#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99459	uniprotkb:Q8WYA6	intact:EBI-374880|uniprotkb:Q76N46|uniprotkb:Q99974|ensembl:ENSP00000360532	intact:EBI-748128|uniprotkb:Q0VAL9|uniprotkb:Q53HI8|uniprotkb:Q5JWZ2|uniprotkb:Q5JWZ3|uniprotkb:Q5JWZ7|uniprotkb:Q5JWZ8|uniprotkb:Q8N454|uniprotkb:Q8NCL2|uniprotkb:Q8TBD6|uniprotkb:Q96KD2|uniprotkb:Q9H7A5|uniprotkb:Q9NQF9|uniprotkb:Q9NTX0|uniprotkb:B4DE16|uniprotkb:Q0VAM0|uniprotkb:Q9Y3M7|intact:EBI-11161095|ensembl:ENSP00000355050	psi-mi:cdc5l_human(display_long)|uniprotkb:CDC5L(gene name)|psi-mi:CDC5L(display_short)|uniprotkb:Pombe cdc5-related protein(gene name synonym)|uniprotkb:KIAA0432(gene name synonym)|uniprotkb:PCDC5RP(gene name synonym)	psi-mi:ctbl1_human(display_long)|uniprotkb:Nuclear-associated protein(gene name synonym)|uniprotkb:Testis development protein NYD-SP19(gene name synonym)|uniprotkb:PP8304(orf name)|uniprotkb:CTNNBL1(gene name)|psi-mi:CTNNBL1(display_short)|uniprotkb:C20orf33(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ganesh et al. (2013)	pubmed:24269683|imex:IM-21761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8845269|imex:IM-21761-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|rcsb pdb:6ID1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071352"(cellular response to interleukin-2)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990646"(cellular response to prolactin)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q99459|rcsb pdb:2DIM|rcsb pdb:2DIN|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|ensembl:ENSG00000096401(gene)|ensembl:ENST00000371477(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|refseq:NP_001244.1|dip:DIP-31731N	refseq:NP_110517.2|refseq:XP_011527219.1|refseq:NP_001268424.1|ensembl:ENSG00000132792(gene)|ensembl:ENST00000361383(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016445"(somatic diversification of immunoglobulins)|go:"GO:0019899"(enzyme binding)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013180(Protein of unknown function DUF1716, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039678|mint:Q8WYA6|rcsb pdb:4CB8|rcsb pdb:4CB9|rcsb pdb:4CBA|rcsb pdb:4HM9|rcsb pdb:4HNM|rcsb pdb:4MFU|rcsb pdb:4MFV|rcsb pdb:7ABI|reactome:R-HSA-72163	-	-	-	figure legend:f4b sf5|comment:"Multiple  mutants  of  CTNNBL1  were  also  generated  that  carried  amino  acid  substitutions  in  the  putative  NLS  recognition  groove  (Figure  4A).  Strikingly,  all  mutants  retained  the  ability  to  interact  with  the  CDC5L  NLS3  as  judged  by  a  pulldown  assay  (Figure  4C).  Indeed,  not  only  was  NLS  binding  retained  by  these  mutants,  but  the  affinity  of  binding  to  the  CDC5L  NLS3  (as  well  as  to  the  Prp31  NLS)  peptide,  as  monitored  by  ITC,  was  little  affected  by  these  amino  acid  changes;  the  small  differences  in  binding  affinity,  such  as  the  deletion  mutant  K1,  might  reflect  a  minor  influence  on  the  stability  of  the  protein  (Supplementary  Figure  5)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-6(molar)	2013/11/07	2014/10/16	rogid:ZNRraJHn//46wKLSx7xtZju/lr09606	rogid:P9jJGHEpem4pEqr5O0mAosbiWZI9606	intact-crc:0B66AB3B1BD2D0E4|rigid:ADVfj3Qwkr47cPcYksjXTanxWeM	false	binding-associated region:200-206	binding-associated region:77-563	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WWY3	uniprotkb:Q8WYA6	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	intact:EBI-748128|uniprotkb:Q0VAL9|uniprotkb:Q53HI8|uniprotkb:Q5JWZ2|uniprotkb:Q5JWZ3|uniprotkb:Q5JWZ7|uniprotkb:Q5JWZ8|uniprotkb:Q8N454|uniprotkb:Q8NCL2|uniprotkb:Q8TBD6|uniprotkb:Q96KD2|uniprotkb:Q9H7A5|uniprotkb:Q9NQF9|uniprotkb:Q9NTX0|uniprotkb:B4DE16|uniprotkb:Q0VAM0|uniprotkb:Q9Y3M7|intact:EBI-11161095|ensembl:ENSP00000355050	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:ctbl1_human(display_long)|uniprotkb:Nuclear-associated protein(gene name synonym)|uniprotkb:Testis development protein NYD-SP19(gene name synonym)|uniprotkb:PP8304(orf name)|uniprotkb:CTNNBL1(gene