#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HB15	uniprotkb:Q9Y2T1	intact:EBI-8993941|ensembl:ENSP00000327611	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:kcnkc_human(display_long)|uniprotkb:KCNK12(gene name)|psi-mi:KCNK12(display_short)|uniprotkb:Tandem pore domain halothane-inhibited potassium channel 2(gene name synonym)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8993945|imex:IM-21669-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071338.1|ensembl:ENSG00000184261(gene)|ensembl:ENST00000327876(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR005410(Potassium channel, two pore-domain, THIK)|interpro:IPR013099(Ion transport 2)|mint:Q9HB15|reactome:R-HSA-5576886	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:2aR4CU4EprdC1ODX2tV8/+qHGWE9606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	intact-crc:7380844EC7311DB3|rigid:QVkU9BerV0444+hpb0T3QuQd04M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46060	uniprotkb:Q9Y2T1	intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8993980|imex:IM-21669-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	intact-crc:2689AB36CD7BEE35|rigid:DAx4UNiFGq2C1o/bNARWvjKAq9E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2T1	uniprotkb:Q06830	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8993967|imex:IM-21669-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	intact-crc:54E829A25CCC01A8|rigid:f0X+tPIC+J32cyg27q/KceTRx7s	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A0AVI4	uniprotkb:Q96H12	intact:EBI-8994022|ensembl:ENSP00000372394|ensembl:ENSP00000441812|uniprotkb:A6NI98|uniprotkb:A6NH49|uniprotkb:D3DVP8	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	psi-mi:tm129_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TM129(gene name synonym)|uniprotkb:TMEM129(gene name)|psi-mi:TMEM129(display_short)	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994019|imex:IM-21669-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR018801|mint:A0AVI4|reactome:R-HSA-8866654|ensembl:ENSG00000168936(gene)|ensembl:ENST00000382936(transcript)|ensembl:ENST00000536901(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|refseq:NP_001120738.1|refseq:NP_612394.1	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	psi-mi:"MI:0471"(mint)	-	comment:mint|comment:homomint	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cpStvTXqqbxztzMAmFgzdElhHUc9606	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	intact-crc:2855EFCA7335F311|rigid:02z6zn7k+33WhBpkyPcNNS4Qbak	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:P35080	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-473138|uniprotkb:Q8WVF9|uniprotkb:Q9HBK2|uniprotkb:B2R4C8|uniprotkb:Q4VBQ4|uniprotkb:D3DNI4|ensembl:ENSP00000239940	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:prof2_human(display_long)|uniprotkb:PFN2(gene name)|psi-mi:PFN2(display_short)|uniprotkb:Profilin II(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994006|imex:IM-21669-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:NP_002619.1|refseq:NP_444252.1|ensembl:ENSG00000070087(gene)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010633"(negative regulation of epithelial cell migration)|ensembl:ENST00000239940(transcript)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900028"(negative regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029891|interpro:IPR036140|mint:P35080|rcsb pdb:1D1J|reactome:R-HSA-376176|reactome:R-HSA-5663220	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:064T9afVEb7WrgJPLVbKByJDUXc9606	intact-crc:0098C0639AB9FB01|rigid:uxmnawzvH7IW9uGMS4rSUObWRDk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:P63092	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-1047114|uniprotkb:P04895|uniprotkb:Q12927|uniprotkb:Q5JWD2|uniprotkb:Q5JWD4|uniprotkb:Q5JWD5|uniprotkb:Q6NR75|uniprotkb:Q6NXS0|uniprotkb:Q8TBC0|uniprotkb:Q96H70|uniprotkb:Q14433|uniprotkb:Q32P26|uniprotkb:E1P5G5|ensembl:ENSP00000360126|uniprotkb:A6NI00|intact:EBI-10977858	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:gnas2_human(display_long)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:GSP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8993993|imex:IM-21669-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:NP_001070958.1|refseq:NP_001296769.1|refseq:NP_536350.2|refseq:NP_000507.1|refseq:NP_001070956.1|refseq:NP_001070957.1|ensembl:ENSG00000087460(gene)|ensembl:ENST00000371085(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0046907"(intracellular transport)|go:"GO:0048589"(developmental growth)|go:"GO:0050890"(cognition)|go:"GO:0060348"(bone development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P63092|rcsb pdb:5G53|rcsb pdb:5UZ7|rcsb pdb:5VAI|rcsb pdb:6AU6|rcsb pdb:6B3J|rcsb pdb:6E3Y|rcsb pdb:6E67|rcsb pdb:6EG8|rcsb pdb:6GDG|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LPB|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6ORV|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VN7|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XOX|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7BPH|rcsb pdb:7BW0|rcsb pdb:7BZ2|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX3|rcsb pdb:7CX4|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7D7M|rcsb pdb:7DHI|rcsb pdb:7DHR|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7KH0|rcsb pdb:7LCI|rcsb pdb:7LJC|rcsb pdb:7LJD|rcsb pdb:7MBX|reactome:R-HSA-163359|reactome:R-HSA-164378|reactome:R-HSA-381676|reactome:R-HSA-392851|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-432040|reactome:R-HSA-5610787|reactome:R-HSA-9660821|refseq:NP_536351.1	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:fUnrdxwx4bBAqE3iO2cCB3UInyg9606	intact-crc:C695F61DEDAF791E|rigid:MQOAJ9WLdqrkfZ7FiZ3iemXDyZM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:Q8TAG5	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-8994042|uniprotkb:B5MC94|uniprotkb:A4D2E9|ensembl:ENSP00000384967	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:vtm2a_human(display_long)|uniprotkb:VSTM2A(gene name)|psi-mi:VSTM2A(display_short)|uniprotkb:VSTM2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994039|imex:IM-21669-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:NP_001304772.1|refseq:NP_872352.2|ensembl:ENSG00000170419(gene)|ensembl:ENST00000407838(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0070352"(positive regulation of white fat cell proliferation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8TAG5	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:YI0+7ILyCVN0d+N6FTVmJhG5tQQ9606	intact-crc:1BEC99273A803171|rigid:BN0FwLvVs0Lyk1cEJ9zwzfdcy94	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QB1	uniprotkb:O00154	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	intact:EBI-948905|ensembl:ENSP00000367086|uniprotkb:O43703|uniprotkb:Q53Y78|uniprotkb:Q5JYL2|uniprotkb:Q5JYL3|uniprotkb:Q5JYL4|uniprotkb:Q5JYL5|uniprotkb:Q5JYL6|uniprotkb:Q5TGR4|uniprotkb:Q9UJM9|uniprotkb:Q9Y539|uniprotkb:Q9Y540|uniprotkb:A8K0K7|uniprotkb:A8K232|uniprotkb:A8K6B8|uniprotkb:A8K837|uniprotkb:B3KQ12	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:bach_human(display_long)|uniprotkb:Long chain acyl-CoA thioester hydrolase(gene name synonym)|uniprotkb:Acyl-CoA thioesterase 7(gene name synonym)|uniprotkb:CTE-IIa(gene name synonym)|uniprotkb:Brain acyl-CoA hydrolase(gene name synonym)|uniprotkb:BACH(gene name synonym)|uniprotkb:ACOT7(gene name)|psi-mi:ACOT7(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994058|imex:IM-21669-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	go:"GO:0051792"(medium-chain fatty acid biosynthetic process)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1900535"(palmitic acid biosynthetic process)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR033120|interpro:IPR040170|mint:O00154|rcsb pdb:2QQ2|reactome:R-HSA-77289|go:"GO:0047617"(acyl-CoA hydrolase activity)|ensembl:ENSG00000097021(gene)|ensembl:ENST00000377855(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0036114"(medium-chain fatty-acyl-CoA catabolic process)|go:"GO:0036116"(long-chain fatty-acyl-CoA catabolic process)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_863655.1|refseq:NP_863656.1|refseq:NP_009205.3|refseq:NP_863654.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	rogid:Tv8nHSqfXMmzZqj71+Gec6+29/s9606	intact-crc:8D9D75B6367D3057|rigid:yUz67jBbgwTZBVoWjuGioEp/f9k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14618	uniprotkb:Q96QB1	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994084|imex:IM-21669-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:4C2A3CBDCDBD75BD|rigid:tgARd8Dk1ELboK+BUZ2lhyQHxSk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QB1	uniprotkb:P08237	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	intact:EBI-514788|uniprotkb:Q16814|uniprotkb:Q16815|uniprotkb:J3KNX3|uniprotkb:Q6ZTT1|ensembl:ENSP00000309438|ensembl:ENSP00000352842|ensembl:ENSP00000446945|ensembl:ENSP00000448253|ensembl:ENSP00000449426|ensembl:ENSP00000450369	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:pfkam_human(display_long)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme A(gene name synonym)|uniprotkb:PFKM(gene name)|psi-mi:PFKM(display_short)|uniprotkb:6-phosphofructokinase type A(gene name synonym)|uniprotkb:PFKX(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994071|imex:IM-21669-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	refseq:NP_000280.1|refseq:NP_001160158.1|refseq:NP_001160159.1|refseq:NP_001160160.1|refseq:XP_016874957.1|refseq:XP_005269034.1|refseq:XP_005269035.1|refseq:XP_005269036.1|refseq:XP_011536790.1|ensembl:ENSG00000152556(gene)|ensembl:ENST00000312352(transcript)|ensembl:ENST00000359794(transcript)|ensembl:ENST00000547587(transcript)|ensembl:ENST00000550345(transcript)|ensembl:ENST00000550924(transcript)|ensembl:ENST00000551339(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0093001"(glycolysis from storage polysaccharide through glucose-1-phosphate)|go:"GO:0097228"(sperm principal piece)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P08237|rcsb pdb:4OMT|reactome:R-HSA-70171	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	rogid:tB7V3jdmnyITZLPqyAYjrTWo/UE9606	intact-crc:F4A642E2E5FBEFE7|rigid:vOaXlB2lswAqKds5G86sTyhZqGc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A0AVI4	uniprotkb:Q96QB1	intact:EBI-8994022|ensembl:ENSP00000372394|ensembl:ENSP00000441812|uniprotkb:A6NI98|uniprotkb:A6NH49|uniprotkb:D3DVP8	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:tm129_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TM129(gene name synonym)|uniprotkb:TMEM129(gene name)|psi-mi:TMEM129(display_short)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994110|imex:IM-21669-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR018801|mint:A0AVI4|reactome:R-HSA-8866654|ensembl:ENSG00000168936(gene)|ensembl:ENST00000382936(transcript)|ensembl:ENST00000536901(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|refseq:NP_001120738.1|refseq:NP_612394.1	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cpStvTXqqbxztzMAmFgzdElhHUc9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:07E04E856A280459|rigid:Rpy0zQvN7oDUh9frrc/7ESZreCk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08AK7	uniprotkb:Q96QB1	intact:EBI-8994123	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:q08ak7_human(display_long)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994127|imex:IM-21669-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR038765|interpro:IPR028889|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|refseq:NP_003354.2|mint:Q08AK7|interpro:IPR035927|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:aFyS0LJAVQlnSJdV5XWLXi7PwMA9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:14A4EDCB68C86232|rigid:mFR+9iRFjwy/l0Pd1PP2n/iT+FU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QB1	uniprotkb:P46060	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994097|imex:IM-21669-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606	intact-crc:A3760E82382699D7|rigid:2Lx6fFScLu2ABLKXOjvqzh/hdvs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P02686	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994190|imex:IM-21669-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:C564B79FAF2A59F9|rigid:UVxskePPE6k3NlaUwgazVycJ0vo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P53778	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-602406|uniprotkb:Q6IC53|uniprotkb:Q14260|uniprotkb:Q99588|uniprotkb:Q99672|ensembl:ENSP00000215659	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:mk12_human(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:MAPK12(gene name)|psi-mi:MAPK12(display_short)|uniprotkb:ERK6(gene name synonym)|uniprotkb:SAPK3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994177|imex:IM-21669-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_001290181.1|refseq:NP_002960.2|dip:DIP-34241N|ensembl:ENSG00000188130(gene)|ensembl:ENST00000215659(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|mint:P53778|rcsb pdb:1CM8|rcsb pdb:4QUM|rcsb pdb:6UNA|rcsb pdb:7CGA|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-2151209|reactome:R-HSA-376172|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5675221	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:S+3tRoF9CGZSsMEsejxLUOpMN5g9606	intact-crc:E9DCE32AB10DA7BD|rigid:nEHy6TchWoS8IItoBHFIRYYmxoE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q12797	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-2967294|ensembl:ENSP00000368767|uniprotkb:B4E2K4|uniprotkb:F5H667|uniprotkb:Q9NRI0|uniprotkb:Q9Y4J0|uniprotkb:Q9H2C4|uniprotkb:A6NDF4|uniprotkb:Q9NRI1|uniprotkb:A6NHI2|uniprotkb:B4DIC9|uniprotkb:B7ZM95|uniprotkb:E5RGP5|uniprotkb:Q6NXR7|uniprotkb:Q8TB28|uniprotkb:Q9H291|intact:EBI-8994140|uniprotkb:A0A0A0MSK8	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:asph_human(display_long)|uniprotkb:ASPH(gene name)|psi-mi:ASPH(display_short)|uniprotkb:Aspartate beta-hydroxylase(gene name synonym)|uniprotkb:Peptide-aspartate beta-dioxygenase(gene name synonym)|uniprotkb:BAH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994164|imex:IM-21669-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	ensembl:ENSG00000198363(gene)|ensembl:ENST00000379454(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009055"(electron transfer activity)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033198"(response to ATP)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0062101"(peptidyl-aspartic acid 3-dioxygenase activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR007803(Aspartyl/Asparaginyl beta-hydroxylase)|interpro:IPR007943(Aspartyl beta-hydroxylase, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5APA|rcsb pdb:5JQY|interpro:IPR019734|rcsb pdb:5JTC|interpro:IPR027443|interpro:IPR039038|rcsb pdb:5JZ6|mint:Q12797|rcsb pdb:5JZ8|rcsb pdb:5JZA|rcsb pdb:5JZU|rcsb pdb:6Q9F|rcsb pdb:6Q9I|rcsb pdb:6QA5|rcsb pdb:6RK9|rcsb pdb:6YYU|rcsb pdb:6YYV|rcsb pdb:6YYW|rcsb pdb:6YYX|rcsb pdb:6YYY|rcsb pdb:6Z6Q|rcsb pdb:6Z6R|rcsb pdb:7BMI|rcsb pdb:7BMJ|rcsb pdb:7E6J|reactome:R-HSA-5578775|reactome:R-HSA-2672351|refseq:NP_001158222.1|refseq:NP_004309.2|refseq:NP_064549.1|refseq:NP_115855.1|refseq:NP_115856.1|refseq:NP_001158223.1|refseq:NP_001158225.1|refseq:NP_001158227.1|refseq:NP_001158228.1|refseq:NP_115857.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:8Sv1CuwqdVCK6/PF6kL0hkX3/tw9606	intact-crc:A66BCFC0BFE58D0E|rigid:gk/uQmc/S5kwNG7qW53kNjH2ZQ8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P46060	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994216|imex:IM-21669-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606	intact-crc:92A57A41336AEC19|rigid:wcYUqy+MGvfg6+tlFcH0lntVLzE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q14515	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-2682673|uniprotkb:B4E2Z0|uniprotkb:E7ESU2|uniprotkb:Q14800|ensembl:ENSP00000282470|ensembl:ENSP00000414856	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:sprl1_human(display_long)|uniprotkb:High endothelial venule protein(gene name synonym)|uniprotkb:MAST 9(gene name synonym)|uniprotkb:SPARCL1(gene name)|psi-mi:SPARCL1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994229|imex:IM-21669-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_001278905.1|refseq:NP_001278906.1|refseq:NP_001121782.1|refseq:NP_004675.3|ensembl:ENSG00000152583(gene)|ensembl:ENST00000282470(transcript)|ensembl:ENST00000418378(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR016359(SPARC-like protein 1)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|mint:Q14515|reactome:R-HSA-381426|reactome:R-HSA-8957275	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:0HWQK3GxsY5R4UiaTQdwJKFKo509606	intact-crc:DB63E5BC467B05EA|rigid:td8+fJk1K/zNbO7lyVxZ9incWZU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P08237	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-514788|uniprotkb:Q16814|uniprotkb:Q16815|uniprotkb:J3KNX3|uniprotkb:Q6ZTT1|ensembl:ENSP00000309438|ensembl:ENSP00000352842|ensembl:ENSP00000446945|ensembl:ENSP00000448253|ensembl:ENSP00000449426|ensembl:ENSP00000450369	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:pfkam_human(display_long)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme A(gene name synonym)|uniprotkb:PFKM(gene name)|psi-mi:PFKM(display_short)|uniprotkb:6-phosphofructokinase type A(gene name synonym)|uniprotkb:PFKX(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994203|imex:IM-21669-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_000280.1|refseq:NP_001160158.1|refseq:NP_001160159.1|refseq:NP_001160160.1|refseq:XP_016874957.1|refseq:XP_005269034.1|refseq:XP_005269035.1|refseq:XP_005269036.1|refseq:XP_011536790.1|ensembl:ENSG00000152556(gene)|ensembl:ENST00000312352(transcript)|ensembl:ENST00000359794(transcript)|ensembl:ENST00000547587(transcript)|ensembl:ENST00000550345(transcript)|ensembl:ENST00000550924(transcript)|ensembl:ENST00000551339(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0093001"(glycolysis from storage polysaccharide through glucose-1-phosphate)|go:"GO:0097228"(sperm principal piece)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P08237|rcsb pdb:4OMT|reactome:R-HSA-70171	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:tB7V3jdmnyITZLPqyAYjrTWo/UE9606	intact-crc:B265312CE8AB45DB|rigid:BnqFVZUybUslDLj7GgB6qJefKlE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:A0AVI4	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-8994022|ensembl:ENSP00000372394|ensembl:ENSP00000441812|uniprotkb:A6NI98|uniprotkb:A6NH49|uniprotkb:D3DVP8	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:tm129_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TM129(gene name synonym)|uniprotkb:TMEM129(gene name)|psi-mi:TMEM129(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994242|imex:IM-21669-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR018801|mint:A0AVI4|reactome:R-HSA-8866654|ensembl:ENSG00000168936(gene)|ensembl:ENST00000382936(transcript)|ensembl:ENST00000536901(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|refseq:NP_001120738.1|refseq:NP_612394.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:cpStvTXqqbxztzMAmFgzdElhHUc9606	intact-crc:1F33334470681DE9|rigid:V+bQdxk822JY2yeBzE5nhVABLCE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:Q9BQY9	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-747462|uniprotkb:Q9BQZ0|uniprotkb:Q9BVL1|uniprotkb:Q9H1F6|uniprotkb:Q9NWZ0|uniprotkb:Q9NY07|uniprotkb:Q9NZ31|uniprotkb:Q5QPV4|uniprotkb:Q331S6|uniprotkb:Q5QPV6|ensembl:ENSP00000361805	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:dbnd2_human(display_long)|uniprotkb:HSMNP1(gene name synonym)|uniprotkb:DBNDD2(gene name)|psi-mi:DBNDD2(display_short)|uniprotkb:C20orf35(gene name synonym)|uniprotkb:Casein kinase-1 binding protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994255|imex:IM-21669-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:NP_001041686.1|refseq:NP_001041688.1|refseq:NP_001184068.1|refseq:NP_001184069.1|refseq:NP_060948.3|refseq:NP_001041687.1|refseq:NP_001041689.1|refseq:NP_001041690.2|ensembl:ENSG00000244274(gene)|ensembl:ENST00000372720(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|interpro:IPR007531(Dysbindin)|mint:Q9BQY9	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:IT5u7NdF81804lkkMO0KM3zBCzc9606	intact-crc:853907B9C5CFA081|rigid:9NYkPsFg/fFEKDHRVUmGuLlaFcw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:P26641	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994275|imex:IM-21669-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	intact-crc:486435395562B645|rigid:jZFhHfGL19GYiIFGRbOTNnsUw7E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:Q96CW1	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994301|imex:IM-21669-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	intact-crc:B02DA6B9C1384DD0|rigid:TN/md3xhA0+6J3zhuVKZKXZntLw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:P12532	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994314|imex:IM-21669-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606	intact-crc:9A0E17BC58897597|rigid:qx9pIjsDlbOrFCZlg8ky6XR1CIE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:P08237	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-514788|uniprotkb:Q16814|uniprotkb:Q16815|uniprotkb:J3KNX3|uniprotkb:Q6ZTT1|ensembl:ENSP00000309438|ensembl:ENSP00000352842|ensembl:ENSP00000446945|ensembl:ENSP00000448253|ensembl:ENSP00000449426|ensembl:ENSP00000450369	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:pfkam_human(display_long)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme A(gene name synonym)|uniprotkb:PFKM(gene name)|psi-mi:PFKM(display_short)|uniprotkb:6-phosphofructokinase type A(gene name synonym)|uniprotkb:PFKX(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994288|imex:IM-21669-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:NP_000280.1|refseq:NP_001160158.1|refseq:NP_001160159.1|refseq:NP_001160160.1|refseq:XP_016874957.1|refseq:XP_005269034.1|refseq:XP_005269035.1|refseq:XP_005269036.1|refseq:XP_011536790.1|ensembl:ENSG00000152556(gene)|ensembl:ENST00000312352(transcript)|ensembl:ENST00000359794(transcript)|ensembl:ENST00000547587(transcript)|ensembl:ENST00000550345(transcript)|ensembl:ENST00000550924(transcript)|ensembl:ENST00000551339(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0093001"(glycolysis from storage polysaccharide through glucose-1-phosphate)|go:"GO:0097228"(sperm principal piece)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P08237|rcsb pdb:4OMT|reactome:R-HSA-70171	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:tB7V3jdmnyITZLPqyAYjrTWo/UE9606	intact-crc:DC82E6C0B22C843F|rigid:w3xr5YL4HZFgWQXTbptaD3g7+bM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:P25054	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994362|imex:IM-21669-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:1EE4EE108D7ECAA9|rigid:3KVPx4pR98nghV6NWgh/DZ2UQK8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08237	uniprotkb:Q6FHJ7	intact:EBI-514788|uniprotkb:Q16814|uniprotkb:Q16815|uniprotkb:J3KNX3|uniprotkb:Q6ZTT1|ensembl:ENSP00000309438|ensembl:ENSP00000352842|ensembl:ENSP00000446945|ensembl:ENSP00000448253|ensembl:ENSP00000449426|ensembl:ENSP00000450369	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:pfkam_human(display_long)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme A(gene name synonym)|uniprotkb:PFKM(gene name)|psi-mi:PFKM(display_short)|uniprotkb:6-phosphofructokinase type A(gene name synonym)|uniprotkb:PFKX(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994349|imex:IM-21669-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000280.1|refseq:NP_001160158.1|refseq:NP_001160159.1|refseq:NP_001160160.1|refseq:XP_016874957.1|refseq:XP_005269034.1|refseq:XP_005269035.1|refseq:XP_005269036.1|refseq:XP_011536790.1|ensembl:ENSG00000152556(gene)|ensembl:ENST00000312352(transcript)|ensembl:ENST00000359794(transcript)|ensembl:ENST00000547587(transcript)|ensembl:ENST00000550345(transcript)|ensembl:ENST00000550924(transcript)|ensembl:ENST00000551339(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0093001"(glycolysis from storage polysaccharide through glucose-1-phosphate)|go:"GO:0097228"(sperm principal piece)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P08237|rcsb pdb:4OMT|reactome:R-HSA-70171	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tB7V3jdmnyITZLPqyAYjrTWo/UE9606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:C924D9A79EB5A044|rigid:wX86rter/h+N/84slX6LT/qjDSU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:Q9UHQ1	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-2876604|uniprotkb:B3KPX2|uniprotkb:K4DI98|intact:EBI-10964477|intact:EBI-8994327|intact:EBI-4395842|uniprotkb:A6NCJ3|uniprotkb:Q96AY9|uniprotkb:Q9BWC6|ensembl:ENSP00000309899	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:narf_human(display_long)|uniprotkb:NARF(gene name)|psi-mi:NARF(display_short)|uniprotkb:Iron-only hydrogenase-like protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994336|imex:IM-21669-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	refseq:XP_011521843.1|refseq:NP_001033707.1|refseq:NP_001077077.1|refseq:NP_036468.1|refseq:NP_114174.1|refseq:XP_005256397.1|ensembl:ENSG00000141562(gene)|ensembl:ENST00000309794(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0031981"(nuclear lumen)|interpro:IPR003149(Iron hydrogenase, small subunit-like)|interpro:IPR004108(Iron hydrogenase, large subunit, C-terminal)|interpro:IPR009016(Iron hydrogenase)|mint:Q9UHQ1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:fjsvsPlOTpCHvHIZ/Px5eC7rJqk9606	intact-crc:87CD195AA781BEB6|rigid:cqTmO44qbox/y8y9THL4OzCDwA8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P25054	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994375|imex:IM-21669-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:8B6EDBC5205397F5|rigid:wZd46lGHZvBAxFj/yqlmc/M7wcQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:P25054	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994394|imex:IM-21669-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:D186BCEF64EB63AC|rigid:MjCENueiBKh45ZF3rBQuQeiXYG0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:Q00597	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994431|imex:IM-21669-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:B17A78BC82C38581|rigid:nFrE+ksNJ+nxl9dB2roJgHbo7EQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60911	uniprotkb:P25054	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994418|imex:IM-21669-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:53D158521F651710|rigid:GEF1Wjhwg1SlP9e4xB2ONOrCzQY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:P25054	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994457|imex:IM-21669-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:D86EA670A6E37826|rigid:BYo19vhUOG4OJbMMzJ+FAocgWhs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:P25054	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994470|imex:IM-21669-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:60C495D4F753192A|rigid:CSsfKSHhlZEr2NG4WXA+rJq7u8E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:P09467	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994444|imex:IM-21669-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:F812835F10C62A7D|rigid:uT3LanWwp7Cptp1irRC9wyvmcfo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:Q15797	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994523|imex:IM-21669-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:AF710758A50D3FBD|rigid:4yTTl+O4A+Q9t9jzhz2YyZC1rMA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:P20936	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994509|imex:IM-21669-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:01ADDB6A0A1B471C|rigid:G3idkuk9ljQn0TFutMM9EM6viIE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:Q96LZ3	