#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:D3ZAR1	uniprotkb:P98158-PRO_0000017322	intact:EBI-9250714|ensembl:ENSRNOP00000000163	intact:EBI-9251342	psi-mi:arh_rat(display_long)|uniprotkb:Ldlrap1(gene name)|psi-mi:Ldlrap1(display_short)|uniprotkb:Arh(gene name synonym)|uniprotkb:Autosomal recessive hypercholesterolemia protein homolog(gene name synonym)	psi-mi:p98158-pro_0000017322(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:Megalin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9250708|imex:IM-22979-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1563417|dip:DIP-60041N|ensembl:ENSRNOG00000000151(gene)|ensembl:ENSRNOT00000000163(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3SO6|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8964026|reactome:R-RNO-8964038	intact:EBI-6306650(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:4660	figure legend:Fig 1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/02/27	2014/10/16	rogid:7IcLthFzVgxoP5yB+BSHTWAqzuU10116	rogid:nlScfd6XHV5DuwEyJreFucfLKjI10116	intact-crc:F71F722C636A7307|rigid:BEkk7BA624UEM0H5SHhvCarxmIU	false	sufficient binding region:44-306	sufficient binding region:4423-4558	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:D3ZAR1	uniprotkb:P98158-PRO_0000017322	intact:EBI-9250714|ensembl:ENSRNOP00000000163	intact:EBI-9251342	psi-mi:arh_rat(display_long)|uniprotkb:Ldlrap1(gene name)|psi-mi:Ldlrap1(display_short)|uniprotkb:Arh(gene name synonym)|uniprotkb:Autosomal recessive hypercholesterolemia protein homolog(gene name synonym)	psi-mi:p98158-pro_0000017322(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:Megalin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9251279|imex:IM-22979-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1563417|dip:DIP-60041N|ensembl:ENSRNOG00000000151(gene)|ensembl:ENSRNOT00000000163(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3SO6|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8964026|reactome:R-RNO-8964038	intact:EBI-6306650(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:4660	figure legend:Fig 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/02/27	2014/10/16	rogid:7IcLthFzVgxoP5yB+BSHTWAqzuU10116	rogid:nlScfd6XHV5DuwEyJreFucfLKjI10116	intact-crc:A631853703AD46B6|rigid:BEkk7BA624UEM0H5SHhvCarxmIU	false	-	sufficient binding region:4490-4511	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07954-PRO_0000017317	uniprotkb:D3ZAR1	intact:EBI-9251585	intact:EBI-9250714|ensembl:ENSRNOP00000000163	psi-mi:q07954-pro_0000017317(display_long)|uniprotkb:LRP1(gene name)|psi-mi:LRP1(display_short)|uniprotkb:A2MR(gene name synonym)|uniprotkb:APR(gene name synonym)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:Apolipoprotein E receptor(gene name synonym)	psi-mi:arh_rat(display_long)|uniprotkb:Ldlrap1(gene name)|psi-mi:Ldlrap1(display_short)|uniprotkb:Arh(gene name synonym)|uniprotkb:Autosomal recessive hypercholesterolemia protein homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9251563|imex:IM-22979-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1046087(chain-parent)	rgd:1563417|dip:DIP-60041N|ensembl:ENSRNOG00000000151(gene)|ensembl:ENSRNOT00000000163(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3SO6|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8964026|reactome:R-RNO-8964038	-	chain-seq-start:20|chain-seq-end:4544	-	figure legend:Fig 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/02/27	2014/10/16	rogid:FnO8/F6BpuCa7RsogDIqzStkQwc9606	rogid:7IcLthFzVgxoP5yB+BSHTWAqzuU10116	intact-crc:B58ED5F1CEE29345|rigid:c0iUxeleqRKKjKg7V73gu9fcNqg	false	sufficient binding region:4476-4497	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01130-PRO_0000017312	uniprotkb:D3ZAR1	intact:EBI-9251608	intact:EBI-9250714|ensembl:ENSRNOP00000000163	psi-mi:p01130-pro_0000017312(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short)	psi-mi:arh_rat(display_long)|uniprotkb:Ldlrap1(gene name)|psi-mi:Ldlrap1(display_short)|uniprotkb:Arh(gene name synonym)|uniprotkb:Autosomal recessive hypercholesterolemia protein homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9251603|imex:IM-22979-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-988319(chain-parent)	rgd:1563417|dip:DIP-60041N|ensembl:ENSRNOG00000000151(gene)|ensembl:ENSRNOT00000000163(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3SO6|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8964026|reactome:R-RNO-8964038	-	chain-seq-start:22|chain-seq-end:860	-	figure legend:Fig 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2014/02/27	2014/10/16	rogid:1PatfKwYvnhsGr4zWejRIfhK8OY9606	rogid:7IcLthFzVgxoP5yB+BSHTWAqzuU10116	intact-crc:021C03310691D7AF|rigid:Qb3zDC7iaGmO2jcihElu4NTVSww	false	sufficient binding region:795-816	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P98158-PRO_0000017322	uniprotkb:D3ZAR1	intact:EBI-9251342	intact:EBI-9250714|ensembl:ENSRNOP00000000163	psi-mi:p98158-pro_0000017322(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:Megalin(gene name synonym)	psi-mi:arh_rat(display_long)|uniprotkb:Ldlrap1(gene name)|psi-mi:Ldlrap1(display_short)|uniprotkb:Arh(gene name synonym)|uniprotkb:Autosomal recessive hypercholesterolemia protein homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9251763|imex:IM-22979-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6306650(chain-parent)	rgd:1563417|dip:DIP-60041N|ensembl:ENSRNOG00000000151(gene)|ensembl:ENSRNOT00000000163(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3SO6|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8964026|reactome:R-RNO-8964038	-	chain-seq-start:26|chain-seq-end:4660	-	figure legend:Fig 3A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/27	2014/10/16	rogid:nlScfd6XHV5DuwEyJreFucfLKjI10116	rogid:7IcLthFzVgxoP5yB+BSHTWAqzuU10116	intact-crc:FCDE1A0746DFAA83|rigid:BEkk7BA624UEM0H5SHhvCarxmIU	false	glutathione s tranferase tag:n-n|sufficient binding region:4423-4635	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P98158-PRO_0000017322	uniprotkb:Q5SW96	intact:EBI-9251342	intact:EBI-747813|uniprotkb:A2BHI5|uniprotkb:Q6TQS9|uniprotkb:Q8N2Y0|uniprotkb:Q9UFI9|intact:EBI-28971912|ensembl:ENSP00000363458	psi-mi:p98158-pro_0000017322(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:Megalin(gene name synonym)	psi-mi:arh_human(display_long)|uniprotkb:Autosomal recessive hypercholesterolemia protein(gene name synonym)|uniprotkb:LDLRAP1(gene name)|psi-mi:LDLRAP1(display_short)|uniprotkb:ARH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9253264|imex:IM-22979-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6306650(chain-parent)	ensembl:ENSP00000363458|refseq:NP_056442.2|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090205"(positive regulation of cholesterol metabolic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2G30|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|ensembl:ENSG00000157978(gene)|ensembl:ENST00000374338(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030424"(axon)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)	-	chain-seq-start:26|chain-seq-end:4660	-	figure legend:Fi. 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2014/02/27	2014/10/16	rogid:nlScfd6XHV5DuwEyJreFucfLKjI10116	rogid:dtBWLcVpVD/R0aKQZr9Nucfa1oo9606	intact-crc:22DA3F5C8759E650|rigid:3VKbxA7X4/24zP0SdzJA8djQVps	false	sufficient binding region:3440-4635	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:D3ZAR1	uniprotkb:P98158	intact:EBI-9250714|ensembl:ENSRNOP00000000163	intact:EBI-6306650	psi-mi:arh_rat(display_long)|uniprotkb:Ldlrap1(gene name)|psi-mi:Ldlrap1(display_short)|uniprotkb:Arh(gene name synonym)|uniprotkb:Autosomal recessive hypercholesterolemia protein homolog(gene name synonym)	psi-mi:lrp2_rat(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:Megalin(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9253407|imex:IM-22979-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1563417|dip:DIP-60041N|ensembl:ENSRNOG00000000151(gene)|ensembl:ENSRNOT00000000163(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3SO6|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8964026|reactome:R-RNO-8964038	go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033280"(response to vitamin D)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|rcsb pdb:2I1P|rcsb pdb:3V2O|rcsb pdb:3V2X|rgd:68407|refseq:NP_110454.1|dip:DIP-44866N|reactome:R-RNO-196791|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-975634	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0055037"(recycling endosome)	-	-	figure legend:Fig 6, 7, 8C, 8F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-l2 yolk sac cells)|taxid:10116(rat-L2 yolk sac cells)	-	2014/02/27	2014/10/16	rogid:7IcLthFzVgxoP5yB+BSHTWAqzuU10116	rogid:ewHsW5Lja6xqFQ9T6manhy6X+fE10116	intact-crc:966114464318736A|rigid:PlbprTAJxpE4VyVN660i9kMBWkk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:D3ZAR1	uniprotkb:P98158	intact:EBI-9250714|ensembl:ENSRNOP00000000163	intact:EBI-6306650	psi-mi:arh_rat(display_long)|uniprotkb:Ldlrap1(gene name)|psi-mi:Ldlrap1(display_short)|uniprotkb:Arh(gene name synonym)|uniprotkb:Autosomal recessive hypercholesterolemia protein homolog(gene name synonym)	psi-mi:lrp2_rat(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:Megalin(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Nagai et al. (2003)	imex:IM-22979|pubmed:14528014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9253511|imex:IM-22979-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1563417|dip:DIP-60041N|ensembl:ENSRNOG00000000151(gene)|ensembl:ENSRNOT00000000163(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3SO6|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8964026|reactome:R-RNO-8964038	go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033280"(response to vitamin D)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|rcsb pdb:2I1P|rcsb pdb:3V2O|rcsb pdb:3V2X|rgd:68407|refseq:NP_110454.1|dip:DIP-44866N|reactome:R-RNO-196791|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-975634	go:"GO:0055037"(recycling endosome)|go:"GO:0030125"(clathrin vesicle coat)	-	-	figure legend:Fig. 9|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-l2 yolk sac cells)|taxid:10116(rat-L2 yolk sac cells)	-	2014/02/27	2014/10/16	rogid:7IcLthFzVgxoP5yB+BSHTWAqzuU10116	rogid:ewHsW5Lja6xqFQ9T6manhy6X+fE10116	intact-crc:1EC26E05831E1971|rigid:PlbprTAJxpE4VyVN660i9kMBWkk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)