#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O00499 uniprotkb:P27958-PRO_0000037576 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-8753518 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:p27958-pro_0000037576(display_long) psi-mi:"MI:0018"(two hybrid) Nanda et al. (2006) pubmed:16530520|imex:IM-25841 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9526071|imex:IM-25841-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N intact:EBI-706378(chain-parent) - - chain-seq-start:1973|chain-seq-end:2420 figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/05/15 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 intact-crc:9892E59FF980CDBF|rigid:sjS1NPHI9Xpb/Ux/Af2n6PsYB8s false - binding-associated region:1-384 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O00499 uniprotkb:P27958-PRO_0000037576 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-8753518 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:p27958-pro_0000037576(display_long) psi-mi:"MI:0018"(two hybrid) Nanda et al. (2006) pubmed:16530520|imex:IM-25841 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9540946|imex:IM-25841-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N intact:EBI-706378(chain-parent) - - chain-seq-start:1973|chain-seq-end:2420 figure legend:1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/05/15 2017/09/02 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 intact-crc:1ABB4973F51AFD2A|rigid:sjS1NPHI9Xpb/Ux/Af2n6PsYB8s false - mutation decreasing interaction:354-354,353-353,355-355|necessary binding region:335-360 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P27958-PRO_0000037576 uniprotkb:O00499 intact:EBI-8753518 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:p27958-pro_0000037576(display_long) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0096"(pull down) Nanda et al. (2006) pubmed:16530520|imex:IM-25841 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9540960|imex:IM-25841-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706378(chain-parent) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - chain-seq-start:1973|chain-seq-end:2420 - figure legend:3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/05/15 2014/10/16 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:37E5D7A57E513B42|rigid:sjS1NPHI9Xpb/Ux/Af2n6PsYB8s false glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P27958-PRO_0000037576 uniprotkb:O00499 intact:EBI-8753518 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:p27958-pro_0000037576(display_long) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nanda et al. (2006) pubmed:16530520|imex:IM-25841 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9540933|imex:IM-25841-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706378(chain-parent) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - chain-seq-start:1973|chain-seq-end:2420 - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/05/15 2014/10/16 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:E9177B5A2ED43B0E|rigid:sjS1NPHI9Xpb/Ux/Af2n6PsYB8s false binding-associated region:1-384 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P27958-PRO_0000037576 uniprotkb:O00499 intact:EBI-8753518 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:p27958-pro_0000037576(display_long) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Nanda et al. (2006) pubmed:16530520|imex:IM-25841 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9540978|imex:IM-25841-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706378(chain-parent) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - chain-seq-start:1973|chain-seq-end:2420 - figure legend:3B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2014/05/15 2014/10/16 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:7EDDF46DD7463476|rigid:sjS1NPHI9Xpb/Ux/Af2n6PsYB8s false flag tag:?-?|mutation decreasing interaction:355-355,353-353,354-354 - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P27958-PRO_0000037576 uniprotkb:O00499 intact:EBI-8753518 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:p27958-pro_0000037576(display_long) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Nanda et al. (2006) pubmed:16530520|imex:IM-25841 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-9540994|imex:IM-25841-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706378(chain-parent) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N - chain-seq-start:1973|chain-seq-end:2420 - figure legend:4|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2014/05/15 2014/10/16 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:92E69D3D8D402ED1|rigid:sjS1NPHI9Xpb/Ux/Af2n6PsYB8s false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:O00499 uniprotkb:Q9WMX2-PRO_0000037551 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 intact:EBI-6863748 psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Nanda et al. (2006) pubmed:16530520|imex:IM-25841 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9544889|imex:IM-25841-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N intact:EBI-710918(chain-parent) - - chain-seq-start:1973|chain-seq-end:2419 figure legend:3C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2014/05/15 2014/10/16 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 intact-crc:9B1F797607706CF3|rigid:yQwvVCHwuzv1TqSBrnCEz9Eoy2w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)