#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75509	uniprotkb:Q15628	intact:EBI-2313231|uniprotkb:B2RDI9|uniprotkb:Q0D2P5|uniprotkb:Q96D86|ensembl:ENSP00000296861	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:tnr21_human(display_long)|uniprotkb:TNFRSF21(gene name)|psi-mi:TNFRSF21(display_short)|uniprotkb:DR6(gene name synonym)|uniprotkb:Death receptor 6(gene name synonym)|uniprotkb:UNQ437/PRO868(orf name)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2013)	imex:IM-22023|pubmed:24374337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9032087|imex:IM-22023-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055267.1|dip:DIP-53299N|ensembl:ENSG00000146072(gene)|ensembl:ENST00000296861(transcript)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0030424"(axon)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042552"(myelination)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097252"(oligodendrocyte apoptotic process)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022330|interpro:IPR034034|interpro:IPR034037|rcsb pdb:2DBH|rcsb pdb:3QO4|rcsb pdb:3U3P|rcsb pdb:3U3Q|rcsb pdb:3U3S|rcsb pdb:3U3T|rcsb pdb:3U3V|reactome:R-HSA-1989781|go:"GO:0051402"(neuron apoptotic process)	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	-	-	-	figure legend:f6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/12/11	2014/10/16	rogid:U26UBHuKo6Efzen1takNKjzhtcg9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	intact-crc:24D0661D7B1F6A9F|rigid:0COOlK5F0+TnhANdVIoRgqfozpM	false	binding-associated region:370-655	flag tag:?-?|binding-associated region:195-312	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)