#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99XU0	uniprotkb:P04196	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-3915012|uniprotkb:B9EK35|uniprotkb:D3DNU7|ensembl:ENSP00000232003	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:hrg_human(display_long)|uniprotkb:HRG(gene name)|psi-mi:HRG(display_short)|uniprotkb:Histidine-proline-rich glycoprotein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_000403.1|ensembl:ENSG00000113905(gene)|ensembl:ENST00000232003(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002839"(positive regulation of immune response to tumor cell)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015886"(heme transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0020037"(heme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036019"(endolysosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000504"(positive regulation of blood vessel remodeling)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|mint:P04196|reactome:R-HSA-114608|reactome:R-HSA-75205|go:"GO:0043254"(regulation of protein-containing complex assembly)|dip:DIP-47264N	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:o/MnMkd+IKLRtprrFoOapUuoVEs9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:P08603	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:P01024	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:P02647	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-701692|uniprotkb:Q6LDN9|uniprotkb:Q6Q785|uniprotkb:A8K866|uniprotkb:Q9UCS8|uniprotkb:Q9UCT8|ensembl:ENSP00000236850|ensembl:ENSP00000352471|ensembl:ENSP00000364469|ensembl:ENSP00000364472	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:apoa1_human(display_long)|uniprotkb:APOA1(gene name)|psi-mi:APOA1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_000030.1|refseq:NP_001304946.1|refseq:NP_001304947.1|refseq:NP_001304950.1|dip:DIP-29619N|ensembl:ENSG00000118137(gene)|ensembl:ENST00000236850(transcript)|ensembl:ENST00000359492(transcript)|ensembl:ENST00000375320(transcript)|ensembl:ENST00000375323(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02647|rcsb pdb:1AV1|rcsb pdb:1GW3|rcsb pdb:1GW4|rcsb pdb:1ODP|rcsb pdb:1ODQ|rcsb pdb:1ODR|rcsb pdb:2MSC|rcsb pdb:2MSD|rcsb pdb:2MSE|rcsb pdb:2N5E|rcsb pdb:3K2S|rcsb pdb:3R2P|rcsb pdb:4V6M|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CLZ|rcsb pdb:6CM1|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:7KJR|reactome:R-HSA-114608|reactome:R-HSA-1369062|reactome:R-HSA-1989781|reactome:R-HSA-2168880|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-5682113|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963896|reactome:R-HSA-8963901|reactome:R-HSA-8964011|reactome:R-HSA-8964058|reactome:R-HSA-9707616|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:yEzPDeU8Uu/43dkLLOBAy6ey1vs9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:P02768	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:P01009	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-986224|uniprotkb:Q7M4R2|uniprotkb:Q86U18|uniprotkb:Q86U19|uniprotkb:Q96BF9|uniprotkb:Q96ES1|uniprotkb:Q9P1P0|uniprotkb:A6PX14|uniprotkb:Q0PVP5|uniprotkb:Q13672|uniprotkb:Q53XB8|uniprotkb:Q5U0M1|uniprotkb:B2RDQ8|uniprotkb:Q9UCE6|uniprotkb:Q9UCM3|ensembl:ENSP00000348068|ensembl:ENSP00000376802|ensembl:ENSP00000376803|ensembl:ENSP00000385960|ensembl:ENSP00000390299|ensembl:ENSP00000408474|ensembl:ENSP00000416066|ensembl:ENSP00000416354|ensembl:ENSP00000490054	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:a1at_human(display_long)|uniprotkb:Alpha-1 protease inhibitor(gene name synonym)|uniprotkb:Alpha-1-antiproteinase(gene name synonym)|uniprotkb:AAT(gene name synonym)|uniprotkb:PI(gene name synonym)|uniprotkb:PRO0684(orf name)|uniprotkb:PRO2209(orf name)|uniprotkb:SERPINA1(gene name)|psi-mi:SERPINA1(display_short)|uniprotkb:Serpin