#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P55090	uniprotkb:P35353	intact:EBI-9030248|ensembl:ENSRNOP00000008037	intact:EBI-9030306|ensembl:ENSRNOP00000006764	psi-mi:ucn1_rat(display_long)|uniprotkb:Ucn(gene name)|psi-mi:Ucn(display_short)|uniprotkb:Corticotensin(gene name synonym)	psi-mi:crfr1_rat(display_long)|uniprotkb:Crhr1(gene name)|psi-mi:Crhr1(display_short)|uniprotkb:Crhr(gene name synonym)|uniprotkb:Corticotropin-releasing hormone receptor 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Coin et al. (2013)	pubmed:24290358|imex:IM-21812	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032200|imex:IM-21812-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3929|refseq:NP_062023.1|ensembl:ENSRNOG00000006090(gene)|ensembl:ENSRNOT00000008037(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008306"(associative learning)|go:"GO:0009060"(aerobic respiration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032355"(response to estradiol)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035176"(social behavior)|go:"GO:0035483"(gastric emptying)|go:"GO:0042311"(vasodilation)|go:"GO:0042756"(drinking behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043196"(varicosity)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046811"(histone deacetylase inhibitor activity)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048265"(response to pain)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051431"(corticotropin-releasing hormone receptor 2 binding)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000187(Corticotropin-releasing factor, CRF)|interpro:IPR003620(Urocortin/corticotropin-releasing factor)|interpro:IPR018446|reactome:R-RNO-373080	rgd:61276|refseq:NP_112261.1|ensembl:ENSRNOG00000004900(gene)|ensembl:ENSRNOT00000006764(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008542"(visual learning)|go:"GO:0010578"(regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway)|go:"GO:0015056"(corticotrophin-releasing factor receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030425"(dendrite)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042277"(peptide binding)|go:"GO:0042596"(fear response)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043404"(corticotropin-releasing hormone receptor activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051424"(corticotropin-releasing hormone binding)|go:"GO:0051458"(corticotropin secretion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051867"(general adaptation syndrome, behavioral process)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000852"(regulation of corticosterone secretion)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003051(GPCR, family 2, corticotropin releasing factor receptor)|interpro:IPR003052(GPCR, family 2, corticotropin releasing factor receptor, type 1)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|reactome:R-RNO-373080	-	-	-	figure legend:Supp. Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/10	2014/10/16	rogid:xcP4dabCsa7T3CpyeGKA1+RNEpQ10116	rogid:/CafKo2vcglQicCvIkfAWPl15bs10116	intact-crc:CA98A9B6401B34DA|rigid:/ltLWisxktaJf3bOecXVRNvQzl0	false	sufficient binding region:81-120|mutation:92-92|mutation:94-94|mutation:86-86|mutation:88-88|mutation:90-90	flag tag:c-c|mutation:116-116|mutation:73-73|mutation:262-262	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)|psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:76649"	uniprotkb:P35353	intact:EBI-9031815	intact:EBI-9030306|ensembl:ENSRNOP00000006764	psi-mi:astressin(display_short)|psi-mi:"CHEBI:76649"(display_long)	psi-mi:crfr1_rat(display_long)|uniprotkb:Crhr1(gene name)|psi-mi:Crhr1(display_short)|uniprotkb:Crhr(gene name synonym)|uniprotkb:Corticotropin-releasing hormone receptor 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Coin et al. (2013)	pubmed:24290358|imex:IM-21812	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032176|imex:IM-21812-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:61276|refseq:NP_112261.1|ensembl:ENSRNOG00000004900(gene)|ensembl:ENSRNOT00000006764(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008542"(visual learning)|go:"GO:0010578"(regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway)|go:"GO:0015056"(corticotrophin-releasing factor receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030425"(dendrite)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042277"(peptide binding)|go:"GO:0042596"(fear response)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043404"(corticotropin-releasing hormone receptor activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051424"(corticotropin-releasing hormone binding)|go:"GO:0051458"(corticotropin secretion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051867"(general adaptation syndrome, behavioral process)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000852"(regulation of corticosterone secretion)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003051(GPCR, family 2, corticotropin