#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8N944 uniprotkb:Q9Y2T1 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625 psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8869585|imex:IM-21815-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880 - - - figure legend:f3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma) - 2013/11/20 2014/10/16 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606 intact-crc:238F475DF8E9AFD3|rigid:3ZwyXQd/ugtNB5lIY3ZM+dEhP74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N944 uniprotkb:Q5JTC6 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 intact:EBI-6169747|uniprotkb:A2IB86|uniprotkb:Q8N885|ensembl:ENSP00000364003 psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:amer1_human(display_long)|uniprotkb:AMER1(gene name)|psi-mi:AMER1(display_short)|uniprotkb:FAM123B(gene name synonym)|uniprotkb:Protein FAM123B(gene name synonym)|uniprotkb:WTX(gene name synonym)|uniprotkb:Wilms tumor gene on the X chromosome protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8869585|imex:IM-21815-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 refseq:NP_689637.3|reactome:R-HSA-5467348|ensembl:ENSG00000184675(gene)|ensembl:ENST00000374869(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060348"(bone development)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1904713"(beta-catenin destruction complex binding)|interpro:IPR019003|mint:Q5JTC6|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340 - - - figure legend:f3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma) - 2013/11/20 2014/10/16 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 rogid:sRFifjRWQ45q8lSqsBPcCpYxM0Y9606 intact-crc:238F475DF8E9AFD3|rigid:3ZwyXQd/ugtNB5lIY3ZM+dEhP74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N944 uniprotkb:P25054 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8869585|imex:IM-21815-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 - - - figure legend:f3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma) - 2013/11/20 2014/10/16 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 intact-crc:238F475DF8E9AFD3|rigid:3ZwyXQd/ugtNB5lIY3ZM+dEhP74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N944 uniprotkb:P25054 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869670|imex:IM-21815-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 - - - figure legend:f4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 intact-crc:9702CEF50CE9279E|rigid:fCvY8+qzbxF+QUqc8brf6SKA2qw false flag tag:?-? yellow fluorescent protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N944 uniprotkb:P25054 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869681|imex:IM-21815-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 - - - figure legend:f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 intact-crc:DECE4E99CF261608|rigid:fCvY8+qzbxF+QUqc8brf6SKA2qw false flag tag:?-? enhanced green fluorescent protein tag:?-?|sufficient binding region:308-789|mutation disrupting interaction:507-507 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25054 uniprotkb:Q8N944 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869723|imex:IM-21815-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - - - figure legend:f4c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:DECFFE99CF261608|rigid:fCvY8+qzbxF+QUqc8brf6SKA2qw false - enhanced green fluorescent protein tag:?-?|binding-associated region:243-251,413-424 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O88566 uniprotkb:Q8N944 intact:EBI-7690990|ensembl:ENSMUSP00000051331|uniprotkb:Q6PFZ9|uniprotkb:Q9QXJ6|intact:MINT-1951339 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:axin2_mouse(display_long)|uniprotkb:Axin2(gene name)|psi-mi:Axin2(display_short)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)|uniprotkb:Axin-like protein(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869818|imex:IM-21815-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000000142(gene)|ensembl:ENSMUST00000052915(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008219"(cell death)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O88566|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-5689880|refseq:NP_056547.3|refseq:XP_006532120.1|refseq:XP_006532121.1|refseq:XP_006532122.1|refseq:XP_006532123.1|dip:DIP-42640N refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - comment:mint|comment:homomint|function:Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B - figure legend:f5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:pe97ZaMiGSH6OBLnomdG1TmcqwU10090 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:D7E98791FCDF128B|rigid:/NpWjoN0vF57GLU0aA2EaP5oEFo false flag tag:?-?|binding-associated region:69-197 enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O88566 uniprotkb:Q8N944 intact:EBI-7690990|ensembl:ENSMUSP00000051331|uniprotkb:Q6PFZ9|uniprotkb:Q9QXJ6|intact:MINT-1951339 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:axin2_mouse(display_long)|uniprotkb:Axin2(gene name)|psi-mi:Axin2(display_short)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)|uniprotkb:Axin-like protein(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869830|imex:IM-21815-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000000142(gene)|ensembl:ENSMUST00000052915(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008219"(cell death)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O88566|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-5689880|refseq:NP_056547.3|refseq:XP_006532120.1|refseq:XP_006532121.1|refseq:XP_006532122.1|refseq:XP_006532123.1|dip:DIP-42640N refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - comment:mint|comment:homomint|function:Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B - figure legend:f5c f5d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:pe97ZaMiGSH6OBLnomdG1TmcqwU10090 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:BA4B24833D875372|rigid:/NpWjoN0vF57GLU0aA2EaP5oEFo false flag tag:?