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994483|imex:IM-21669-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	intact-crc:48BC368C647BCBA4|rigid:lSNHv+gVdHc9xYKVs9hQ7r8C30o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IYR6	uniprotkb:P25054	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994555|imex:IM-21669-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:0C459A0DAD9D9FC1|rigid:Nk2JM3miT5n9WesTE4YRIijPU04	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:P01137	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994536|imex:IM-21669-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:5B965136EC473320|rigid:NOYk/VNS188RrytL8HQNPq/W8oQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:P28289	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994568|imex:IM-21669-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:7659FEFB55AB2CF1|rigid:rGZAmwDbSwrNp+vJypN2Ai6bsaQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25054	uniprotkb:Q9Y2H8	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994581|imex:IM-21669-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:FE04D7F1E32B129C|rigid:FTIemD1kmTa5G/vzNE/lhuT6OMo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14965	uniprotkb:P31749	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994594|imex:IM-21669-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:BC45A2873BA51B70|rigid:1945iD170gqCBIAAKm0y1CM7f3E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:O14965	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994607|imex:IM-21669-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:5E4271781247F1D0|rigid:/WD1krW9nhWO3qNs5jiNr7a80F0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:O14965	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994620|imex:IM-21669-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:7FDC54AFB27B2D4D|rigid:63ar8pXfqjfBv29l2wqdt3MDhdo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49336	uniprotkb:O14965	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994659|imex:IM-21669-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:C375A212555C5C9A|rigid:7pSfNeUo06Mf1CEqnFBWGSsFN70	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BU70	uniprotkb:O14965	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994633|imex:IM-21669-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:20D1D2E7FED35850|rigid:5xiAhUUIREG1MIT4kCPwGcHX8oM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:O14965	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994646|imex:IM-21669-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:723A2A99E3D9B8D8|rigid:/EAYZUPF7fE2MgV7elUKASmVIC4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92828	uniprotkb:O14965	intact:EBI-2835660|uniprotkb:Q92829|uniprotkb:Q5TBR5|uniprotkb:Q9BWS5|ensembl:ENSP00000343746|ensembl:ENSP00000364218	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:cor2a_human(display_long)|uniprotkb:CORO2A(gene name)|psi-mi:CORO2A(display_short)|uniprotkb:IR10(gene name synonym)|uniprotkb:WDR2(gene name synonym)|uniprotkb:WD repeat-containing protein 2(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994672|imex:IM-21669-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517288.1|refseq:NP_003380.3|refseq:NP_438171.1|ensembl:ENSG00000106789(gene)|ensembl:ENST00000343933(transcript)|ensembl:ENST00000375077(transcript)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027335|interpro:IPR036322|mint:Q92828|dip:DIP-59202N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:SOiS8h0Kv33gF44syiD028dKduM9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:9A7C692BD46AC0D6|rigid:tm5B/4NaCYDvt6bms6wBt19bNLU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:O14965	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994685|imex:IM-21669-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:09645A5BF09439B2|rigid:KaBb1B/X/9ahp2IAUT6oy9onx0c	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17936	uniprotkb:O14965	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994730|imex:IM-21669-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:9330E76F1D89EF1E|rigid:IDCp/rBigMilLaAguWItNe0xHKc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14965	uniprotkb:O00757	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994704|imex:IM-21669-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	intact-crc:93EA248B5529588F|rigid:reXfGIDQbd4sFv0teU/ZMgVR2w8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:O14965	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994717|imex:IM-21669-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:B757634C5FD24B55|rigid:tnGTifA2tKBby64H59ZYnu4Xc9U	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16644	uniprotkb:O14965	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994769|imex:IM-21669-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:91AB383DA08962EB|rigid:EdHFU517q8A9qXfuIn4wR+Ghnm4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14965	uniprotkb:Q9UJU2	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994743|imex:IM-21669-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	intact-crc:78826CECED0FFF64|rigid:7Ii4yf6paUqOWsY5J004Pu7sbsU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14965	uniprotkb:Q02750	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994756|imex:IM-21669-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:02DA210728C8EBA0|rigid:YejjfX7fP7kd78BE71L46cBfHTs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14965	uniprotkb:Q9NR45	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994782|imex:IM-21669-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	intact-crc:576B14A36F751011|rigid:RvuafPVrPupBNFg87te5eOCCBms	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14965	uniprotkb:P62714	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994795|imex:IM-21669-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	intact-crc:F51EBAEC8095BE10|rigid:GEsNTyzKN5q08qJcxS8eJrZYtho	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60468	uniprotkb:O14965	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994834|imex:IM-21669-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:D7163629A41F2817|rigid:1n+AAnkiDX6ttxH5pK8x5QnVmFU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LZ3	uniprotkb:O14965	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994808|imex:IM-21669-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:2D12B4ECE8507284|rigid:8yCqznHg2Ig1EHDCusT/BXB2rX8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20936	uniprotkb:O14965	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994821|imex:IM-21669-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:1678CAB2452AF722|rigid:OjXp3WZrP3HYhJNLVZyWcthuKbM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYX2	uniprotkb:O14965	intact:EBI-8994876|uniprotkb:B4DQ05|uniprotkb:Q9H6A2|uniprotkb:Q7L1K8|uniprotkb:Q8WYT1|uniprotkb:Q9NSH4|uniprotkb:Q6IPC7|uniprotkb:Q5TBQ5|uniprotkb:Q59EU0|uniprotkb:B9A6J7|uniprotkb:B3KWD1|ensembl:ENSP00000481721	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:tbd2a_human(display_long)|uniprotkb:TBC1D2(gene name)|psi-mi:TBC1D2(display_short)|uniprotkb:Armus(gene name synonym)|uniprotkb:PARIS1(gene name synonym)|uniprotkb:PP8997(gene name synonym)|uniprotkb:Prostate antigen recognized and identified by SEREX 1(gene name synonym)|uniprotkb:TBC1D2A(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994873|imex:IM-21669-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517145.1|refseq:NP_001254500.1|refseq:NP_001254501.1|refseq:NP_060891.3|ensembl:ENSG00000095383(gene)|ensembl:ENST00000465784(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:Q9BYX2|rcsb pdb:2DHK|reactome:R-HSA-8854214	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YBtho8cxmsRKBKR8FXiMQuQK5Uw9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:7FAF3A0AEB3D4BC2|rigid:q2F3qxYu2Niz7c8fbMG7QLBgbHY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:O14965	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994847|imex:IM-21669-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:F13FF02C6F7A1215|rigid:1Pvap6lVpGnS2UleyGR1RusX7Dg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:O14965	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994860|imex:IM-21669-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:22AD57F8B6937158|rigid:hDcUxjU01jGSUAa+0gdXiDeF5Ys	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:O14965	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994900|imex:IM-21669-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:6944509D2F929FB2|rigid:6ZaMupeC2qijlH1sqMaAokD02oc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23025	uniprotkb:O14965	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994913|imex:IM-21669-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:A397954E7BB43B31|rigid:7dJdSONOlnpuebAsrsS1oQdCEdQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:O14965	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994938|imex:IM-21669-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:4AE68E63F18B5ADF|rigid:cRHwfHQIIuH9Gcl1mHyrLhHvgXA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:O14965	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994951|imex:IM-21669-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	intact-crc:AEB64C997E0C40C5|rigid:Od2zesbFlaQlIuhVlPW0oo4qnxY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09467	uniprotkb:Q9Y2T1	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994964|imex:IM-21669-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	intact-crc:913E3C8142D53979|rigid:/YVI05gB40HTtqxbBDq9aDemUjA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2T1	uniprotkb:Q15797	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995003|imex:IM-21669-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:8DE78A9C20E22C7E|rigid:hZ5yrtkhd7aHoHbxkIT2t/ksB6w	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:Q9Y2T1	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994977|imex:IM-21669-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	intact-crc:C9C14A69FB27F10F|rigid:jZ1MDkk1XgdqmoV4U5ezQDYExDg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2T1	uniprotkb:Q9BXL5	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8994990|imex:IM-21669-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:118D55AC932D3904|rigid:qXILMk1m1S42k4oVPaq2dA0vHkQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07812	uniprotkb:Q92688	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995056|imex:IM-21669-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:19363BE5D149F908|rigid:4HtkfVM0oMhs0jgED08Cj9I2+IQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:Q9Y2T1	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995016|imex:IM-21669-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	intact-crc:41BBECE9B151A4B1|rigid:l9+vF/BrGkb+/z08qTyzzta58zw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:Q9Y2T1	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995029|imex:IM-21669-74	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	intact-crc:0BA84C67EC524A22|rigid:1XMES6qCt5cjzkVjuQFDFGcN3aY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJU2	uniprotkb:Q07812	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995069|imex:IM-21669-76	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	intact-crc:A5E329642D0F82E4|rigid:KJHuhn5bJsUJIxabU+d16p+ht3Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:Q07812	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995082|imex:IM-21669-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	intact-crc:6CFF085C6B0AB82A|rigid:pUpc/EoUGwwlsuefmMFT2939SsQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95999	uniprotkb:P31749	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995095|imex:IM-21669-78	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:5F22325650EF5785|rigid:boTQsgh/KEdXutyj4+uVnz40tBY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95999	uniprotkb:Q92688	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995108|imex:IM-21669-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:4128F0A77F054EAF|rigid:o2d33aSXKomWzuhnvsQvcj2d+G8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:O95999	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995121|imex:IM-21669-80	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	intact-crc:7FA8D476D73F04F2|rigid:WHORvulyzXmco60cJKAZ4WPo7Hg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95999	uniprotkb:P09467	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995160|imex:IM-21669-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:3B9A5A374D0D1253|rigid:k9GXWp6JykxNPaYelZ1NFVjVnFg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95999	uniprotkb:Q9BU70	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995134|imex:IM-21669-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:23B155268F9C0028|rigid:ErnPijM7slT/sHjNj8SG76COt/8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60729	uniprotkb:O95999	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995147|imex:IM-21669-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	intact-crc:AA1A6EA0F76E7434|rigid:mZRo+zAjuzNx6op+fYeXqIchudg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95999	uniprotkb:Q9BXL5	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995173|imex:IM-21669-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:4229FC9B208D7E80|rigid:rFgYEm+CbXrvCr4VQnuu2yxTUPo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1Z9	uniprotkb:O95999	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995186|imex:IM-21669-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	intact-crc:45C1CE318944F0FE|rigid:gTqY0tSklb13sKCTvXNmkpvCU2o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95999	uniprotkb:Q9NR45	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995209|imex:IM-21669-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	intact-crc:4209976A1724EEAE|rigid:dW13pMxnPVonbFUyTWhV3d8lZqo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20936	uniprotkb:O95999	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995222|imex:IM-21669-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	intact-crc:1D1E53603763D85D|rigid:Jzyr+np+pqqqErLciQ0cZi+BNb4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BU70	uniprotkb:P36894	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995261|imex:IM-21669-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:0273C08440080225|rigid:KO02QPk2x20Vi0m7lt0XuzlT78U	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:O95999	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-958922|ensembl:ENSP00000498104|uniprotkb:Q5VUF1	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:bcl10_human(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)|uniprotkb:CIPER(gene name synonym)|uniprotkb:CLAP(gene name synonym)|uniprotkb:Cellular homolog of vCARMEN(gene name synonym)|uniprotkb:Mammalian CARD-containing adapter molecule E10(gene name synonym)|uniprotkb:Cellular-E10(gene name synonym)|uniprotkb:CARD-like apoptotic protein(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 10(gene name synonym)|uniprotkb:CED-3/ICH-1 prodomain homologous E10-like regulator(gene name synonym)|uniprotkb:CARD-containing molecule enhancing NF-kappa-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995235|imex:IM-21669-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	ensembl:ENSG00000142867(gene)|ensembl:ENST00000648566(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0002020"(protease binding)|go:"GO:0002096"(polkadots)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032094"(response to food)|go:"GO:0032449"(CBM complex)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR033238|interpro:IPR042143|mint:O95999|rcsb pdb:2MB9|rcsb pdb:6BZE|rcsb pdb:6GK2|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866654|refseq:NP_003912.1|dip:DIP-29740N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:BUrlS8JdWGi4LWWgp0FfpILCeDY9606	intact-crc:D830C15B52CA0EEB|rigid:sYeQoNgUvyWs1DL8nf6O7sl5FXs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P05062	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995248|imex:IM-21669-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:A32B1DA079049719|rigid:X2yo+KMA+DmEmx11v8lfKBJDtBM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:P36894	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995284|imex:IM-21669-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:2287D6F80E4E8F49|rigid:mvXgOKzjwDGqwY4p4rn+H78YyvE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:P36894	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995297|imex:IM-21669-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:BBBED64CBCE3D869|rigid:p8/fd8eGCcg8QiywDjymKNxCZFE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49336	uniprotkb:P36894	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995310|imex:IM-21669-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:07D8A961E48794B2|rigid:jvms6wISfqpPAlXz58yw+hX+juo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60911	uniprotkb:P36894	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995323|imex:IM-21669-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:4D7077075FDAAA23|rigid:q8DKO1CrSXxlUETimVlqYLvoev4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:P36894	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995362|imex:IM-21669-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:2259C3E7F397ABA7|rigid:iNQvDzrEchIwM4XQhJQN3UyiTS0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:Q00597	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995336|imex:IM-21669-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:A87DEDB5AF2E61DF|rigid:Z6gwdTjJ62vEK6ZDRJB6JrE31a4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09467	uniprotkb:P36894	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995349|imex:IM-21669-96	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:92A0BB19596CA20B|rigid:dEhs3SE1/P9dI8Oiik9LwGKcUMA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:P36894	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995383|imex:IM-21669-98	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:09472BF04D010726|rigid:aYMwTDtseSdr9ienDHuwV+NQ234	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:P36894	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995396|imex:IM-21669-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:51EA0690B9CB8F64|rigid:ng5sC1TFb/qWKKb9kURSCZbv83E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P17936	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995409|imex:IM-21669-100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	intact-crc:78FE69214C528D3E|rigid:QiStwripa7SjcuhfWYYPI3C8Ik0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60468	uniprotkb:P36894	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995448|imex:IM-21669-103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:DAA32C551DC16E1B|rigid:jlIsA0EWMFh8CDJCU+GEayrFgi8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:P36894	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995422|imex:IM-21669-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:81702A6E991CB484|rigid:I5rapRHf/nO0dp25mKKYnQQ8tMA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P20936	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995435|imex:IM-21669-102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:5C13E82150A46EB3|rigid:Q88XsqWdoxEu1SsS1KF4HXD1ggg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:P36894	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995461|imex:IM-21669-104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:0A36CC2CEF2F3238|rigid:jDKkHfXrV5kpwhw4PkVApQFYwS0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:Q6FHJ7	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995474|imex:IM-21669-105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:7997F243CDB9B311|rigid:h3ydUCXullqb8Oac7MSkMpccKfE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:P36894	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995487|imex:IM-21669-106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:37699C4293E252CC|rigid:J0RudiO1DmpYr4A7Dfiw9PNr9C4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:P36894	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995500|imex:IM-21669-107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:5F306369ABFDFFD3|rigid:vmQGj7O21JnKf8GdSkaZk57x+OM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23025	uniprotkb:P36894	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995513|imex:IM-21669-108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:D0331361133635D0|rigid:9DauD6OadjpK4uZty1U8iC544/c	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P36894	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995526|imex:IM-21669-109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:4932CEF5E6F8BA2C|rigid:GW6muvg7K95IsImpRJeMy/Fg4lk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15056	uniprotkb:O60911	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995539|imex:IM-21669-110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	intact-crc:9D9E579812C83E49|rigid:tUL98Sw8oYzahre4zFbypbRQeuo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15056	uniprotkb:P09467	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995552|imex:IM-21669-111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:904C8B9A0D778CD5|rigid:fSz9DUYqRSkwlmJhK9g/ooPLH3g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37058	uniprotkb:P15056	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995565|imex:IM-21669-112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	intact-crc:EA6548AE1B1C5C0D|rigid:0OEbNuM99rTi68yEtNtwR4i9bhU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16644	uniprotkb:P15056	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995578|imex:IM-21669-113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	intact-crc:C170CF522BE83F42|rigid:DXyBlSL4clFDwzFV1BCUdO0P7Xw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P15056	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995591|imex:IM-21669-114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	intact-crc:71C2E87DA2EE5ADB|rigid:T28QZOyxb+T8eo+ou4Adb226zas	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15056	uniprotkb:Q9Y2H8	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995604|imex:IM-21669-115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:6364BFFBF26E17C3|rigid:SaiGq0lTX1wA4AKAi52ckKoL5u4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31749	uniprotkb:O43683	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995617|imex:IM-21669-116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:8E80116AEE07CF09|rigid:/vC7CDrZF1ymn/8PJXHYBfk37N4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P05062	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995630|imex:IM-21669-117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:494B4082465EEF17|rigid:ZV4z1KqV+0bUYVHNEX7ENvFjsr0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q9BU70	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995669|imex:IM-21669-120	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:121673082F69775E|rigid:am/QNI0KY0pTLhcmN1he2mPqNQU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:O43683	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995643|imex:IM-21669-118	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:A99CDC8ED8F1F9CD|rigid:YVYQEzy1CIbMp83KBxzP4z1rg8Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:O43683	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995656|imex:IM-21669-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:5308F84B60D9B493|rigid:b5irFOMbBceSy8caLkCDQui+v3g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:O43683	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995682|imex:IM-21669-121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:DDF47C6E703055D8|rigid:R9vLLCaoQP/BnYhgKyX0Ghn6yUc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:O43683	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995695|imex:IM-21669-122	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:8BC668D0DB8DB7BB|rigid:S3qSNK69CXMwWEQQeDUYJgyz2Dk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:O43683	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995708|imex:IM-21669-123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:C5EF8C66217E4D69|rigid:lrp5HLt8rDQVKNWA2RDFPI52GQ4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60729	uniprotkb:O43683	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995721|imex:IM-21669-124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:103C9A60F33B3699|rigid:BDe9ieKLWKLYsbN509dzbxDRCpE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P49336	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995734|imex:IM-21669-125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:B1B918E896F6BB7F|rigid:IEMR/wgpx05tnAiN6YalqX4nsMs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q92828	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-2835660|uniprotkb:Q92829|uniprotkb:Q5TBR5|uniprotkb:Q9BWS5|ensembl:ENSP00000343746|ensembl:ENSP00000364218	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:cor2a_human(display_long)|uniprotkb:CORO2A(gene name)|psi-mi:CORO2A(display_short)|uniprotkb:IR10(gene name synonym)|uniprotkb:WDR2(gene name synonym)|uniprotkb:WD repeat-containing protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995747|imex:IM-21669-126	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:XP_011517288.1|refseq:NP_003380.3|refseq:NP_438171.1|ensembl:ENSG00000106789(gene)|ensembl:ENST00000343933(transcript)|ensembl:ENST00000375077(transcript)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027335|interpro:IPR036322|mint:Q92828|dip:DIP-59202N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:SOiS8h0Kv33gF44syiD028dKduM9606	intact-crc:95AAC4CC16C846F6|rigid:fZCBRVxvGJgmM5vcuu1gCaASXg0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60911	uniprotkb:O43683	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995760|imex:IM-21669-127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:0451ABB43E4B6B85|rigid:WMXaL+KTB6tsvblo827ZOcJQvFE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:O43683	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995773|imex:IM-21669-128	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:F3B2F2A4362A2ACF|rigid:qneb3LjgKG4LEfwtTSGWGy9W6uE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:O14640	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995786|imex:IM-21669-129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:1FA8E85618C18016|rigid:z1PMRysrwvlUHREEeo9nk5aPYps	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q00597	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995799|imex:IM-21669-130	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:73105D3DDB496720|rigid:iAfERNJXcoaWZMm2le15c667bxA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P09467	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995812|imex:IM-21669-131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:B93C7E08FDE88764|rigid:Wvqp239bzHd/Nuc3N4eNtm1O9C8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:O43683	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995825|imex:IM-21669-132	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:DEF3BF5ED7A10332|rigid:KwTRwUDZZXXZ7nZObjHGsiJwnLM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:O75474	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995838|imex:IM-21669-133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	intact-crc:CBC259399BE7B1E3|rigid:oBRW0f+Iev7wViXHNaHpb2uomiQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:O43683	