#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13563	uniprotkb:Q91908	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-9633447	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:q91908_xenla(display_long)|uniprotkb:itpr1.S(gene name)|psi-mi:itpr1.S(display_short)|uniprotkb:itpr1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2005)	imex:IM-23022|pubmed:16223735	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9633236|imex:IM-23022-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_001084015.1|interpro:IPR016024(Armadillo-type fold)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR035910|interpro:IPR036300|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Fig. 4A, 5A, C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:443947(xenopus laevis laevis-oocyte)|taxid:443947(Xenopus laevis laevis)	-	2014/06/25	2014/10/16	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:TtuqU4vwJeDBp6VGTHzzi4K0PQ08355	intact-crc:E301101A77D7285F|rigid:jiIkXXTbfubV5vb77Tt9cwE5Hqs	false	myc tag:n-n|sufficient binding region:577-872	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13563	uniprotkb:Q91908	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-9633447	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:q91908_xenla(display_long)|uniprotkb:itpr1.S(gene name)|psi-mi:itpr1.S(display_short)|uniprotkb:itpr1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2005)	imex:IM-23022|pubmed:16223735	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9633250|imex:IM-23022-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_001084015.1|interpro:IPR016024(Armadillo-type fold)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR035910|interpro:IPR036300|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Fig. 4A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:443947(xenopus laevis laevis-oocyte)|taxid:443947(Xenopus laevis laevis)	-	2014/06/25	2014/10/16	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:TtuqU4vwJeDBp6VGTHzzi4K0PQ08355	intact-crc:86B364FA428C3423|rigid:jiIkXXTbfubV5vb77Tt9cwE5Hqs	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)