#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H2X3 uniprotkb:Q03463-PRO_0000278734 intact:EBI-1391211|uniprotkb:Q69F40|uniprotkb:Q969M4|uniprotkb:Q96QP3|uniprotkb:Q96QP4|uniprotkb:Q96QP5|uniprotkb:Q96QP6|uniprotkb:Q9BXS3|uniprotkb:Q9H2Q9|uniprotkb:Q9H8F0|uniprotkb:Q9Y2A8|uniprotkb:A6NKI4|uniprotkb:A8K8B3|ensembl:ENSP00000316228 intact:EBI-9257330 psi-mi:clc4m_human(display_long)|uniprotkb:CD209 antigen-like protein 1(gene name synonym)|uniprotkb:Dendritic cell-specific ICAM-3-grabbing non-integrin 2(gene name synonym)|uniprotkb:DC-SIGN-related protein(gene name synonym)|uniprotkb:Liver/lymph node-specific ICAM-3-grabbing non-integrin(gene name synonym)|uniprotkb:CLEC4M(gene name)|psi-mi:CLEC4M(display_short)|uniprotkb:CD209L(gene name synonym)|uniprotkb:CD209L1(gene name synonym)|uniprotkb:CD299(gene name synonym) psi-mi:q03463-pro_0000278734(display_long) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Lozach et al. (2003) pubmed:12609975|imex:IM-25967 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9257417|imex:IM-25967-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006722678.1|refseq:NP_001138377.1|refseq:NP_001138378.1|refseq:NP_001138379.1|refseq:NP_001138380.1|refseq:NP_001138381.1|refseq:NP_001138382.1|refseq:NP_001138383.1|refseq:NP_055072.3|ensembl:ENSG00000104938(gene)|ensembl:ENST00000327325(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009988"(cell-cell recognition)|go:"GO:0016020"(membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019079"(viral genome replication)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0043657"(host cell)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0075733"(intracellular transport of virus)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|rcsb pdb:1K9J|rcsb pdb:1SL6|rcsb pdb:1XAR|rcsb pdb:1XPH|rcsb pdb:1Z0Y|rcsb pdb:3JQH intact:EBI-1266801(chain-parent) - - chain-seq-start:384|chain-seq-end:746 figure legend:Fig. 3B|comment:"Interaction occur in the presence (sE2man) or absence (sE2cpx) of 1-manosidase I and II inhibitors 1-deoxymannojirimycin hydrochloride (DMJ, 1 mM, Calbiochem) and swainsonine (5 mM, Sigma). HIV protein p140/160, reference proteome P04578-PRO_0000239240) or manna (CHEBI:288080) competed with this interaction."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/03/12 2017/09/02 rogid:FR9EEv0vaGUvH/qu0Hg6gLa0yOw9606 rogid:pS//ht2XN9jLvH6H89nhQKZVtjQ421877 intact-crc:9489E75D828AFF4A|rigid:or8uBcAEUwcEDikhb3i2x1w8d+Y false - 35s radiolabel:?-?|sufficient binding region:1-326 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q9NNX6 uniprotkb:Q03463-PRO_0000278734 intact:EBI-9257341|uniprotkb:A8KAM4|uniprotkb:A8MVQ9|uniprotkb:G5E9C4|uniprotkb:Q2TB19|uniprotkb:Q96QP7|uniprotkb:Q96QP8|uniprotkb:Q96QP9|uniprotkb:Q96QQ0|uniprotkb:Q96QQ1|uniprotkb:Q96QQ2|uniprotkb:Q96QQ3|uniprotkb:Q96QQ4|uniprotkb:Q96QQ5|uniprotkb:Q96QQ6|uniprotkb:Q96QQ7|uniprotkb:Q96QQ8|ensembl:ENSP00000315477 intact:EBI-9257330 psi-mi:cd209_human(display_long)|uniprotkb:CD209(gene name)|psi-mi:CD209(display_short)|uniprotkb:CLEC4L(gene name synonym)|uniprotkb:C-type lectin domain family 4 member L(gene name synonym)|uniprotkb:Dendritic cell-specific ICAM-3-grabbing non-integrin 1(gene name synonym) psi-mi:q03463-pro_0000278734(display_long) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Lozach et al. (2003) pubmed:12609975|imex:IM-25967 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9257328|imex:IM-25967-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138365.1|refseq:NP_001138366.1|refseq:NP_001138367.1|refseq:NP_001138368.1|refseq:NP_001138369.1|refseq:NP_066978.1|dip:DIP-60629N|ensembl:ENSG00000090659(gene)|ensembl:ENST00000315599(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0009988"(cell-cell