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995851|imex:IM-21669-134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:7632977F3C742DA8|rigid:R2orkyeS4ohncRR1J9WRfYCHEUo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q9BXL5	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995864|imex:IM-21669-135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:0A90CDA99864A7D3|rigid:QqoDWN8Fxc9KtylYyWHKkWYPb6o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P01112	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995877|imex:IM-21669-136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:9696DE6ADF0517DD|rigid:a9wOPNbTA36Ax4SQ2/pRPHm5Xx4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P37058	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995890|imex:IM-21669-137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	intact-crc:8D6103214ACE865A|rigid:0CDMXFyRagN3HMeY8Sfjs7+8hMo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P17936	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995903|imex:IM-21669-138	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	intact-crc:71FB5A81CC267FF4|rigid:KheZ6xwdhV7fuyaM47bpEZjAVho	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJU2	uniprotkb:O43683	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995929|imex:IM-21669-140	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:F35ECF032AAE56BC|rigid:NpByAv+xPH3xNYf1eE56w7otwiM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q9P1Z9	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995916|imex:IM-21669-139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:4772EF122CA74156|rigid:/FupQzz5Ay+q2MFDnZtvPFxdpz4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q16644	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995955|imex:IM-21669-142	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:AF6D84D56B215DF2|rigid:Lb8pj2nzh4s5FY6p/paZJdur40Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:O43683	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995942|imex:IM-21669-141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:0D1B9BE6EE63E1E0|rigid:M0r16R+fWvGbXO7FZD2vfJo3wWQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q9NR45	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995968|imex:IM-21669-143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	intact-crc:CAB8BE5CAEDB55AE|rigid:2h3toZPq3dtEQ61HHFGT8c/N0tc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:O43683	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995981|imex:IM-21669-144	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:D4D40515473D5A7E|rigid:qUNo6FUOJxkQZJ1cRWsfgeOnH6I	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q96LZ3	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8995994|imex:IM-21669-145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	intact-crc:C3C10D1030FE5579|rigid:P4XLRvUkn6gUEN3jpuGwCJ/hfZk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P20936	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996007|imex:IM-21669-146	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:B2A27056829837C3|rigid:o4WcFkmGdQVFFGnSP7BIpnJ9Sfk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P60468	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996020|imex:IM-21669-147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:5BDA82D763A37E2F|rigid:reJIJWaKupVtj83jnNp2O/eoCSY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:O43683	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996033|imex:IM-21669-148	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:A25460BE9A44C185|rigid:3Za0xBE7WIuGI/CMRFwyyvblHYw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q6FHJ7	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996046|imex:IM-21669-149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:37E15CC7A0DC4981|rigid:LyflZmjxQV314CIgUsrc0EzzA1g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:Q15797	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996072|imex:IM-21669-151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:D50E3FD2EB8C97AD|rigid:qgWoka7SSC9sIirLwN+IwyeyOOo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P29353	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996059|imex:IM-21669-150	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:B898C222981F6ADD|rigid:Q5YjC+3EOBTkjXkhDIYn02mR0kE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:O43683	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996085|imex:IM-21669-152	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:D07CE01E732CA232|rigid:O52gk8QR9fiucNrYkQpar0dLOdY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYX2	uniprotkb:O43683	intact:EBI-8994876|uniprotkb:B4DQ05|uniprotkb:Q9H6A2|uniprotkb:Q7L1K8|uniprotkb:Q8WYT1|uniprotkb:Q9NSH4|uniprotkb:Q6IPC7|uniprotkb:Q5TBQ5|uniprotkb:Q59EU0|uniprotkb:B9A6J7|uniprotkb:B3KWD1|ensembl:ENSP00000481721	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:tbd2a_human(display_long)|uniprotkb:TBC1D2(gene name)|psi-mi:TBC1D2(display_short)|uniprotkb:Armus(gene name synonym)|uniprotkb:PARIS1(gene name synonym)|uniprotkb:PP8997(gene name synonym)|uniprotkb:Prostate antigen recognized and identified by SEREX 1(gene name synonym)|uniprotkb:TBC1D2A(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996098|imex:IM-21669-153	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517145.1|refseq:NP_001254500.1|refseq:NP_001254501.1|refseq:NP_060891.3|ensembl:ENSG00000095383(gene)|ensembl:ENST00000465784(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:Q9BYX2|rcsb pdb:2DHK|reactome:R-HSA-8854214	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YBtho8cxmsRKBKR8FXiMQuQK5Uw9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:7C7785F6329E8205|rigid:tyh6WvmpoUy4Mqp5WhfskKF0D6M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHU6	uniprotkb:O43683	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996118|imex:IM-21669-154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:88DBEDC03DD41A44|rigid:osOZIiItwpoBQoI9ynNkuTOjS6k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:O43683	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996131|imex:IM-21669-155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:C480ED64F1224674|rigid:YicffBkxC0it15CvOUk5tY5zoyk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P28289	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996157|imex:IM-21669-157	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:4F32C173052E3F9A|rigid:rA3QxPv7OYyN/I33nHxEE6guBlY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IYR6	uniprotkb:O43683	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996144|imex:IM-21669-156	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:BD39AA91F919B605|rigid:0vjGFVsxGJf2LByDFqZHfycT+xk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:O43683	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996183|imex:IM-21669-159	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:4123249B3B22BD38|rigid:ZVeRmyn7CyAYhrRN8JRgtMVMJxY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43683	uniprotkb:P23025	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996170|imex:IM-21669-158	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:8B513FB9A112E678|rigid:lKDlqb2rmIzAlRPVYDbsMeiO7c4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:O43683	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996196|imex:IM-21669-160	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	intact-crc:9276F46ABCB4FA8C|rigid:JbAcYhwxJ7P1DIruGmIY6oVqBbk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BU70	uniprotkb:P24385	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996209|imex:IM-21669-161	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:216EBF1C986B2FB2|rigid:2SoizfRIbBFlMMZXpvkib6q+t40	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:P24385	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996222|imex:IM-21669-162	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:C38446628565CEFB|rigid:mc35DiK+em3ZjTMYXFigtGX2A3o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60729	uniprotkb:P24385	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996235|imex:IM-21669-163	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:A2ED8EB6491618BF|rigid:tONKPxaAQJC2EAgSa5/RILorGwc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24385	uniprotkb:P49336	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996248|imex:IM-21669-164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:C2CBCEE531E30DA8|rigid:WLlohy94Zq8tReSk5Nd+0LCpeJE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17936	uniprotkb:P24385	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996274|imex:IM-21669-166	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:E729AD33F13531A6|rigid:JbS/L+4htZW5xqrTh6LzNNJvFF8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:P24385	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996261|imex:IM-21669-165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:FB698B286654F4BA|rigid:Op9P0kNzAnLMKEnaxHElVAYGpJI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:P24385	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996300|imex:IM-21669-168	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:9078FBC8458BEE84|rigid:CPxUicWeBprv9ZWdH+hJqHI9Q/Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24385	uniprotkb:Q96LZ3	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996287|imex:IM-21669-167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	intact-crc:6DABCE1C83F0CE1D|rigid:1/FsLl8UPfTBO+gtJIWRKbUUbSI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYX2	uniprotkb:P24385	intact:EBI-8994876|uniprotkb:B4DQ05|uniprotkb:Q9H6A2|uniprotkb:Q7L1K8|uniprotkb:Q8WYT1|uniprotkb:Q9NSH4|uniprotkb:Q6IPC7|uniprotkb:Q5TBQ5|uniprotkb:Q59EU0|uniprotkb:B9A6J7|uniprotkb:B3KWD1|ensembl:ENSP00000481721	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:tbd2a_human(display_long)|uniprotkb:TBC1D2(gene name)|psi-mi:TBC1D2(display_short)|uniprotkb:Armus(gene name synonym)|uniprotkb:PARIS1(gene name synonym)|uniprotkb:PP8997(gene name synonym)|uniprotkb:Prostate antigen recognized and identified by SEREX 1(gene name synonym)|uniprotkb:TBC1D2A(gene name synonym)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996313|imex:IM-21669-169	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517145.1|refseq:NP_001254500.1|refseq:NP_001254501.1|refseq:NP_060891.3|ensembl:ENSG00000095383(gene)|ensembl:ENST00000465784(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:Q9BYX2|rcsb pdb:2DHK|reactome:R-HSA-8854214	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YBtho8cxmsRKBKR8FXiMQuQK5Uw9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:FD1F4BE99A8F5FBF|rigid:W9mH5ESApuLqWOn5Mn+/q79i2cw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHU6	uniprotkb:P24385	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996326|imex:IM-21669-170	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:1AB320CE83CD20F9|rigid:1OW/iDGHTQy6MXuQw+1rQFbHTPQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:P24385	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996339|imex:IM-21669-171	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	intact-crc:28003F6A0FA13D98|rigid:j7hDfnCh5hi015eANiQyXvhoQCw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:P12830	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996365|imex:IM-21669-173	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:97DF6D98A897BC9A|rigid:On8nbR/jqhKbyqQWiGk95wp5MVo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12830	uniprotkb:P31749	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996352|imex:IM-21669-172	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:A0B01F9B21BE6649|rigid:rJZZnoUiypDZWAzsYS/vjhgqRRI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:P12830	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996378|imex:IM-21669-174	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:C4E0613314294F2E|rigid:+KNboh8AVLl8TVYj61VWE1y+O9E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49336	uniprotkb:P12830	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996391|imex:IM-21669-175	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:418011034A506E4C|rigid:D5fUwIuDwTUDL4hOJjxVQtcQ9Ls	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:P12830	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996404|imex:IM-21669-176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:2B0E9694F3C603ED|rigid:jHtCfAPV+DGg220hW5AQY1TT0EY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:P12830	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996417|imex:IM-21669-177	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:65A8CA505BD2F67F|rigid:ya4OnAKuOp0xhaf/fuVAZdBo5oA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:P12830	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996430|imex:IM-21669-178	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:F5229F226F3E24E7|rigid:He8EwgKw5MlTwY7weYxKrCAEKE4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:P12830	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996456|imex:IM-21669-180	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:9B2A9C1B39C74741|rigid:vfuWdlaMFPxUIoa7tVlRCrOoXos	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12830	uniprotkb:P37058	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996443|imex:IM-21669-179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	intact-crc:AB4D09C19A7DD2AD|rigid:kL4DCyo6lO/z3XAJs99ndz8dWIw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:P12830	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996482|imex:IM-21669-182	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:FD99B8A37C6DD14E|rigid:bwEbCdpKNYIwqC1YJF3pc+PljU8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12830	uniprotkb:Q16644	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996469|imex:IM-21669-181	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:634D8838B7835C4F|rigid:sDXoA8jpNLQ5p1HFbepCd45myF0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:P12830	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996495|imex:IM-21669-183	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:DE647C465EF564B9|rigid:e8AviKDhphqHkwTZ0UxL/ptvxlo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:P12830	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996508|imex:IM-21669-184	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:505EE2EDAA9A5923|rigid:M+S3apnWX3OcP3XxoCob6X80Rc4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12830	uniprotkb:P28289	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996521|imex:IM-21669-185	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:A902D785C2968499|rigid:U3Utmkmr/Om27l75oHBYghqssRY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:P12830	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996534|imex:IM-21669-186	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:EB43E8817518B200|rigid:J2/lc634uvDLiWwC7zZp60ewKsU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q14032	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996560|imex:IM-21669-188	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	intact-crc:CBE1C4B2412775ED|rigid:h0jdk/tQMqHfLzgvGPTpYcKpht0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:P05062	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996547|imex:IM-21669-187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:351BE97D3E345238|rigid:866FT/Prts7g1VaeoD7IjPEHXWk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q8N6M6	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996573|imex:IM-21669-189	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	intact-crc:A355AD7695959D97|rigid:o6DEs1HbrSB1nqkh/4i6GroSEaI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:O60729	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996586|imex:IM-21669-190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	intact-crc:3913B57DAF58845E|rigid:Lw25k6OyR7gUTQai7d/hLmE7zKg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:O60911	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996599|imex:IM-21669-191	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	intact-crc:D45B87C40FE6A135|rigid:dh13aiRQjvEnuzOACrNGCwHiTx8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q14093	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996612|imex:IM-21669-192	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	intact-crc:82862FDB47DC49D6|rigid:N1UlOqpvgxFPD+a8jitdU2t3m88	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:O75474	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996625|imex:IM-21669-193	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	intact-crc:24BC2670F10C361C|rigid:SiNBNEipjMLSoMNrtNcrQRzqs1U	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:P01112	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996651|imex:IM-21669-195	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:0DD3E159E0F3F9D6|rigid:llkJSqAY5K77Dehk/brpvbiSieA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q8IXK2	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996638|imex:IM-21669-194	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	intact-crc:80BB05AB26020A8B|rigid:kaYveafJ1UqlP/zB+JgNXwHvD9g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q02750	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996677|imex:IM-21669-197	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:11923B976B9428F9|rigid:gPdOem1hCwW2sePxAzBhqSIXI1M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q9P1Z9	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996664|imex:IM-21669-196	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:6569B7F76A9B1B30|rigid:8bUxJr/4Rd5uf1XZpOwv9k6L5/M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q16644	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996690|imex:IM-21669-198	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:8875E581AEEF3431|rigid:3X3PaVO4XpEsbiXZmCUfA+xJBIc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:P20936	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996703|imex:IM-21669-199	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:8E251EFD0D8D65BE|rigid:O/Ezg01j8zzGWSgAz01VpYSaIl4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:P60468	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996716|imex:IM-21669-200	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	intact-crc:6E77A0CA2BB024BA|rigid:ceruGwQoVGBDvqPHm/rxc6mZme8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:P01137	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996742|imex:IM-21669-202	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:2C1381BDF1CA14D8|rigid:Bn4OgbdK9RRRIEE02wHAJmJy+3I	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q6FHJ7	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996729|imex:IM-21669-201	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:CC04657B62CE69E9|rigid:A3961O3fhXNP5o1e9NlHRaENAmM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:P28289	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996768|imex:IM-21669-204	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:37FF310244664085|rigid:1/9U9fV7+tr9HPOcv/WB48e0vcA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N726	uniprotkb:Q8IYR6	intact:EBI-625922|uniprotkb:Q13195|uniprotkb:Q13399|uniprotkb:Q16360|uniprotkb:Q7KZR9|ensembl:ENSP00000432664|ensembl:ENSP00000462950|uniprotkb:D3DRK2	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	psi-mi:arf_human(display_long)|uniprotkb:p14ARF(gene name synonym)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:MLM(gene name synonym)|uniprotkb:Alternative reading frame(gene name synonym)|uniprotkb:Cyclin-dependent kinase inhibitor 2A(gene name synonym)	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996755|imex:IM-21669-203	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147889(gene)|ensembl:ENST00000530628(transcript)|ensembl:ENST00000579755(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090398"(cellular senescence)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR010868(Cyclin-dependent kinase inhibitor 2a p19Arf, N-terminal)|mint:Q8N726|reactome:R-HSA-111471|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-6804757|reactome:R-HSA-69541|reactome:R-HSA-8941858|reactome:R-HSA-9645722|reactome:R-HSA-9646303|reactome:R-HSA-9646304|refseq:NP_478102.2|dip:DIP-24171N	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zdbvJmkrI/zJFL+Enq5jTM1Csdw9606	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	intact-crc:321B492F4BDF4ADF|rigid:Lx3bLEDZjm1b+WcLUmwQAF3dHhg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31749	uniprotkb:P35221	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996781|imex:IM-21669-205	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:4778499CFBD893BC|rigid:pEKLzoC1ji3/HfApZQ6Asmij2Vg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P35221	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996807|imex:IM-21669-207	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:64341643D51EECD2|rigid:MEa4z1c5qS6JyJ8NwzRZK+tqSKE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05062	uniprotkb:P35221	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996794|imex:IM-21669-206	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:52F91566081738F5|rigid:xvZ3oNFv7ogk75TxDS1+cMQ0yz0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:O60911	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996820|imex:IM-21669-208	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	intact-crc:07B274D23DDC3F79|rigid:zQqgT+eMTw2L6qcKI3vJfbn3v8M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:P09467	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996833|imex:IM-21669-209	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:3463A5CA2063E18C|rigid:BJ+0siqlYMj2hEm+66R7gJ9Rrw8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:P35221	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996846|imex:IM-21669-210	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:B699CC26899AE83E|rigid:sgvASvd778RE8DWQnBfB6BN/6/8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:O75474	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996859|imex:IM-21669-211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	intact-crc:3F49C16BD5367E94|rigid:cN8Od6GpRvYi0m+BqlWg1fmzW64	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:P01112	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996872|imex:IM-21669-212	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:12251159C1CCD869|rigid:/NiaatWT2fLdLaLdU9jMd7WDuNM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:P37058	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996885|imex:IM-21669-213	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	intact-crc:D05DF731E31D457E|rigid:HEH88EyOvj0DzoIKnPQuBm7xv2g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:P35221	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996911|imex:IM-21669-215	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:5D2C79EC5AA26F73|rigid:HNe8wu6i+W89kQqwdjOEw7syCNc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1Z9	uniprotkb:P35221	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996898|imex:IM-21669-214	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:865019028A77CA8A|rigid:X0GzjB3zuDKi87SrkkgjPvaweW4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:Q9NR45	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996924|imex:IM-21669-216	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	intact-crc:C79759411D1D7AF1|rigid:bOLsPqYUe4Uaz4/RJlCWhjh42jc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:P35221	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996937|imex:IM-21669-217	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:276094A532834462|rigid:qscTIYZCxsKE9Yr1hXh/HDZximk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:Q6FHJ7	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996950|imex:IM-21669-218	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:97D3BBDF150F3FFF|rigid:mgGNWH2vrkrO+TtSKNLCiptVxB8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:P35221	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996963|imex:IM-21669-219	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:A63DDAC0565011D0|rigid:fawZy2X0SXQMuI+FWAGRREIEWu4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:P56962	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996976|imex:IM-21669-220	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:51430B0ED2F53832|rigid:Kk6PnL261FPpsnOLp7/4AcjKp6k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:Q8NHU6	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8996989|imex:IM-21669-221	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:E0E318D0980B0C39|rigid:SFGpyoZ72DrfJoopXGge3e7e618	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P35221	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997002|imex:IM-21669-222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	intact-crc:A6E2DA2198FF39B0|rigid:vofGsD9v109WyFDSSbR9GaBLZGI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35221	uniprotkb:Q9Y2H8	intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997015|imex:IM-21669-223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:3D561E6D066D9865|rigid:m3XJ+20lRxJz/9m36p5MuOXxWCk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43146	uniprotkb:P05062	intact:EBI-1222919|ensembl:ENSP00000389140	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997028|imex:IM-21669-224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:341540FAC54351D9|rigid:q0ex1qvt93fqpCEpv7fct/qQoGg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:P43146	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-1222919|ensembl:ENSP00000389140	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997041|imex:IM-21669-225	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	intact-crc:C954471085D71F53|rigid:GVRGSXSAT+BK4gFanj7af/Hvmgw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43146	uniprotkb:Q9BU70	intact:EBI-1222919|ensembl:ENSP00000389140	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997054|imex:IM-21669-226	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:5AC1EF8B7F415559|rigid:ks/kZo+W4zHoV5oXt39l39rUfOI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:P43146	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-1222919|ensembl:ENSP00000389140	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997067|imex:IM-21669-227	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	intact-crc:6F271DE77E4802D3|rigid:wQEfETHl69teEdsuDEVjRhrGzVE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60911	uniprotkb:P43146	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	intact:EBI-1222919|ensembl:ENSP00000389140	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997093|imex:IM-21669-229	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	intact-crc:74513B48E19A7875|rigid:5RBcLzVWcUht/Kn/TY6LNgCpzpg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43146	uniprotkb:Q92828	intact:EBI-1222919|ensembl:ENSP00000389140	intact:EBI-2835660|uniprotkb:Q92829|uniprotkb:Q5TBR5|uniprotkb:Q9BWS5|ensembl:ENSP00000343746|ensembl:ENSP00000364218	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:cor2a_human(display_long)|uniprotkb:CORO2A(gene name)|psi-mi:CORO2A(display_short)|uniprotkb:IR10(gene name synonym)|uniprotkb:WDR2(gene name synonym)|uniprotkb:WD repeat-containing protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997080|imex:IM-21669-228	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	refseq:XP_011517288.1|refseq:NP_003380.3|refseq:NP_438171.1|ensembl:ENSG00000106789(gene)|ensembl:ENST00000343933(transcript)|ensembl:ENST00000375077(transcript)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027335|interpro:IPR036322|mint:Q92828|dip:DIP-59202N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	