#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q02078	uniprotkb:Q99697-3	intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9	intact:EBI-1175243|ensembl:ENSP00000347192|ensembl:ENSP00000484909	psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym)	psi-mi:q99697-3(display_long)|uniprotkb:ARP1A(isoform synonym)|uniprotkb:PITX2(gene name)|psi-mi:PITX2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:RGS(gene name synonym)|uniprotkb:RIEG(gene name synonym)|uniprotkb:RIEG1(gene name synonym)|uniprotkb:ALL1-responsive protein ARP1(gene name synonym)|uniprotkb:Homeobox protein PITX2(gene name synonym)|uniprotkb:Paired-like homeodomain transcription factor 2(gene name synonym)|uniprotkb:RIEG bicoid-related homeobox transcription factor(gene name synonym)|uniprotkb:Solurshin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Toro et al. (2004)	pubmed:15466416|imex:IM-22941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9634099|imex:IM-22941-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078	intact:EBI-1175211(pitx2_human)|ensembl:ENSG00000164093(gene)|ensembl:ENST00000355080(transcript)|ensembl:ENST00000616641(transcript)	-	-	isoform-comment:"Variant in position: 58:F->L (in ASGD4)."	figure legend:Fig 1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/06/27	2014/10/16	rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606	rogid:lbwqpXFBKq9v3kQyno+c46b48Wo9606	intact-crc:50A5F53059467E78|rigid:jxNr2mIyAXA2gHpBV21nCiV70k8	false	-	sufficient binding region:39-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99697-3	uniprotkb:Q02078	intact:EBI-1175243|ensembl:ENSP00000347192|ensembl:ENSP00000484909	intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9	psi-mi:q99697-3(display_long)|uniprotkb:ARP1A(isoform synonym)|uniprotkb:PITX2(gene name)|psi-mi:PITX2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:RGS(gene name synonym)|uniprotkb:RIEG(gene name synonym)|uniprotkb:RIEG1(gene name synonym)|uniprotkb:ALL1-responsive protein ARP1(gene name synonym)|uniprotkb:Homeobox protein PITX2(gene name synonym)|uniprotkb:Paired-like homeodomain transcription factor 2(gene name synonym)|uniprotkb:RIEG bicoid-related homeobox transcription factor(gene name synonym)|uniprotkb:Solurshin(gene name synonym)	psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Toro et al. (2004)	pubmed:15466416|imex:IM-22941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9634167|imex:IM-22941-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1175211(pitx2_human)|ensembl:ENSG00000164093(gene)|ensembl:ENST00000355080(transcript)|ensembl:ENST00000616641(transcript)	refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078	-	isoform-comment:"Variant in position: 58:F->L (in ASGD4)."	-	figure legend:Fig. 2B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/10/16	rogid:lbwqpXFBKq9v3kQyno+c46b48Wo9606	rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606	intact-crc:8E00DEFC23ACD86D|rigid:jxNr2mIyAXA2gHpBV21nCiV70k8	false	glutathione s tranferase tag:?-?|sufficient binding region:39-98	35s radiolabel:?-?|sufficient binding region:1-86(IPR002100)	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q99697	uniprotkb:Q99697	intact:EBI-1175211|uniprotkb:O60578|uniprotkb:O60579|uniprotkb:O60580|uniprotkb:Q9BY17|ensembl:ENSP00000347004|ensembl:ENSP00000378095|ensembl:ENSP00000481951|ensembl:ENSP00000484763|uniprotkb:B2RA02|uniprotkb:B3KXS0|uniprotkb:Q3KQX9|uniprotkb:A8K6C6	intact:EBI-1175211|uniprotkb:O60578|uniprotkb:O60579|uniprotkb:O60580|uniprotkb:Q9BY17|ensembl:ENSP00000347004|ensembl:ENSP00000378095|ensembl:ENSP00000481951|ensembl:ENSP00000484763|uniprotkb:B2RA02|uniprotkb:B3KXS0|uniprotkb:Q3KQX9|uniprotkb:A8K6C6	psi-mi:pitx2_human(display_long)|uniprotkb:RIEG bicoid-related homeobox transcription factor(gene name synonym)|uniprotkb:Solurshin(gene name synonym)|uniprotkb:ALL1-responsive protein ARP1(gene name synonym)|uniprotkb:PITX2(gene name)|psi-mi:PITX2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:RGS(gene name synonym)|uniprotkb:RIEG(gene name synonym)|uniprotkb:RIEG1(gene name synonym)|uniprotkb:Paired-like homeodomain transcription factor 2(gene name synonym)|uniprotkb:Homeobox protein PITX2(gene name synonym)	psi-mi:pitx2_human(display_long)|uniprotkb:RIEG bicoid-related homeobox transcription factor(gene name synonym)|uniprotkb:Solurshin(gene name synonym)|uniprotkb:ALL1-responsive protein ARP1(gene name synonym)|uniprotkb:PITX2(gene name)|psi-mi:PITX2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:RGS(gene name synonym)|uniprotkb:RIEG(gene name synonym)|uniprotkb:RIEG1(gene name synonym)|uniprotkb:Paired-like homeodomain transcription factor 2(gene name synonym)|uniprotkb:Homeobox protein PITX2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Toro et al. (2004)	pubmed:15466416|imex:IM-22941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9634230|imex:IM-22941-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164093(gene)|ensembl:ENST00000354925(transcript)|ensembl:ENST00000394595(transcript)|ensembl:ENST00000613094(transcript)|ensembl:ENST00000614423(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_000316.2|refseq:NP_001191326.1|refseq:NP_001191327.1|refseq:NP_001191328.1|refseq:NP_700475.1|refseq:NP_700476.1|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060126"(somatotropin secreting cell differentiation)|go:"GO:0060127"(prolactin secreting cell differentiation)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0070986"(left/right axis specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR016233(Homeobox Pitx/unc30)|interpro:IPR017970|mint:Q99697|rcsb pdb:2L7F|rcsb pdb:2L7M|rcsb pdb:2LKX|reactome:R-HSA-8866906|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|refseq:XP_011530329.1	ensembl:ENSG00000164093(gene)|ensembl:ENST00000354925(transcript)|ensembl:ENST00000394595(transcript)|ensembl:ENST00000613094(transcript)|ensembl:ENST00000614423(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_000316.2|refseq:NP_001191326.1|refseq:NP_001191327.1|refseq:NP_001191328.1|refseq:NP_700475.1|refseq:NP_700476.1|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060126"(somatotropin secreting cell differentiation)|go:"GO:0060127"(prolactin secreting cell differentiation)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0070986"(left/right axis specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR016233(Homeobox Pitx/unc30)|interpro:IPR017970|mint:Q99697|rcsb pdb:2L7F|rcsb pdb:2L7M|rcsb pdb:2LKX|reactome:R-HSA-8866906|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|refseq:XP_011530329.1	-	-	-	figure legend:Fig. 2B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/10/16	rogid:JWKFsTNDJOefVhq9VKgHa4A1C8g9606	rogid:JWKFsTNDJOefVhq9VKgHa4A1C8g9606	intact-crc:5B6EF11A92824F6F|rigid:iTLW1VrXRGU7ryngh1/6d8EwP0Y	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)