releasing factor receptor)|interpro:IPR003052(GPCR, family 2, corticotropin releasing factor receptor, type 1)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|reactome:R-RNO-373080	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/10	2014/10/16	-	rogid:/CafKo2vcglQicCvIkfAWPl15bs10116	intact-crc:F438E026C1CC8A14	false	-	flag tag:c-c|mutation:123-123	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)|psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:76649"	uniprotkb:P55090	intact:EBI-9031815	intact:EBI-9030248|ensembl:ENSRNOP00000008037	psi-mi:astressin(display_short)|psi-mi:"CHEBI:76649"(display_long)	psi-mi:ucn1_rat(display_long)|uniprotkb:Ucn(gene name)|psi-mi:Ucn(display_short)|uniprotkb:Corticotensin(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Coin et al. (2013)	pubmed:24290358|imex:IM-21812	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032176|imex:IM-21812-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:3929|refseq:NP_062023.1|ensembl:ENSRNOG00000006090(gene)|ensembl:ENSRNOT00000008037(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008306"(associative learning)|go:"GO:0009060"(aerobic respiration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032355"(response to estradiol)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035176"(social behavior)|go:"GO:0035483"(gastric emptying)|go:"GO:0042311"(vasodilation)|go:"GO:0042756"(drinking behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043196"(varicosity)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046811"(histone deacetylase inhibitor activity)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048265"(response to pain)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051431"(corticotropin-releasing hormone receptor 2 binding)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000187(Corticotropin-releasing factor, CRF)|interpro:IPR003620(Urocortin/corticotropin-releasing factor)|interpro:IPR018446|reactome:R-RNO-373080	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/10	2014/10/16	-	rogid:xcP4dabCsa7T3CpyeGKA1+RNEpQ10116	intact-crc:F438E026C1CC8A14	false	-	sufficient binding region:81-120	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55090	uniprotkb:P35353	intact:EBI-9030248|ensembl:ENSRNOP00000008037	intact:EBI-9030306|ensembl:ENSRNOP00000006764	psi-mi:ucn1_rat(display_long)|uniprotkb:Ucn(gene name)|psi-mi:Ucn(display_short)|uniprotkb:Corticotensin(gene name synonym)	psi-mi:crfr1_rat(display_long)|uniprotkb:Crhr1(gene name)|psi-mi:Crhr1(display_short)|uniprotkb:Crhr(gene name synonym)|uniprotkb:Corticotropin-releasing hormone receptor 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Coin et al. (2013)	pubmed:24290358|imex:IM-21812	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030354|imex:IM-21812-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3929|refseq:NP_062023.1|ensembl:ENSRNOG00000006090(gene)|ensembl:ENSRNOT00000008037(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008306"(associative learning)|go:"GO:0009060"(aerobic respiration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032355"(response to estradiol)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035176"(social behavior)|go:"GO:0035483"(gastric emptying)|go:"GO:0042311"(vasodilation)|go:"GO:0042756"(drinking behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043196"(varicosity)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046811"(histone deacetylase inhibitor activity)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048265"(response to pain)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051431"(corticotropin-releasing hormone receptor 2 binding)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000187(Corticotropin-releasing factor, CRF)|interpro:IPR003620(Urocortin/corticotropin-releasing factor)|interpro:IPR018446|reactome:R-RNO-373080	rgd:61276|refseq:NP_112261.1|ensembl:ENSRNOG00000004900(gene)|ensembl:ENSRNOT00000006764(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008542"(visual learning)|go:"GO:0010578"(regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway)|go:"GO:0015056"(corticotrophin-releasing factor receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030425"(dendrite)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042277"(peptide binding)|go:"GO:0042596"(fear response)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043404"(corticotropin-releasing hormone receptor activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051424"(corticotropin-releasing hormone binding)|go:"GO:0051458"(corticotropin secretion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051867"(general adaptation syndrome, behavioral process)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000852"(regulation of corticosterone secretion)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003051(GPCR, family 2, corticotropin releasing factor receptor)|interpro:IPR003052(GPCR, family 2, corticotropin releasing factor receptor, type 1)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|reactome:R-RNO-373080	-	-	-	figure legend:Fig. 1E, 2, 3A, Supp. Fig. 2, 3A|comment:"Azi was systematically incorporated throughout all positions of the juxta-membrane region (J region) of CRF1R, including the three extracellular loops and the extracellular halves of the trans-membrane helices, as well as the hinge region joining helix I to the extra-cellular domain. Only 6 mutants (Asp-49, Asn-166, Ala-186, Arg-189, Thr-201, and Gly-356) failed to express. 