#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q80VX4 uniprotkb:Q9UKY1 intact:EBI-9259183|uniprotkb:G3V6P3|ensembl:ENSRNOP00000007326 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:zhx2_rat(display_long)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Raf(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0018"(two hybrid) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9259181|imex:IM-22284-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:727926|refseq:NP_001257985.1|refseq:XP_006241716.1|refseq:XP_017450346.1|ensembl:ENSRNOG00000005417(gene)|ensembl:ENSRNOT00000007326(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057 ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/03/19 2019/01/24 rogid:3sMfmDwFeOKT0AiK2oAci5C77a410116 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:FD0C2C0F6E6F1416|rigid:pnN5YygQTSXscqAYaGTp27uHqMo false sufficient binding region:195-358 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y6X8 uniprotkb:P23511 intact:EBI-948566|ensembl:ENSP00000314709 intact:EBI-389739|uniprotkb:Q8IXU0|ensembl:ENSP00000345702 psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:nfya_human(display_long)|uniprotkb:NFYA(gene name)|psi-mi:NFYA(display_short)|uniprotkb:Nuclear transcription factor Y subunit A(gene name synonym)|uniprotkb:CAAT box DNA-binding protein subunit A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9301672|imex:IM-22284-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 refseq:NP_002496.1|refseq:NP_068351.1|ensembl:ENSG00000001167(gene)|ensembl:ENST00000341376(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016602"(CCAAT-binding factor complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR001289(CCAAT-binding transcription factor, subunit B)|interpro:IPR018362|rcsb pdb:4AWL|rcsb pdb:6QMP|rcsb pdb:6QMQ|rcsb pdb:6QMS|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-380994|reactome:R-HSA-381183|reactome:R-HSA-9614657 - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/03/19 2014/10/16 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 rogid:ZzEyS17rD3653YFSvnBoGdl1T3s9606 intact-crc:2CA123B7BF861AA1|rigid:K5mtJxFuHLDYBhQuv7YFL45VSHc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23708 uniprotkb:Q9Y6X8 intact:EBI-862337|ensembl:ENSMUSP00000077853 intact:EBI-948566|ensembl:ENSP00000314709 psi-mi:nfya_mouse(display_long)|uniprotkb:Nuclear transcription factor Y subunit A(gene name synonym)|uniprotkb:CAAT box DNA-binding protein subunit A(gene name synonym)|uniprotkb:Nfya(gene name)|psi-mi:Nfya(display_short) psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9294001|imex:IM-22284-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035043.1|refseq:NP_001334330.1|refseq:NP_001334331.1|dip:DIP-2661N|ensembl:ENSMUSG00000023994(gene)|ensembl:ENSMUST00000078800(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016602"(CCAAT-binding factor complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR001289(CCAAT-binding transcription factor, subunit B)|interpro:IPR018362|mint:P23708 ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 - - - figure legend:Fig. 4A, 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/03/19 2014/10/16 rogid:Woerhp2MzO8JALm38TO8N3XWmuo10090 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 intact-crc:7275AE6DB0599383|rigid:e7TYBrsJadYrmh0FsUJK3ylBtAE false necessary binding region:141-172 sufficient binding region:263-497 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q80VX4 uniprotkb:Q9UKY1 intact:EBI-9259183|uniprotkb:G3V6P3|ensembl:ENSRNOP00000007326 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:zhx2_rat(display_long)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Raf(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0018"(two hybrid) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9259205|imex:IM-22284-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:727926|refseq:NP_001257985.1|refseq:XP_006241716.1|refseq:XP_017450346.1|ensembl:ENSRNOG00000005417(gene)|ensembl:ENSRNOT00000007326(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057 ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) - - - figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/03/19 2019/01/24 rogid:3sMfmDwFeOKT0AiK2oAci5C77a410116 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:A1C1B808D379C684|rigid:pnN5YygQTSXscqAYaGTp27uHqMo