#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8NHX9	uniprotkb:O00165	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lam et al. (2013)	pubmed:24188827|imex:IM-21709	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8817387|imex:IM-21709-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	-	-	-	figure legend:f1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/10/23	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	intact-crc:B45E5747AD3C6B82|rigid:sEpTWLVf0kaDA6a2TvL1f58o53E	false	fusion protein:?-?|binding-associated region:694-752	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8NHX9	uniprotkb:O00165	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lam et al. (2013)	pubmed:24188827|imex:IM-21709	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8817406|imex:IM-21709-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	-	-	-	figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/10/23	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	intact-crc:C39BEE972E0928D9|rigid:sEpTWLVf0kaDA6a2TvL1f58o53E	false	fusion protein:?-?|binding-associated region:694-752	binding-associated region:?-?|fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00165	uniprotkb:Q9ULQ1	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lam et al. (2013)	pubmed:24188827|imex:IM-21709	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8817427|imex:IM-21709-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/10/23	2014/10/16	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	intact-crc:47D6C0C3ABDF6C0D|rigid:ak6JnoZJ+kw0BOL/b+5PGmHI2Gs	false	binding-associated region:178-279|fusion protein:?-?	fusion protein:?-?|binding-associated region:686-816	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ULQ1	uniprotkb:O00165	intact:EBI-5239895|uniprotkb:A7E258|uniprotkb:Q86XS9|uniprotkb:Q8NC20|ensembl:ENSP00000335300|intact:EBI-28984906	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	psi-mi:tpc1_human(display_long)|uniprotkb:TPCN1(gene name)|psi-mi:TPCN1(display_short)|uniprotkb:KIAA1169(gene name synonym)|uniprotkb:TPC1(gene name synonym)|uniprotkb:Voltage-dependent calcium channel protein TPC1(gene name synonym)|uniprotkb:Two pore calcium channel protein 1(gene name synonym)	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lam et al. (2013)	pubmed:24188827|imex:IM-21709	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8817474|imex:IM-21709-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288143.1|refseq:XP_011536792.1|refseq:XP_011536794.1|refseq:NP_001137291.1|refseq:NP_060371.2|ensembl:ENSP00000335300|ensembl:ENST00000541517|ensembl:ENSP00000438125|ensembl:ENST00000550785|ensembl:ENSP00000448083|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028801|mint:Q9ULQ1|reactome:R-HSA-2672351|ensembl:ENSG00000186815(gene)|ensembl:ENST00000335509(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0036019"(endolysosome)|go:"GO:0042802"(identical protein binding)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/23	2014/10/16	rogid:8zThqZP+dyRH9kbK2im/+UrcH5Y9606	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	intact-crc:876A3222A0FDD585|rigid:ak6JnoZJ+kw0BOL/b+5PGmHI2Gs	false	binding-associated region:686-816	binding-associated region:178-279|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00165	uniprotkb:Q8NHX9	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lam et al. (2013)	pubmed:24188827|imex:IM-21709	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8817451|imex:IM-21709-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	-	-	-	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/23	2014/10/16	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	intact-crc:67C0D1B9546EC8AD|rigid:sEpTWLVf0kaDA6a2TvL1f58o53E	false	binding-associated region:178-279	glutathione s tranferase tag:?-?|binding-associated region:694-752	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHX9	uniprotkb:O00165	intact:EBI-5239949|uniprotkb:Q9NT82|ensembl:ENSP00000294309	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	psi-mi:tpc2_human(display_long)|uniprotkb:TPCN2(gene name)|psi-mi:TPCN2(display_short)|uniprotkb:TPC2(gene name synonym)|uniprotkb:Two pore calcium channel protein 2(gene name synonym)	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lam et al. (2013)	pubmed:24188827|imex:IM-21709	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8817507|imex:IM-21709-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620714.2|ensembl:ENSG00000162341(gene)|ensembl:ENST00000294309(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090117"(endosome to lysosome transport of low-density lipoprotein particle)|go:"GO:0097682"(intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028798|mint:Q8NHX9|rcsb pdb:6NQ0|rcsb pdb:6NQ1|rcsb pdb:6NQ2|reactome:R-HSA-2672351	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	-	-	-	figure legend:f3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/10/23	2014/10/16	rogid:hL3SJZ/o2w2IO+ClOexTZmsRf0Q9606	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	intact-crc:1F575291BA3753ED|rigid:sEpTWLVf0kaDA6a2TvL1f58o53E	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)