#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35625	uniprotkb:O75581	intact:EBI-2365912	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2003)	pubmed:12897152|imex:IM-22576	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9348073|imex:IM-22576-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	-	-	-	figure legend:Fig. 1D|agonist:GSK3-beta, Wnt-1|comment:The overexpressed wt LRP6 does not interact with Axin in the absence of GSK3beta and Wnt1. The authors suggest that the extracellular region of LRP6 is inhibiting the interaction of LRP6 with Axin, however, other explanations are also plausible.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/02/07	2014/10/16	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	intact-crc:5A1E5F0DE0738AE0|rigid:hA2NniExDc8S5eryayv0xrTTydc	false	myc tag:?-?	flag tag:n-n|sufficient binding region:1-19,1370..1370-1613	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75581	uniprotkb:O75581	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2003)	pubmed:12897152|imex:IM-22576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9349122|imex:IM-22576-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	-	-	-	figure legend:Fig. 3D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/02/07	2014/10/16	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	intact-crc:1CA2BD27276D070B|rigid:eT/w1yV9YssQ0/zH9LDkxRkBvJI	false	sufficient binding region:629..629-1244..1244|sufficient binding region:20-628..628|sufficient binding region:20-628..628|myc tag:?-?|sufficient binding region:629..629-1244..1244	sufficient binding region:20-628..628|sufficient binding region:629..629-1244|sufficient binding region:629..629-1244|flag tag:n-n|sufficient binding region:20-628..628	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75581	uniprotkb:O75581	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2003)	pubmed:12897152|imex:IM-22576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9348924|imex:IM-22576-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	-	-	-	figure legend:Fig. 2A-B, 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/02/07	2014/10/16	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	intact-crc:EB88A727CCDB5DC4|rigid:eT/w1yV9YssQ0/zH9LDkxRkBvJI	false	myc tag:c-c	sufficient binding region:629..629-1244|flag tag:n-n|sufficient binding region:20-628..628	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27467	uniprotkb:O75581	intact:EBI-2899665|ensembl:ENSMUSP00000010044	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	psi-mi:wnt3a_mouse(display_long)|uniprotkb:Wnt3a(gene name)|psi-mi:Wnt3a(display_short)|uniprotkb:Wnt-3a(gene name synonym)	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2003)	pubmed:12897152|imex:IM-22576	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9349932|imex:IM-22576-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000009900(gene)|ensembl:ENSMUST00000010044(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0022008"(neurogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4641262|reactome:R-MMU-4641263|go:"GO:1901215"(negative regulation of neuron death)|refseq:NP_033548.1|dip:DIP-55954N	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	-	-	-	figure legend:Fig. 6B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/02/07	2014/10/16	rogid:8qMbzAMqZA12Q/4DcX5Qea3CdSQ10090	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	intact-crc:1AB8D4DDB8821B7C|rigid:H99DskZ+rsdBf2HucbTWwO5cmcU	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)