rogid:SOiS8h0Kv33gF44syiD028dKduM9606	intact-crc:A76758594DEC5DD3|rigid:/z4TVCrHMHdaxPDgrrH431rhhHY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43146	uniprotkb:P09467	intact:EBI-1222919|ensembl:ENSP00000389140	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997106|imex:IM-21669-230	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:1E91F241FD3CF3CB|rigid:XS/vxc9wPswvV1hkE4w6kr6z/FY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43146	uniprotkb:Q9BXL5	intact:EBI-1222919|ensembl:ENSP00000389140	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997119|imex:IM-21669-231	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:C8424E3CD240B64B|rigid:amPhugFDNWep3zxSyGyuOmUz/BE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16644	uniprotkb:P43146	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	intact:EBI-1222919|ensembl:ENSP00000389140	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997132|imex:IM-21669-232	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	intact-crc:79B21E413E01F93A|rigid:pO2nfsVPw3Y6y9CU9a2hVJXksMM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20936	uniprotkb:P43146	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-1222919|ensembl:ENSP00000389140	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997145|imex:IM-21669-233	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	intact-crc:7233A276F0FBB782|rigid:MszR0fXInQXq16iDYI6FbdQCnGY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYX2	uniprotkb:P43146	intact:EBI-8994876|uniprotkb:B4DQ05|uniprotkb:Q9H6A2|uniprotkb:Q7L1K8|uniprotkb:Q8WYT1|uniprotkb:Q9NSH4|uniprotkb:Q6IPC7|uniprotkb:Q5TBQ5|uniprotkb:Q59EU0|uniprotkb:B9A6J7|uniprotkb:B3KWD1|ensembl:ENSP00000481721	intact:EBI-1222919|ensembl:ENSP00000389140	psi-mi:tbd2a_human(display_long)|uniprotkb:TBC1D2(gene name)|psi-mi:TBC1D2(display_short)|uniprotkb:Armus(gene name synonym)|uniprotkb:PARIS1(gene name synonym)|uniprotkb:PP8997(gene name synonym)|uniprotkb:Prostate antigen recognized and identified by SEREX 1(gene name synonym)|uniprotkb:TBC1D2A(gene name synonym)	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997171|imex:IM-21669-235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517145.1|refseq:NP_001254500.1|refseq:NP_001254501.1|refseq:NP_060891.3|ensembl:ENSG00000095383(gene)|ensembl:ENST00000465784(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:Q9BYX2|rcsb pdb:2DHK|reactome:R-HSA-8854214	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YBtho8cxmsRKBKR8FXiMQuQK5Uw9606	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	intact-crc:50B70A7E79B5C480|rigid:aKFV7q6kjVKYArxF7o3XaiFfiGM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:P43146	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-1222919|ensembl:ENSP00000389140	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997158|imex:IM-21669-234	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	intact-crc:CB91EF2ED173139C|rigid:U1oqRsYUTFi9IdSYFFwconTp5Ak	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43146	uniprotkb:Q8NHU6	intact:EBI-1222919|ensembl:ENSP00000389140	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997184|imex:IM-21669-236	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:401F624660FAF5EB|rigid:TA+ycE/FgX0vb4bMC+AmgZjbN7E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43146	uniprotkb:P28289	intact:EBI-1222919|ensembl:ENSP00000389140	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:dcc_human(display_long)|uniprotkb:DCC(gene name)|psi-mi:DCC(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym)|uniprotkb:Colorectal cancer suppressor(gene name synonym)|uniprotkb:IGDCC1(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 1(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997197|imex:IM-21669-237	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005206.2|dip:DIP-38423N|ensembl:ENSG00000187323(gene)|ensembl:ENST00000442544(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2ED7|rcsb pdb:2ED8|rcsb pdb:2ED9|rcsb pdb:2EDB|rcsb pdb:2EDD|rcsb pdb:2EDE|rcsb pdb:3AU4|rcsb pdb:4URT|rcsb pdb:5X83|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418889|reactome:R-HSA-418890|reactome:R-HSA-428542	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:1Spe7wn0fsPMSm9kxF+FCKrtqqk9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:C1EA848BA115BA59|rigid:Abxv6xj3eihmVifqUbYYphb7ZHY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:Q96QB1	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997210|imex:IM-21669-238	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:4EBD0A57E7FF98D4|rigid:Z4AE14OLGKOCdBQwjcErcvbvhUA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BU70	uniprotkb:Q96QB1	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997223|imex:IM-21669-239	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:57621C08AA8B47D3|rigid:pxwI8PD87eeKNeo8Q+ozSkNWgmo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:Q96QB1	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997236|imex:IM-21669-240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:47067D83254DA42B|rigid:nzOIYI3M1FFZqY5iAGyyJ8+fXNo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QB1	uniprotkb:O60729	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997249|imex:IM-21669-241	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	intact-crc:645C608D0799EFA4|rigid:Fc+2Fc9rvS6GlcVIMLJ6SfpAe7E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92828	uniprotkb:Q96QB1	intact:EBI-2835660|uniprotkb:Q92829|uniprotkb:Q5TBR5|uniprotkb:Q9BWS5|ensembl:ENSP00000343746|ensembl:ENSP00000364218	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:cor2a_human(display_long)|uniprotkb:CORO2A(gene name)|psi-mi:CORO2A(display_short)|uniprotkb:IR10(gene name synonym)|uniprotkb:WDR2(gene name synonym)|uniprotkb:WD repeat-containing protein 2(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997262|imex:IM-21669-242	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517288.1|refseq:NP_003380.3|refseq:NP_438171.1|ensembl:ENSG00000106789(gene)|ensembl:ENST00000343933(transcript)|ensembl:ENST00000375077(transcript)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027335|interpro:IPR036322|mint:Q92828|dip:DIP-59202N	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:SOiS8h0Kv33gF44syiD028dKduM9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:BCF392741CC70F3D|rigid:KIXpFq/JYGo1LNip23rGS8c3FLQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60911	uniprotkb:Q96QB1	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997275|imex:IM-21669-243	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:451D4734B02D894C|rigid:6uQKEauK5jgTCZhvtr0dhckAZEY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:Q96QB1	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997288|imex:IM-21669-244	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:D63040FAF5637F28|rigid:yRKKeL0kqo+414kiTEMkUVATvjI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:Q96QB1	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997314|imex:IM-21669-246	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:FEF0A7BB1796C8B8|rigid:yuyjEzfWZNbNXWpw/5vRhXVLZ/8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:Q96QB1	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997301|imex:IM-21669-245	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:B730EADA1475B910|rigid:KTh7VK5jpF3x0t2AUTdM4YDN+2E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37058	uniprotkb:Q96QB1	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997327|imex:IM-21669-247	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:2C9C7C1B44E59487|rigid:f6Mz0SU7Z/4DfApOwGILa3wcxB4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1Z9	uniprotkb:Q96QB1	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997340|imex:IM-21669-248	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:1C3E6E18CB571CB3|rigid:oc8YfodUCSAWrbrFPYMqNFRFBH0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16644	uniprotkb:Q96QB1	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997353|imex:IM-21669-249	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:F52E24631E22A915|rigid:PA0+qbrPAka5ybaZeVRB6UbwelU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LZ3	uniprotkb:Q96QB1	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997366|imex:IM-21669-250	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:48DC06237B8018C1|rigid:/x833aIqUJGLzETedOhMf5s5WEM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20936	uniprotkb:Q96QB1	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997379|imex:IM-21669-251	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:7362C302BA527AC2|rigid:XjMQo02tk5+To7Nh8cUndP+Dcyg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:Q96QB1	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997392|imex:IM-21669-252	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:AE57A398C30C4DEA|rigid:gRyDl8MFmyDqjIRLF7+vHZK3d4k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:Q96QB1	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997405|imex:IM-21669-253	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:D9183E31D5BF6368|rigid:eVJXdjbJyXiKv//YRuJMOP5HTrI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:Q96QB1	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997418|imex:IM-21669-254	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:912B9EB3D9A3A673|rigid:jwxnkhY4l596pZb5V57eIzlcDms	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QB1	uniprotkb:Q8NHU6	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997431|imex:IM-21669-255	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:EE17825B964CD82C|rigid:aYfCDZ1vyvEB9S0M/7I5DtYS14M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:Q96QB1	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997444|imex:IM-21669-256	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:205A434F5C1C459E|rigid:efUk0YsvHSXLCv5xSrJ95BJwP/c	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IYR6	uniprotkb:Q96QB1	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997457|imex:IM-21669-257	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:155B89DAF10629D7|rigid:0OV46/3SonChqvD5+EUAXmeiA34	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QB1	uniprotkb:P28289	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997470|imex:IM-21669-258	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:03B4F9FAF4A888FA|rigid:yxDL8gSNb0lznKewGwAsbC8aHVM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96QB1	uniprotkb:P23025	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997483|imex:IM-21669-259	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:1C593051F8DD307C|rigid:cjOYb715xy72XeLWQmOI5aB5szw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:Q96QB1	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997496|imex:IM-21669-260	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:3852EAD5100B34E1|rigid:aaxap8aXH5TdQ7wGoAaOilpFupA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:Q96QB1	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997509|imex:IM-21669-261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606	intact-crc:A7169F7C3E544673|rigid:nWmiWG9cDm4Y2Uro8KE8ZxB8xdI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:Q9BU70	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997522|imex:IM-21669-262	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:C0FF8571114B0913|rigid:jzoLr6lxGAHZviWBUGTAe5qEA58	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:P00533	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997535|imex:IM-21669-263	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:C70689094616A7E6|rigid:2pXqwjjfZ/bese6mOxHYMUOHuJA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:P00533	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997548|imex:IM-21669-264	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:3B1464191A4E9CDA|rigid:EgM8EM6olrtT4LhTeJuQoZLkbUc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:Q00597	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997574|imex:IM-21669-266	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:0DF7A95AF07AF69B|rigid:GBXsmb7jf9h0CglQ4YwhSX5YAX0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:P00533	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997561|imex:IM-21669-265	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:B0511FD21B119C7A|rigid:VMUEwcFYYOT82psFqG2vIAQDf6A	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:O75474	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997587|imex:IM-21669-267	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	intact-crc:526D1BE984DBECBF|rigid:eDS1Uq7Cu7k00U+AKl5hbYv/rLs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:Q16644	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997613|imex:IM-21669-269	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:8C8F68A25C093C45|rigid:TrpIeIXdWNQQEdAltsRq1etLJ7Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:P00533	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997600|imex:IM-21669-268	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:5E782CDBA05C4E91|rigid:mgOeXCt9mSUSYXMUfyQbbQL9oeA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:Q9NR45	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997626|imex:IM-21669-270	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	intact-crc:CE544B3981E8F790|rigid:AjUpSD/SbfoZUnBJxuYSRwMFvIk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:P62714	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997639|imex:IM-21669-271	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	intact-crc:9A27E573631C1CDC|rigid:H1jsMrdN79uiX7wxa/TTe9ZCH7Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:P01137	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997665|imex:IM-21669-273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:B17B0E12CB05182F|rigid:lDi4LdmEjeK6LenPdO1Fo/g+dFU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:P00533	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997652|imex:IM-21669-272	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:319E0E7C4505E6C1|rigid:0Xv5AifhBThbDJ+TqI6ApgyszyY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00533	uniprotkb:Q9Y2H8	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997678|imex:IM-21669-274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:D985011F9B9B2C39|rigid:oMuMpBism5B5Ce+RCsMzwC8Dyls	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P04626	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997691|imex:IM-21669-275	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:0DEFC9F47817F9DB|rigid:nlU7XFL2eaKI7oJIFGpJDQjcT0c	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BU70	uniprotkb:P04626	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997704|imex:IM-21669-276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:F9FE48AB22B6A5E7|rigid:SCXGVxbrXwB+6UkhPvfpqdfxaG4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04626	uniprotkb:P49336	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997717|imex:IM-21669-277	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:8A5C2E4D943DF815|rigid:6UtuBr634gnW/9vusL9CnOiE+3M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:P04626	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997730|imex:IM-21669-278	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:7155CF1223FFB414|rigid:ZdlKSIdLfv6wS1bcciuPpxOfHqI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75474	uniprotkb:P04626	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997756|imex:IM-21669-280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:5EC70A3E3081C59E|rigid:ReWI+S7UmBl1vWwgvyU/k8Q9Pdo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09467	uniprotkb:P04626	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997743|imex:IM-21669-279	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:D4D94EBDE1353155|rigid:Sws5pqERsJf47GT1ODoXe4gHkkc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37058	uniprotkb:P04626	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997769|imex:IM-21669-281	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:668A2B834718E074|rigid:xaq4Pl9hakxZWJAeqsDkHm1Ok2s	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04626	uniprotkb:Q9P1Z9	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997782|imex:IM-21669-282	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:DE9DD1A53A76652A|rigid:qzFCGnKXgdTBC0lcIXT5xyhaxXE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04626	uniprotkb:Q02750	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997795|imex:IM-21669-283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:BFEFB54EE2ABA9F2|rigid:QdaJQ2ev7/7tfE3Uqse3FaaiksE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04626	uniprotkb:P20936	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997808|imex:IM-21669-284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:C25F45F8845B1022|rigid:FrX33M7HHd76M15qX9QK5n+1r3E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:P04626	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997821|imex:IM-21669-285	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:380A7060A31FE205|rigid:V3oFdFFyhPDT3L0rb0mjTpLBI1I	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04626	uniprotkb:Q15797	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997834|imex:IM-21669-286	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:ECEC1C79E24288B0|rigid:mEIcFO/NwlzT/7q7eQRw0P7efJE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P04626	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997860|imex:IM-21669-288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:EB781971705A1F03|rigid:T072F6fdmv4p3NnULzpMaCgirwQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04626	uniprotkb:P01137	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997847|imex:IM-21669-287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:F261A0ED205D33CC|rigid:wInIDh4cbb7EoEjvtU03xsM4bxg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969H0	uniprotkb:P31749	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997873|imex:IM-21669-289	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:50FE08027A588DBD|rigid:L6YOoNYTXtW4h6OZtAADRL75z4Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:Q969H0	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997886|imex:IM-21669-290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:1DDE6C59B2BF5082|rigid:hdJxAlQaLByO/jwOMAqjpCew5sY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14640	uniprotkb:Q969H0	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997899|imex:IM-21669-291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:284FC9A3D57D1740|rigid:LC28Miy7bGtAU262j8yHyb9tzgY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:Q969H0	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997912|imex:IM-21669-292	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:551D308AEE1B638F|rigid:jjM55LF83flU1GscqCooqLHKo3A	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09467	uniprotkb:Q969H0	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997925|imex:IM-21669-293	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:74F3E556ACE64531|rigid:dqoae3vgiP6WwkFSHu2LhKreunU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:Q969H0	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997938|imex:IM-21669-294	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:381398B11B1190E7|rigid:qI6v3pi2lx3OLwWo5/suSq9wYNU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969H0	uniprotkb:Q9BXL5	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997964|imex:IM-21669-296	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:498E424F917DB046|rigid:feq+K/k/d0fnKfiYQ+TOtOquJ2k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:Q969H0	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997951|imex:IM-21669-295	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:D8D2AD2684AC1DCE|rigid:YCbUS4NBxKDK1JYFRwLFTkBDLFk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:Q969H0	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997977|imex:IM-21669-297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:C2AE4ADF5556B99B|rigid:zKJIDQ/OsZcbpc5Vq7XOWzXTunI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17936	uniprotkb:Q969H0	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8997990|imex:IM-21669-298	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:5CB52D75A5D1E320|rigid:/KfOkQSZTfRmcCw3Fa1Lid6F7bo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:Q969H0	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998003|imex:IM-21669-299	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:4BFA8001C63ECAFB|rigid:KmhtpB3Oo4lgUCD3PLCr9qKdNzQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969H0	uniprotkb:Q16644	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998016|imex:IM-21669-300	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:28125B021856D12E|rigid:yfak91LDMFFqUTjepyGYsTI/G3o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:Q969H0	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998029|imex:IM-21669-301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:A8B83EA6ADCBBAD2|rigid:GiWPuSjJ+aMFoQ+GMvfbFzb/3+Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969H0	uniprotkb:Q96LZ3	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998042|imex:IM-21669-302	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	intact-crc:10CD80E020E1DCD4|rigid:I5FjbXC28HdLPkNhkZtg9ktb3WQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60468	uniprotkb:Q969H0	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998055|imex:IM-21669-303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:B01919589D0DD230|rigid:D3LIwFkumD3DLOZxu1pY+m1HCbE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29353	uniprotkb:Q969H0	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998068|imex:IM-21669-304	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:937D71CFE7E41707|rigid:Y5aCOQ0xo4LP3fRmghcfk3NLtLw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:Q969H0	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998081|imex:IM-21669-305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:CC344951DCCF8260|rigid:glyGEVTQ4QCwwR0qY/tFXz/0GgU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:Q969H0	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998094|imex:IM-21669-306	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:AD6F352954706DBE|rigid:TMOZIZ+2jHS94PKTohhBql0C/cw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28289	uniprotkb:Q969H0	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998107|imex:IM-21669-307	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:A5948189EAD50823|rigid:J/Dfmf7C5qirN8TkGQwoiihdGP4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969H0	uniprotkb:P23025	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998120|imex:IM-21669-308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:9A714037EEB41A0B|rigid:8Zbv+KsUeoX6kjwrjeVTlOmBFxc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NFG4	uniprotkb:P05062	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998146|imex:IM-21669-310	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:5396D8F4413C3C4F|rigid:MnmnKDc7tA0V9aiTnRjSL1ys7OA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:Q969H0	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998133|imex:IM-21669-309	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	intact-crc:09657E82BEA17BCA|rigid:0CAZpl6vcKbkRKkOLJB5H8Y8HTA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:Q8NFG4	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998159|imex:IM-21669-311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	intact-crc:18CBECF0B8934118|rigid:V+SMdmRQPLfVlzkxWTpuUekYE0Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09467	uniprotkb:Q8NFG4	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998172|imex:IM-21669-312	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	intact-crc:52117241615824E4|rigid:D+lMk4UFkjP2Ylmd7TbETjhGj14	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:Q8NFG4	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998185|imex:IM-21669-313	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	intact-crc:0F25A2BF724385C6|rigid:QAEuvCSpRbm4htG9Jz1m7aDiUCo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1Z9	uniprotkb:Q8NFG4	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998198|imex:IM-21669-314	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	intact-crc:99F1896E0483C49F|rigid:fCCbNsv3d0RgfL87D3il08BWw6g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:Q8NFG4	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998211|imex:IM-21669-315	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	intact-crc:170BDF5C46FCABD8|rigid:CHrk23KRuHPvkQCPXS0kbh+oc9s	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IYR6	uniprotkb:Q8NFG4	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998224|imex:IM-21669-316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	intact-crc:1B8273BE31CF6C53|rigid:jN7kQ7gNwN1KJq5iRzTTCUDMPro	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01116	uniprotkb:P49336	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998237|imex:IM-21669-317	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:A1E486D70C99B41D|rigid:U7/NNDF2sWLm3qufmCBXAxNpO20	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:P01116	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998250|imex:IM-21669-318	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:5C5EDF0C4838BE9B|rigid:LUQNw6ZyruY0tk9YF02BdKDfJwQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75474	uniprotkb:P01116	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998263|imex:IM-21669-319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:15A8965069C99373|rigid:a9Rw+OKGaUtEnBcTi0SEByvpQJU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:P01116	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998276|imex:IM-21669-320	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:FBC15E870216D05B|rigid:Jsk6EfSLGz9pkp2NWpr9mlvxxOQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17936	uniprotkb:P01116	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998289|imex:IM-21669-321	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:31A0C2AD4A4359AD|rigid:6f7ap4ITIkAgojdPybwCqZFhqpU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01116	uniprotkb:P62714	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998302|imex:IM-21669-322	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	intact-crc:DA819D33C4546C2B|rigid:/wrN2BARB6Z1GSJ5Und6AC1f+Jg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:P01116	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998315|imex:IM-21669-323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:57307830FD4F39C8|rigid:ICvdxOlHtQMNNk9MtPkONvTmKzI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P01116	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998328|imex:IM-21669-324	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:911A89183919CF37|rigid:0NadLMtQDbJI9ic/6gi3VzlfHg8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45985	uniprotkb:P05062	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998341|imex:IM-21669-325	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:EF2F3C1895D0009C|rigid:lsnshe+b7IVGkBqmQu2uQx4V9ZI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:P45985	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998354|imex:IM-21669-326	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	intact-crc:6FF8082A9C28936F|rigid:zb8Us+1fEyNPC+FW0U8q9YYpR7c	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45985	uniprotkb:O00757	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998367|imex:IM-21669-327	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	intact-crc:815BFB4D1F48DB2F|rigid:6x4inT6Be9Su8bfB1RfEB3NNukg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:P45985	