-?|binding-associated region:2-345 enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2T1 uniprotkb:Q8N944 intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869843|imex:IM-21815-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880 refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - - - figure legend:f5e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:D4AC15671FCE0A2B|rigid:0YydMJmbvRnZnn8aK2N/LY3uyoU false binding-associated region:71-211|flag tag:?-? enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25054 uniprotkb:Q5JTC6 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 intact:EBI-6169747|uniprotkb:A2IB86|uniprotkb:Q8N885|ensembl:ENSP00000364003 psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:amer1_human(display_long)|uniprotkb:AMER1(gene name)|psi-mi:AMER1(display_short)|uniprotkb:FAM123B(gene name synonym)|uniprotkb:Protein FAM123B(gene name synonym)|uniprotkb:WTX(gene name synonym)|uniprotkb:Wilms tumor gene on the X chromosome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869869|imex:IM-21815-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 refseq:NP_689637.3|reactome:R-HSA-5467348|ensembl:ENSG00000184675(gene)|ensembl:ENST00000374869(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060348"(bone development)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1904713"(beta-catenin destruction complex binding)|interpro:IPR019003|mint:Q5JTC6|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340 - - - figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 rogid:sRFifjRWQ45q8lSqsBPcCpYxM0Y9606 intact-crc:DFA6B7972DC571AF|rigid:1adCEQUh5QoG4VhJw3NVzfEdtDU false enhanced green fluorescent protein tag:?-?|binding-associated region:308-789 flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N944 uniprotkb:Q5JTC6 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 intact:EBI-6169747|uniprotkb:A2IB86|uniprotkb:Q8N885|ensembl:ENSP00000364003 psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:amer1_human(display_long)|uniprotkb:AMER1(gene name)|psi-mi:AMER1(display_short)|uniprotkb:FAM123B(gene name synonym)|uniprotkb:Protein FAM123B(gene name synonym)|uniprotkb:WTX(gene name synonym)|uniprotkb:Wilms tumor gene on the X chromosome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869861|imex:IM-21815-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 refseq:NP_689637.3|reactome:R-HSA-5467348|ensembl:ENSG00000184675(gene)|ensembl:ENST00000374869(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060348"(bone development)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1904713"(beta-catenin destruction complex binding)|interpro:IPR019003|mint:Q5JTC6|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340 - - - figure legend:f6a f6b sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 rogid:sRFifjRWQ45q8lSqsBPcCpYxM0Y9606 intact-crc:8D60E53B98029894|rigid:4PY/qk4Pn8C4olwhkawtSly0TEE false enhanced green fluorescent protein tag:?-?|binding-associated region:153-236 flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5JTC6 uniprotkb:Q8N944 intact:EBI-6169747|uniprotkb:A2IB86|uniprotkb:Q8N885|ensembl:ENSP00000364003 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:amer1_human(display_long)|uniprotkb:AMER1(gene name)|psi-mi:AMER1(display_short)|uniprotkb:FAM123B(gene name synonym)|uniprotkb:Protein FAM123B(gene name synonym)|uniprotkb:WTX(gene name synonym)|uniprotkb:Wilms tumor gene on the X chromosome protein(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8870383|imex:IM-21815-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689637.3|reactome:R-HSA-5467348|ensembl:ENSG00000184675(gene)|ensembl:ENST00000374869(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060348"(bone development)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1904713"(beta-catenin destruction complex binding)|interpro:IPR019003|mint:Q5JTC6|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340 refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - - - figure legend:sf4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:sRFifjRWQ45q8lSqsBPcCpYxM0Y9606 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:22CA1A719E940140|rigid:4PY/qk4Pn8C4olwhkawtSly0TEE false enhanced green fluorescent protein tag:?-?|binding-associated region:601-714 flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25054 uniprotkb:Q8N7J2 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 intact:EBI-8869886|uniprotkb:Q5RL80|uniprotkb:Q5VX56|uniprotkb:Q8N593|uniprotkb:Q96NN5|intact:EBI-28984421|ensembl:ENSP00000426528 psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:amer2_human(display_long)|uniprotkb:AMER2(gene name)|psi-mi:AMER2(display_short)|uniprotkb:FAM123A(gene name synonym)|uniprotkb:Protein FAM123A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869879|imex:IM-21815-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 ensembl:ENST00000357816|ensembl:ENSP00000350469|ensembl:ENSP00000426528|refseq:NP_689917.2|refseq:NP_954589.1|refseq:XP_005266336.1|refseq:XP_005266337.1|refseq:XP_016875904.1|ensembl:ENSG00000165566(gene)|ensembl:ENST00000515384(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007398"(ectoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N7J2 - - - figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 rogid:lNfIi3+XW/UYl1zj8pJQQee8XQQ9606 intact-crc:D7965B891BDBF8C0|rigid:26WxMUDdGcVbRnlD8UMw4O1Sfnk false binding-associated region:308-789|enhanced green fluorescent protein tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25054 uniprotkb:Q8N944 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8869743|imex:IM-21815-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - - - figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/11/20 2014/10/16 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:0CA9FD2FA9CB762C|rigid:fCvY8+qzbxF+QUqc8brf6SKA2qw false - binding-associated region:243-251,413-424|enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25054 uniprotkb:Q8N944 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8869759|imex:IM-21815-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 go:"GO:0005874"(microtubule) - - figure legend:f4e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2013/11/20 2014/10/16 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:E72183AE8A564B70|rigid:fCvY8+qzbxF+QUqc8brf6SKA2qw false binding-associated region:1-1466 binding-associated region:243-251,413-424|enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q8N944 uniprotkb:Q5JTC6 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 intact:EBI-6169747|uniprotkb:A2IB86|uniprotkb:Q8N885|ensembl:ENSP00000364003 psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:amer1_human(display_long)|uniprotkb:AMER1(gene name)|psi-mi:AMER1(display_short)|uniprotkb:FAM123B(gene name synonym)|uniprotkb:Protein FAM123B(gene name synonym)|uniprotkb:WTX(gene name synonym)|uniprotkb:Wilms tumor gene on the X chromosome protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8869917|imex:IM-21815-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 refseq:NP_689637.3|reactome:R-HSA-5467348|ensembl:ENSG00000184675(gene)|ensembl:ENST00000374869(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060348"(bone development)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1904713"(beta-catenin destruction complex binding)|interpro:IPR019003|mint:Q5JTC6|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340 go:"GO:0005886"(plasma membrane) - - figure legend:f6c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2013/11/20 2014/10/16 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 rogid:sRFifjRWQ45q8lSqsBPcCpYxM0Y9606 intact-crc:6055481027611EE0|rigid:4PY/qk4Pn8C4olwhkawtSly0TEE false binding-associated region:153-236|enhanced green fluorescent protein tag:?-? flag tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:P25054 uniprotkb:Q8N944 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8870355|imex:IM-21815-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - - - figure legend:sf3|comment:"Protein fragments containing either region A1 or A2 fused to a LexA DNA binding domain interacted with the VP16-fused armadillo repeats in yeast two-hybrid assays, indicating direct binding (Fig. S3). To narrow down the interaction sites, mutations of A1 and A2 were generated by deleting the highly conserved amino acid stretches within these regions (Fig. S3A). Mutated protein fragments with deletions A1 and A2 2 no longer bound the armadillo repeats of APC in yeast two-hybrid assays, whereas the deletion A2 1 had no effect on the interaction (Fig. S3B)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2013/11/20 2014/10/16 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:24DAC31EFD3D5ECD|rigid:fCvY8+qzbxF+QUqc8brf6SKA2qw false fusion protein:?-?|binding-associated region:308-789 fusion protein:?-?|binding-associated region:243-251 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25054 uniprotkb:Q8N944 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 intact:EBI-8869590|uniprotkb:B7ZLH6|ensembl:ENSP00000314914|ensembl:ENSP00000392700 psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:amer3_human(display_long)|uniprotkb:AMER3(gene name)|psi-mi:AMER3(display_short)|uniprotkb:FAM123C(gene name synonym)|uniprotkb:Protein FAM123C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Brauburger et al. (2013) pubmed:24251807|imex:IM-21815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8870368|imex:IM-21815-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 refseq:XP_011509095.1|refseq:NP_001098663.1|refseq:NP_001098664.1|refseq:NP_001098665.1|refseq:NP_689911.2|ensembl:ENSG00000178171(gene)|ensembl:ENST00000321420(transcript)|ensembl:ENST00000423981(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR019003|mint:Q8N944 - - - figure legend:sf3|comment:"Protein fragments containing either region A1 or A2 fused to a LexA DNA binding domain interacted with the VP16-fused armadillo repeats in yeast two-hybrid assays, indicating direct binding (Fig. S3). To narrow down the interaction sites, mutations of A1 and A2 were generated by deleting the highly conserved amino acid stretches within these regions (Fig. S3A). Mutated protein fragments with deletions A1 and A2 2 no longer bound the armadillo repeats of APC in yeast two-hybrid assays, whereas the deletion A2 1 had no effect on the interaction (Fig. S3B)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2013/11/20 2014/10/16 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 rogid:NL2qdlVr1uq180gxfqA37hOat+A9606 intact-crc:5047E2DA7B2B6D22|rigid:fCvY8+qzbxF+QUqc8brf6SKA2qw false fusion protein:?-?|binding-associated region:308-789 fusion protein:?-?|binding-associated region:413-424 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)