#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14680	uniprotkb:P10961	intact:EBI-20777|uniprotkb:D6VW43|ensemblfungi:YJL141C	intact:EBI-8672|ensemblfungi:YGL073W|uniprotkb:P11529|uniprotkb:D6VU70	psi-mi:yak1_yeast(display_long)|uniprotkb:J0652(orf name)|uniprotkb:YJL141C(locus name)|uniprotkb:YAK1(gene name)|psi-mi:YAK1(display_short)	psi-mi:hsf_yeast(display_long)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:Heat shock factor protein(gene name synonym)|uniprotkb:YGL073W(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Peter et al. (2013)	imex:IM-21652|pubmed:24140345	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8789308|imex:IM-21652-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012394.1|sgd:S000003677|mint:P14680|ensemblfungi:YJL141C(gene)|ensemblfungi:YJL141C_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032106"(positive regulation of response to extracellular stimulus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-3899300|dip:DIP-1374N	interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|reactome:R-SCE-3371453|reactome:R-SCE-3371511|reactome:R-SCE-3371571|ensemblfungi:YGL073W(gene)|ensemblfungi:YGL073W_mRNA(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009408"(response to heat)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070202"(regulation of establishment of protein localization to chromosome)|go:"GO:1904262"(negative regulation of TORC1 signaling)|refseq:NP_011442.3|sgd:S000003041|mint:P10961|dip:DIP-2374N	-	crc64:E0B7C56FAA35E056	-	figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/07	2014/10/16	rogid:LweeqHk6a9SyakRTDkdzgh72Jsc559292	rogid:/3UCbfNT+uMa3xJ4Ys9cPjU3q0c559292	intact-crc:D5A39EFD120209EF|rigid:WW6h9jAz0DlFMjnDrqYprBbbpXQ	false	glutathione s tranferase tag:?-?	binding-associated region:1-155|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P43565	uniprotkb:P10961	intact:EBI-15150|uniprotkb:D6VTJ8|ensemblfungi:YFL033C	intact:EBI-8672|ensemblfungi:YGL073W|uniprotkb:P11529|uniprotkb:D6VU70	psi-mi:rim15_yeast(display_long)|uniprotkb:RIM15(gene name)|psi-mi:RIM15(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:YFL033C(locus name)	psi-mi:hsf_yeast(display_long)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:Heat shock factor protein(gene name synonym)|uniprotkb:YGL073W(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Peter et al. (2013)	imex:IM-21652|pubmed:24140345	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8789291|imex:IM-21652-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116620.1|sgd:S000001861|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051039"(positive regulation of transcription involved in meiotic cell cycle)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|go:"GO:1903452"(positive regulation of G1 to G0 transition)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011006(CheY-like)|interpro:IPR011009(Protein kinase-like)|ensemblfungi:YFL033C(gene)|ensemblfungi:YFL033C_mRNA(transcript)|dip:DIP-2510N|mint:P43565	interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|reactome:R-SCE-3371453|reactome:R-SCE-3371511|reactome:R-SCE-3371571|ensemblfungi:YGL073W(gene)|ensemblfungi:YGL073W_mRNA(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009408"(response to heat)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070202"(regulation of establishment of protein localization to chromosome)|go:"GO:1904262"(negative regulation of TORC1 signaling)|refseq:NP_011442.3|sgd:S000003041|mint:P10961|dip:DIP-2374N	-	crc64:DC1064825000FAFF	-	figure legend:f2b f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/07	2014/10/16	rogid:yXNouNrS2rAbyu7RM73XEvvCICg559292	rogid:/3UCbfNT+uMa3xJ4Ys9cPjU3q0c559292	intact-crc:FE140D7C3C3C21D4|rigid:+XS8biws1QPkvIIsGls8WMBnxrs	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:1176-1176,823-823	glutathione s tranferase tag:?-?