false sufficient binding region:195-358 sufficient binding region:272-564 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y6X8 uniprotkb:Q9Y6X8 intact:EBI-948566|ensembl:ENSP00000314709 intact:EBI-948566|ensembl:ENSP00000314709 psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9259267|imex:IM-22284-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/03/19 2014/10/16 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 intact-crc:5D50FAAF4B8C0B7B|rigid:jNBTfEJcRgEYc0wX9xvmcLO8DdQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q80VX4 uniprotkb:Q80VX4 intact:EBI-9259183|uniprotkb:G3V6P3|ensembl:ENSRNOP00000007326 intact:EBI-9259183|uniprotkb:G3V6P3|ensembl:ENSRNOP00000007326 psi-mi:zhx2_rat(display_long)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Raf(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym) psi-mi:zhx2_rat(display_long)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Raf(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9259259|imex:IM-22284-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:727926|refseq:NP_001257985.1|refseq:XP_006241716.1|refseq:XP_017450346.1|ensembl:ENSRNOG00000005417(gene)|ensembl:ENSRNOT00000007326(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057 rgd:727926|refseq:NP_001257985.1|refseq:XP_006241716.1|refseq:XP_017450346.1|ensembl:ENSRNOG00000005417(gene)|ensembl:ENSRNOT00000007326(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/03/19 2019/01/24 rogid:3sMfmDwFeOKT0AiK2oAci5C77a410116 rogid:3sMfmDwFeOKT0AiK2oAci5C77a410116 intact-crc:512CDA79E291765F|rigid:QAzj/8SrHN3QyrcfhQhlQvSBACY false sufficient binding region:195-358 sufficient binding region:195-358 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y6X8 uniprotkb:Q80VX4 intact:EBI-948566|ensembl:ENSP00000314709 intact:EBI-9259183|uniprotkb:G3V6P3|ensembl:ENSRNOP00000007326 psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:zhx2_rat(display_long)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Raf(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9259278|imex:IM-22284-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 rgd:727926|refseq:NP_001257985.1|refseq:XP_006241716.1|refseq:XP_017450346.1|ensembl:ENSRNOG00000005417(gene)|ensembl:ENSRNOT00000007326(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/03/19 2019/01/24 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 rogid:3sMfmDwFeOKT0AiK2oAci5C77a410116 intact-crc:29C30C17BFA15C7E|rigid:Tcrrx29RyRBSgDdfcWQK7NZgxTw false - sufficient binding region:195-358 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y6X8 uniprotkb:Q9UKY1 intact:EBI-948566|ensembl:ENSP00000314709 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0096"(pull down) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9259220|imex:IM-22284-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) - - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/03/19 2014/10/16 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:7BF468663B3576B8|rigid:127rKoMfxlqoZ/S68MHoNBNfvKs false sufficient binding region:263-497|glutathione s tranferase tag:n-n 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9Y6X8 uniprotkb:Q9Y6X8 intact:EBI-948566|ensembl:ENSP00000314709 intact:EBI-948566|ensembl:ENSP00000314709 psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:zhx2_human(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:ZHX2(gene name)|psi-mi:ZHX2(display_short)|uniprotkb:AFR1(gene name synonym)|uniprotkb:KIAA0854(gene name synonym)|uniprotkb:RAF(gene name synonym) psi-mi:"MI:0096"(pull down) Kawata et al. (2003) imex:IM-22284|pubmed:12741956 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9259240|imex:IM-22284-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 ensembl:ENSG00000178764(gene)|ensembl:ENST00000314393(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2DMP|rcsb pdb:3NAU|refseq:NP_055758.1|refseq:XP_011515233.1|refseq:XP_011515234.1|refseq:XP_005250893.1|refseq:XP_005250894.1 - - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/03/19 2014/10/16 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 rogid:E8GZEZG6tlb2fHpC+xgJoP8D85Y9606 intact-crc:D39914B73AC6F92F|rigid:jNBTfEJcRgEYc0wX9xvmcLO8DdQ false 35s radiolabel:?-? glutathione s tranferase tag:n-n|sufficient binding region:1-837 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)