name)|psi-mi:CTNNBL1(display_short)|uniprotkb:C20orf33(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ganesh et al. (2013)	pubmed:24269683|imex:IM-21761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8845282|imex:IM-21761-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	refseq:NP_110517.2|refseq:XP_011527219.1|refseq:NP_001268424.1|ensembl:ENSG00000132792(gene)|ensembl:ENST00000361383(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016445"(somatic diversification of immunoglobulins)|go:"GO:0019899"(enzyme binding)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013180(Protein of unknown function DUF1716, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039678|mint:Q8WYA6|rcsb pdb:4CB8|rcsb pdb:4CB9|rcsb pdb:4CBA|rcsb pdb:4HM9|rcsb pdb:4HNM|rcsb pdb:4MFU|rcsb pdb:4MFV|rcsb pdb:7ABI|reactome:R-HSA-72163	-	-	-	figure legend:f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:12.0x10^-6(molar)	2013/11/07	2014/10/16	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rogid:P9jJGHEpem4pEqr5O0mAosbiWZI9606	intact-crc:2D3517AD92C44633|rigid:7mY1yyT9QD7nLCio1j+edIYWHxM	false	binding-associated region:351-365	binding-associated region:77-563	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99459	uniprotkb:Q8WYA6	intact:EBI-374880|uniprotkb:Q76N46|uniprotkb:Q99974|ensembl:ENSP00000360532	intact:EBI-748128|uniprotkb:Q0VAL9|uniprotkb:Q53HI8|uniprotkb:Q5JWZ2|uniprotkb:Q5JWZ3|uniprotkb:Q5JWZ7|uniprotkb:Q5JWZ8|uniprotkb:Q8N454|uniprotkb:Q8NCL2|uniprotkb:Q8TBD6|uniprotkb:Q96KD2|uniprotkb:Q9H7A5|uniprotkb:Q9NQF9|uniprotkb:Q9NTX0|uniprotkb:B4DE16|uniprotkb:Q0VAM0|uniprotkb:Q9Y3M7|intact:EBI-11161095|ensembl:ENSP00000355050	psi-mi:cdc5l_human(display_long)|uniprotkb:CDC5L(gene name)|psi-mi:CDC5L(display_short)|uniprotkb:Pombe cdc5-related protein(gene name synonym)|uniprotkb:KIAA0432(gene name synonym)|uniprotkb:PCDC5RP(gene name synonym)	psi-mi:ctbl1_human(display_long)|uniprotkb:Nuclear-associated protein(gene name synonym)|uniprotkb:Testis development protein NYD-SP19(gene name synonym)|uniprotkb:PP8304(orf name)|uniprotkb:CTNNBL1(gene name)|psi-mi:CTNNBL1(display_short)|uniprotkb:C20orf33(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ganesh et al. (2013)	pubmed:24269683|imex:IM-21761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8845303|imex:IM-21761-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|rcsb pdb:6ID1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071352"(cellular response to interleukin-2)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990646"(cellular response to prolactin)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q99459|rcsb pdb:2DIM|rcsb pdb:2DIN|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|ensembl:ENSG00000096401(gene)|ensembl:ENST00000371477(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|refseq:NP_001244.1|dip:DIP-31731N	refseq:NP_110517.2|refseq:XP_011527219.1|refseq:NP_001268424.1|ensembl:ENSG00000132792(gene)|ensembl:ENST00000361383(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016445"(somatic diversification of immunoglobulins)|go:"GO:0019899"(enzyme binding)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013180(Protein of unknown function DUF1716, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039678|mint:Q8WYA6|rcsb pdb:4CB8|rcsb pdb:4CB9|rcsb pdb:4CBA|rcsb pdb:4HM9|rcsb pdb:4HNM|rcsb pdb:4MFU|rcsb pdb:4MFV|rcsb pdb:7ABI|reactome:R-HSA-72163	-	-	-	figure legend:f4c|comment:"Multiple mutants of CTNNBL1 were also generated that  carried amino acid substitutions in the putative NLS recognition groove (Figure 4A). Strikingly, all mutants  retained the ability to interact with the CDC5L NLS3 as judged by a pulldown assay (Figure 4C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/07	2014/10/16	rogid:ZNRraJHn//46wKLSx7xtZju/lr09606	rogid:P9jJGHEpem4pEqr5O0mAosbiWZI9606	intact-crc:525A6F59EDAE6957|rigid:ADVfj3Qwkr47cPcYksjXTanxWeM	false	glutathione s tranferase tag:?-?	binding-associated region:77-563|his tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)