#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00482-2	uniprotkb:Q92786	intact:EBI-9257474|ensembl:ENSP00000236914	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9256600|imex:IM-23104-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	-	-	-	figure legend:Fig.1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/03/11	2014/10/16	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	intact-crc:B5A91D1D52AA6F41|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	sufficient binding region:141-481	sufficient binding region:55-553	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O00482-2	uniprotkb:Q92786	intact:EBI-9257474|ensembl:ENSP00000236914	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9256673|imex:IM-23104-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	-	-	-	figure legend:Fig. 2B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/03/11	2014/10/16	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	intact-crc:52379A602629198E|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	-	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00482-2	uniprotkb:Q92786	intact:EBI-9257474|ensembl:ENSP00000236914	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9698871|imex:IM-23104-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	-	-	-	figure legend:Fig. 4B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/03/11	2014/10/16	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	intact-crc:10326D4FF46B5950|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	sufficient binding region:141-495	sufficient binding region:55-553|mutation disrupting interaction:70-70,73-73	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00482-2	uniprotkb:Q92786	intact:EBI-9257474|ensembl:ENSP00000236914	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9256797|imex:IM-23104-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	-	-	-	figure legend:Fig. 2C, 3A, 4C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/03/11	2014/10/16	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	intact-crc:39DBDA4A576F5596|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	sufficient binding region:256-495|sufficient binding region:34-141	sufficient binding region:55-553	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00482-2	uniprotkb:Q92786	intact:EBI-9257474|ensembl:ENSP00000236914	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9256825|imex:IM-23104-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 2D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/03/11	2014/10/16	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	intact-crc:5024ACBA1226425B|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	-	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q92786	uniprotkb:O00482-2	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	intact:EBI-9257474|ensembl:ENSP00000236914	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9256847|imex:IM-23104-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 2D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos)|taxid:9534(Chlorocebus aethiops)	-	2014/03/11	2014/10/16	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	intact-crc:92C387DC346410CC|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O00482-2	uniprotkb:Q92786	intact:EBI-9257474|ensembl:ENSP00000236914	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9698991|imex:IM-23104-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	-	-	-	figure legend:Fig 4A|comment:The interaction with GST-hLRH-1 186-495 is dramatically reduced when they use Prox1 fragments 76-333 and 55-253|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/11	2014/10/16	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	intact-crc:3A8A5616E74934A1|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	sufficient binding region:186-495|glutathione s tranferase tag:n-n	sufficient binding region:55-253|35s radiolabel:?-?|sufficient binding region:76-333	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O00482-2	uniprotkb:Q92786	intact:EBI-9257474|ensembl:ENSP00000236914	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9699072|imex:IM-23104-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	-	-	-	figure legend:Fig 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/11	2014/10/16	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	intact-crc:EE200A9DCABFAAC2|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	sufficient binding region:186-495|sufficient binding region:34-141|glutathione s tranferase tag:n-n	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q92786	uniprotkb:O00482-2	intact:EBI-3912635|uniprotkb:Q8TB91|uniprotkb:A6NK29|uniprotkb:Q5SW76|uniprotkb:A8K2B1|ensembl:ENSP00000261454|ensembl:ENSP00000355925|ensembl:ENSP00000400694|ensembl:ENSP00000420283	intact:EBI-9257474|ensembl:ENSP00000236914	psi-mi:prox1_human(display_long)|uniprotkb:PROX1(gene name)|psi-mi:PROX1(display_short)|uniprotkb:Homeobox prospero-like protein PROX1(gene name synonym)	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:"MI:0096"(pull down)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9257050|imex:IM-23104-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002754.2|refseq:NP_001257545.1|ensembl:ENSG00000117707(gene)|ensembl:ENST00000261454(transcript)|ensembl:ENST00000366958(transcript)|ensembl:ENST00000435016(transcript)|ensembl:ENST00000498508(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001709"(cell fate determination)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002194"(hepatocyte cell migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030324"(lung development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031016"(pancreas development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043049"(otic placode formation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046619"(lens placode formation involved in camera-type eye formation)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060214"(endocardium formation)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|go:"GO:0061114"(branching involved in pancreas morphogenesis)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070858"(negative regulation of bile acid biosynthetic process)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090425"(acinar cell differentiation)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1901978"(positive regulation of cell cycle checkpoint)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000979"(positive regulation of forebrain neuron differentiation)|interpro:IPR007738(Homeobox prospero-like)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|mint:Q92786|rcsb pdb:2LMD|refseq:XP_016857322.1	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	-	-	-	figure legend:Fig 3D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/11	2014/10/16	rogid:80GpGEDggRkdm+tl6WhIz3FDfos9606	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	intact-crc:6E51B06D653A80FE|rigid:gVePiMCw/Th1IDexyVXSzdQa8GM	false	35s radiolabel:?-?	glutathione s tranferase tag:n-n|mutation disrupting interaction:273-273,281-281,282-282|mutation decreasing interaction:301-301,305-305,308-308|mutation decreasing interaction:326-326,327-327,329-329|mutation disrupting interaction:453-453,454-454|sufficient binding region:186-495	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
ensembl:ENSG00000167910	uniprotkb:O00482-2	intact:EBI-9973316	intact:EBI-9257474|ensembl:ENSP00000236914	uniprotkb:CYP7A1(gene name)|psi-mi:CYP7A1(display_short)|uniprotkb:CYP7(gene name synonym)|intact:CYPVII(synonym)|intact:Cholesterol 7-alpha-hydroxylase(synonym)|intact:Cytochrome P450 7A1(synonym)|ensembl:cp7a1_human_gene(shortlabel)|psi-mi:ENSG00000167910(display_long)	psi-mi:o00482-2(display_long)|uniprotkb:CPF(gene name synonym)|uniprotkb:FTF(gene name synonym)|uniprotkb:Alpha-1-fetoprotein transcription factor(gene name synonym)|uniprotkb:B1-binding factor(gene name synonym)|uniprotkb:CYP7A promoter-binding factor(gene name synonym)|uniprotkb:Hepatocytic transcription factor(gene name synonym)|uniprotkb:Liver receptor homolog 1(gene name synonym)|uniprotkb:NR5A2(gene name)|psi-mi:NR5A2(display_short)|uniprotkb:B1F(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Qin et al. (2004)	pubmed:15205472|imex:IM-23104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9257707|imex:IM-23104-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	intact:EBI-781320(isoform-parent)|uniprotkb:O00482-2(isoform-parent)|ensembl:ENSG00000116833(gene)|ensembl:ENST00000236914(transcript)	-	-	-	figure legend:Fig. 7|antagonist:"Prox 1  (it binds to LRH blocking the DNA protein interaction)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/11	2014/11/06	-	rogid:Bj6gTmToIa+yA1BCc5wZ4LekbyE9606	intact-crc:49594C1D20BADEEE	false	binding-associated region:?-?|32p radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)