|binding-associated region:155-833	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P43565	uniprotkb:P53897	intact:EBI-15150|uniprotkb:D6VTJ8|ensemblfungi:YFL033C	intact:EBI-28967|uniprotkb:D6W126|ensemblfungi:YNL157W	psi-mi:rim15_yeast(display_long)|uniprotkb:RIM15(gene name)|psi-mi:RIM15(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:YFL033C(locus name)	psi-mi:igo1_yeast(display_long)|uniprotkb:IGO1(gene name)|psi-mi:IGO1(display_short)|uniprotkb:Initiation of G zero protein 1(gene name synonym)|uniprotkb:N1743(orf name)|uniprotkb:YNL157W(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Peter et al. (2013)	imex:IM-21652|pubmed:24140345	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8789280|imex:IM-21652-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116620.1|sgd:S000001861|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051039"(positive regulation of transcription involved in meiotic cell cycle)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|go:"GO:1903452"(positive regulation of G1 to G0 transition)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011006(CheY-like)|interpro:IPR011009(Protein kinase-like)|ensemblfungi:YFL033C(gene)|ensemblfungi:YFL033C_mRNA(transcript)|dip:DIP-2510N|mint:P43565	refseq:NP_014242.1|sgd:S000005101|dip:DIP-2011N|mint:P53897|ensemblfungi:YNL157W(gene)|ensemblfungi:YNL157W_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:1900152"(negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|go:"GO:1903452"(positive regulation of G1 to G0 transition)|go:"GO:1905183"(negative regulation of protein serine/threonine phosphatase activity)|go:"GO:1905184"(positive regulation of protein serine/threonine phosphatase activity)|interpro:IPR006760(cAMP-regulated phosphoprotein/endosulphine conserved region)|go:"GO:0005737"(cytoplasm)	-	crc64:DC1064825000FAFF	crc64:9534A95F1BD2CFFB	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/07	2014/10/16	rogid:yXNouNrS2rAbyu7RM73XEvvCICg559292	rogid:TmsLp1eQIObHtJvrUUEqgNaKJHE559292	intact-crc:2D445BDA6FC69183|rigid:O/3mIl0cMy6tbtkmqXHJgD0JgJE	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:1176-1176,823-823	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P33748	uniprotkb:P43565	intact:EBI-11407|ensemblfungi:YMR037C|uniprotkb:D6VZL2	intact:EBI-15150|uniprotkb:D6VTJ8|ensemblfungi:YFL033C	psi-mi:msn2_yeast(display_long)|uniprotkb:MSN2(gene name)|psi-mi:MSN2(display_short)|uniprotkb:YMR037C(locus name)|uniprotkb:YM9532.02C(orf name)|uniprotkb:Multicopy suppressor of SNF1 protein 2(gene name synonym)	psi-mi:rim15_yeast(display_long)|uniprotkb:RIM15(gene name)|psi-mi:RIM15(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:YFL033C(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Peter et al. (2013)	imex:IM-21652|pubmed:24140345	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8789327|imex:IM-21652-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YMR037C(gene)|ensemblfungi:YMR037C_mRNA(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0036278"(positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation)|go:"GO:0042594"(response to starvation)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0061395"(positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance)|go:"GO:0061402"(positive regulation of transcription from RNA polymerase II promoter in response to acidic pH)|go:"GO:0061403"(positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress)|go:"GO:0061405"(positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0061407"(positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061409"(positive regulation of transcription from RNA polymerase II promoter in response to freezing)|go:"GO:0061410"(positive regulation of transcription from RNA polymerase II promoter in response to ethanol)|go:"GO:0061411"(positive regulation of transcription from RNA polymerase II promoter in response to cold)|go:"GO:0061412"(positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation)|go:"GO:0061422"(positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH)|go:"GO:0071483"(cellular response to blue light)|go:"GO:0080144"(amino acid homeostasis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_013751.1|sgd:S000004640|mint:P33748|dip:DIP-8185N	refseq:NP_116620.1|sgd:S000001861|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051039"(positive regulation of transcription involved in meiotic cell cycle)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|go:"GO:1903452"(positive regulation of G1 to G0 transition)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011006(CheY-like)|interpro:IPR011009(Protein kinase-like)|ensemblfungi:YFL033C(gene)|ensemblfungi:YFL033C_mRNA(transcript)|dip:DIP-2510N|mint:P43565	-	crc64:EDF6F07446819DF1	crc64:DC1064825000FAFF	figure legend:f4b f4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/07	2014/10/16	rogid:rltXrQ1KL4NLcOXqtpUirMJ0xRA559292	rogid:yXNouNrS2rAbyu7RM73XEvvCICg559292	intact-crc:8C9F126D2CC6BB16|rigid:x4FBkpjDEZbyt+xciegZZlQ0eAs	false	glutathione s tranferase tag:?-?	mutation disrupting interaction:1176-1176,823-823|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)