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-447868|uniprotkb:D3DTS5|uniprotkb:Q5U0B8|uniprotkb:B2R7N7|uniprotkb:B3KYB2|uniprotkb:Q6FHX4|uniprotkb:Q6P9H2|uniprotkb:Q6PIE6|intact:EBI-28973354|ensembl:ENSP00000262445	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:mp2k4_human(display_long)|uniprotkb:JNK-activating kinase 1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 1(gene name synonym)|uniprotkb:SAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K4(gene name)|psi-mi:MAP2K4(display_short)|uniprotkb:JNKK1(gene name synonym)|uniprotkb:MKK4(gene name synonym)|uniprotkb:PRKMK4(gene name synonym)|uniprotkb:SERK1(gene name synonym)|uniprotkb:MEK4(gene name synonym)|uniprotkb:MAPK/ERK kinase 4(gene name synonym)|uniprotkb:SKK1(gene name synonym)|uniprotkb:SEK1(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998380|imex:IM-21669-328	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	refseq:NP_003001.1|ensembl:ENSP00000262445|ensembl:ENST00000415385|ensembl:ENSP00000410402|refseq:NP_001268364.1|ensembl:ENST00000353533(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009611"(response to wounding)|go:"GO:0030424"(axon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P45985|rcsb pdb:3ALN|rcsb pdb:3ALO|rcsb pdb:3VUT|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-5210891|reactome:R-HSA-5684264|ensembl:ENSG00000065559(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:/ndhkIbnc9oTm68r4DwDUyfXDF89606	intact-crc:09240D95DC2F02AE|rigid:2gZWyIkCRAVcZIkme/2ItVi3I0Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05062	uniprotkb:P23508	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998393|imex:IM-21669-329	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:3D4E3DF0E6656FFC|rigid:oYOp1oF7R1aAw4GhJtLaNUWw4lo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23508	uniprotkb:Q92688	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998406|imex:IM-21669-330	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:3135677B4D388ACA|rigid:fQod5FAmeF+cQfObjGt79LVP7MQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P23508	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998419|imex:IM-21669-331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:5AB053A8E911EBEB|rigid:ZTKkCqgM/LVGU0hYndZ8FNk5H64	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23508	uniprotkb:Q9BU70	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998432|imex:IM-21669-332	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:C2BCC3EAA7A20EE5|rigid:eX/V1IUdApp/lU+uuxuKTNdDxek	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:P23508	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998445|imex:IM-21669-333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:4870D730434671E0|rigid:cKox8HTnkrheBR9pcxYYD8WThew	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:P23508	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998458|imex:IM-21669-334	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:93482797A5B4EE6D|rigid:Ey+kXiA/D5gW6lk70jUU+vnZxgM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23508	uniprotkb:O60729	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998471|imex:IM-21669-335	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	intact-crc:194669E2630265F4|rigid:eHKiscDBX9VbKjKcTv5gl/uF+KA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:P23508	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998497|imex:IM-21669-337	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:8717495DA2F45132|rigid:zPB3z07ZVOueMfSd0l68QPDRSYo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23508	uniprotkb:P49336	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998484|imex:IM-21669-336	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:0410AE171E2089A6|rigid:gskJDO+o0dFNu/0fMOwo+XOvuGc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75474	uniprotkb:P23508	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998510|imex:IM-21669-338	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:0DE1FBEA3F43FE86|rigid:iFcP87VFubtY7HIFCLddI95Ljzk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23508	uniprotkb:Q9BXL5	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998523|imex:IM-21669-339	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:38386D5C00B01AF5|rigid:qR5eB4PLplcs1S4NNM9IayU/F0Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37058	uniprotkb:P23508	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998536|imex:IM-21669-340	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:3FDBA1D6DB07D483|rigid:xhiuluHOXv4MBvGYPxVrm8dDafs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23508	uniprotkb:Q9P1Z9	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998549|imex:IM-21669-341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:7FCB54FDB16196C0|rigid:kJODM/RZPxc7oab6o2bE/IQubdk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:P23508	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998562|imex:IM-21669-342	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:740113BF251A5DC7|rigid:XGuLD20R/52LbfNbRgZNh8okoPM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60468	uniprotkb:P23508	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998575|imex:IM-21669-343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:92772C30F0784784|rigid:yUFN7I+/iIVLb2/nET2qlOj+tNA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:P23508	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998588|imex:IM-21669-344	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:E450F43B3912AFCA|rigid:eGSsUTkjuxBDYLnC/wJBdte0JGE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:P23508	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998601|imex:IM-21669-345	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:E45251322C95CB4F|rigid:fgTYgBR4isdJBFTFc83C5WWguxs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P23508	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-307531|intact:EBI-28976081|ensembl:ENSP00000305617|uniprotkb:Q6ZR04|uniprotkb:D3DT05	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:crcm_human(display_long)|uniprotkb:MCC(gene name)|psi-mi:MCC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998614|imex:IM-21669-346	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	ensembl:ENSG00000171444(gene)|ensembl:ENST00000302475(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019536|interpro:IPR040171|mint:P23508|rcsb pdb:6MTU|rcsb pdb:6MTV|ensembl:ENSP00000305617|ensembl:ENST00000408903|ensembl:ENSP00000386227|refseq:NP_001078846.1|refseq:NP_002378.1|dip:DIP-27599N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:zvmoD6/L4gqN193+FUqkECxbiTQ9606	intact-crc:1C44F6B2698215CD|rigid:4u7wyw2OVOOwMHjVvSq1cXsiSfQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:P05062	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998627|imex:IM-21669-347	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:2D8DBA3933AD9CAF|rigid:uqLrDlxup99NynWX5ygLirMJ0RM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P40692	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998640|imex:IM-21669-348	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:5EEA24E9CAB32F12|rigid:daxgb3QYKFCaiFN7SYAr0WAl3cA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:Q9BU70	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998653|imex:IM-21669-349	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:53E6B1AE8915C2E3|rigid:Vg3hGAmi2thzZmrJ0iHcNfd1JDs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60911	uniprotkb:P40692	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998666|imex:IM-21669-350	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:53C0C69C1B753DFA|rigid:08IIPRtygNyYsMlElAqfH3YgcTk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:P40692	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998679|imex:IM-21669-351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:A746210E9A571BE2|rigid:f+8sSbluABnfM4EUPFgq4N6P8ss	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:O75474	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998692|imex:IM-21669-352	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	intact-crc:4D3C622CFC826E4E|rigid:XUCBSfi0KMbr210tXkh7K7idmjY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:Q9P1Z9	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998705|imex:IM-21669-353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:4C8421A198DBF3E7|rigid:Ds4SUdg1kThIvmVvSgn7m2QVsrc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJU2	uniprotkb:P40692	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998718|imex:IM-21669-354	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:7BAC16AF9FC9C642|rigid:ROHqlESk742O6Cq6iwhyjtBQLT0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:P40692	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998731|imex:IM-21669-355	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:3632D2ACF454B8C5|rigid:wbyo8cJxXIuhU7UZuV/7OazTSTw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:P40692	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998744|imex:IM-21669-356	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:3EFCF57C54E8BC36|rigid:+zQpXbqhy46nnjyjtlUHlQuUBnM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:P56962	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998757|imex:IM-21669-357	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:AA8025A7DE597F76|rigid:ILJpl5KvsYKL6iK4zjPe+OOr4W8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHU6	uniprotkb:P40692	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998770|imex:IM-21669-358	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:953D35758AACB6D2|rigid:sCWasqov/FaCYeWGNLBep6xG1MM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:P23025	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998783|imex:IM-21669-359	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:D294A9EE45919C39|rigid:RBxjYUOZnrob19hTO7j24AOX1/g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31749	uniprotkb:Q9UHC1	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998796|imex:IM-21669-360	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:916C1A473C6943FA|rigid:a/ucMRGpwPi58vLA50jCChCEVWc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05062	uniprotkb:Q9UHC1	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998809|imex:IM-21669-361	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:5AE540A1D8A40040|rigid:6Gm6t56boEOw6UOz+m3Hj+4FAtA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:Q92688	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998822|imex:IM-21669-362	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:63506D14E794C0F4|rigid:J0jajFY5ai3utETsi9iBLmmxp6s	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:Q9UHC1	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998836|imex:IM-21669-363	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:4F0E6770AABCE9A8|rigid:vEpugG1Kp0nRDtpcAlyHEN32diY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:Q9UHC1	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998849|imex:IM-21669-364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:1EB31EAE610B500C|rigid:/rr6NFs4mwDPCkpB58yCC8CvGwM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:Q9UHC1	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998862|imex:IM-21669-365	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:3B033CAAFD0A311C|rigid:yOms8IzYr6kVyUlA7DllFUgtOWk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:Q9UHC1	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998875|imex:IM-21669-366	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:3CBC6DA82C14033E|rigid:/CziuhhuBX6Z4cxOPxe2DRYyS4s	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60729	uniprotkb:Q9UHC1	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998888|imex:IM-21669-367	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:F1E402B049CD4B87|rigid:Eyk9pmFPoFsraZiQVIlzw4qRaMI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:P49336	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998901|imex:IM-21669-368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:B87984BBBD93351D|rigid:qokCXnTihH0+EWbEQjjdW+rNi/0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:O60911	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998914|imex:IM-21669-369	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	intact-crc:B6AF3914EC664EEA|rigid:P7N/6FwtUravEMdjQgFQ+PKuF6Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:Q9UHC1	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998927|imex:IM-21669-370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:60629105A4536106|rigid:cfzJTFaTA1brST6BXaJ5F2VUQa8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14640	uniprotkb:Q9UHC1	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998940|imex:IM-21669-371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:47D5DDEE81585A91|rigid:JIsNSIepzaFavmmWPOpebwkxkCQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:Q9UHC1	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998953|imex:IM-21669-372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:0D9B2FDDA828C760|rigid:Zc21h7v/VC/92UQt0zpSyt/PQxw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:P09467	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998966|imex:IM-21669-373	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:A87EE506F6D9C011|rigid:9mwPl2QAk19zWjOgcpH/CuuGRgo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:Q9UHC1	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998979|imex:IM-21669-374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:B69B9FFA4F22979C|rigid:eI7U/cwKjq15P5q2HKvSmDFoCaI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75474	uniprotkb:Q9UHC1	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8998992|imex:IM-21669-375	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:3D4A81B9108357E1|rigid:QPo2drz+qkhA4ODw0vXH2BPorJU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:Q9UHC1	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999005|imex:IM-21669-376	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:D84BB567CD960FFD|rigid:uSIN3jh5uY98yafgaYNu5MvOd9I	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:Q9UHC1	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999031|imex:IM-21669-378	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:7728588308759F2E|rigid:6kc/ijsEe4ZwuFnl1uYAJ9rLa3U	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:Q9UHC1	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999018|imex:IM-21669-377	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:EBC2803F2F36E1A8|rigid:H9QPVUvXjbAT9qUEv3pDHWN+xt8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37058	uniprotkb:Q9UHC1	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999044|imex:IM-21669-379	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:A136142007ACFCD4|rigid:5sV2dAJrgUnnXp3a17qVCYlRS1U	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17936	uniprotkb:Q9UHC1	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999057|imex:IM-21669-380	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:302B2E3FFBECC9F6|rigid:Aj2ZUY3K5jA/aHp7DN5YVzognCc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:Q9P1Z9	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999070|imex:IM-21669-381	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:148215378E13DE48|rigid:bH9z+730pAq3QiHs6DJdQsZdkPY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJU2	uniprotkb:Q9UHC1	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999083|imex:IM-21669-382	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:F0B1DDE524DEBE5E|rigid:cpET/TGkGq7AeEQ8ueRuGHgkiT8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:Q02750	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999096|imex:IM-21669-383	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:957F8A4490016C4B|rigid:UKQodRYbST/OAFlWJXFg1U8F0TY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:Q9NR45	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999109|imex:IM-21669-384	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	intact-crc:7A9ABF3BBD415DAD|rigid:Vq4zjLvIc+R2fk0lcHoB463Tows	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:Q9UHC1	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999122|imex:IM-21669-385	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:F2945EED86A2BE99|rigid:j3B7fVKo5lp584OUggxmIcoJUJU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LZ3	uniprotkb:Q9UHC1	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999135|imex:IM-21669-386	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:966D661227DFF9BE|rigid:UUTv3eG2UFm/pnXX3qWBG06qGX0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:P20936	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999148|imex:IM-21669-387	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:76C1BA21F003129E|rigid:y4uAwir7p5+Lq+2tLA0vXifylnM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60468	uniprotkb:Q9UHC1	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999161|imex:IM-21669-388	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:15871319C72171D2|rigid:R/FTWkUXpJ7CQIeDUu+po/wXNVs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:Q9UHC1	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999174|imex:IM-21669-389	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:7BAEDAE3F43262F0|rigid:o0t+R8AgSLHWw7jcMmGhue0X65M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:Q15797	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999187|imex:IM-21669-390	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:3FA24D099BE12749|rigid:6wvfprTO9rqGf6oFDyLuk+83Jw0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:Q9UHC1	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999200|imex:IM-21669-391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:0796FA8582FC26C0|rigid:4A8JVn814MsfA2cBGM0EDYJq4jQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYX2	uniprotkb:Q9UHC1	intact:EBI-8994876|uniprotkb:B4DQ05|uniprotkb:Q9H6A2|uniprotkb:Q7L1K8|uniprotkb:Q8WYT1|uniprotkb:Q9NSH4|uniprotkb:Q6IPC7|uniprotkb:Q5TBQ5|uniprotkb:Q59EU0|uniprotkb:B9A6J7|uniprotkb:B3KWD1|ensembl:ENSP00000481721	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:tbd2a_human(display_long)|uniprotkb:TBC1D2(gene name)|psi-mi:TBC1D2(display_short)|uniprotkb:Armus(gene name synonym)|uniprotkb:PARIS1(gene name synonym)|uniprotkb:PP8997(gene name synonym)|uniprotkb:Prostate antigen recognized and identified by SEREX 1(gene name synonym)|uniprotkb:TBC1D2A(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999213|imex:IM-21669-392	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517145.1|refseq:NP_001254500.1|refseq:NP_001254501.1|refseq:NP_060891.3|ensembl:ENSG00000095383(gene)|ensembl:ENST00000465784(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:Q9BYX2|rcsb pdb:2DHK|reactome:R-HSA-8854214	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YBtho8cxmsRKBKR8FXiMQuQK5Uw9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:4BCCD29554F6793B|rigid:v4N45ZEYT44npt7YzgabePi5g34	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:Q8NHU6	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999226|imex:IM-21669-393	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:D7BAE97AD81E66AE|rigid:mObWCho8usF6csmYUmhF/sMcdw8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IYR6	uniprotkb:Q9UHC1	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999252|imex:IM-21669-395	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:D2F3E9FCA6547DF8|rigid:Ih4q/EsxE6kzn3PWk093pNT3C8c	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:P01137	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999239|imex:IM-21669-394	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:EFFE276F0052BE51|rigid:9ACLneDBvhkI8YwIJWAGjaSEWYk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:P28289	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999265|imex:IM-21669-396	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:090F87D4A6EC1F51|rigid:nJUkkQwl8xSaTqG52CNy0ceZb6M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHC1	uniprotkb:P23025	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999278|imex:IM-21669-397	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:65F24D7ABF9D4295|rigid:Fsy3hy6m6/SYIq/m6/95kQKIKI8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:Q9UHC1	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-3893094|uniprotkb:P49751|uniprotkb:Q56DK9|uniprotkb:Q9P292|uniprotkb:Q9UHC0|ensembl:ENSP00000348020	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:mlh3_human(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999291|imex:IM-21669-398	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	refseq:XP_016876708.1|refseq:XP_006720179.1|refseq:NP_001035197.1|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005712"(chiasma)|go:"GO:0006298"(mismatch repair)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007144"(female meiosis I)|go:"GO:0008104"(protein localization)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|reactome:R-HSA-912446|ensembl:ENSG00000119684(gene)|ensembl:ENST00000355774(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:8FpSX4YxQWxM9HBykG4bJME7HzQ9606	intact-crc:C48AE081A3CE58D2|rigid:EehjCr3RBrdJD3meUKKNcWYkrJo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31749	uniprotkb:P43246	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999304|imex:IM-21669-399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:104703EC15978270|rigid:CQAq/QpCAnNO7deApPLlxxyYc38	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43246	uniprotkb:O60729	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999317|imex:IM-21669-400	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	intact-crc:D6D416087D2B55EC|rigid:IEbxHBxCI7zv0dJ5e6wvGIDcVtY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43246	uniprotkb:O14640	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999330|imex:IM-21669-401	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:ECEBCB5EA8A146A2|rigid:Ms5zmHDGcYGnM/vPkiJ2aMV06vE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09467	uniprotkb:P43246	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999343|imex:IM-21669-402	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:0759FEB5CE3EF685|rigid:n0opE+4W5byR+IbkfL6N2MuDc88	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43246	uniprotkb:O00757	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999356|imex:IM-21669-403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	intact-crc:98BF965061DC8347|rigid:qsQpRlryRotRtnVQPxxR9m2044I	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:P43246	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999369|imex:IM-21669-404	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:47F20552E345B642|rigid:uBJ3bN2tI5C+H/8HUdlmAeiyFl8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:P43246	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999382|imex:IM-21669-405	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:E001452D3B9805D3|rigid:MQ3bynjm8fxdSMNdm5UHNZ8ZM78	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1Z9	uniprotkb:P43246	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999395|imex:IM-21669-406	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:EBBA682AEE8CF8F4|rigid:GSp1CJu5VlrPpAW63T0+OscdmxY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJU2	uniprotkb:P43246	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999408|imex:IM-21669-407	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:B2845734F3886EC4|rigid:3NoZjvH6QTf80FN9aTJtFdIkeCo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:P43246	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999434|imex:IM-21669-409	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:27DABAED3DBDAE03|rigid:km+QB/THV3LauM8idFFaIszkDdY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LZ3	uniprotkb:P43246	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999421|imex:IM-21669-408	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:58159127FBDBCE82|rigid:hgm4VEfpkt/z9mpdzxptfGvOSas	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43246	uniprotkb:P56962	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999447|imex:IM-21669-410	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:70B8773DA5065C97|rigid:CJxsTFl1yMtIBxMBXMAy/rgzJoU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43246	uniprotkb:Q8NHU6	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999460|imex:IM-21669-411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:461873E1E5ECCF93|rigid:oL9ztfNlX4Vn9AS+NvZwgtvuzZQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:P43246	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999473|imex:IM-21669-412	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:51A87A477388E5EB|rigid:F/OMi1OHQC4Sbjjsxp2Uzta0npM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:P52701	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-395529|uniprotkb:O43706|uniprotkb:O43917|uniprotkb:Q8TCX4|uniprotkb:Q9BTB5|ensembl:ENSP00000234420|uniprotkb:B4DF41|uniprotkb:B4E3I4|uniprotkb:F5H2F9	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:msh6_human(display_long)|uniprotkb:MSH6(gene name)|psi-mi:MSH6(display_short)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:GTBP(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999486|imex:IM-21669-413	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	refseq:NP_000170.1|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P52701|rcsb pdb:2GFU|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:6OQM|reactome:R-HSA-5358565|reactome:R-HSA-5632928|reactome:R-HSA-5632968|ensembl:ENSG00000116062(gene)|ensembl:ENST00000234420(transcript)|refseq:NP_001268421.1|refseq:NP_001268422.1|refseq:NP_001268423.1|dip:DIP-32972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:YPpiWmh4fSjXapWgA/rXbMrLAGg9606	intact-crc:9C2810CAEA46CE1C|rigid:abeLBv5KPsetHkTzYHbEc3mk0Lk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52701	uniprotkb:Q02750	intact:EBI-395529|uniprotkb:O43706|uniprotkb:O43917|uniprotkb:Q8TCX4|uniprotkb:Q9BTB5|ensembl:ENSP00000234420|uniprotkb:B4DF41|uniprotkb:B4E3I4|uniprotkb:F5H2F9	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:msh6_human(display_long)|uniprotkb:MSH6(gene name)|psi-mi:MSH6(display_short)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:GTBP(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999499|imex:IM-21669-414	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000170.1|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P52701|rcsb pdb:2GFU|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:6OQM|reactome:R-HSA-5358565|reactome:R-HSA-5632928|reactome:R-HSA-5632968|ensembl:ENSG00000116062(gene)|ensembl:ENST00000234420(transcript)|refseq:NP_001268421.1|refseq:NP_001268422.1|refseq:NP_001268423.1|dip:DIP-32972N	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YPpiWmh4fSjXapWgA/rXbMrLAGg9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:64399FCFE19B1D2F|rigid:2ucMY9CP/T+vEJ1cmaNDH1KkHeM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:P52701	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-395529|uniprotkb:O43706|uniprotkb:O43917|uniprotkb:Q8TCX4|uniprotkb:Q9BTB5|ensembl:ENSP00000234420|uniprotkb:B4DF41|uniprotkb:B4E3I4|uniprotkb:F5H2F9	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:msh6_human(display_long)|uniprotkb:MSH6(gene name)|psi-mi:MSH6(display_short)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:GTBP(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999512|imex:IM-21669-415	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	refseq:NP_000170.1|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P52701|rcsb