#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
matrixdb:MULT_1_human	uniprotkb:Q15113	intact:EBI-2529702|reactome:R-HSA-215989|signor:SIGNOR-C183	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:lm-111_human(display_short)|psi-mi:MULT_1_human(display_long)|intact:Laminin-111 complex(complex recommended name)|intact:LM-111(complex synonym)|intact:Laminin-1 complex(complex synonym)|intact:EHS laminin(complex synonym)|intact:"LAMA1:LAMB1:LAMC1"(complex systematic name)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-8869640|imex:IM-21580-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:17453709(see-also)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0030155"(regulation of cell adhesion)|evidence ontology:"ECO:0005547"|complex portal:CPX-1770(complex-primary)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	complex-properties:"Complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end."|curated-complex:Major component of basment membranes which binds to cells via a high affinity, cell-surface receptor.  Role in the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Found in the subendothelium of vascular vessels and mediates platelet adhesion under static and shear conditions.|complex-assembly:Heterotrimer.	-	figure legend:"Table 1: Identification of new binding partners of PCPE-1 by SPR imaging"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2016/06/28	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:93ED02521E5796E5	false	-	sufficient binding region:37-273(IPR000859)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:Q15113	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9028595|imex:IM-21580-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	chain-seq-start:1572|chain-seq-end:1754	-	figure legend:"Table 1: Identification of new binding partners of PCPE-1 by SPR imaging"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:021C18ED8F5420FB|rigid:pvCesd6FUk3adRfkNo+h8Z6PBY8	false	flag tag:n-n	sufficient binding region:318-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	matrixdb:MULT_8_human	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2465980|reactome:R-HSA-381923	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:collagen_vi_human(display_short)|psi-mi:MULT_8_human(display_long)|intact:Collagen type VI trimer(complex recommended name)|intact:Type VI collagen(complex synonym)|intact:"COL6A1:COL6A2:COL6A3"(complex systematic name)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9075924|imex:IM-21580-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	evidence ontology:"ECO:0005547"|pubmed:17876790(see-also)|pubmed:1916105(see-also)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005201"(extracellular matrix structural constituent)|complex portal:CPX-1736(complex-primary)	-	-	curated-complex:May play a role as an interface between the main collagen fibril network and the cells.|complex-assembly:Heterotrimer.|complex-properties:Forms a short triple helical domain, containing a single cysteine/chain, with prominent globular ends. It dimerises by antiparallel association and tetramerises by lateral association of dimers. The association of tetramers is via their extremities which forms beaded filaments.	figure legend:"Table 1: Identification of new binding partners of PCPE-1 by SPR imaging"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2019/02/06	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	-	intact-crc:F68418708E819DF4	false	sufficient binding region:37-273(IPR000859)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:Q15113	intact:EBI-821758	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9075948|imex:IM-21580-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919|interpro:IPR000859(CUB)	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:"Table 1: Identification of new binding partners of PCPE-1 by SPR