#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JJ50	uniprotkb:P54256	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994539	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639119|imex:IM-22997-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	-	figure legend:no figure|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:36D3F0325E10B61F|rigid:cjvjZsDhRZVAKjYLwnqJ/NMvtZc	false	-	sufficient binding region:246-425	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JJ50	uniprotkb:P54256	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994539	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639186|imex:IM-22997-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	-	figure legend:1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:7E3E9CE6F8B790EC|rigid:cjvjZsDhRZVAKjYLwnqJ/NMvtZc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JJ50	uniprotkb:P54256-1	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994549	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:p54256-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0096"(pull down)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639166|imex:IM-22997-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	intact:EBI-994539(hap1_rat)	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	-	figure legend:1C and 2B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:01B5E377F3635E90|rigid:mWNgA5ROIM/gpwl2Qs1Su+VC8HM	false	glutathione s tranferase tag:?-?|sufficient binding region:225-541	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JJ50	uniprotkb:P54256-2	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994554	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0096"(pull down)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639166|imex:IM-22997-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	intact:EBI-994539(hap1_rat)	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	isoform-comment:Contains a phosphothreonine at position 598.	figure legend:1C and 2B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116	intact-crc:01B5E377F3635E90|rigid:mWNgA5ROIM/gpwl2Qs1Su+VC8HM	false	glutathione s tranferase tag:?-?|sufficient binding region:225-541	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JJ50	uniprotkb:P54256	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994539	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0096"(pull down)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639148|imex:IM-22997-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	-	figure legend:1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:A776AD9A47FC7FCD|rigid:cjvjZsDhRZVAKjYLwnqJ/NMvtZc	false	glutathione s tranferase tag:?-?	sufficient binding region:246-425|his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JJ50	uniprotkb:P54256-2	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994554	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0096"(pull down)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639196|imex:IM-22997-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	intact:EBI-994539(hap1_rat)	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	isoform-comment:Contains a phosphothreonine at position 598.	figure legend:2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116	intact-crc:387FD232944B72ED|rigid:FZnyfrkmQvVva+FcU4iqFevQKiA	false	his tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:246-372	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JJ50	uniprotkb:P54256	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994539	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639134|imex:IM-22997-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	-	figure legend:no figure|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:CFE52236E306D125|rigid:cjvjZsDhRZVAKjYLwnqJ/NMvtZc	false	-	sufficient binding region:246-425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JJ50	uniprotkb:P54256-2	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994554	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639224|imex:IM-22997-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	intact:EBI-994539(hap1_rat)	go:"GO:0031410"(cytoplasmic vesicle)	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	isoform-comment:Contains a phosphothreonine at position 598.	figure legend:3C-F|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116	intact-crc:12922303D2E7B271|rigid:FZnyfrkmQvVva+FcU4iqFevQKiA	false	ha tag:n-n	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9JJ50	uniprotkb:P54256-2	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994554	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639215|imex:IM-22997-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	intact:EBI-994539(hap1_rat)	go:"GO:0031410"(cytoplasmic vesicle)	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	isoform-comment:Contains a phosphothreonine at position 598.	figure legend:3C-F|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116	intact-crc:ED1A7D7EFF8A5C07|rigid:FZnyfrkmQvVva+FcU4iqFevQKiA	false	enhanced green fluorescent protein tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9JJ50	uniprotkb:P54256	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994539	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9674555|imex:IM-22997-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	go:"GO:0044306"(neuron projection terminus)	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	-	figure legend:3AB|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:3D72403ABD60528F|rigid:cjvjZsDhRZVAKjYLwnqJ/NMvtZc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9JJ50	uniprotkb:P54256-1	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994549	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:p54256-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639244|imex:IM-22997-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	intact:EBI-994539(hap1_rat)	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	-	figure legend:5|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:EDABA9C79CF883A6|rigid:mWNgA5ROIM/gpwl2Qs1Su+VC8HM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JJ50	uniprotkb:P54256-2	intact:EBI-7092491|intact:MINT-107197|uniprotkb:Q76N76|uniprotkb:Q5XIV8|uniprotkb:P97847	intact:EBI-994554	psi-mi:hgs_rat(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)|uniprotkb:Hrs2(gene name synonym)|uniprotkb:SNAP-25-interacting protein Hrs-2(gene name synonym)	psi-mi:p54256-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Li et al. (2002)	imex:IM-22997|pubmed:12021262	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639244|imex:IM-22997-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-9706019|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|refseq:NP_062260.2|interpro:IPR024641|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|rgd:69225|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|reactome:R-RNO-9013420|reactome:R-RNO-182971|reactome:R-RNO-432720|reactome:R-RNO-5689880|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-917729	intact:EBI-994539(hap1_rat)	-	comment:mint|function:"Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex"	isoform-comment:Contains a phosphothreonine at position 598.	figure legend:5|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2014/07/09	2014/10/16	rogid:uLV3neAYCL8bo2c7fBXRDirk8no10116	rogid:wybvRRwigIlRInTvs3WtFsSmFkc10116	intact-crc:EDABA9C79CF883A6|rigid:mWNgA5ROIM/gpwl2Qs1Su+VC8HM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)