#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UK17	uniprotkb:Q9NZI2	intact:EBI-9825212|uniprotkb:O60576|uniprotkb:O60577|uniprotkb:Q14D71|uniprotkb:Q5T0M0|uniprotkb:Q9UH85|uniprotkb:Q9UH86|uniprotkb:Q9UK16|ensembl:ENSP00000306923|ensembl:ENSP00000319591	intact:EBI-2120635|uniprotkb:Q5U822|uniprotkb:B7Z7B4|ensembl:ENSP00000395323|uniprotkb:Q3YAD2|uniprotkb:Q3YAD0|uniprotkb:Q3YAD1|uniprotkb:Q3YAD3|intact:EBI-12174367|uniprotkb:A0A0C4DFQ7	psi-mi:kcnd3_human(display_long)|uniprotkb:KCND3(gene name)|psi-mi:KCND3(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv4.3(gene name synonym)	psi-mi:kcip1_human(display_long)|uniprotkb:KCNIP1(gene name)|psi-mi:KCNIP1(display_short)|uniprotkb:KCHIP1(gene name synonym)|uniprotkb:VABP(gene name synonym)|uniprotkb:A-type potassium channel modulatory protein 1(gene name synonym)|uniprotkb:Potassium channel-interacting protein 1(gene name synonym)|uniprotkb:Vesicle APC-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2007)	pubmed:17187064|imex:IM-23329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9826891|imex:IM-23329-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004971.2|refseq:NP_751948.1|refseq:XP_005270908.1|refseq:XP_006710692.1|refseq:XP_016856733.1|refseq:XP_006710693.1|ensembl:ENSG00000171385(gene)|ensembl:ENST00000302127(transcript)|ensembl:ENST00000315987(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005250"("A-type (transient outward) potassium channel activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099625"(ventricular cardiac muscle cell membrane repolarization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003975(Potassium channel, voltage dependent, Kv4)|interpro:IPR004056(Potassium channel, voltage dependent, Kv4.3)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR021645|interpro:IPR024587|interpro:IPR027359|interpro:IPR028325|rcsb pdb:1S1G|rcsb pdb:2NZ0|reactome:R-HSA-5576894|reactome:R-HSA-1296072	refseq:NP_001030009.1|refseq:NP_055407.1|refseq:NP_001030010.1|refseq:NP_001265268.1|refseq:NP_001265269.1|refseq:XP_016864896.1|dip:DIP-29246N|ensembl:ENSG00000182132(gene)|ensembl:ENST00000411494(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:Q9NZI2|rcsb pdb:1S1E|rcsb pdb:2NZ0|reactome:R-HSA-5576894|rcsb pdb:2I2R	-	-	-	figure legend:Fig. 3b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/26	2014/11/26	rogid:AtzYb4Wc6Fz/N3TdAnfa2lHGE+Q9606	rogid:+4k81JjvVvA1ODWgsux/34foDFY9606	intact-crc:80D7E069DB0DE035|rigid:rwqxVM3oXheiTjPRFFvTTr7n764	false	binding-associated region:6-245|his tag:?-?	binding-associated region:38-217(IPR011992)|mutation disrupting interaction:134-134|glutathione s tranferase tag:n-n	4	4	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9NZI2	uniprotkb:Q9UK17	intact:EBI-2120635|uniprotkb:Q5U822|uniprotkb:B7Z7B4|ensembl:ENSP00000395323|uniprotkb:Q3YAD2|uniprotkb:Q3YAD0|uniprotkb:Q3YAD1|uniprotkb:Q3YAD3|intact:EBI-12174367|uniprotkb:A0A0C4DFQ7	intact:EBI-9825212|uniprotkb:O60576|uniprotkb:O60577|uniprotkb:Q14D71|uniprotkb:Q5T0M0|uniprotkb:Q9UH85|uniprotkb:Q9UH86|uniprotkb:Q9UK16|ensembl:ENSP00000306923|ensembl:ENSP00000319591	psi-mi:kcip1_human(display_long)|uniprotkb:KCNIP1(gene name)|psi-mi:KCNIP1(display_short)|uniprotkb:KCHIP1(gene name synonym)|uniprotkb:VABP(gene name synonym)|uniprotkb:A-type potassium channel modulatory protein 1(gene name synonym)|uniprotkb:Potassium channel-interacting protein 1(gene name synonym)|uniprotkb:Vesicle APC-binding protein(gene name synonym)	psi-mi:kcnd3_human(display_long)|uniprotkb:KCND3(gene name)|psi-mi:KCND3(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv4.3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2007)	pubmed:17187064|imex:IM-23329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9982712|imex:IM-23329-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001030009.1|refseq:NP_055407.1|refseq:NP_001030010.1|refseq:NP_001265268.1|refseq:NP_001265269.1|refseq:XP_016864896.1|dip:DIP-29246N|ensembl:ENSG00000182132(gene)|ensembl:ENST00000411494(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:Q9NZI2|rcsb pdb:1S1E|rcsb