pdb:2GFU|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:6OQM|reactome:R-HSA-5358565|reactome:R-HSA-5632928|reactome:R-HSA-5632968|ensembl:ENSG00000116062(gene)|ensembl:ENST00000234420(transcript)|refseq:NP_001268421.1|refseq:NP_001268422.1|refseq:NP_001268423.1|dip:DIP-32972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:YPpiWmh4fSjXapWgA/rXbMrLAGg9606	intact-crc:C691A471A7311744|rigid:YT0JEeiF4THBJVIZjbW9/HKucU8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:Q9UIF7	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999525|imex:IM-21669-416	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	intact-crc:DB44318DB95B1705|rigid:XAjSqegCzme0VKY916MwfZU2St8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:Q9UIF7	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999538|imex:IM-21669-417	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	intact-crc:EE4D6F4DF9FED18D|rigid:BtImBipoLYXmirEKdu2x1xNCDas	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:Q9UIF7	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999551|imex:IM-21669-418	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	intact-crc:12F0274834F1A035|rigid:0Zz6IZV9c2Mjl9YlrCHzNAqNA1E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:Q9UIF7	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999564|imex:IM-21669-419	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	intact-crc:8729C5F7B9AAB04E|rigid:Sk3cpxOKUqK9/rldVhvSSU9n0hs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIF7	uniprotkb:Q00597	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999577|imex:IM-21669-420	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:B9DF673FBBC65EC4|rigid:GDAMudmbp6HzvKZBEesMOfJegUM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIF7	uniprotkb:P01112	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999590|imex:IM-21669-421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:CD64167D0592E18A|rigid:F5yEUxcvRcAj+mkfnoeiXJk6brw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60468	uniprotkb:Q9UIF7	intact:EBI-1788819|uniprotkb:P38390|uniprotkb:P38391|uniprotkb:Q6IBC1|ensembl:ENSP00000223641	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:sc61b_human(display_long)|uniprotkb:SEC61B(gene name)|psi-mi:SEC61B(display_short)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999603|imex:IM-21669-422	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006799.1|dip:DIP-40997N|ensembl:ENSG00000106803(gene)|ensembl:ENST00000223641(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031205"(endoplasmic reticulum Sec complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671|mint:P60468|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339|reactome:R-HSA-9609523	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hmJI1Sb6h53BUHLoKTSJPyTbPF89606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	intact-crc:52C65DF2D2CD5CEB|rigid:kQBhJu2M5tt7SqHO4Sfzqgc6GX0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:Q9UIF7	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999616|imex:IM-21669-423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	intact-crc:72F309E49D1D5D67|rigid:2AKdUeWneihIl41yuZKDe0QBJPo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIF7	uniprotkb:Q8NHU6	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999629|imex:IM-21669-424	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:1AF1A792DFF5A62F|rigid:kLYoStVEtcdsuiojpsyLh5+GZcI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23025	uniprotkb:Q9UIF7	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999642|imex:IM-21669-425	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	intact-crc:02B71796B5685B25|rigid:zjcOUEoDYycOZMu+UtHx4nPKfqM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:P31749	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999655|imex:IM-21669-426	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:D6C6CD4777B3BC10|rigid:6AUUZ6eaSXvmgkAOH6DlDm+9eLU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05062	uniprotkb:P01111	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999668|imex:IM-21669-427	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:F01999ADC4F3AF83|rigid:pjGry1nRtbFCZae1ENA3WVxv4vc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:Q9BU70	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999681|imex:IM-21669-428	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:E251B633B9CFA446|rigid:t6j+bPL8FdiACXNFgoH6scwauww	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:P01111	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999694|imex:IM-21669-429	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:C6A4B543FB9568FD|rigid:tQm0RWX2kM/nDbymstnRivK82KE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92828	uniprotkb:P01111	intact:EBI-2835660|uniprotkb:Q92829|uniprotkb:Q5TBR5|uniprotkb:Q9BWS5|ensembl:ENSP00000343746|ensembl:ENSP00000364218	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:cor2a_human(display_long)|uniprotkb:CORO2A(gene name)|psi-mi:CORO2A(display_short)|uniprotkb:IR10(gene name synonym)|uniprotkb:WDR2(gene name synonym)|uniprotkb:WD repeat-containing protein 2(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999707|imex:IM-21669-430	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517288.1|refseq:NP_003380.3|refseq:NP_438171.1|ensembl:ENSG00000106789(gene)|ensembl:ENST00000343933(transcript)|ensembl:ENST00000375077(transcript)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027335|interpro:IPR036322|mint:Q92828|dip:DIP-59202N	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:SOiS8h0Kv33gF44syiD028dKduM9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:83EC06F18E769E94|rigid:AZFg/tkB5ETTLFK6MrDVp2y4hoc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:P01111	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999720|imex:IM-21669-431	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:A3EF3D8CB199BC96|rigid:o9UKnALJ6alNxRB8PzUXTQ+yUGY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:P01111	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999733|imex:IM-21669-432	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:B95782014DE52676|rigid:xWZNEemezfHZ1/w+0J3JiWnssFQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:O00757	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999746|imex:IM-21669-433	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	intact-crc:8226C82D170C6099|rigid:wGLJPArvBIRwin7BT9RfMdFYsHk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:O75474	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999759|imex:IM-21669-434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	intact-crc:67F6C97155A372B1|rigid:Wr3aLZJ8MWp5pasPn53H2AkiLYw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:P01111	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999772|imex:IM-21669-435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:33C1078014C10C28|rigid:w0dL4KLfV11LP3xsIcU9brlgcOw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P1Z9	uniprotkb:P01111	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999785|imex:IM-21669-436	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:8F2D3A22B00BC487|rigid:YZ9+NdKvrr4DVqnA+4Lp+dWiWGM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:Q9UJU2	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999798|imex:IM-21669-437	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	intact-crc:F60F093EBD1FA46E|rigid:zq654/PrqpbsUGtxf1vEqPSdvNo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16644	uniprotkb:P01111	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999811|imex:IM-21669-438	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:C53253FEF89E5D75|rigid:9zJ1TTHIVkAjJRZ/QVU6N6WBPOw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:P01111	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999824|imex:IM-21669-439	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:6882CD29DB89996D|rigid:loJLbS+qqe68ekP+1wLIm3VjSb0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:P20936	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999837|imex:IM-21669-440	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:ACF3AD6E1D231041|rigid:q0Y1buUB2KUUqH9pcIEbnZGF5qI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:P01111	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999850|imex:IM-21669-441	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:68A898E23061227F|rigid:MRmlY8E9ziP9OQjrdoaPQ5h7vcU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:Q15797	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999863|imex:IM-21669-442	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:5F50E9FA733DD3B0|rigid:2Oz6+rfqpXHTJiTT/2bOoMo4J2w	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:P01111	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999876|imex:IM-21669-443	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:16273F3DE29BBA53|rigid:9pBWbXTq9MYGFFRSwVNEslS6Wd0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01111	uniprotkb:Q8NHU6	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999889|imex:IM-21669-444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:799F3AF6BD6386BB|rigid:QeY/Wd1fG69enJKHv/N1HYvGG00	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23025	uniprotkb:P01111	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999902|imex:IM-21669-445	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:980BF48029B581ED|rigid:2ZJ+u9ZNxb+LIyEkWv9hggjlxNA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P11926	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999915|imex:IM-21669-446	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	intact-crc:2CD8B4AB60C1DCBB|rigid:6ooSSqHZFmFjywDTMpySR7mwbWU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:P11926	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999928|imex:IM-21669-447	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	intact-crc:EB3BD59C2D7D5ABD|rigid:UJJIN1yqc7AvevGMLeGNY4f5ouA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:P11926	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999941|imex:IM-21669-448	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	intact-crc:7D4F8654876E792B|rigid:DtQ3Ye7DUyf+UENtanNcA6dh6wc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11926	uniprotkb:Q02750	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999954|imex:IM-21669-449	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:CFDFCE10E87A9639|rigid:VABUZJDXIg06k1o6ejeg8LXh/qY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:P11926	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999967|imex:IM-21669-450	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	intact-crc:9D62E0AFB7C3526F|rigid:Bpc8rLX9b1u8a5RN7T07QtYEuHE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11926	uniprotkb:P56962	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999980|imex:IM-21669-451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:62A4B9F36D39A339|rigid:O+TviflRZROIuBtx/rt+VGEMxow	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHU6	uniprotkb:P11926	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8999993|imex:IM-21669-452	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	intact-crc:4507AF2725C5B26D|rigid:YZRI1BvlWuQQ+K8DTGVDxij1uy0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11926	uniprotkb:P28289	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000006|imex:IM-21669-453	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:C6EE87981B3FABCF|rigid:DHGYGOpGLVwChE5s76pEv3vn+BU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11926	uniprotkb:Q9Y2H8	intact:EBI-1044287|uniprotkb:Q6LDS9|ensembl:ENSP00000234111|ensembl:ENSP00000385333|uniprotkb:Q53TU3	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:dcor_human(display_long)|uniprotkb:ODC1(gene name)|psi-mi:ODC1(display_short)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000019|imex:IM-21669-454	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002530.1|ensembl:ENSG00000115758(gene)|ensembl:ENST00000234111(transcript)|ensembl:ENST00000405333(transcript)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:1D7K|rcsb pdb:2ON3|rcsb pdb:2OO0|rcsb pdb:4ZGY|rcsb pdb:5BWA|reactome:R-HSA-350562|reactome:R-HSA-351202|interpro:IPR002433(Ornithine decarboxylase)|refseq:NP_001274118.1|refseq:NP_001274119.1	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pOgmLLuK6aMc9YaPxjQdcs5PSwM9606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:E1B8BA84A5A06813|rigid:fMyc6SxQNohpX9BXVECcL7jWyn0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q14032	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000032|imex:IM-21669-455	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	intact-crc:C462798AECA74E9B|rigid:remNwretwuyfNKgvtlfnmpiEBGM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:O60911	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000045|imex:IM-21669-456	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	intact-crc:7AD625EDB3688D42|rigid:q+Dx5ovtGtFkj2kW/6ufCu345TI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q00597	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000058|imex:IM-21669-457	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:F5F32632E12EFE61|rigid:iegYb/9gbyjuIbuwJmg2nunQTUA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:O00757	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000071|imex:IM-21669-458	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	intact-crc:88E0931D1737767E|rigid:ce0GKi0+PEoIXFKe2fIl0ovWgBM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P01112	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000084|imex:IM-21669-459	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:0B4C49764B650810|rigid:F6pMwlV4EE3xKy2GCXJs5MTLa8o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q9P1Z9	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000097|imex:IM-21669-460	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:3E4B7FC802F01813|rigid:CYsS33DyUPTKNYndfn6GTrplres	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q02750	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000110|imex:IM-21669-461	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:1C0184B4D801E6C8|rigid:QZjrGPJaUilEaJn0CcsLcXrHewg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q16644	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000123|imex:IM-21669-462	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:A649191D55748265|rigid:t/EDdSBBVCJOquKiuBD8k/zsAjs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q9NR45	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000136|imex:IM-21669-463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	intact-crc:6994319A9A90E418|rigid:3KTDVYxLAIh+ZZe0jA4qWgNmF6I	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P62714	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000149|imex:IM-21669-464	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	intact-crc:86E65118D3A01147|rigid:LCYSUyNtZ8kX/ZgEEO6P2ePpOzc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q96LZ3	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000162|imex:IM-21669-465	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	intact-crc:0CFC9FD615BAC04D|rigid:nbIvhhl6BHGsXlfZdYqrQJyHTqI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q6FHJ7	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000175|imex:IM-21669-466	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:DEC6C201998B3BAC|rigid:X3P8H0MXPMogoG5ZHpQ20HjpfBs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q15797	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000188|imex:IM-21669-467	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:4239AF05D3DD9582|rigid:1g5RxD6T/+KIuI17/yAA7vbQ3iA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q9BYX2	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-8994876|uniprotkb:B4DQ05|uniprotkb:Q9H6A2|uniprotkb:Q7L1K8|uniprotkb:Q8WYT1|uniprotkb:Q9NSH4|uniprotkb:Q6IPC7|uniprotkb:Q5TBQ5|uniprotkb:Q59EU0|uniprotkb:B9A6J7|uniprotkb:B3KWD1|ensembl:ENSP00000481721	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:tbd2a_human(display_long)|uniprotkb:TBC1D2(gene name)|psi-mi:TBC1D2(display_short)|uniprotkb:Armus(gene name synonym)|uniprotkb:PARIS1(gene name synonym)|uniprotkb:PP8997(gene name synonym)|uniprotkb:Prostate antigen recognized and identified by SEREX 1(gene name synonym)|uniprotkb:TBC1D2A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000201|imex:IM-21669-468	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:XP_011517145.1|refseq:NP_001254500.1|refseq:NP_001254501.1|refseq:NP_060891.3|ensembl:ENSG00000095383(gene)|ensembl:ENST00000465784(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:Q9BYX2|rcsb pdb:2DHK|reactome:R-HSA-8854214	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:YBtho8cxmsRKBKR8FXiMQuQK5Uw9606	intact-crc:62430F240BC6D6F5|rigid:BXlRlLKdQpX2zgJuyFoqDl63UVk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P01137	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000214|imex:IM-21669-469	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:35962C885D562AEE|rigid:YpTl3Qlrn7zy/uc1DoA2mTMdlDw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:P23025	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000227|imex:IM-21669-470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:3B924A9AEA879F12|rigid:QhsESpi5ahKkg13kxChRdlTTvCg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15198	uniprotkb:Q9Y2H8	intact:EBI-8994158|uniprotkb:A8K085|uniprotkb:Q6FH04|ensembl:ENSP00000251630|ensembl:ENSP00000444211	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:pgfrl_human(display_long)|uniprotkb:PDGFRL(gene name)|psi-mi:PDGFRL(display_short)|uniprotkb:PDGF receptor beta-like tumor suppressor(gene name synonym)|uniprotkb:PRLTS(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000240|imex:IM-21669-471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006198.1|ensembl:ENSG00000104213(gene)|ensembl:ENST00000251630(transcript)|ensembl:ENST00000541323(transcript)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042495|mint:Q15198	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:bQP5Egk8chyxXg+YtjNHI371i789606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:255174A694F6F8BD|rigid:zdKDggQ3S404Tpo2xqMconnVyZY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42336	uniprotkb:Q00597	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000253|imex:IM-21669-472	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:D7B7C22E17078B5F|rigid:FEoykoTGUhO6Iuz9wUCu+mY97zo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:P42336	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000266|imex:IM-21669-473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	intact-crc:E68F1676EC371E2E|rigid:vRO/AuD80yDQpKqquTP0k02eLuo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:P42336	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000279|imex:IM-21669-474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	intact-crc:35ACA7C4B5B27090|rigid:6+bPO/Jc+iuze460rUrcl7O+9HU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:P42336	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000292|imex:IM-21669-475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	intact-crc:B3A705E5373BB1FF|rigid:aiqVPUfLNA2FtXpzMpBoOCra/p4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42336	uniprotkb:Q6FHJ7	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000305|imex:IM-21669-476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:3C59C3DB6781CF5F|rigid:cbSV0tmUH5LBYBCYJ1DP6Z84PoE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:P42336	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000318|imex:IM-21669-477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	intact-crc:031169A6F5FD228F|rigid:+zfX50LwV9+sc7/k6HpvDid9Qqo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42336	uniprotkb:P28289	intact:EBI-2116585|uniprotkb:Q14CW1|uniprotkb:Q99762|ensembl:ENSP00000263967	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	psi-mi:pk3ca_human(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:PIK3CA(gene name)|psi-mi:PIK3CA(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase alpha(gene name synonym)	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000331|imex:IM-21669-478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511196.1|refseq:XP_006713721.1|refseq:NP_006209.2|dip:DIP-42728N|ensembl:ENSG00000121879(gene)|ensembl:ENST00000263967(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001944"(vasculature development)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043276"(anoikis)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|mint:P42336|rcsb pdb:2ENQ|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3ZIM|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4TUU|rcsb pdb:4TV3|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5DXT|rcsb pdb:5FI4|rcsb pdb:5ITD|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|rcsb pdb:5SX9|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBR|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5UL1|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6GVF|rcsb pdb:6GVG|rcsb pdb:6GVH|rcsb pdb:6GVI|rcsb pdb:6NCT|rcsb pdb:6OAC|rcsb pdb:6PYS|rcsb pdb:6VO7|rcsb pdb:7JIU|rcsb pdb:7K6M|rcsb pdb:7K6N|rcsb pdb:7K6O|rcsb pdb:7K71|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-180292|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9009391|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9027276|reactome:R-HSA-9028335|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|rcsb pdb:5DXH|reactome:R-HSA-9703465|reactome:R-HSA-9703648	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:YIZWt9VfCmyBCWYkqAEaMAEsl3w9606	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	intact-crc:B7936C831C37B2B2|rigid:MRLS9yschrvrwyH8+TBT5jl2RLI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31749	uniprotkb:P54278	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000344|imex:IM-21669-479	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	intact-crc:D3AE750629AA26A2|rigid:k4mUFGTQ0H8wkfmKaDMykgmZXms	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:P54278	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000357|imex:IM-21669-480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	intact-crc:8DA22F26196D25C4|rigid:zjajHJREwvO6wdtf8OnCGKiHrhU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BU70	uniprotkb:P54278	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000370|imex:IM-21669-481	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	intact-crc:E6248CBDF7ED23B4|rigid:35Ub/5l92MpIbK2p8r12McY5blY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:P54278	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000383|imex:IM-21669-482	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	intact-crc:9D2DB78F05C9AE7A|rigid:QatzyhvLyYYGfaMk8pJYiUKqNjo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:P54278	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000414|imex:IM-21669-483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	intact-crc:4E1074D5ECE153F6|rigid:QKXZVZy7HXSwJSaBsO9ZD2TdMRE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54278	uniprotkb:Q9P1Z9	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000427|imex:IM-21669-484	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:B85F14AEF53AFC9B|rigid:q+rNAl3qLRyXHVzUOp9hXqF+C3Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:P54278	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000440|imex:IM-21669-485	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	intact-crc:58E7E3B48FB737A6|rigid:7SQ/CJM5ZEodKwNSaiIz+ImtkRc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54278	uniprotkb:P20936	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000453|imex:IM-21669-486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:CF0AD771FDD7AD6B|rigid:ni70m2mVHV0vF6ADeCAguYYI+9g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54278	uniprotkb:Q6FHJ7	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000466|imex:IM-21669-487	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:7CDAA56C6E46BCAA|rigid:8KxwpglgIh0BsLY/7Nps1V4+8M4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54278	uniprotkb:P23025	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000479|imex:IM-21669-488	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:AC212835B6508592|rigid:LCIjCiwr+5zs9T2AxVoYBBjKjsc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P54278	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000492|imex:IM-21669-489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	intact-crc:483EF6BA5A8A9D6C|rigid:9xvUVdXqRiUFV9+/EBODVi2qj9E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:P60484	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000505|imex:IM-21669-490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	intact-crc:4A37BB918366B95B|rigid:l2sumtDCqEQP+j47v6pko9xhmF4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60484	uniprotkb:Q9BU70	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000518|imex:IM-21669-491	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:F0B1090F79FEC9EF|rigid:I0PNvkl34YWmAm9iQKwsbrLoL78	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60484	uniprotkb:Q9P1Z9	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000531|imex:IM-21669-492	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:DAC58A166027D6C2|rigid:5GwNb3JRy91br8KOGB3ENH7M3vU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IYR6	uniprotkb:P60484	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000544|imex:IM-21669-493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	intact-crc:6E84CB8FBA874AFD|rigid:Fl9MKjBdHI7sBxJyabMHNo3rT8E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05209	uniprotkb:Q92688	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000557|imex:IM-21669-494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	intact-crc:2A517403623DF9DA|rigid:EnEr3kkO4fqrjFWOPMy1S9i2OPY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05209	uniprotkb:Q00597	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000570|imex:IM-21669-495	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:428FC5A99E65432B|rigid:jRwk6jvnxMMZvz8BJer0UP5TTHs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75474	uniprotkb:Q05209	intact:EBI-6256130|ensembl:ENSP00000360058|uniprotkb:Q5JTI0|uniprotkb:Q8WUL9|uniprotkb:Q9BYG2	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	psi-mi:frat2_human(display_long)|uniprotkb:FRAT2(gene name)|psi-mi:FRAT2(display_short)|uniprotkb:Frequently rearranged in advanced T-cell lymphomas 2(gene name synonym)	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000583|imex:IM-21669-496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181274(gene)|ensembl:ENST00000371019(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR008014(Glycogen synthase kinase-3 binding protein)|interpro:IPR039202|reactome:R-HSA-196299|reactome:R-HSA-4641262|refseq:NP_036215.1	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:2UaN6aA5uPWatygaU1dEKzv9DxY9606	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	intact-crc:DF4F67CE36DB090B|rigid:Y+CoNxHG1uNLOOi3CtfQhsa83e8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05209	uniprotkb:Q9P1Z9	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000596|imex:IM-21669-497	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:35B55C998577764B|rigid:qAlXL/ny7VoG8/OmYW4/l+WoZ5w	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LZ3	uniprotkb:Q05209	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000609|imex:IM-21669-498	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	intact-crc:B217BC8E8225FD93|rigid:AaEyC3VFJWTMwuF2geBNW12/oV4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6FHJ7	uniprotkb:Q05209	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000622|imex:IM-21669-499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	intact-crc:7820E453150290B5|rigid:wQdVX3Vfs7SRgehdexMhG8PDGtw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29353	uniprotkb:Q05209	