A1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_000286.3|refseq:NP_001002235.1|refseq:NP_001002236.1|refseq:NP_001121172.1|refseq:NP_001121173.1|refseq:NP_001121174.1|refseq:NP_001121175.1|refseq:NP_001121176.1|refseq:NP_001121177.1|refseq:NP_001121178.1|refseq:NP_001121179.1|refseq:XP_016876859.1|dip:DIP-35493N|ensembl:ENSG00000197249(gene)|ensembl:ENST00000355814(transcript)|ensembl:ENST00000393087(transcript)|ensembl:ENST00000393088(transcript)|ensembl:ENST00000404814(transcript)|ensembl:ENST00000437397(transcript)|ensembl:ENST00000440909(transcript)|ensembl:ENST00000448921(transcript)|ensembl:ENST00000449399(transcript)|ensembl:ENST00000636712(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006953"(acute-phase response)|go:"GO:0007596"(blood coagulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01009|rcsb pdb:1ATU|rcsb pdb:1EZX|rcsb pdb:1HP7|rcsb pdb:1D5S|rcsb pdb:1IZ2|rcsb pdb:1KCT|rcsb pdb:1OO8|rcsb pdb:1OPH|rcsb pdb:1PSI|rcsb pdb:1QLP|rcsb pdb:1QMB|rcsb pdb:2D26|rcsb pdb:2QUG|rcsb pdb:3CWL|rcsb pdb:3CWM|rcsb pdb:3DRM|rcsb pdb:3DRU|rcsb pdb:3NDD|rcsb pdb:3NDF|rcsb pdb:3NE4|rcsb pdb:3T1P|rcsb pdb:4PYW|rcsb pdb:5IO1|rcsb pdb:5NBU|rcsb pdb:5NBV|rcsb pdb:6HX4|rcsb pdb:6I4V|rcsb pdb:6I7U|rcsb pdb:6IAY|rcsb pdb:6ROD|rcsb pdb:7AEL|rcsb pdb:7API|rcsb pdb:7NPK|rcsb pdb:7NPL|rcsb pdb:8API|rcsb pdb:9API|reactome:R-HSA-114608|reactome:R-HSA-204005|reactome:R-HSA-381426|reactome:R-HSA-5694530|reactome:R-HSA-6798695|reactome:R-HSA-8957275	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:eIbjQWRWsWv+B28IcSUIKJ+Eros9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:P04275	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-981819|uniprotkb:Q8TCE8|uniprotkb:Q99806|ensembl:ENSP00000261405	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:vwf_human(display_long)|uniprotkb:VWF(gene name)|psi-mi:VWF(display_short)|uniprotkb:F8VWF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_000543.2|ensembl:ENSG00000110799(gene)|ensembl:ENST00000261405(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0007599"(hemostasis)|go:"GO:0009611"(response to wounding)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|dip:DIP-29667N|reactome:R-HSA-9672391|reactome:R-HSA-9672393|rcsb pdb:5BV8|rcsb pdb:6FWN|rcsb pdb:6N29|rcsb pdb:7KWO|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-430116|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75892|reactome:R-HSA-76009|rcsb pdb:4NT5|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR032361|interpro:IPR036084|interpro:IPR036465|interpro:IPR037578|mint:P04275|rcsb pdb:1AO3|rcsb pdb:1ATZ|rcsb pdb:1AUQ|rcsb pdb:1FE8|rcsb pdb:1FNS|rcsb pdb:1IJB|rcsb pdb:1IJK|rcsb pdb:1M10|rcsb pdb:1OAK|rcsb pdb:1SQ0|rcsb pdb:1U0N|rcsb pdb:1UEX|rcsb pdb:2ADF|rcsb pdb:2MHP|rcsb pdb:2MHQ|rcsb pdb:3GXB|rcsb pdb:3HXO|rcsb pdb:3HXQ|rcsb pdb:3PPV|go:"GO:0070062"(extracellular exosome)|rcsb pdb:3PPW|rcsb pdb:3PPX|rcsb pdb:3PPY|rcsb pdb:3ZQK|rcsb pdb:4C29|rcsb pdb:4C2A|rcsb pdb:4C2B|rcsb pdb:4DMU	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:yeGxC2SyyvUZ3hNciww1o8TmY5Q9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:P02760	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-2115136|uniprotkb:P00977|uniprotkb:P02759|uniprotkb:P78491|uniprotkb:Q2TU33|uniprotkb:Q5TBD7|uniprotkb:Q9UC58|uniprotkb:Q9UDI8|ensembl:ENSP00000265132	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:ambp_human(display_long)|uniprotkb:AMBP(gene name)|psi-mi:AMBP(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:ITIL(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852714|imex:IM-21724-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_001624.1|ensembl:ENSG00000106927(gene)|ensembl:ENST00000265132(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019862"(IgA binding)|go:"GO:0020037"(heme binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046904"(calcium oxalate binding)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002968(Alpha-1-microglobulin)|interpro:IPR012674(Calycin)|interpro:IPR020901|interpro:IPR022272|interpro:IPR029856|interpro:IPR036880|rcsb pdb:1BIK|rcsb pdb:3QKG|rcsb pdb:4ES7|rcsb pdb:4U30|rcsb pdb:6EJ7|rcsb pdb:6EJ8|rcsb pdb:6EJ9|rcsb pdb:6EJA|rcsb pdb:6EJB|rcsb pdb:6EJC|rcsb pdb:6EJD|reactome:R-HSA-2168880	-	-	-	figure legend:5, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:os91tgT4TUMZ1qCf3SRbW5mwlGI9606	intact-crc:12FE691E1405596E|rigid:0FyaooVffJledqorn6hPoYkexvg	false	tandem tag:n-n|sufficient binding region:3-98	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99XU0	uniprotkb:Q99XU0	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8852768|pdbe:4mer|imex:IM-21724-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	-	-	-	figure legend:3, table 1|3d-resolution:2.4A|3d-r-factors:Rwork=2.29%  Rfree=2.69%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	intact-crc:175406A0C704CDFD|rigid:QQN3lPImQqbqFHwWL+Q6jLF/NT4	false	sufficient binding region:3-98	sufficient binding region:3-98	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99XU0	uniprotkb:Q99XU0	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:"MI:0028"(cosedimentation in solution)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8854011|imex:IM-21724-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	intact-crc:5EF5184EA0637E3F|rigid:QQN3lPImQqbqFHwWL+Q6jLF/NT4	false	sufficient binding region:3-98	sufficient binding region:3-98	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04196	uniprotkb:Q99XU0	intact:EBI-3915012|uniprotkb:B9EK35|uniprotkb:D3DNU7|ensembl:ENSP00000232003	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	psi-mi:hrg_human(display_long)|uniprotkb:HRG(gene name)|psi-mi:HRG(display_short)|uniprotkb:Histidine-proline-rich glycoprotein(gene name synonym)	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:"MI:0107"(surface plasmon resonance)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8853742|imex:IM-21724-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000403.1|ensembl:ENSG00000113905(gene)|ensembl:ENST00000232003(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002839"(positive regulation of immune response to tumor cell)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015886"(heme transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0020037"(heme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036019"(endolysosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000504"(positive regulation of blood vessel remodeling)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|mint:P04196|reactome:R-HSA-114608|reactome:R-HSA-75205|go:"GO:0043254"(regulation of protein-containing complex assembly)|dip:DIP-47264N	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	-	-	-	figure legend:6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:12.0x10^-6(molar)	2013/11/18	2014/10/16	rogid:o/MnMkd+IKLRtprrFoOapUuoVEs9606	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	intact-crc:CDDB1B3D92DF1BA4|rigid:8vd8mDLchrTfBx0snqtYyA36teY	false	his tag:c-c	sufficient binding region:3-98	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99XU0	uniprotkb:P04196	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	intact:EBI-3915012|uniprotkb:B9EK35|uniprotkb:D3DNU7|ensembl:ENSP00000232003	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:hrg_human(display_long)|uniprotkb:HRG(gene name)|psi-mi:HRG(display_short)|uniprotkb:Histidine-proline-rich glycoprotein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9635867|imex:IM-21724-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	refseq:NP_000403.1|ensembl:ENSG00000113905(gene)|ensembl:ENST00000232003(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002839"(positive