#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43026	uniprotkb:P36894	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Seemann et al. (2005)	pubmed:16127465|imex:IM-23687	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9391945|imex:IM-23687-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	-	comment:mint	-	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:21.3x10^-9(molar)	2014/04/11	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:C6DB3C9F3A3131CF|rigid:gu6kQO3e+tD0AKELwjO6EpvVuWE	false	mutation increasing interaction strength:438-438|mutation disrupting interaction rate:441-441	biotin tag:?-?|tag:n-n|sufficient binding region:24-152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:O00238	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Seemann et al. (2005)	pubmed:16127465|imex:IM-23687	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9391984|imex:IM-23687-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)	-	comment:mint	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-9(mol)	2014/04/11	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:D207508F86BDEEB0|rigid:ZwwaoOLCVU9mHAMPacKVxMXmW0M	false	mutation decreasing interaction strength:441-441	tag:c-c|his tag:c-c|sufficient binding region:14-126	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:Q13253	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-1035205|ensembl:ENSP00000328181	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:nogg_human(display_long)|uniprotkb:NOG(gene name)|psi-mi:NOG(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Seemann et al. (2005)	pubmed:16127465|imex:IM-23687	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9392000|imex:IM-23687-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1	refseq:NP_005441.1|ensembl:ENSG00000183691(gene)|ensembl:ENST00000332822(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001839"(neural plate morphogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019955"(cytokine binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021533"(cell differentiation in hindbrain)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060173"(limb development)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0060825"(fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0061053"(somite development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090193"(positive regulation of glomerulus development)|go:"GO:1905006"(negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:2000313"(regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR008717(Noggin)|interpro:IPR029034|mint:Q13253|rcsb pdb:1M4U|reactome:R-HSA-201451	-	comment:mint	-	figure legend:Table 1|comment:GDF5 variations/mutations arg438leu and leu441pro do not change the affinity|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.8x10^-9(mol)	2014/04/11	2020/01/02	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:y87SXdQNC1QEsDmhf0xe7db+rdQ9606	intact-crc:4AAFF911480001D2|rigid:WU7us5S9vOUPJmgTENyWSge5rKY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)