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000635|imex:IM-21669-500	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	intact-crc:66FC85F0809E9A1E|rigid:D3G0LoqGtmPdrm1MqqQ2MDDRbd4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:Q05209	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000648|imex:IM-21669-501	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	intact-crc:4AC49C465A5D343D|rigid:c4CgeEah3TK/A7loUh8qXO7ZV3k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:Q05209	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000661|imex:IM-21669-502	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	intact-crc:AB9110E9B2A6C9F6|rigid:Y0aai62RZ5/6+YpicoI/ktcCmBI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05209	uniprotkb:Q9Y2H8	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000674|imex:IM-21669-503	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:F4A250EA036DA6E6|rigid:3C5tcX0EVvmZA9jEKM0HsaMqLAQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:Q12913	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000687|imex:IM-21669-504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:5F1211866F4F1BBC|rigid:3xJ8gxvGfKxLH/EwY/OCqGQRhL0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:Q12913	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000700|imex:IM-21669-505	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:3788295ADC7121FA|rigid:5B9ea58x8fv5HsZf04t3mJyOX2s	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12913	uniprotkb:Q9BU70	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000713|imex:IM-21669-506	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:A189BA1981DBBF84|rigid:mcCyE2PmW+Tnf4+htCVrQBwy5xI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:Q12913	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000726|imex:IM-21669-507	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:1E7B46778ACEB7F1|rigid:30oM4t5DcyL9BJtPDvvEoEXe8Ps	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:Q12913	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000739|imex:IM-21669-508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:308197EE719C3497|rigid:fdcXFwyy8N1OBVoODoZS0JV/sm0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12913	uniprotkb:P09467	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000752|imex:IM-21669-509	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:9C755533296A36A1|rigid:sRqNjkuqyxmUK4KmytFbj5i6r8M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12913	uniprotkb:Q9BXL5	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000765|imex:IM-21669-510	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:A21313AB2BD527EE|rigid:o5Grl4XfQphaIAy/uPjmHLnC5X8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:Q12913	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000778|imex:IM-21669-511	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:EB21F2B3D1D5FCDF|rigid:YHGKEQ76JV+PAIQpCClPEhnlZl4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:Q12913	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000791|imex:IM-21669-512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:897A2C6351B03042|rigid:uXGN6u7E4ThBl4Cs1583gbDijUU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:Q12913	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000804|imex:IM-21669-513	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:513179581364782D|rigid:JD4msRy/sdeCV7kCWvb3jMyjlpM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:Q12913	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000817|imex:IM-21669-514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:6F92EAC7570CA9EF|rigid:qo/SlbyPmehCCO0ScnwDk7TMmLQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LZ3	uniprotkb:Q12913	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000830|imex:IM-21669-515	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:6A47D7029D597394|rigid:9jCY+RlYopJ3bkwOY265HJUAnzw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12913	uniprotkb:P20936	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000843|imex:IM-21669-516	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:2CCB15112BB7E2FB|rigid:WTWjMU5EKXi5hMZhA7LsQmz8qQ8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12913	uniprotkb:Q6FHJ7	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000856|imex:IM-21669-517	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:AD6F9DD6116105D2|rigid:JkXGFKvxZ4e3wh6X7iKEnGfIkpQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IYR6	uniprotkb:Q12913	intact:EBI-8994549|uniprotkb:Q13086|uniprotkb:Q8N3T8|ensembl:ENSP00000364013	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	psi-mi:teff1_human(display_long)|uniprotkb:TMEFF1(gene name)|psi-mi:TMEFF1(display_short)|uniprotkb:C9orf2(gene name synonym)|uniprotkb:H7365(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and one follistatin-like domain(gene name synonym)	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000869|imex:IM-21669-518	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185741.1|refseq:NP_003683.2|ensembl:ENSG00000241697(gene)|ensembl:ENST00000374879(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|mint:Q8IYR6	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:IgTcpiVfHAutuJbz58gFuLN/X3A9606	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	intact-crc:DBB474965BB650FC|rigid:hbkmx2nu8rkVGm4PlMykmKtNYyM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12913	uniprotkb:Q9Y2H8	intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000882|imex:IM-21669-519	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:D4E4356F1C0186DB|rigid:XfllGiDf2RvFvmf95aBnSKOh1PY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:Q9Y620	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-740830|ensembl:ENSP00000336606|uniprotkb:F6WBS8	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:ra54b_human(display_long)|uniprotkb:RAD54 homolog B(gene name synonym)|uniprotkb:RAD54B(gene name)|psi-mi:RAD54B(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000895|imex:IM-21669-520	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	refseq:NP_001192192.1|refseq:NP_036547.1|ensembl:ENSG00000197275(gene)|ensembl:ENST00000336148(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042493"|interpro:IPR000330(SNF2-related)|go:"GO:0070615"|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:iTt59TOYXOu8h7jjuydTUtcBcpg9606	intact-crc:46529D9F80A64CEA|rigid:S7JPNolgDLs1dHHV0UCFy9iwjRk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BU70	uniprotkb:Q9Y620	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-740830|ensembl:ENSP00000336606|uniprotkb:F6WBS8	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:ra54b_human(display_long)|uniprotkb:RAD54 homolog B(gene name synonym)|uniprotkb:RAD54B(gene name)|psi-mi:RAD54B(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000908|imex:IM-21669-521	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	refseq:NP_001192192.1|refseq:NP_036547.1|ensembl:ENSG00000197275(gene)|ensembl:ENST00000336148(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042493"|interpro:IPR000330(SNF2-related)|go:"GO:0070615"|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:iTt59TOYXOu8h7jjuydTUtcBcpg9606	intact-crc:F34C5E42313183E3|rigid:pKVjGS2Tc9Uld9QGmDu7zP7ZIIA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y620	uniprotkb:P17936	intact:EBI-740830|ensembl:ENSP00000336606|uniprotkb:F6WBS8	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	psi-mi:ra54b_human(display_long)|uniprotkb:RAD54 homolog B(gene name synonym)|uniprotkb:RAD54B(gene name)|psi-mi:RAD54B(display_short)	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000921|imex:IM-21669-522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192192.1|refseq:NP_036547.1|ensembl:ENSG00000197275(gene)|ensembl:ENST00000336148(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042493"|interpro:IPR000330(SNF2-related)|go:"GO:0070615"|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:iTt59TOYXOu8h7jjuydTUtcBcpg9606	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	intact-crc:C36AC3C3C8E5E589|rigid:E2sm7BW4WKTG6NafkJ/A/IeQ9YU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:Q9Y620	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-740830|ensembl:ENSP00000336606|uniprotkb:F6WBS8	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:ra54b_human(display_long)|uniprotkb:RAD54 homolog B(gene name synonym)|uniprotkb:RAD54B(gene name)|psi-mi:RAD54B(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000934|imex:IM-21669-523	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	refseq:NP_001192192.1|refseq:NP_036547.1|ensembl:ENSG00000197275(gene)|ensembl:ENST00000336148(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006312"(mitotic recombination)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042493"|interpro:IPR000330(SNF2-related)|go:"GO:0070615"|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:iTt59TOYXOu8h7jjuydTUtcBcpg9606	intact-crc:26ED2B00DE2C999E|rigid:hgM6NOBOlSVZxMqikAaVKIShU6o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P06400	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000947|imex:IM-21669-524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:717B31D952C8C88D|rigid:WzlxzhfzWhlTe9BQdk5/r9MSi1k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:Q9BU70	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000960|imex:IM-21669-525	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:D86BBC931265CD8A|rigid:qFgO6XEnfmgKD175XaJzPp++VjQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:Q92828	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-2835660|uniprotkb:Q92829|uniprotkb:Q5TBR5|uniprotkb:Q9BWS5|ensembl:ENSP00000343746|ensembl:ENSP00000364218	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:cor2a_human(display_long)|uniprotkb:CORO2A(gene name)|psi-mi:CORO2A(display_short)|uniprotkb:IR10(gene name synonym)|uniprotkb:WDR2(gene name synonym)|uniprotkb:WD repeat-containing protein 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000973|imex:IM-21669-526	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:XP_011517288.1|refseq:NP_003380.3|refseq:NP_438171.1|ensembl:ENSG00000106789(gene)|ensembl:ENST00000343933(transcript)|ensembl:ENST00000375077(transcript)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027335|interpro:IPR036322|mint:Q92828|dip:DIP-59202N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:SOiS8h0Kv33gF44syiD028dKduM9606	intact-crc:FFC61A502AD3B504|rigid:9G7JPfzVkw+fU31dA3pxLMscDXs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:O60911	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000986|imex:IM-21669-527	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	intact-crc:0D9EDFC49E83BF3D|rigid:feMSCPfifrrogGLA8PK1p/MWUI8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14640	uniprotkb:P06400	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9000999|imex:IM-21669-528	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:ECEE313CE9A73911|rigid:UnpK8MlvUzsOzZ5Ik8iwEHX/yyA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:P06400	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001012|imex:IM-21669-529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:E07E98ACE45DF8A8|rigid:0KAJtxpBbEjkizuZLnLBeoFuwQ8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:P09467	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001025|imex:IM-21669-530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:B445B284DEFD5DB4|rigid:ogbAvUVnKbd5VSByCXVo/sceHa0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:P06400	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001038|imex:IM-21669-531	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:50A6782A35C282D0|rigid:tS9X0iBVWxdEiWGJPinGELenELY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:P06400	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001051|imex:IM-21669-532	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:97575BF00F7BE225|rigid:8H7l+Y32MJSStFO7WOBQFrTWBF4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:Q9P1Z9	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001064|imex:IM-21669-533	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:681E349F12A4DC98|rigid:K6/uC8crENeRtChRaYs4yx5Q1YU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:Q9UJU2	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001077|imex:IM-21669-534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	intact-crc:833801941AAF171E|rigid:fI2lNXBQuudDd7XDrjUNMiMeYjE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16644	uniprotkb:P06400	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001090|imex:IM-21669-535	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	rogid:xidCNX96KlQzu160polvT61k4Zw9606	intact-crc:87055C535D36ED9C|rigid:Dn029MrZ1v88B7Scsu/trhnbTUU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:P20936	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001103|imex:IM-21669-536	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:6CC6A2D8A3903D10|rigid:8Yb062jBLEy/ZdHKXwuV+7/2bWc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:P29353	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001116|imex:IM-21669-537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:BEF602B6A40BF71A|rigid:3Y9F5dZE8dr0BWeE/uI92OJre74	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:P56962	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001129|imex:IM-21669-538	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:D01D299B52390485|rigid:pCEd2JZqusLoevRT02a317tRuTs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06400	uniprotkb:P23025	intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001142|imex:IM-21669-539	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xidCNX96KlQzu160polvT61k4Zw9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:D22DE223841FB0D4|rigid:+usakPZpwdBXziF36VD6sGdI2Zw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31749	uniprotkb:Q15796	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001155|imex:IM-21669-540	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:5A19813949985209|rigid:kGdCgv2tzyy+DdLiyhC9mBr+38Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15796	uniprotkb:Q9BU70	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001168|imex:IM-21669-541	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:2B0E51BE21A8F04E|rigid:P5Xi2y6luY0ngeNO281cw9sa9xQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92828	uniprotkb:Q15796	intact:EBI-2835660|uniprotkb:Q92829|uniprotkb:Q5TBR5|uniprotkb:Q9BWS5|ensembl:ENSP00000343746|ensembl:ENSP00000364218	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:cor2a_human(display_long)|uniprotkb:CORO2A(gene name)|psi-mi:CORO2A(display_short)|uniprotkb:IR10(gene name synonym)|uniprotkb:WDR2(gene name synonym)|uniprotkb:WD repeat-containing protein 2(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001181|imex:IM-21669-542	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517288.1|refseq:NP_003380.3|refseq:NP_438171.1|ensembl:ENSG00000106789(gene)|ensembl:ENST00000343933(transcript)|ensembl:ENST00000375077(transcript)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027335|interpro:IPR036322|mint:Q92828|dip:DIP-59202N	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:SOiS8h0Kv33gF44syiD028dKduM9606	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:85ADE076120271FF|rigid:vN+0Tjl5gUTD99IG4IGVzwSfUpE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:Q15796	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001194|imex:IM-21669-543	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:B00B0D77C6BE5815|rigid:MkQ57oRTzg4iePopBQiliJVXbRg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:Q15796	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001207|imex:IM-21669-544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:73FD19992BDABD0F|rigid:zoESf/m8omw+WCp5iakPxZ47Csk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15796	uniprotkb:P37058	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	intact:EBI-2932988|ensembl:ENSP00000364412|uniprotkb:Q5U0Q6	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:dhb3_human(display_long)|uniprotkb:HSD17B3(gene name)|psi-mi:HSD17B3(display_short)|uniprotkb:EDH17B3(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase type 3(gene name synonym)|uniprotkb:Testicular 17-beta-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 2(gene name synonym)|uniprotkb:SDR12C2(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001220|imex:IM-21669-545	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	ensembl:ENSG00000130948(gene)|ensembl:ENST00000375263(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030539"(male genitalia development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061370"(testosterone biosynthetic process)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR033281|interpro:IPR036291|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0047045"("testosterone 17-beta-dehydrogenase (NADP+) activity")|refseq:XP_011516920.1|refseq:XP_011516921.1|refseq:XP_016870160.1|refseq:XP_016870161.1|refseq:NP_000188.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	rogid:tDL/Q/3c7h9QRflFhXeGWlrcPfQ9606	intact-crc:65559647704515D7|rigid:+DTzt8mStWMeKB65fsOzXDwt3zQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:Q15796	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001233|imex:IM-21669-546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:BC0B022EE5FEEE25|rigid:SygVR2TGf3tPchWObH12jxAP21E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15796	uniprotkb:P20936	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001246|imex:IM-21669-547	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:75A33E5483EA57F9|rigid:W7mNjEqoSPLcD8We4eW0p3ajW9k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15796	uniprotkb:P23025	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001259|imex:IM-21669-548	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	intact-crc:DF93D31EC0763464|rigid:o/2iXQk4AaWlbzLfZfVgeNUUTck	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15796	uniprotkb:Q9Y2H8	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001272|imex:IM-21669-549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:7670D5C0A46CB4A8|rigid:QvoVFI3ao7CCW48ewqssHMFEnTs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05062	uniprotkb:Q13485	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001285|imex:IM-21669-550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:D2F5E03D61FE922E|rigid:QIec7w+9B//s/CD2fdYeOBqh5L0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:Q13485	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001298|imex:IM-21669-551	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:C0893A3A912EB791|rigid:NfO72YTbtd6pE9N83MKvRijd24s	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6M6	uniprotkb:Q13485	intact:EBI-8995274|uniprotkb:Q96M23|uniprotkb:Q5T9B3|uniprotkb:Q5T9B4|uniprotkb:Q96SS1|uniprotkb:Q5T9B1|uniprotkb:Q8WUL6|ensembl:ENSP00000364464	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:ampo_human(display_long)|uniprotkb:AOPEP(gene name)|psi-mi:AOPEP(display_short)|uniprotkb:C9orf3(gene name synonym)|uniprotkb:ONPEP(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001311|imex:IM-21669-552	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870719.1|refseq:XP_016870720.1|refseq:NP_001180258.1|refseq:NP_001180260.1|refseq:NP_116212.3|refseq:XP_006717369.1|ensembl:ENSG00000148120(gene)|ensembl:ENST00000375315(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR033577|interpro:IPR038502|interpro:IPR042097|reactome:R-HSA-2022377	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:olmZNkycowTYW3VOf45D8fTHtKs9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:9B79A71E9ECB255E|rigid:ulvxOjXVgYeeRRbmw8LScl9lVcs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96H12	uniprotkb:Q13485	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001324|imex:IM-21669-553	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	comment:mint|comment:homomint	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:3A49A6A4366EFE07|rigid:vqQwqrwENM0I0JmhUnpgCgB5eRw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5T7W7	uniprotkb:Q13485	intact:EBI-8994397|uniprotkb:Q8WY73|uniprotkb:Q6ZQZ6|uniprotkb:Q96ML6|uniprotkb:Q96MU1|uniprotkb:A6NMJ4|uniprotkb:A8K584|uniprotkb:Q8IYM3|ensembl:ENSP00000342499	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:tstd2_human(display_long)|uniprotkb:TSTD2(gene name)|psi-mi:TSTD2(display_short)|uniprotkb:C9orf97(gene name synonym)|uniprotkb:Rhodanese domain-containing protein 2(gene name synonym)|uniprotkb:PP4189(orf name)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001337|imex:IM-21669-554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_640339.4|ensembl:ENSG00000136925(gene)|ensembl:ENST00000341170(transcript)|interpro:IPR001763(Rhodanese-like)|interpro:IPR020936|interpro:IPR022111|interpro:IPR036873|interpro:IPR040503|mint:Q5T7W7	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BGPz78uJrnzSR+IWBIydtPxslUw9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:CE7D551BD68848A4|rigid:SqPKH8MjxDXu9i1mJUm2IvcVc5E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60729	uniprotkb:Q13485	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001350|imex:IM-21669-555	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:A1F5BB3CF48BE7DD|rigid:TOiM73a5CYubqp1hR6NdYU8cDpM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13485	uniprotkb:Q00597	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001363|imex:IM-21669-556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:3E9F804D0B777B28|rigid:FVfxFKsPIU1u+78i8IQtp5NjDqk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:Q13485	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001376|imex:IM-21669-557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:8C973160E87E6BD4|rigid:b2ME4MZemhKaTPK8TRanvuuXS9E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13485	uniprotkb:Q9BXL5	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001389|imex:IM-21669-558	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:970303D96D8FA046|rigid:u81VIPiyRsc187dW20QMj34jrAE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01112	uniprotkb:Q13485	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001402|imex:IM-21669-559	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:7C24F700BC26346F|rigid:B9qZynk+Ez0O2bOEVvq2q97uavA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13485	uniprotkb:Q9P1Z9	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001415|imex:IM-21669-560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:EFE73264C54F6FED|rigid:Oco9YOuN0oED6IAhJOVFTw0Xm/E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:Q13485	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001428|imex:IM-21669-561	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:459CF96931F76149|rigid:89uP3K3ifSg0nkZO2z33D3FaobA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LZ3	uniprotkb:Q13485	intact:EBI-3906025|uniprotkb:Q5VTR4|uniprotkb:Q7Z4V8|uniprotkb:Q8WYJ4|ensembl:ENSP00000363939	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:canb2_human(display_long)|uniprotkb:PPP3RL(gene name synonym)|uniprotkb:PPP3R1-like(gene name synonym)|uniprotkb:PPP3R2(gene name)|psi-mi:PPP3R2(display_short)|uniprotkb:CBLP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcineurin BII(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 2(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B beta isoform(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001441|imex:IM-21669-562	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_671709.1|ensembl:ENSG00000188386(gene)|ensembl:ENST00000374806(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:Q96LZ3	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8xugf2KUTBvGCgEcRVd/nqpD2Yw9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:B046C969D51F7171|rigid:BijqJ44ZUWxTJceMoT2RqPdGer4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HF1	uniprotkb:Q13485	intact:EBI-8994258|uniprotkb:Q9HAP5|uniprotkb:B3KQR2|uniprotkb:O14778|ensembl:ENSP00000274063	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:sfrp2_human(display_long)|uniprotkb:SFRP2(gene name)|psi-mi:SFRP2(display_short)|uniprotkb:FRP2(gene name synonym)|uniprotkb:SARP1(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)|uniprotkb:FKSG12(orf name)|uniprotkb:UNQ361/PRO697(orf name)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001454|imex:IM-21669-563	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003004.1|ensembl:ENSG00000145423(gene)|ensembl:ENST00000274063(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR036790|interpro:IPR041764|mint:Q96HF1|reactome:R-HSA-201681|reactome:R-HSA-3772470|interpro:IPR026558	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:b3K8GZvcYQ33QAarW786LiK848Q9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:10DFB9C666B78EFE|rigid:1u1S3CXT2S2KZRHg+lz6ipC8tNY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13485	uniprotkb:Q6FHJ7	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-2854879|uniprotkb:Q6FHM0|uniprotkb:Q6PD64|uniprotkb:O14877|uniprotkb:Q05BG7|uniprotkb:Q1ZYW2|uniprotkb:B4DYC1|uniprotkb:Q4G124|ensembl:ENSP00000410715	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:sfrp4_human(display_long)|uniprotkb:SFRP4(gene name)|psi-mi:SFRP4(display_short)|uniprotkb:FRPHE(gene name synonym)|uniprotkb:Frizzled protein, human endometrium(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001467|imex:IM-21669-564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	refseq:NP_003005.2|ensembl:ENSG00000106483(gene)|ensembl:ENST00000436072(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000119"(negative regulation of sodium-dependent phosphate transport)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026560|interpro:IPR036790|mint:Q6FHJ7|go:"GO:0002092"(positive regulation of receptor internalization)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:tN5GTld1BI//Zfm0kSeixyebS9U9606	intact-crc:31718AAA5C2FD1EC|rigid:A4rJhVImODAs2hpwfmKSB5ayg5M	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13485	uniprotkb:P29353	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001480|imex:IM-21669-565	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:4FFDC4001E9674D1|rigid:+vH1HKdYQD1uW7r+lgGqH73fkT8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13485	uniprotkb:Q15797	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001493|imex:IM-21669-566	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:mPu190hmySGV54KAtldys/IHuo89606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:B888E4B401767E15|rigid:p9fE9KQSdBzsx5uEluIc00Nq8/4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:Q13485	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001506|imex:IM-21669-567	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:C395450C29A83B52|rigid:t4yljS1ZKKAoo5/KqYTMZOyz1ps	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:Q13485	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001519|imex:IM-21669-568	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:4CF9227FFB129B9E|rigid:56LELdXqbZaHfUhoYuddk7LXg7I	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:Q13485	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001532|imex:IM-21669-569	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:D8E129164640F17D|rigid:Snr72ltCS8GUFZ6MAE6KWwci2Rs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12931	uniprotkb:P05062	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001545|imex:IM-21669-570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	intact-crc:65E49AAAB357FC58|rigid:8SwXd371M3SucxaN+mnaW04O+OM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14032	uniprotkb:P12931	intact:EBI-8994378|uniprotkb:Q3B7W9|uniprotkb:Q96L31|ensembl:ENSP00000259407|ensembl:ENSP00000378491|ensembl:ENSP00000484063|ensembl:ENSP00000501610	