pdb:2NZ0|reactome:R-HSA-5576894|rcsb pdb:2I2R	refseq:NP_004971.2|refseq:NP_751948.1|refseq:XP_005270908.1|refseq:XP_006710692.1|refseq:XP_016856733.1|refseq:XP_006710693.1|ensembl:ENSG00000171385(gene)|ensembl:ENST00000302127(transcript)|ensembl:ENST00000315987(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005250"("A-type (transient outward) potassium channel activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099625"(ventricular cardiac muscle cell membrane repolarization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003975(Potassium channel, voltage dependent, Kv4)|interpro:IPR004056(Potassium channel, voltage dependent, Kv4.3)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR021645|interpro:IPR024587|interpro:IPR027359|interpro:IPR028325|rcsb pdb:1S1G|rcsb pdb:2NZ0|reactome:R-HSA-5576894|reactome:R-HSA-1296072	-	-	-	figure legend:Fig. 3b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/26	2014/11/21	rogid:+4k81JjvVvA1ODWgsux/34foDFY9606	rogid:AtzYb4Wc6Fz/N3TdAnfa2lHGE+Q9606	intact-crc:8BB711B3E5472C53|rigid:rwqxVM3oXheiTjPRFFvTTr7n764	false	binding-associated region:38-217(IPR011992)|his tag:?-?|mutation disrupting interaction:134-134	glutathione s tranferase tag:n-n|binding-associated region:6-145|mutation disrupting interaction:8-8,10-10,15-15	4	4	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9UK17	uniprotkb:Q9NZI2	intact:EBI-9825212|uniprotkb:O60576|uniprotkb:O60577|uniprotkb:Q14D71|uniprotkb:Q5T0M0|uniprotkb:Q9UH85|uniprotkb:Q9UH86|uniprotkb:Q9UK16|ensembl:ENSP00000306923|ensembl:ENSP00000319591	intact:EBI-2120635|uniprotkb:Q5U822|uniprotkb:B7Z7B4|ensembl:ENSP00000395323|uniprotkb:Q3YAD2|uniprotkb:Q3YAD0|uniprotkb:Q3YAD1|uniprotkb:Q3YAD3|intact:EBI-12174367|uniprotkb:A0A0C4DFQ7	psi-mi:kcnd3_human(display_long)|uniprotkb:KCND3(gene name)|psi-mi:KCND3(display_short)|uniprotkb:Voltage-gated potassium channel subunit Kv4.3(gene name synonym)	psi-mi:kcip1_human(display_long)|uniprotkb:KCNIP1(gene name)|psi-mi:KCNIP1(display_short)|uniprotkb:KCHIP1(gene name synonym)|uniprotkb:VABP(gene name synonym)|uniprotkb:A-type potassium channel modulatory protein 1(gene name synonym)|uniprotkb:Potassium channel-interacting protein 1(gene name synonym)|uniprotkb:Vesicle APC-binding protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2007)	pubmed:17187064|imex:IM-23329	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9825210|imex:IM-23329-1|pdbe:2nz0	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004971.2|refseq:NP_751948.1|refseq:XP_005270908.1|refseq:XP_006710692.1|refseq:XP_016856733.1|refseq:XP_006710693.1|ensembl:ENSG00000171385(gene)|ensembl:ENST00000302127(transcript)|ensembl:ENST00000315987(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005250"("A-type (transient outward) potassium channel activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099625"(ventricular cardiac muscle cell membrane repolarization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003975(Potassium channel, voltage dependent, Kv4)|interpro:IPR004056(Potassium channel, voltage dependent, Kv4.3)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR021645|interpro:IPR024587|interpro:IPR027359|interpro:IPR028325|rcsb pdb:1S1G|rcsb pdb:2NZ0|reactome:R-HSA-5576894|reactome:R-HSA-1296072	refseq:NP_001030009.1|refseq:NP_055407.1|refseq:NP_001030010.1|refseq:NP_001265268.1|refseq:NP_001265269.1|refseq:XP_016864896.1|dip:DIP-29246N|ensembl:ENSG00000182132(gene)|ensembl:ENST00000411494(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:Q9NZI2|rcsb pdb:1S1E|rcsb pdb:2NZ0|reactome:R-HSA-5576894|rcsb pdb:2I2R	-	-	-	figure legend:Fig. 1|causality statement:Q9NZI2 increases activity of Q9UK17|3d-resolution:3.2 Angstrom|3d-r-factors:R = 0.26 Rwork = 0.26 Rfree = 0.31|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/26	2014/11/21	rogid:AtzYb4Wc6Fz/N3TdAnfa2lHGE+Q9606	rogid:+4k81JjvVvA1ODWgsux/34foDFY9606	intact-crc:B4E49E1692BCD4DD|rigid:rwqxVM3oXheiTjPRFFvTTr7n764	false	binding-associated region:6-145(IPR011333)	binding-associated region:38-217(IPR011992)	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)