imaging"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2017/03/06	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:AC20387786BDBC37|rigid:+6epkRBBWpXm3EUtWU6AFYZTxlw	false	-	sufficient binding region:37-273	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16112	uniprotkb:Q15113	intact:EBI-9076211|uniprotkb:Q13650|uniprotkb:Q9UCD3|uniprotkb:Q9UCP4|uniprotkb:Q9UCP5|uniprotkb:Q9UDE0|uniprotkb:B9EK55|uniprotkb:E7ENV9|uniprotkb:E7EX88|uniprotkb:H0YM81|ensembl:ENSP00000387356	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:pgca_human(display_long)|uniprotkb:ACAN(gene name)|psi-mi:ACAN(display_short)|uniprotkb:AGC1(gene name synonym)|uniprotkb:CSPG1(gene name synonym)|uniprotkb:MSK16(gene name synonym)|uniprotkb:Cartilage-specific proteoglycan core protein(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 1(gene name synonym)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076261|imex:IM-21580-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001126.3|refseq:NP_037359.3|refseq:XP_011519616.1|ensembl:ENSG00000157766(gene)|ensembl:ENST00000439576(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|rcsb pdb:4MD4|reactome:R-HSA-1474228|reactome:R-HSA-2022854|reactome:R-HSA-2022857|reactome:R-HSA-3000178|reactome:R-HSA-3656225|reactome:R-HSA-3656243|reactome:R-HSA-3656244	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2018/04/06	rogid:LZ89ZDUWHqLtFYDp4dNgMtm6fd09606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:7F2E91CDBFD49D50|rigid:a2bRF97/Pt2x0YXld16jEkvj0Tw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P05067-PRO_0000000092	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-821758	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076266|imex:IM-21580-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2017/03/06	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	intact-crc:085E5C22CD533C20|rigid:+6epkRBBWpXm3EUtWU6AFYZTxlw	false	sufficient binding region:318-437	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P21810	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-762076|uniprotkb:P13247|uniprotkb:D3DWU3|ensembl:ENSP00000327336	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:pgs1_human(display_long)|uniprotkb:SLRR1A(gene name synonym)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:BGN(gene name)|psi-mi:BGN(display_short)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076271|imex:IM-21580-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	refseq:NP_001702.1|refseq:XP_016885213.1|ensembl:ENSG00000182492(gene)|ensembl:ENST00000331595(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|mint:P21810|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:G7A6TRMpSIqTBpXtm67XG0GfM2w9606	intact-crc:5BEEA0AA4F56F3AD|rigid:5WtPaWrHWPjgOs4c0nRpNcKeSfw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-2089970	uniprotkb:Q15113	intact:EBI-2325312|matrixdb:MULT_3_human|reactome:R-HSA-2467139|reactome:R-HSA-2396132|reactome:R-HSA-2396423|reactome:R-HSA-2396135|reactome:R-HSA-2396296|reactome:R-HSA-2396322|reactome:R-HSA-2428941|reactome:R-HSA-2396033|reactome:R-HSA-2396048	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:collagen_i_human(display_short)|psi-mi:R-HSA-2089970(display_long)|intact:Collagen type I trimer(complex recommended name)|intact:Type I collagen(complex synonym)|intact:"2xCOL1A1:COL1A2"(complex systematic name)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076276|imex:IM-21580-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|complex portal:CPX-1650(complex-primary)|intact:EBI-25750246(exp-evidence)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030199"(collagen fibril organization)|evidence ontology:"ECO:0000353"	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	curated-complex:Forms the fibrils of tendon, ligaments and bones, also present in skin. In bones the fibrils are mineralized with calcium hydroxyapatite.|assembly:Heterotrimer|complex-properties:"Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the center of the superhelix. Propeptides (telopeptides) at both ends of the molecular precursor undergo highly complex fibrillogenesis."	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2016/06/28	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:5C4F409BE5F0C1FD	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18250"	uniprotkb:Q15113	intact:EBI-2566560	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:chondroitin_sulfate(display_short)|psi-mi:"CHEBI:18250"(display_long)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076301|imex:IM-21580-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	matrixdb:GAG_4(source reference)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:382C712626E30370	false	-	sufficient binding region:318-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18376"	uniprotkb:Q15113	intact:EBI-2566541	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:dermatan_sulfate(display_short)|psi-mi:"CHEBI:18376"(display_long)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076329|imex:IM-21580-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	matrixdb:GAG_3(source reference)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:C9F849B4D7ED7D13	false	-	sufficient binding region:318-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01133-PRO_0000007541	uniprotkb:Q15113	intact:EBI-9076336	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:p01133-pro_0000007541(display_long)|uniprotkb:EGF(gene name)|psi-mi:EGF(display_short)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076334|imex:IM-21580-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-640857(chain-parent)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	chain-seq-start:971|chain-seq-end:1023	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:PwlLsbaKSKke1lpKx0Gyh5RId2w9606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:487BE3C4B3C019B1|rigid:PfYSUfg4J5dTuob9WbWNfN4qjKk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:Q15113	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076345|imex:IM-21580-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	chain-seq-start:1572|chain-seq-end:1754	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:5238EC1EF7192821|rigid:pvCesd6FUk3adRfkNo+h8Z6PBY8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P00742	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-719750|uniprotkb:Q14340|ensembl:ENSP00000364709	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:fa10_human(display_long)|uniprotkb:Stuart factor(gene name synonym)|uniprotkb:Stuart-Prower factor(gene name synonym)|uniprotkb:F10(gene name)|psi-mi:F10(display_short)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076358|imex:IM-21580-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	refseq:NP_000495.1|ensembl:ENSG00000126218(gene)|ensembl:ENST00000375559(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|mint:P00742|rcsb pdb:1C5M|rcsb pdb:1EZQ|rcsb pdb:1F0R|rcsb pdb:1F0S|rcsb pdb:1FAX|rcsb pdb:1FJS|rcsb pdb:1FXY|rcsb pdb:1G2L|rcsb pdb:1G2M|rcsb pdb:1HCG|rcsb pdb:1IOE|rcsb pdb:1IQE|rcsb pdb:1IQF|rcsb pdb:1IQG|rcsb pdb:1IQH|rcsb pdb:1IQI|rcsb pdb:1IQJ|rcsb pdb:1IQK|rcsb pdb:1IQL|rcsb pdb:1IQM|rcsb pdb:1IQN|rcsb pdb:1KSN|rcsb pdb:1LPG|rcsb pdb:1LPK|rcsb pdb:1LPZ|rcsb pdb:1LQD|rcsb pdb:1MQ5|rcsb pdb:1MQ6|rcsb pdb:1MSX|rcsb pdb:1NFU|rcsb pdb:1NFW|rcsb pdb:1NFX|rcsb pdb:1NFY|rcsb pdb:1NL8|rcsb pdb:1P0S|rcsb pdb:1V3X|rcsb pdb:1WU1|rcsb pdb:1XKA|rcsb pdb:1XKB|rcsb pdb:1Z6E|rcsb pdb:2BMG|rcsb pdb:2BOH|rcsb pdb:2BOK|rcsb pdb:2BQ6|rcsb pdb:2BQ7|rcsb pdb:2BQW|rcsb pdb:2CJI|rcsb pdb:2D1J|rcsb pdb:2EI6|rcsb pdb:2EI7|rcsb pdb:2EI8|rcsb pdb:2FZZ|rcsb pdb:2G00|rcsb pdb:2GD4|rcsb pdb:2H9E|rcsb pdb:2J2U|rcsb pdb:2J34|rcsb pdb:2J38|rcsb pdb:2J4I|rcsb pdb:2J94|rcsb pdb:2J95|rcsb pdb:2P16|rcsb pdb:2P3F|rcsb pdb:2P3T|rcsb pdb:2P3U|rcsb pdb:2P93|rcsb pdb:2P94|rcsb pdb:2P95|rcsb pdb:2PHB|rcsb pdb:2PR3|rcsb pdb:2Q1J|rcsb pdb:2RA0|rcsb pdb:2UWL|rcsb pdb:2UWO|rcsb pdb:2UWP|rcsb pdb:2VH0|rcsb pdb:2VH6|rcsb pdb:2VVC|rcsb pdb:2VVU|rcsb pdb:2VVV|rcsb pdb:2VWL|rcsb pdb:2VWM|rcsb pdb:2VWN|rcsb pdb:2VWO|rcsb pdb:2W26|rcsb pdb:2W3I|rcsb pdb:2W3K|rcsb pdb:2WYG|rcsb pdb:2WYJ|rcsb pdb:2XBV|rcsb pdb:2XBW|rcsb pdb:2XBX|rcsb pdb:2XBY|rcsb pdb:2XC0|rcsb pdb:2JKH|rcsb pdb:2XC4|rcsb pdb:2XC5|rcsb pdb:2Y5F|rcsb pdb:2Y5G|rcsb pdb:2Y5H|rcsb pdb:2Y7X|rcsb pdb:2Y7Z|rcsb pdb:2Y80|rcsb pdb:2Y81|rcsb pdb:2Y82|rcsb pdb:3CEN|rcsb pdb:3CS7|rcsb pdb:3ENS|rcsb pdb:3FFG|rcsb pdb:3HPT|rcsb pdb:3IIT|rcsb pdb:3K9X|rcsb pdb:3KL6|rcsb pdb:3KQB|rcsb pdb:3KQC|rcsb pdb:3KQD|rcsb pdb:3KQE|rcsb pdb:3LIW|rcsb pdb:3M36|rcsb pdb:3M37|rcsb pdb:3Q3K|rcsb pdb:3SW2|rcsb pdb:3TK6|rcsb pdb:4A7I|rcsb pdb:4BTI|rcsb pdb:4BTT|rcsb pdb:4BTU|rcsb pdb:4Y6D|rcsb pdb:4Y71|rcsb pdb:4Y76|rcsb pdb:4Y79|rcsb pdb:4Y7A|rcsb pdb:4Y7B|rcsb pdb:4ZH8|rcsb pdb:4ZHA|rcsb pdb:5JQY|rcsb pdb:5JTC|rcsb pdb:5JZ8|rcsb pdb:5JZU|rcsb pdb:5K0H|rcsb pdb:5VOE|rcsb pdb:5VOF|rcsb pdb:6Q9F|rcsb pdb:6Q9I|rcsb pdb:6RK9|rcsb pdb:6YYW|rcsb pdb:6YYX|rcsb pdb:6YYY|rcsb pdb:6Z6Q|rcsb pdb:6Z6R|rcsb pdb:7BMI|rcsb pdb:7BMJ|rcsb pdb:7E6J|rcsb pdb:3TK5|reactome:R-HSA-140834|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-9672383|reactome:R-HSA-9672396|reactome:R-HSA-9673202|refseq:NP_001299603.1|refseq:NP_001299604.1|dip:DIP-29896N	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:EiG38fLKwrbGJftF5k4xjLvlYhA9606	intact-crc:524F8B1ADB5BD2F2|rigid:DPBsZy40e8hHnVo67H34KOkx088	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16336"	uniprotkb:Q15113	intact:EBI-2566617	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:hyaluronan(display_short)|psi-mi:"CHEBI:16336"(display_long)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076365|imex:IM-21580-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	matrixdb:GAG_9(source reference)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:A44D867A3A83FE48	false	-	sufficient binding region:318-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28815"	uniprotkb:Q15113	intact:EBI-2566501	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076370|imex:IM-21580-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	matrixdb:GAG_2(source reference)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:44B0DCD9C8877A9A	false	-	sufficient binding region:318-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28304"	uniprotkb:Q15113	intact:EBI-1379423	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076374|imex:IM-21580-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:4F3425B9D136D0BB	false	-	sufficient binding region:318-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:Q14766	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-947693|uniprotkb:A1L3V1|uniprotkb:P22064|uniprotkb:Q53SD8|uniprotkb:Q53SF3|uniprotkb:Q53SG1|uniprotkb:Q59HF7|uniprotkb:Q8TD95|ensembl:ENSP00000386043	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:ltbp1_human(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076378|imex:IM-21580-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	refseq:NP_000618.3|refseq:NP_001159736.1|refseq:NP_001159737.1|refseq:NP_001159738.1|refseq:NP_996826.2|refseq:XP_011531155.1|dip:DIP-50011N|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q14766|rcsb pdb:1KSQ|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606	intact-crc:24530304ECFECCEF|rigid:auS/XbEGeZWiPNfHx7Q0Rqas5Xk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:Q9H6X2	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-905643|uniprotkb:Q96P02|uniprotkb:Q9NVP3|uniprotkb:J7K7G4|uniprotkb:J7KF88|uniprotkb:A8K7U8|uniprotkb:Q4ZFV6|uniprotkb:Q53QD8|intact:EBI-28987980|ensembl:ENSP00000301945	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:antr1_human(display_long)|uniprotkb:ANTXR1(gene name)|psi-mi:ANTXR1(display_short)|uniprotkb:ATR(gene name synonym)|uniprotkb:TEM8(gene name synonym)|uniprotkb:Tumor endothelial marker 8(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076382|imex:IM-21580-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	refseq:NP_060623.2|refseq:NP_115584.1|refseq:NP_444262.1|ensembl:ENSP00000301945|ensembl:ENST00000409349|ensembl:ENSP00000386494|ensembl:ENST00000409829|ensembl:ENSP00000387058|ensembl:ENST00000463335|ensembl:ENSP00000506719|ensembl:ENSG00000169604(gene)|ensembl:ENST00000303714(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022414"(reproductive process)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:1901202"(negative regulation of extracellular matrix assembly)|go:"GO:1901998"(toxin transport)|go:"GO:1905050"(positive regulation of metallopeptidase activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR008399(Anthrax toxin receptor, C-terminal)|interpro:IPR008400(Anthrax toxin receptor, extracellular)|interpro:IPR017360(Anthrax toxin receptor 2)|interpro:IPR036465|rcsb pdb:3N2N|rcsb pdb:6ADL|rcsb pdb:6ADM|rcsb pdb:6ADR|rcsb pdb:6CX1|reactome:R-HSA-5210891	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:AtdL6Qm9CaH6Eb00jQly4K04AFg9606	intact-crc:06CA1A0F0B02BA3C|rigid:5T/HjPrBhSw2vtgHoMQV32JzLCI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P22105	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2821024|uniprotkb:Q9UC12|uniprotkb:Q5ST74|uniprotkb:Q08AM0|uniprotkb:Q9NPK9|uniprotkb:Q9UC11|uniprotkb:Q59GU7|uniprotkb:P78530|uniprotkb:Q9UC10|uniprotkb:Q08424|uniprotkb:Q9UMG7|uniprotkb:Q08AM1|uniprotkb:Q7L8Q4|uniprotkb:Q9UC13|uniprotkb:Q5SQD3|uniprotkb:Q8N4R1|uniprotkb:P78531|ensembl:ENSP00000364393|ensembl:ENSP00000447694|ensembl:ENSP00000448326|ensembl:ENSP00000496448	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:tenx_human(display_long)|uniprotkb:TNXB(gene name)|psi-mi:TNXB(display_short)|uniprotkb:HXBL(gene name synonym)|uniprotkb:TNX(gene name synonym)|uniprotkb:TNXB1(gene name synonym)|uniprotkb:TNXB2(gene name synonym)|uniprotkb:XB(gene name synonym)|uniprotkb:Hexabrachion-like protein(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076393|imex:IM-21580-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	refseq:NP_061978.6|refseq:NP_115859.2|ensembl:ENSG00000168477(gene)|ensembl:ENSG00000229353(gene)|ensembl:ENSG00000236236(gene)|ensembl:ENST00000375244(transcript)|ensembl:ENST00000546684(transcript)|ensembl:ENST00000550539(transcript)|ensembl:ENST00000644971(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098633"(collagen fibril binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR033081|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P22105|rcsb pdb:2CUH|rcsb pdb:2CUI|rcsb pdb:2CUM|reactome:R-HSA-3000178	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2018/09/18	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:5O4kj1Cs1NRP1yGON0AEupG2l+M9606	intact-crc:58F4F07042E0F9D4|rigid:OXVfwpJie9hExinILojmoel/RNQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P21980	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-727668|uniprotkb:Q16436|uniprotkb:Q9BTN7|uniprotkb:Q9UH35|uniprotkb:Q6B838|uniprotkb:E1P5V9|ensembl:ENSP00000355330|uniprotkb:Q9H035	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:tgm2_human(display_long)|uniprotkb:TGM2(gene name)|psi-mi:TGM2(display_short)|uniprotkb:Tissue transglutaminase(gene name synonym)|uniprotkb:Transglutaminase C(gene name synonym)|uniprotkb:Transglutaminase-2(gene name synonym)|uniprotkb:Transglutaminase H(gene name synonym)|uniprotkb:Erythrocyte transglutaminase(gene name synonym)|uniprotkb:"Heart G alpha(h)"(gene name synonym)|uniprotkb:Isopeptidase TGM2(gene name synonym)|uniprotkb:"Protein G alpha(h)"(gene name synonym)|uniprotkb:Protein-glutamine deamidase TGM2(gene name synonym)|uniprotkb:Protein-glutamine dopaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine histaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine noradrenalinyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine serotonyltransferase TGM2(gene name synonym)|uniprotkb:Transglutaminase II(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076404|imex:IM-21580-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	refseq:NP_004604.2|refseq:NP_945189.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0018153"("isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine")|go:"GO:0018277"(protein deamination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|ensembl:ENSG00000198959(gene)|ensembl:ENST00000361475(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050568"(protein-glutamine glutaminase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0120295"(histone serotonyltransferase activity)|go:"GO:0120297"(histone dopaminyltransferase activity)|go:"GO:0120298"(peptide noradrenalinyltransferase activity)|go:"GO:0120299"(peptide histaminyltransferase activity)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904015"(cellular response to serotonin)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P21980|rcsb pdb:1FAU|rcsb pdb:1KV3|rcsb pdb:2Q3Z|rcsb pdb:3LY6|rcsb pdb:3S3J|rcsb pdb:3S3P|rcsb pdb:3S3S|rcsb pdb:4PYG|rcsb pdb:6A8P|rcsb pdb:6KZB|go:"GO:2000425"(regulation of apoptotic cell clearance)|refseq:XP_011527330.1|refseq:NP_001310245.1|dip:DIP-33557N	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:S61on+x/CwI9G/k/0UhS6pFO+wE9606	intact-crc:6422AF66F642AC79|rigid:sm5nFv56WEBBkBROS+S1e13yaIM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07996	uniprotkb:Q15113	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076416|imex:IM-21580-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:16D55565C3D4000D|rigid:j3PjzLuCt9KhVcHV+oVDHd539IE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	reactome:R-HSA-215984	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2461456|matrixdb:MULT_4_VAR3_human|reactome:R-HSA-2127428|reactome:R-HSA-2468137	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:collagen_iv_human-3(display_short)|psi-mi:R-HSA-215984(display_long)|intact:Collagen type IV trimer variant 3(complex recommended name)|intact:Type IV collagen variant 3(complex synonym)|intact:"COL4A3:COL4A5:COL4A6"(complex systematic name)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9077531|imex:IM-21580-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919|interpro:IPR000859(CUB)	go:"GO:0005587"(collagen type IV trimer)|pubmed:1916105(see-also)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0005201"(extracellular matrix structural constituent)|pubmed:17876790(see-also)|evidence ontology:"ECO:0005547"|complex portal:CPX-1725(complex-primary)	-	-	curated-complex:Basement membranes are formed by a fine network of collagen IV fibres  that are laced together and entrap large associated molecules.|complex-assembly:Heterotrimer.|complex-properties:"This assembly process requires lateral interactions between triple helices at two levels. In the short N-terminal triple-helical 7S domain, four  triple helical domains from four different molecules assemble head to tail to form the structure known as a spider whose legs are made of a long triple helical region made of several triple helical domains interrupted by short nontriple helical sequences. In the tissue the molecules interact laterally by this region in a staggered fashion. Finally, interactions of nontriple helical COOH-terminal NC1 domains (IPR001442) to form dimers are responsible for tail-to-tail binding of type IV  molecules."	figure legend:"Table 1: Identification of new binding partners of PCPE-1 by SPR imaging"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2019/09/03	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	-	intact-crc:458D9B8DE6F0A3D5	false	necessary binding region:37-273,318-437	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07996	uniprotkb:Q15113	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9077543|imex:IM-21580-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919|interpro:IPR000859(CUB)	-	-	-	figure legend:"Table 1: Identification of new binding partners of PCPE-1 by SPR imaging"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:F1827BA30AB9B647|rigid:j3PjzLuCt9KhVcHV+oVDHd539IE	false	-	necessary binding region:318-437,37-273	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00747	uniprotkb:Q15113	intact:EBI-999394|uniprotkb:Q15146|uniprotkb:Q5TEH4|uniprotkb:Q6PA00|ensembl:ENSP00000308938	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:plmn_human(display_long)|uniprotkb:PLG(gene name)|psi-mi:PLG(display_short)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0921"(surface plasmon resonance array)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9077589|imex:IM-21580-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000292.1|ensembl:ENSG00000122194(gene)|ensembl:ENST00000308192(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1990405"(protein antigen binding)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P00747|rcsb pdb:1B2I|rcsb pdb:1BML|rcsb pdb:1BUI|rcsb pdb:1CEA|rcsb pdb:1CEB|rcsb pdb:1DDJ|rcsb pdb:1HPJ|rcsb pdb:1HPK|rcsb pdb:1I5K|rcsb pdb:1KI0|rcsb pdb:1KRN|rcsb pdb:1L4D|rcsb pdb:1L4Z|rcsb pdb:1PK4|rcsb pdb:1PKR|rcsb pdb:1PMK|rcsb pdb:1QRZ|rcsb pdb:1RJX|rcsb pdb:2DOH|rcsb pdb:2DOI|rcsb pdb:2KNF|rcsb pdb:2L0S|rcsb pdb:2PK4|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:3UIR|rcsb pdb:4A5T|rcsb pdb:4CIK|rcsb pdb:4DCB|rcsb pdb:4DUR|rcsb pdb:4DUU|rcsb pdb:5HPG|rcsb pdb:5UGD|rcsb pdb:5UGG|rcsb pdb:6D3X|rcsb pdb:6D3Y|rcsb pdb:6D3Z|rcsb pdb:6D40|rcsb pdb:6OG4|rcsb pdb:6OQJ|rcsb pdb:6OQK|rcsb pdb:6Q1U|rcsb pdb:6UZ4|rcsb pdb:6UZ5|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-186797|reactome:R-HSA-381426|reactome:R-HSA-75205	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 3 Screening of potential binding partners of PCPE-1 by SPR imaging|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:f9Y+uCcA1jrDN1AD/clsKtkZWEQ9606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:B18A14F3991C820B|rigid:YILPBDZs7LdiCIMKYbuQpajkHW4	false	-	sufficient binding region:318-437	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:Q15113	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9076883|imex:IM-21580-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	chain-seq-start:1572|chain-seq-end:1754	-	figure legend:Figure 3 Endostatin is pulled down by immobilized PCPE-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/20	2014/10/16	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:A26D658E4E30916D|rigid:pvCesd6FUk3adRfkNo+h8Z6PBY8	false	flag tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15113	uniprotkb:P39060-PRO_0000005794	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9077607|imex:IM-21580-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	intact:EBI-981314(chain-parent)	-	-	chain-seq-start:1572|chain-seq-end:1754	figure legend:Table 4 Kinetics and affinity of PCPE-1 interactions|kinetics:Heterogeneous ligand model|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.0x10^-8 ~0.19(molar)|kd:1.1x10^-9 ~0.1(molar)|kon:5.81x10^3(per mole per second)|kon:9140.0x10^3(per mole per second)|koff:15.4x10^-7(second -1)|koff:9.3x10^-3(second -1)	2013/11/20	2014/10/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	intact-crc:36AB7495ADABAC20|rigid:pvCesd6FUk3adRfkNo+h8Z6PBY8	false	-	-	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	reactome:R-HSA-215992	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2461395|matrixdb:MULT_4_VAR1_human|wwpdb:1li1|reactome:R-HSA-2127348|reactome:R-HSA-2468115	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:collagen_iv_human-1(display_short)|psi-mi:R-HSA-215992(display_long)|intact:Collagen type IV trimer variant 1(complex recommended name)|intact:Type