35 mutated residues intensely photo-crosslinking, a further 104 positions showed lower levels of crosslinking."|comment:The addition of Dithiothreitol was necessary to achieve complete separation of non-crosslinked Ucn1 from the reaction mixture|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/10	2014/10/16	rogid:xcP4dabCsa7T3CpyeGKA1+RNEpQ10116	rogid:/CafKo2vcglQicCvIkfAWPl15bs10116	intact-crc:CC88203B0C915232|rigid:/ltLWisxktaJf3bOecXVRNvQzl0	false	sufficient binding region:81-120	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)|psi-mi:"MI:0113"(western blot)
uniprotkb:P55090	uniprotkb:P35353	intact:EBI-9030248|ensembl:ENSRNOP00000008037	intact:EBI-9030306|ensembl:ENSRNOP00000006764	psi-mi:ucn1_rat(display_long)|uniprotkb:Ucn(gene name)|psi-mi:Ucn(display_short)|uniprotkb:Corticotensin(gene name synonym)	psi-mi:crfr1_rat(display_long)|uniprotkb:Crhr1(gene name)|psi-mi:Crhr1(display_short)|uniprotkb:Crhr(gene name synonym)|uniprotkb:Corticotropin-releasing hormone receptor 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Coin et al. (2013)	pubmed:24290358|imex:IM-21812	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032193|imex:IM-21812-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3929|refseq:NP_062023.1|ensembl:ENSRNOG00000006090(gene)|ensembl:ENSRNOT00000008037(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008306"(associative learning)|go:"GO:0009060"(aerobic respiration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032355"(response to estradiol)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035176"(social behavior)|go:"GO:0035483"(gastric emptying)|go:"GO:0042311"(vasodilation)|go:"GO:0042756"(drinking behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043196"(varicosity)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046811"(histone deacetylase inhibitor activity)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048265"(response to pain)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0051431"(corticotropin-releasing hormone receptor 2 binding)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000187(Corticotropin-releasing factor, CRF)|interpro:IPR003620(Urocortin/corticotropin-releasing factor)|interpro:IPR018446|reactome:R-RNO-373080	rgd:61276|refseq:NP_112261.1|ensembl:ENSRNOG00000004900(gene)|ensembl:ENSRNOT00000006764(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0007631"(feeding behavior)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008542"(visual learning)|go:"GO:0010578"(regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway)|go:"GO:0015056"(corticotrophin-releasing factor receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030425"(dendrite)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042277"(peptide binding)|go:"GO:0042596"(fear response)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043404"(corticotropin-releasing hormone receptor activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051424"(corticotropin-releasing hormone binding)|go:"GO:0051458"(corticotropin secretion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051867"(general adaptation syndrome, behavioral process)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000852"(regulation of corticosterone secretion)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003051(GPCR, family 2, corticotropin releasing factor receptor)|interpro:IPR003052(GPCR, family 2, corticotropin releasing factor receptor, type 1)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|reactome:R-RNO-373080	-	-	-	figure legend:Fig. 4C|comment:Cys86-, Cys88-, Cys90-, Cys92-, and Cys94-Ucn1 mutants were crosslinked to CRHR1 with the unnatural amino acid p-2′-fluoroacetyl-phenylalanine substituted at 23 different sites. Each Cys-Ucn1 analog reacted with a subset of Ffact-CRF1R mutants. No intense signals were detected with Cys6- or Cys10-Ucn1.    Cys88-Ucn1  reacted with Gln-273-CRF1R  Cys92-Ucn1  reacted with Leu-329-CRF1R  Cys88-Ucn1 and Cys92-Ucn1 reacted with Phe330-CRF1R  Cys92-Ucn1  reacted with Asn-333-CRF1R  Cys92-Ucn1  reacted with Ile-345-CRF1R  Cys92-Ucn1  reacted with Asn-348-CRF1R  Cys92-Ucn1 and Cys94-Ucn1 reacted with Ser349-CRF1R|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/10	2014/10/16	rogid:xcP4dabCsa7T3CpyeGKA1+RNEpQ10116	rogid:/CafKo2vcglQicCvIkfAWPl15bs10116	intact-crc:4697208A708317C2|rigid:/ltLWisxktaJf3bOecXVRNvQzl0	false	sufficient binding region:81-120	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)|psi-mi:"MI:0113"(western blot)