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:baat_human(display_long)|uniprotkb:BAAT(gene name)|psi-mi:BAAT(display_short)|uniprotkb:Glycine N-choloyltransferase(gene name synonym)|uniprotkb:Long-chain fatty-acyl-CoA hydrolase(gene name synonym)|uniprotkb:Bile acid-CoA thioesterase(gene name synonym)|uniprotkb:Choloyl-CoA hydrolase(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001558|imex:IM-21669-571	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121082.1|refseq:NP_001692.1|ensembl:ENSG00000136881(gene)|ensembl:ENSG00000276559(gene)|ensembl:ENST00000259407(transcript)|ensembl:ENST00000395051(transcript)|ensembl:ENST00000621712(transcript)|ensembl:ENST00000674556(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002152"(bile acid conjugation)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033882"(choloyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047963"(glycine N-choloyltransferase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0052816"(long-chain acyl-CoA hydrolase activity)|go:"GO:0052817"(very long chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|mint:Q14032|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-9033241	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:dJuEipo6mvt2RJDK5m0eoJp9MLk9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:475B84DDD398887F|rigid:LRXy9GXn2mKQ8ms/2w1yjajTj1Y	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12931	uniprotkb:Q9BU70	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001571|imex:IM-21669-572	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:64451D9D912DF587|rigid:ZLe0h+pslEIBFJFxPzRXBq4//qU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60911	uniprotkb:P12931	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001584|imex:IM-21669-573	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:ABAFF0158D84F7BB|rigid:pvAhB/cvBdyzE52Eorg4yBBiNeQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00597	uniprotkb:P12931	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001597|imex:IM-21669-574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:B64F3CAA6C1D2428|rigid:pBjcCbxcrf+HGK3aFWaBLp+wbuQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:P12931	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001610|imex:IM-21669-575	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:E88947F03DC917F1|rigid:AOmTt/n9Q0vXtTIt1LV2PTepqXY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXK2	uniprotkb:P12931	intact:EBI-8995375|uniprotkb:Q9H771|uniprotkb:Q96CT9|uniprotkb:Q8NG54|uniprotkb:Q5TCF7|ensembl:ENSP00000364150	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:glt12_human(display_long)|uniprotkb:GALNT12(gene name)|psi-mi:GALNT12(display_short)|uniprotkb:Polypeptide GalNAc transferase 12(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 12(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12"(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001623|imex:IM-21669-576	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078918.3|refseq:XP_006717350.1|ensembl:ENSG00000119514(gene)|ensembl:ENST00000375011(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:6PXU|reactome:R-HSA-5083636|reactome:R-HSA-913709	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:oepFg2esyZRNRyCv26oaVSJ1pDM9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:6B72E1F0973A1D33|rigid:3bBMN4WqKIl/RQmnKbUhnHCFXXE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12931	uniprotkb:Q9BXL5	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001636|imex:IM-21669-577	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	intact-crc:D1D8A53B213AF74B|rigid:/7fKvdIFhtjdHU9vj4K0UwIfw/A	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12931	uniprotkb:Q9P1Z9	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001649|imex:IM-21669-578	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:2027968997F5DDAF|rigid:2gLiWjevZO7H8b1Frr6o9yJJRPE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:P12931	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001662|imex:IM-21669-579	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:E35EEB75402CCD16|rigid:v1M16uHJwQVregWR8T/UgkdxYmo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12931	uniprotkb:Q16644	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001675|imex:IM-21669-580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:DD27F75CDA758EFB|rigid:f5k+c5mmig23v9u9BKNdsawH53E	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:P12931	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001688|imex:IM-21669-581	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:49E7D9DA0194207A|rigid:euvVeIb5sJrodBD0J1RHtjssmuQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62714	uniprotkb:P12931	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001701|imex:IM-21669-582	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:34857F94EB6F4AEF|rigid:IjTQkGNjc134FU9HCVq0BMcjVB4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56962	uniprotkb:P12931	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001714|imex:IM-21669-583	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:82349190D57E3EC5|rigid:itS2BmXO2Rb7/EYymuRn1AON7JE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23025	uniprotkb:P12931	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001727|imex:IM-21669-584	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:ED02412F124354B1|rigid:C7FV7Qk2XkCILgcoQWDB2SyXFM4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:P12931	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001740|imex:IM-21669-585	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:99FA58EF28BE416D|rigid:B/v7k0SrLxlJadeozMBXsU1tLC0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31749	uniprotkb:Q15831	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001753|imex:IM-21669-586	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:DCC3C7E2B6C5AA33|rigid:40Bo/CmarvaE9P0q3cKX/NwpPIo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05062	uniprotkb:Q15831	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001766|imex:IM-21669-587	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:B850880151094CCF|rigid:k6KN6xyAWH/BSWPKHBbRZnff+y8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:Q15831	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001779|imex:IM-21669-588	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:4F9D251A19E475DD|rigid:6WMTiaJ8QCULKRZMilGNJehL9AM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:Q9BU70	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001792|imex:IM-21669-589	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:CA06958FE7607B57|rigid:JikOosrNOfEEP5ku9QFn+o4Ll7o	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:O60729	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-970231|ensembl:ENSP00000364389|uniprotkb:A6N5X8|uniprotkb:O43183|uniprotkb:O60730|uniprotkb:Q5JU08|uniprotkb:B1AL31|uniprotkb:B1AL32|uniprotkb:A8MQ20	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:cc14b_human(display_long)|uniprotkb:CDC14B(gene name)|psi-mi:CDC14B(display_short)|uniprotkb:CDC14 cell division cycle 14 homolog B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001805|imex:IM-21669-590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	ensembl:ENSG00000081377(gene)|ensembl:ENST00000375241(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|mint:O60729|rcsb pdb:1OHC|rcsb pdb:1OHD|rcsb pdb:1OHE|reactome:R-HSA-5687128|refseq:NP_003662.1|refseq:NP_201588.1|refseq:XP_011517460.1|refseq:NP_001070649.1|refseq:XP_016870732.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:b0+v+nN2fk9Eo6xMg0SlaXHWQAA9606	intact-crc:B85ADA11DA75DDB9|rigid:frc+OF2xkkupt81WJR/n3vL/6ko	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14093	uniprotkb:Q15831	intact:EBI-8994688|uniprotkb:Q5VVJ9|uniprotkb:B2R8F4|ensembl:ENSP00000417674|ensembl:ENSP00000420256|ensembl:ENSP00000478399	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:cylc2_human(display_long)|uniprotkb:CYLC2(gene name)|psi-mi:CYLC2(display_short)|uniprotkb:CYL2(gene name synonym)|uniprotkb:Cylicin II(gene name synonym)|uniprotkb:Multiple-band polypeptide II(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001818|imex:IM-21669-591	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001331.1|ensembl:ENSG00000155833(gene)|ensembl:ENST00000374798(transcript)|ensembl:ENST00000487798(transcript)|ensembl:ENST00000612124(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0033150"(cytoskeletal calyx)|interpro:IPR026189|interpro:IPR029354|mint:Q14093	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:xJmO+t0UJk+iAtsHjag0dQrnSgk9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:C1C75AA729EA8032|rigid:tAWZWqwOH7n7vD/ldX8AO+gWtpE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:P09467	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001831|imex:IM-21669-592	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:41D924B471786639|rigid:McwlKuMsgt1yBwpK70sBYwdyAUo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00757	uniprotkb:Q15831	intact:EBI-719781|uniprotkb:Q17R39|uniprotkb:Q6FI53|ensembl:ENSP00000364486	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:f16p2_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 2(gene name synonym)|uniprotkb:FBP2(gene name)|psi-mi:FBP2(display_short)|uniprotkb:Muscle FBPase(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001844|imex:IM-21669-593	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003828.2|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:O00757|rcsb pdb:3IFA|rcsb pdb:3IFC|rcsb pdb:4HE0|rcsb pdb:4HE1|rcsb pdb:4HE2|rcsb pdb:5ET5|rcsb pdb:5ET6|rcsb pdb:5ET7|rcsb pdb:5ET8|rcsb pdb:5K54|rcsb pdb:5K55|rcsb pdb:5K56|rcsb pdb:5L0A|rcsb pdb:5Q0C|reactome:R-HSA-70263|ensembl:ENSG00000130957(gene)|ensembl:ENST00000375337(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:DffAdQb/uzOCHMWf3WDrQxUqMa49606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:49345050D18BF773|rigid:STXyjDDIO58ppLdM05/aeuZx1To	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:P01112	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001857|imex:IM-21669-594	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:599889339CC5E572|rigid:cFiI8L6ldicruTvMxqcaz5XfZ1g	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:P17936	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001870|imex:IM-21669-595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	intact-crc:9480FE887A422B45|rigid:9/K7Gei/uHRR7m3zPfhQaJeMBD8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:Q9P1Z9	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-8860070|intact:EBI-8995189|uniprotkb:Q2KHR6|uniprotkb:Q5VV25|uniprotkb:Q68DP5|uniprotkb:Q69YV9|uniprotkb:Q6AHY0	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:cc180_human(display_long)|uniprotkb:CCDC180(gene name)|psi-mi:CCDC180(display_short)|uniprotkb:C9orf174(gene name synonym)|uniprotkb:KIAA1529(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001883|imex:IM-21669-596	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	go:"GO:0070062"(extracellular exosome)|interpro:IPR026701|interpro:IPR028089|interpro:IPR027914|refseq:NP_065944.2	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2018/09/18	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:HQMcFcZ4h1H8T9GFJ2meyhN8HR49606	intact-crc:166C1E9BFAB075A0|rigid:OiO5UBRSM0nYpj+qUfpJgSxJ/vA	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:Q9UJU2	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-926131|uniprotkb:B4DG38|uniprotkb:Q3ZCU4|uniprotkb:Q9HAZ0|uniprotkb:B7Z8E2|uniprotkb:E9PDK3|ensembl:ENSP00000265165	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:lef1_human(display_long)|uniprotkb:LEF1(gene name)|psi-mi:LEF1(display_short)|uniprotkb:T cell-specific transcription factor 1-alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001914|imex:IM-21669-597	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001124185.1|refseq:NP_001124186.1|refseq:NP_001159591.1|refseq:NP_057353.1|ensembl:ENSG00000138795(gene)|ensembl:ENST00000265165(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|dip:DIP-29946N|go:"GO:0030879"(mammary gland development)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0042100"(B cell proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061153"(trachea gland development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028769|interpro:IPR036910|mint:Q9UJU2|reactome:R-HSA-201722|reactome:R-HSA-3769402|reactome:R-HSA-4086398|reactome:R-HSA-4411364|reactome:R-HSA-4641265|reactome:R-HSA-8853884|reactome:R-HSA-8951430|reactome:R-HSA-9616222|go:"GO:0140416"(transcription regulator inhibitor activity)	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:UWp+cETOgprhC0+wuj8BYycu2vU9606	intact-crc:504F3384F2B04717|rigid:qgCxMKeh0cDFPXVaXPvv9gPfpGw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:Q02750	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001927|imex:IM-21669-598	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:69C254F00AA38604|rigid:SH/NyiCqghEbFFc8Vi+acoZm1Dc	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:Q16644	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-1384657|uniprotkb:B5BU67|ensembl:ENSP00000350639|ensembl:ENSP00000396467|ensembl:ENSP00000478922	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:mapk3_human(display_long)|uniprotkb:Chromosome 3p kinase(gene name synonym)|uniprotkb:MAPKAPK3(gene name)|psi-mi:MAPKAPK3(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001940|imex:IM-21669-599	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_004626.1|refseq:NP_001230854.1|refseq:NP_001230855.1|reactome:R-HSA-2559580|reactome:R-HSA-4420097|reactome:R-HSA-450302|ensembl:ENSG00000114738(gene)|ensembl:ENST00000357955(transcript)|ensembl:ENST00000446044(transcript)|ensembl:ENST00000621469(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044351"(macropinocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR027442|mint:Q16644|rcsb pdb:3FHR|rcsb pdb:3FXW|rcsb pdb:3R1N|rcsb pdb:3SHE|reactome:R-HSA-171007	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:pb+7uZ1B8LMFi5DrfRi70X9Xbks9606	intact-crc:1D61745DAB2091E9|rigid:HLWdyOnu4268UkZYUN0+TXd1AI0	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:Q15831	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001953|imex:IM-21669-600	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:8EA35FD174DCD868|rigid:jI9Vhk+lWR9MRlL0r/icWkNwWig	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:P62714	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001966|imex:IM-21669-601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	intact-crc:99358B491A00104E|rigid:GnHzSLgbmyfjquxD+iR+zaQ94Ic	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20936	uniprotkb:Q15831	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001979|imex:IM-21669-602	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:B77F6A8E69B31B58|rigid:W8sPm1cV0duLhSSoKGeL5i4WmBU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:P56962	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9001992|imex:IM-21669-603	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:703C28350E49D130|rigid:BpGgzZhoK/u5GOkLQyeQtkc2Lpw	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:Q8NHU6	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002005|imex:IM-21669-604	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	intact-crc:94C41049F5CFDA2E|rigid:kmFZSuMJ2LqbWSAY1zsdtirKKWE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23025	uniprotkb:Q15831	intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002018|imex:IM-21669-605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:AA4897CA203DFE03|rigid:LkrY3sJV4RSfhov5L0WzfKhBc+Q	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75820	uniprotkb:Q15831	intact:EBI-8994926|uniprotkb:Q9UPF0|uniprotkb:Q9UPE9|uniprotkb:Q5T7D9|uniprotkb:Q5T7D7|uniprotkb:Q9UPF1|uniprotkb:O75802|uniprotkb:Q9UBL4|uniprotkb:Q5T7D8|ensembl:ENSP00000342019	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:zn189_human(display_long)|uniprotkb:ZNF189(gene name)|psi-mi:ZNF189(display_short)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002031|imex:IM-21669-606	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016870610.1|refseq:XP_011517300.1|refseq:NP_001265160.1|refseq:NP_001265161.1|refseq:NP_001265169.1|refseq:NP_003443.2|refseq:NP_932094.1|refseq:XP_006717343.1|refseq:XP_006717344.1|ensembl:ENSG00000136870(gene)|ensembl:ENST00000339664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:H50Il3ylj4nmo0SGSRCL0TbLrnA9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:A54B4E5BDAF83030|rigid:VuC6e7I1+VKoT6lFIneQP3w5HyI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	uniprotkb:Q9Y2H8	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002044|imex:IM-21669-607	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	intact-crc:5D7615E16FABFAF5|rigid:AuCAUeuY71iME8krcG94vSuJ9Hk	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37173	uniprotkb:Q9BU70	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002057|imex:IM-21669-608	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	intact-crc:441AA11CDFB22D4C|rigid:jgEQ9lICqzwF+OZ1+A8+1ivLHcQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37173	uniprotkb:Q00597	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002070|imex:IM-21669-609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606	intact-crc:DA1C8035359F131F|rigid:+Jv23Ens3wSbCo6RoLi+1FpESZ8	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37173	uniprotkb:Q02750	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002083|imex:IM-21669-610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:0A1C43FC14ACD799|rigid:g+dX7FWlvKeT64RnugGcGDgVLlI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37173	uniprotkb:P62714	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002096|imex:IM-21669-611	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	intact-crc:A3C8C618ABED4062|rigid:UzDrJ8WRYuvLCswY1rDIfO1cIxM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2H8	uniprotkb:P37173	intact:EBI-3050479|ensembl:ENSP00000223428|ensembl:ENSP00000364379|uniprotkb:Q5SZP5	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	psi-mi:zn510_human(display_long)|uniprotkb:ZNF510(gene name)|psi-mi:ZNF510(display_short)|uniprotkb:KIAA0972(gene name synonym)	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002109|imex:IM-21669-612	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000081386(gene)|ensembl:ENST00000223428(transcript)|ensembl:ENST00000375231(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q9Y2H8|reactome:R-HSA-212436|refseq:NP_055745.1|refseq:NP_001300988.1|refseq:XP_016869972.1	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:NgV6pjt/GhRvtO9sj+pnNg0pW6Q9606	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	intact-crc:D3682370577D215E|rigid:GV7C2LfXdqIhf0BCw0fnyRzfxDQ	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60603	uniprotkb:P31749	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002122|imex:IM-21669-613	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	intact-crc:5728A7E35146C8FC|rigid:UK5dVYIsN/Cfm9idQhqBJ1El6TY	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92688	uniprotkb:O60603	intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym)	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002135|imex:IM-21669-614	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	intact-crc:26337B097DA6A394|rigid:DBGA0w+95lBi69whc0CJZ4aqGzM	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60603	uniprotkb:P09467	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	intact:EBI-712740|ensembl:ENSP00000364475|ensembl:ENSP00000408025|uniprotkb:O75571|uniprotkb:Q53F94|uniprotkb:Q96E46	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:f16p1_human(display_long)|uniprotkb:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1(gene name synonym)|uniprotkb:FBP1(gene name)|psi-mi:FBP1(display_short)|uniprotkb:FBP(gene name synonym)|uniprotkb:Liver FBPase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002148|imex:IM-21669-615	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	ensembl:ENST00000375326(transcript)|ensembl:ENST00000415431(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005986"(sucrose biosynthetic process)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0016208"(AMP binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0035690"|go:"GO:0042132"(fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071286"(cellular response to magnesium ion)|interpro:IPR000146(Inositol phosphatase/fructose-1,6-bisphosphatase)|interpro:IPR020548|interpro:IPR028343|interpro:IPR033391|interpro:IPR044015|mint:P09467|rcsb pdb:1FTA|rcsb pdb:2FHY|rcsb pdb:2FIE|rcsb pdb:2FIX|rcsb pdb:2JJK|rcsb pdb:2VT5|rcsb pdb:2WBB|rcsb pdb:2WBD|rcsb pdb:2Y5K|rcsb pdb:2Y5L|rcsb pdb:3A29|rcsb pdb:3KBZ|rcsb pdb:3KC0|ensembl:ENSG00000165140(gene)|rcsb pdb:3KC1|rcsb pdb:4MJO|rcsb pdb:5LDZ|rcsb pdb:5PZR|rcsb pdb:5PZS|rcsb pdb:5PZT|rcsb pdb:5PZU|rcsb pdb:5PZV|rcsb pdb:5PZW|rcsb pdb:5PZX|rcsb pdb:5PZY|rcsb pdb:5PZZ|rcsb pdb:5Q00|rcsb pdb:5Q01|rcsb pdb:5Q02|rcsb pdb:5Q03|rcsb pdb:5Q04|rcsb pdb:5Q05|rcsb pdb:5Q06|rcsb pdb:5Q07|rcsb pdb:5Q08|rcsb pdb:5Q09|rcsb pdb:5PZQ|rcsb pdb:5Q0A|rcsb pdb:5Q0B|rcsb pdb:6LS5|rcsb pdb:6LW2|rcsb pdb:7C9Q|rcsb pdb:7CVN|reactome:R-HSA-70263|refseq:NP_000498.2|refseq:NP_001121100.1|dip:DIP-46677N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	rogid:DnrtyrU5WL/7ut1qWv7LndveJT89606	intact-crc:4C9BDB9150BFB098|rigid:ZtkcxT5lHKvxXwP6j/O3e3xpyVE	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL5	uniprotkb:O60603	intact:EBI-3916399|uniprotkb:Q9NPC0|uniprotkb:Q6XAR3|uniprotkb:Q86XY5|ensembl:ENSP00000259456|ensembl:ENSP00000480020	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	psi-mi:hemgn_human(display_long)|uniprotkb:HEMGN(gene name)|psi-mi:HEMGN(display_short)|uniprotkb:EDAG(gene name synonym)|uniprotkb:NDR(gene name synonym)|uniprotkb:Erythroid differentiation-associated gene protein(gene name synonym)|uniprotkb:Hemopoietic gene protein(gene name synonym)|uniprotkb:Negative differentiation regulator protein(gene name synonym)|uniprotkb:PRO1037(orf name)|uniprotkb:PRO1620(orf name)	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002161|imex:IM-21669-616	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517147.1|refseq:XP_011517148.1|refseq:NP_060907.2|refseq:NP_932095.1|ensembl:ENSG00000136929(gene)|ensembl:ENST00000259456(transcript)|ensembl:ENST00000616898(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|interpro:IPR033272|mint:Q9BXL5|refseq:XP_005252143.1	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:PS+VR59igJeVEYfNj0b1DMp6sMI9606	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	intact-crc:D227653F3D337D86|rigid:nvqhSuLcSCp++4bYjgw9kWw48/k	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:O60603	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002174|imex:IM-21669-617	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	intact-crc:B5AA3571573FED67|rigid:iBsy9y//t+wzpZeqChZIQgoH0kg	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR45	uniprotkb:O60603	intact:EBI-709675|uniprotkb:Q8WUV9|uniprotkb:Q9BWS6|uniprotkb:Q9NVD4|uniprotkb:B2RE98|ensembl:ENSP00000210444	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	psi-mi:sias_human(display_long)|uniprotkb:N-acetylneuraminate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid synthase(gene name synonym)|uniprotkb:N-acetylneuraminate-9-phosphate synthase(gene name synonym)|uniprotkb:N-acetylneuraminic acid phosphate synthase(gene name synonym)|uniprotkb:NANS(gene name)|psi-mi:NANS(display_short)|uniprotkb:SAS(gene name synonym)	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002187|imex:IM-21669-618	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061819.2|ensembl:ENSG00000095380(gene)|ensembl:ENST00000210444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006055"(CMP-N-acetylneuraminate biosynthetic process)|go:"GO:0008781"(N-acylneuraminate cytidylyltransferase activity)|go:"GO:0016051"(carbohydrate biosynthetic process)|go:"GO:0047444"(N-acylneuraminate-9-phosphate synthase activity)|go:"GO:0050462"(N-acetylneuraminate synthase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|interpro:IPR006013(Antifreeze, type III)|interpro:IPR006190(Antifreeze-like/N-acetylneuraminic acid synthase C-terminal)|interpro:IPR013132(N-acetylneuraminic acid synthase, N-terminal)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR013974(SAF domain)|interpro:IPR036732|mint:Q9NR45|rcsb pdb:1WVO|reactome:R-HSA-4085001	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:kdMBtQ/FC9c+6Bi79j1RkkifZ2k9606	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	intact-crc:AF1C18D6108046DD|rigid:ZlOIgCnMDPRSMb35qJ/Gh/CKXYU	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:O60603	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002200|imex:IM-21669-619	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	intact-crc:59A79D5C46D27184|rigid:/6EO2UCEssVJvO49YM2zm87bCNo	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60603	uniprotkb:P56962	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	intact:EBI-2797775|uniprotkb:Q4VXC2|ensembl:ENSP00000259400|ensembl:ENSP00000433484|ensembl:ENSP00000435981	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:stx17_human(display_long)|uniprotkb:STX17(gene name)|psi-mi:STX17(display_short)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002213|imex:IM-21669-620	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	refseq:XP_011517122.1|refseq:XP_011517123.1|dip:DIP-47297N|refseq:NP_060389.2|ensembl:ENSG00000136874(gene)|ensembl:ENST00000259400(transcript)|ensembl:ENST00000525640(transcript)|ensembl:ENST00000534052(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028676|mint:P56962|rcsb pdb:4WY4|rcsb pdb:7BV4|rcsb pdb:7BV6|reactome:R-HSA-204005	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	rogid:fakGqDYa9LwX59Q3+PRDIQy/OU49606	intact-crc:A9C64490CC6AEF71|rigid:kjq2K5NftC+KJMUujFgPr3z+sfI	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:O60603	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002226|imex:IM-21669-621	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	intact-crc:3D3350FE5D6D0698|rigid:ZGhNOSYizkZxqvKKTE1DQY9t2X4	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28289	uniprotkb:O60603	intact:EBI-2659631|uniprotkb:B2RB77|uniprotkb:Q5T7W3|uniprotkb:Q9BUF1|ensembl:ENSP00000259365|ensembl:ENSP00000378637|intact:EBI-10965302	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	psi-mi:tmod1_human(display_long)|uniprotkb:Erythrocyte tropomodulin(gene name synonym)|uniprotkb:D9S57E(gene name synonym)|uniprotkb:TMOD(gene name synonym)|uniprotkb:TMOD1(gene name)|psi-mi:TMOD1(display_short)	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Arroyo et al. (2014)	imex:IM-21669|pubmed:24412244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002239|imex:IM-21669-622	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159588.1|refseq:NP_003266.1|ensembl:ENST00000259365(transcript)|ensembl:ENST00000395211(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0070307"(lens fiber cell development)|interpro:IPR004934(Tropomodulin)|interpro:IPR030135|interpro:IPR032675|mint:P28289|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4Z8G|rcsb pdb:4Z94|reactome:R-HSA-390522|ensembl:ENSG00000136842(gene)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	psi-mi:"MI:0471"(mint)	-	-	figure legend:table S1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2015/09/23	rogid:xbmnoh2E0cuP4ZYmnhlOo8QDnHw9606	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	intact-crc:868B66FAB2692BF8|rigid:l7axMWx7GQ9RJmLC2W/IgQnMRBs	false	fusion protein:?-?("MI:0240")	fusion protein:?-?("MI:0240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)