#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q03060 ensembl:ENSG00000170345 intact:EBI-3907794|uniprotkb:Q9NZ98|uniprotkb:Q5W1A9|uniprotkb:Q16114|uniprotkb:Q14505|uniprotkb:Q5W1A6|uniprotkb:Q9NZ99|uniprotkb:Q15731|uniprotkb:Q14506|uniprotkb:Q5W1A8|uniprotkb:Q8IVD4|uniprotkb:Q5T9H7|uniprotkb:B4DXC1|uniprotkb:O75519|uniprotkb:Q16116|uniprotkb:Q14503|uniprotkb:Q9NZB9|uniprotkb:Q7Z2Q6|uniprotkb:Q14504|uniprotkb:A8MPQ2|uniprotkb:C9J785|uniprotkb:C9JZ10|uniprotkb:E9PAR4|uniprotkb:E9PHM1|uniprotkb:Q5W1A7|uniprotkb:A8K014|uniprotkb:A8K6A1|uniprotkb:Q5W1B2|uniprotkb:A8K3J7|uniprotkb:Q96AG7|uniprotkb:Q14501|uniprotkb:Q5W1B0|ensembl:ENSP00000393538 intact:EBI-6081475 psi-mi:crem_human(display_long)|uniprotkb:CREM(gene name)|psi-mi:CREM(display_short)|uniprotkb:Inducible cAMP early repressor(gene name synonym) psi-mi:fos_human_gene(display_short)|psi-mi:ENSG00000170345(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Kyttaris et al. (2004) imex:IM-23648|pubmed:15322221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10048480|efo:"EFO:0002690"|imex:IM-23648-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:XP_011517626.1|refseq:XP_011517627.1|refseq:XP_006717441.1|refseq:XP_006717442.1|refseq:XP_006717445.1|refseq:XP_006717446.1|refseq:NP_001872.3|refseq:NP_877572.1|refseq:NP_874389.1|refseq:NP_853549.1|refseq:NP_874387.1|refseq:NP_877570.1|refseq:NP_877571.1|refseq:NP_877573.1|refseq:NP_874386.1|refseq:NP_874390.1|refseq:NP_874392.1|refseq:NP_874393.1|refseq:NP_001254491.1|refseq:NP_001254493.1|refseq:NP_001254499.1|refseq:NP_874388.1|refseq:NP_898829.1|refseq:NP_898830.1|refseq:NP_898831.1|refseq:NP_001254496.1|refseq:NP_898883.1|ensembl:ENSG00000095794(gene)|ensembl:ENST00000429130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0048511"(rhythmic process)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|reactome:R-HSA-400253|refseq:XP_016871211.1 - - - - figure legend:Fig. 1a, 1b, 1c|comment:Chromatin immunoprecipitation was performed with unstimulated T cells from healthy individuals and T cells from SLE patients. The interaction was significantly increased in the latter.|causality statement:Q03060 decreases expression at RNA level of ENSG00000170345|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-t-cell)|taxid:9606(Homo sapiens) - 2014/12/22 2018/09/18 rogid:qZeS07Fyrw2lTZ6t5kgxUy11kpA9606 - intact-crc:4222CB3F1568969E false - binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03060 intact:EBI-10048491 intact:EBI-3907794|uniprotkb:Q9NZ98|uniprotkb:Q5W1A9|uniprotkb:Q16114|uniprotkb:Q14505|uniprotkb:Q5W1A6|uniprotkb:Q9NZ99|uniprotkb:Q15731|uniprotkb:Q14506|uniprotkb:Q5W1A8|uniprotkb:Q8IVD4|uniprotkb:Q5T9H7|uniprotkb:B4DXC1|uniprotkb:O75519|uniprotkb:Q16116|uniprotkb:Q14503|uniprotkb:Q9NZB9|uniprotkb:Q7Z2Q6|uniprotkb:Q14504|uniprotkb:A8MPQ2|uniprotkb:C9J785|uniprotkb:C9JZ10|uniprotkb:E9PAR4|uniprotkb:E9PHM1|uniprotkb:Q5W1A7|uniprotkb:A8K014|uniprotkb:A8K6A1|uniprotkb:Q5W1B2|uniprotkb:A8K3J7|uniprotkb:Q96AG7|uniprotkb:Q14501|uniprotkb:Q5W1B0|ensembl:ENSP00000393538 - psi-mi:crem_human(display_long)|uniprotkb:CREM(gene name)|psi-mi:CREM(display_short)|uniprotkb:Inducible cAMP early repressor(gene name synonym) psi-mi:fos_human_cre-site_dna-probe(display_short)|psi-mi:EBI-10048491(display_long) psi-mi:"MI:0412"(electrophoretic mobility supershift assay) Kyttaris et al. (2004) imex:IM-23648|pubmed:15322221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10048504|efo:"EFO:0002690"|imex:IM-23648-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) refseq:XP_011517626.1|refseq:XP_011517627.1|refseq:XP_006717441.1|refseq:XP_006717442.1|refseq:XP_006717445.1|refseq:XP_006717446.1|refseq:NP_001872.3|refseq:NP_877572.1|refseq:NP_874389.1|refseq:NP_853549.1|refseq:NP_874387.1|refseq:NP_877570.1|refseq:NP_877571.1|refseq:NP_877573.1|refseq:NP_874386.1|refseq:NP_874390.1|refseq:NP_874392.1|refseq:NP_874393.1|refseq:NP_001254491.1|refseq:NP_001254493.1|refseq:NP_001254499.1|refseq:NP_874388.1|refseq:NP_898829.1|refseq:NP_898830.1|refseq:NP_898831.1|refseq:NP_001254496.1|refseq:NP_898883.1|ensembl:ENSG00000095794(gene)|ensembl:ENST00000429130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0048511"(rhythmic process)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|reactome:R-HSA-400253|refseq:XP_016871211.1 ensembl:ENSG00000170345(see-also) - - - figure legend:Fig. 2|comment:Nuclear extracts were prepared from unstimulated T cells from healthy individuals and T cells from SLE patients. The interaction was increased when SLE T cell nuclear extracts were used.|comment:Supershift was also observed when an anti-CREB antibody was used; however, the exact identity of the targeted CREB protein could not be established, hence this interaction was not captured here.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/12/22 2019/02/01 rogid:qZeS07Fyrw2lTZ6t5kgxUy11kpA9606 - intact-crc:46BC21D488D2B825 false - 32p radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:P01100 intact:EBI-10048513 intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245 - psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym) psi-mi:ap1-consensus_dna-probe(display_short)|psi-mi:EBI-10048513(display_long) psi-mi:"MI:0412"(electrophoretic mobility supershift assay) Kyttaris et al. (2004) imex:IM-23648|pubmed:15322221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10048515|imex:IM-23648-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638 - - - - figure legend:Fig. 6a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/12/22 2019/02/01 rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606 - intact-crc:768FBE549F493205 false - 32p radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) intact:EBI-10048513 uniprotkb:P05412 - intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132 psi-mi:ap1-consensus_dna-probe(display_short)|psi-mi:EBI-10048513(display_long) psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym) psi-mi:"MI:0412"(electrophoretic mobility supershift assay) Kyttaris et al. (2004) imex:IM-23648|pubmed:15322221 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10048521|imex:IM-23648-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0319"(deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324 - - - figure legend:Fig. 6a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/12/22 2019/02/01 - rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606 intact-crc:545EA5AC1DD484B7 false 32p radiolabel:?-? - - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography)