#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22736	uniprotkb:Q9Y4D7	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	intact:EBI-310731|ensembl:ENSP00000317128|uniprotkb:Q6PJS9|uniprotkb:Q8IZJ2|uniprotkb:Q9BTQ2|uniprotkb:A7E2C6|uniprotkb:C9JPZ6	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:plxd1_human(display_long)|uniprotkb:PLXND1(gene name)|psi-mi:PLXND1(display_short)|uniprotkb:KIAA0620(gene name synonym)	psi-mi:"MI:0096"(pull down)	Luchino et al. (2013)	pubmed:24139859|imex:IM-21808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9002887|imex:IM-21808-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	ensembl:ENSG00000004399(gene)|ensembl:ENST00000324093(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005886"(plasma membrane)|refseq:NP_055918.2|reactome:R-HSA-9696270|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0007162"(negative regulation of cell adhesion)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0007416"(synapse assembly)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036352|interpro:IPR041019|interpro:IPR042719|mint:Q9Y4D7|rcsb pdb:3H6N|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035904"(aorta development)|go:"GO:0043087"(regulation of GTPase activity)|reactome:R-HSA-416700|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|reactome:R-HSA-9013508	-	-	-	figure legend:7B|antagonist:Sema3E - when cells were grown in the presence of Sema3E, this interaction was abolished.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/27	2014/10/16	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rogid:9feDx1eMDTqGWO2oQ6tMvrHLATE9606	intact-crc:3EEC283C311C45C1|rigid:eb9bj/ff5yDv5nXEotOH/Kos7w4	false	his tag:?-?	vsv tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70275	uniprotkb:Q9Y4D7	intact:EBI-8876322|uniprotkb:O09078|uniprotkb:O09079|uniprotkb:Q9QX23|ensembl:ENSMUSP00000073612	intact:EBI-310731|ensembl:ENSP00000317128|uniprotkb:Q6PJS9|uniprotkb:Q8IZJ2|uniprotkb:Q9BTQ2|uniprotkb:A7E2C6|uniprotkb:C9JPZ6	psi-mi:sem3e_mouse(display_long)|uniprotkb:Sema3e(gene name)|psi-mi:Sema3e(display_short)|uniprotkb:Semah(gene name synonym)|uniprotkb:Semh(gene name synonym)|uniprotkb:Semaphorin-H(gene name synonym)	psi-mi:plxd1_human(display_long)|uniprotkb:PLXND1(gene name)|psi-mi:PLXND1(display_short)|uniprotkb:KIAA0620(gene name synonym)	psi-mi:"MI:0096"(pull down)	Luchino et al. (2013)	pubmed:24139859|imex:IM-21808	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8876319|imex:IM-21808-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035478.2|ensembl:ENSMUSG00000063531(gene)|ensembl:ENSMUST00000073957(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050808"(synapse organization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015513(Semaphorin 3E)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|reactome:R-MMU-416700	ensembl:ENSG00000004399(gene)|ensembl:ENST00000324093(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005886"(plasma membrane)|refseq:NP_055918.2|reactome:R-HSA-9696270|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0007162"(negative regulation of cell adhesion)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0007416"(synapse assembly)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036352|interpro:IPR041019|interpro:IPR042719|mint:Q9Y4D7|rcsb pdb:3H6N|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035904"(aorta development)|go:"GO:0043087"(regulation of GTPase activity)|reactome:R-HSA-416700|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|reactome:R-HSA-9013508	-	-	-	figure legend:3A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/27	2014/10/16	rogid:45S43Pifg2ZrsKCd9c7pgthf6u010090	rogid:9feDx1eMDTqGWO2oQ6tMvrHLATE9606	intact-crc:5A3F541BA9A5162E|rigid:utwidncUvAXURYQXAjMfZqTcFjQ	false	his tag:?-?|alkaline phosphatase tag:?-?	myc tag:c-c|tag:n-n|sufficient binding region:61-531(IPR001627)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y4D7	uniprotkb:P70275	intact:EBI-310731|ensembl:ENSP00000317128|uniprotkb:Q6PJS9|uniprotkb:Q8IZJ2|uniprotkb:Q9BTQ2|uniprotkb:A7E2C6|uniprotkb:C9JPZ6	intact:EBI-8876322|uniprotkb:O09078|uniprotkb:O09079|uniprotkb:Q9QX23|ensembl:ENSMUSP00000073612	psi-mi:plxd1_human(display_long)|uniprotkb:PLXND1(gene name)|psi-mi:PLXND1(display_short)|uniprotkb:KIAA0620(gene name synonym)	psi-mi:sem3e_mouse(display_long)|uniprotkb:Sema3e(gene name)|psi-mi:Sema3e(display_short)|uniprotkb:Semah(gene name synonym)|uniprotkb:Semh(gene name synonym)|uniprotkb:Semaphorin-H(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Luchino et al. (2013)	pubmed:24139859|imex:IM-21808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8993889|imex:IM-21808-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004399(gene)|ensembl:ENST00000324093(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005886"(plasma membrane)|refseq:NP_055918.2|reactome:R-HSA-9696270|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0007162"(negative regulation of cell adhesion)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0007416"(synapse