regulation of immune response to tumor cell)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015886"(heme transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0020037"(heme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036019"(endolysosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000504"(positive regulation of blood vessel remodeling)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|mint:P04196|reactome:R-HSA-114608|reactome:R-HSA-75205|go:"GO:0043254"(regulation of protein-containing complex assembly)|dip:DIP-47264N	-	-	-	figure legend:6c|comment:The assay detects two binding sites with different Kds for this interaction.|variable_condition:pH 7.5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:40.0x10^-9(molar)|kd:200.0x10^-9(molar)	2013/11/18	2014/10/16	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	rogid:o/MnMkd+IKLRtprrFoOapUuoVEs9606	intact-crc:ECAE62F8CB34D4F2|rigid:8vd8mDLchrTfBx0snqtYyA36teY	false	sufficient binding region:3-98	strep ii tag:c-c	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-8853818	uniprotkb:Q99XU0	-	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	psi-mi:hrgshort(display_short)|psi-mi:EBI-8853818(display_long)	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8853767|imex:IM-21724-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	uniprotkb:P04196(see-also)	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	-	-	-	figure legend:6d|comment:The assay detects two binding sites with different Kds for this interaction.|variable_condition:No pH values given for this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:12.0x10^-9 ~4.0(molar)|kd:500.0x10^-9 ~100.0(molar)	2013/11/18	2014/10/16	rogid:hv2GWASB9EeFcnBhJyGe2WTClNw9606	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	intact-crc:F498AFB3ADE604C5|rigid:vlL9r0bSnyaGRnxAf+0wBlvDWe0	false	-	sufficient binding region:3-98	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04196	uniprotkb:Q99XU0	intact:EBI-3915012|uniprotkb:B9EK35|uniprotkb:D3DNU7|ensembl:ENSP00000232003	intact:EBI-8852705|uniprotkb:Q48WC7|ensemblbacteria:AAK34704	psi-mi:hrg_human(display_long)|uniprotkb:HRG(gene name)|psi-mi:HRG(display_short)|uniprotkb:Histidine-proline-rich glycoprotein(gene name synonym)	psi-mi:q99xu0_strp1(display_long)|uniprotkb:SPy_2034(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wisniewska et al. (2014)	imex:IM-21724|pubmed:24825900	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9635836|imex:IM-21724-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000403.1|ensembl:ENSG00000113905(gene)|ensembl:ENST00000232003(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002839"(positive regulation of immune response to tumor cell)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015886"(heme transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0020037"(heme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036019"(endolysosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000504"(positive regulation of blood vessel remodeling)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|mint:P04196|reactome:R-HSA-114608|reactome:R-HSA-75205|go:"GO:0043254"(regulation of protein-containing complex assembly)|dip:DIP-47264N	rcsb pdb:4PZ1|interpro:IPR025384|rcsb pdb:4MER|ensemblbacteria:AAK34704(transcript)|ensemblbacteria:SPy_2034(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|refseq:NP_269983.1	-	-	-	figure legend:6b|variable_condition:pH 5.5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:130.0x10^-9(molar)	2013/11/18	2014/10/16	rogid:o/MnMkd+IKLRtprrFoOapUuoVEs9606	rogid:vWbGEsSbqeeS8bg2Z4KnIyh41fM301447	intact-crc:59152AF9C5F799DE|rigid:8vd8mDLchrTfBx0snqtYyA36teY	false	strep ii tag:c-c	sufficient binding region:3-98	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)