rep protein catalytic  like)|rcsb pdb:5BYG|refseq:YP_680423.1|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)	refseq:NP_061865.1|interpro:IPR011333(BTB/POZ fold)|mint:Q9NXV2|rcsb pdb:3DRX|rcsb pdb:3DRY|rcsb pdb:3DRZ|ensembl:ENSG00000167977(gene)|ensembl:ENST00000301738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	go:"GO:0005634"(nucleus)	comment:Rep78 NLS mutant also interacted.	-	figure legend:6 E and 8G|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/04/30	2014/10/16	rogid:CRl4VPCCbv4a09MrPhwOddP9gG8648242	rogid:KzXA4jgTKUY/EE1ORX+nMLCPfro9606	intact-crc:4CB89AFDE99E92AB|rigid:KubWua1JWNXtvNjkRdnk1OpifQ8	false	-	sufficient binding region:47-234|flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P03132	uniprotkb:Q9NXV2	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1056857|uniprotkb:D3DU96|ensembl:ENSP00000301738	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:kctd5_human(display_long)|uniprotkb:KCTD5(gene name)|psi-mi:KCTD5(display_short)	psi-mi:"MI:0018"(two hybrid)	Weger et al. (2007)	pubmed:17239418|imex:IM-22583	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9514873|imex:IM-22583-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1	refseq:NP_061865.1|interpro:IPR011333(BTB/POZ fold)|mint:Q9NXV2|rcsb pdb:3DRX|rcsb pdb:3DRY|rcsb pdb:3DRZ|ensembl:ENSG00000167977(gene)|ensembl:ENST00000301738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	-	function:Essential for DNA replication|comment:mint	-	figure legend:no figure|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/04/30	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:KzXA4jgTKUY/EE1ORX+nMLCPfro9606	intact-crc:AC19DA6B98E88E50|rigid:w1W8H5AxOu23miNkyj935O9UJ4c	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03132	uniprotkb:Q9NXV2	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1056857|uniprotkb:D3DU96|ensembl:ENSP00000301738	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:kctd5_human(display_long)|uniprotkb:KCTD5(gene name)|psi-mi:KCTD5(display_short)	psi-mi:"MI:0018"(two hybrid)	Weger et al. (2007)	pubmed:17239418|imex:IM-22583	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9514884|imex:IM-22583-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1	refseq:NP_061865.1|interpro:IPR011333(BTB/POZ fold)|mint:Q9NXV2|rcsb pdb:3DRX|rcsb pdb:3DRY|rcsb pdb:3DRZ|ensembl:ENSG00000167977(gene)|ensembl:ENST00000301738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	-	function:Essential for DNA replication|comment:mint	-	figure legend:2B and C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/04/30	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:KzXA4jgTKUY/EE1ORX+nMLCPfro9606	intact-crc:0DF39DDA2BB2A165|rigid:w1W8H5AxOu23miNkyj935O9UJ4c	false	necessary binding region:1-171|necessary binding region:482-514	necessary binding region:204-227|necessary binding region:47-69	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)