assembly)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036352|interpro:IPR041019|interpro:IPR042719|mint:Q9Y4D7|rcsb pdb:3H6N|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035904"(aorta development)|go:"GO:0043087"(regulation of GTPase activity)|reactome:R-HSA-416700|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|reactome:R-HSA-9013508	refseq:NP_035478.2|ensembl:ENSMUSG00000063531(gene)|ensembl:ENSMUST00000073957(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050808"(synapse organization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015513(Semaphorin 3E)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|reactome:R-MMU-416700	-	-	-	figure legend:3B|kinetics:IC50 is 2.5 ug/ml|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/27	2014/10/16	rogid:9feDx1eMDTqGWO2oQ6tMvrHLATE9606	rogid:45S43Pifg2ZrsKCd9c7pgthf6u010090	intact-crc:1BE4F1065146775D|rigid:utwidncUvAXURYQXAjMfZqTcFjQ	false	-	alkaline phosphatase tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4D7	uniprotkb:Q9Y4D7	intact:EBI-310731|ensembl:ENSP00000317128|uniprotkb:Q6PJS9|uniprotkb:Q8IZJ2|uniprotkb:Q9BTQ2|uniprotkb:A7E2C6|uniprotkb:C9JPZ6	intact:EBI-310731|ensembl:ENSP00000317128|uniprotkb:Q6PJS9|uniprotkb:Q8IZJ2|uniprotkb:Q9BTQ2|uniprotkb:A7E2C6|uniprotkb:C9JPZ6	psi-mi:plxd1_human(display_long)|uniprotkb:PLXND1(gene name)|psi-mi:PLXND1(display_short)|uniprotkb:KIAA0620(gene name synonym)	psi-mi:plxd1_human(display_long)|uniprotkb:PLXND1(gene name)|psi-mi:PLXND1(display_short)|uniprotkb:KIAA0620(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Luchino et al. (2013)	pubmed:24139859|imex:IM-21808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8993889|imex:IM-21808-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004399(gene)|ensembl:ENST00000324093(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005886"(plasma membrane)|refseq:NP_055918.2|reactome:R-HSA-9696270|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0007162"(negative regulation of cell adhesion)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0007416"(synapse assembly)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036352|interpro:IPR041019|interpro:IPR042719|mint:Q9Y4D7|rcsb pdb:3H6N|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035904"(aorta development)|go:"GO:0043087"(regulation of GTPase activity)|reactome:R-HSA-416700|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|reactome:R-HSA-9013508	ensembl:ENSG00000004399(gene)|ensembl:ENST00000324093(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005886"(plasma membrane)|refseq:NP_055918.2|reactome:R-HSA-9696270|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0007162"(negative regulation of cell adhesion)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0007416"(synapse assembly)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036352|interpro:IPR041019|interpro:IPR042719|mint:Q9Y4D7|rcsb pdb:3H6N|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035904"(aorta development)|go:"GO:0043087"(regulation of GTPase activity)|reactome:R-HSA-416700|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|reactome:R-HSA-9013508	-	-	-	figure legend:3B|kinetics:IC50 is 2.5 ug/ml|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/27	2014/10/16	rogid:9feDx1eMDTqGWO2oQ6tMvrHLATE9606	rogid:9feDx1eMDTqGWO2oQ6tMvrHLATE9606	intact-crc:1BE4F1065146775D|rigid:utwidncUvAXURYQXAjMfZqTcFjQ	false	-	sufficient binding region:61-531(IPR001627)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22736	uniprotkb:Q9Y4D7	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	intact:EBI-310731|ensembl:ENSP00000317128|uniprotkb:Q6PJS9|uniprotkb:Q8IZJ2|uniprotkb:Q9BTQ2|uniprotkb:A7E2C6|uniprotkb:C9JPZ6	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:plxd1_human(display_long)|uniprotkb:PLXND1(gene name)|psi-mi:PLXND1(display_short)|uniprotkb:KIAA0620(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Luchino et al. (2013)	pubmed:24139859|imex:IM-21808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9002920|imex:IM-21808-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	ensembl:ENSG00000004399(gene)|ensembl:ENST00000324093(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005886"(plasma membrane)|refseq:NP_055918.2|reactome:R-HSA-9696270|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0007162"(negative regulation of cell adhesion)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0007416"(synapse assembly)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036352|interpro:IPR041019|interpro:IPR042719|mint:Q9Y4D7|rcsb pdb:3H6N|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035904"(aorta development)|go:"GO:0043087"(regulation of GTPase activity)|reactome:R-HSA-416700|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|reactome:R-HSA-9013508	-	-	-	figure legend:No figure|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/11/27	2014/10/16	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rogid:9feDx1eMDTqGWO2oQ6tMvrHLATE9606	intact-crc:717A5783A009168D|rigid:eb9bj/ff5yDv5nXEotOH/Kos7w4	false	-	sufficient binding region:1295-1925(IPR013548)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)