recognition)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019079"(viral genome replication)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0043657"(host cell)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0075733"(intracellular transport of virus)|go:"GO:0097323"(B cell adhesion)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|rcsb pdb:1K9I|rcsb pdb:1SL4|rcsb pdb:1SL5|rcsb pdb:2B6B|rcsb pdb:2IT5|rcsb pdb:2IT6|rcsb pdb:2XR5|rcsb pdb:2XR6|rcsb pdb:6GHV|reactome:R-HSA-5621575|reactome:R-HSA-8851680 intact:EBI-1266801(chain-parent) - - chain-seq-start:384|chain-seq-end:746 figure legend:Fig. 3B|comment:"Interaction occur in the presence (sE2man) or absence (sE2cpx) of 1-manosidase I and II inhibitors 1-deoxymannojirimycin hydrochloride (DMJ, 1 mM, Calbiochem) and swainsonine (5 mM, Sigma). HIV protein p140/160, reference proteome P04578-PRO_0000239240) or manna (CHEBI:288080) competed with this interaction."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/03/12 2017/09/02 rogid:veaQUZyFcAP3yYQgh9zN9sEzvUI9606 rogid:pS//ht2XN9jLvH6H89nhQKZVtjQ421877 intact-crc:1ABA48E897EEE520|rigid:DWek7e0GGl0EWC9kHF9Jax19heA false - 35s radiolabel:?-?|sufficient binding region:1-326 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q03463-PRO_0000278734 uniprotkb:Q9NNX6 intact:EBI-9257330 intact:EBI-9257341|uniprotkb:A8KAM4|uniprotkb:A8MVQ9|uniprotkb:G5E9C4|uniprotkb:Q2TB19|uniprotkb:Q96QP7|uniprotkb:Q96QP8|uniprotkb:Q96QP9|uniprotkb:Q96QQ0|uniprotkb:Q96QQ1|uniprotkb:Q96QQ2|uniprotkb:Q96QQ3|uniprotkb:Q96QQ4|uniprotkb:Q96QQ5|uniprotkb:Q96QQ6|uniprotkb:Q96QQ7|uniprotkb:Q96QQ8|ensembl:ENSP00000315477 psi-mi:q03463-pro_0000278734(display_long) psi-mi:cd209_human(display_long)|uniprotkb:CD209(gene name)|psi-mi:CD209(display_short)|uniprotkb:CLEC4L(gene name synonym)|uniprotkb:C-type lectin domain family 4 member L(gene name synonym)|uniprotkb:Dendritic cell-specific ICAM-3-grabbing non-integrin 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Lozach et al. (2003) pubmed:12609975|imex:IM-25967 taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:1335"(HPIDb) intact:EBI-9257437|imex:IM-25967-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1266801(chain-parent) refseq:NP_001138365.1|refseq:NP_001138366.1|refseq:NP_001138367.1|refseq:NP_001138368.1|refseq:NP_001138369.1|refseq:NP_066978.1|dip:DIP-60629N|ensembl:ENSG00000090659(gene)|ensembl:ENST00000315599(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0009988"(cell-cell recognition)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019079"(viral genome replication)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0043657"(host cell)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0075733"(intracellular transport of virus)|go:"GO:0097323"(B cell adhesion)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|rcsb pdb:1K9I|rcsb pdb:1SL4|rcsb pdb:1SL5|rcsb pdb:2B6B|rcsb pdb:2IT5|rcsb pdb:2IT6|rcsb pdb:2XR5|rcsb pdb:2XR6|rcsb pdb:6GHV|reactome:R-HSA-5621575|reactome:R-HSA-8851680 - chain-seq-start:384|chain-seq-end:746 - figure legend:Fig. 5|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.0x10^-8(molar) 2014/03/12 2014/10/16 rogid:pS//ht2XN9jLvH6H89nhQKZVtjQ421877 rogid:veaQUZyFcAP3yYQgh9zN9sEzvUI9606 intact-crc:CA6D825EDE7FABDF|rigid:DWek7e0GGl0EWC9kHF9Jax19heA false sufficient binding region:1-326 binding-associated region:254-404 - 4 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)