IV collagen variant I(complex synonym)|intact:"2xCOL4A1:COL4A2"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9082533|imex:IM-21580-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	go:"GO:0005587"(collagen type IV trimer)|pubmed:1916105(see-also)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0005201"(extracellular matrix structural constituent)|pubmed:17876790(see-also)|intact:EBI-2535681(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1723(complex-primary)	-	-	curated-complex:Basement membranes are formed by a fine network of collagen IV fibres that are laced together and entrap large associated molecules.|complex-assembly:Heterotrimer|complex-properties:"This assembly process requires lateral interactions between triple helices at two levels. In the short N-terminal triple-helical 7S domain, four  triple helical domains from four different molecules assemble head to tail to form the structure known as a spider whose legs are made of a long triple helical region made of several triple helical domains interrupted by short nontriple helical sequences. In the tissue the molecules interact laterally by this region in a staggered fashion. Finally, interactions of nontriple helical COOH-terminal NC1 domains (IPR001442) to form dimers are responsible for tail-to-tail binding of type IV  molecules."	figure legend:Table 4 Kinetics and affinity of PCPE-1 interactions|kinetics:"1:1 model"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:289.0x10^3(per mole per second)|koff:13.3x10^-3(second -1)|kd:49.4x10^-9 ~15.8(molar)	2013/11/20	2019/09/03	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	-	intact-crc:1DF9D8BACE2502AD	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	matrixdb:MULT_8_human	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2465980|reactome:R-HSA-381923	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:collagen_vi_human(display_short)|psi-mi:MULT_8_human(display_long)|intact:Collagen type VI trimer(complex recommended name)|intact:Type VI collagen(complex synonym)|intact:"COL6A1:COL6A2:COL6A3"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9082565|imex:IM-21580-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	evidence ontology:"ECO:0005547"|pubmed:17876790(see-also)|pubmed:1916105(see-also)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005201"(extracellular matrix structural constituent)|complex portal:CPX-1736(complex-primary)	-	-	curated-complex:May play a role as an interface between the main collagen fibril network and the cells.|complex-assembly:Heterotrimer.|complex-properties:Forms a short triple helical domain, containing a single cysteine/chain, with prominent globular ends. It dimerises by antiparallel association and tetramerises by lateral association of dimers. The association of tetramers is via their extremities which forms beaded filaments.	figure legend:Table 4 Kinetics and affinity of PCPE-1 interactions|kinetics:"1:1 model"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:42.8x10^3(per mole per second)|koff:3.88x10^-4(second -1)|kd:9.5x10^-9 ~1.5(molar)	2013/11/20	2019/02/06	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	-	intact-crc:E79F24CE962F3318	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	matrixdb:MULT_1_human	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2529702|reactome:R-HSA-215989|signor:SIGNOR-C183	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:lm-111_human(display_short)|psi-mi:MULT_1_human(display_long)|intact:Laminin-111 complex(complex recommended name)|intact:LM-111(complex synonym)|intact:Laminin-1 complex(complex synonym)|intact:EHS laminin(complex synonym)|intact:"LAMA1:LAMB1:LAMC1"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9082578|imex:IM-21580-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	pubmed:17453709(see-also)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0030155"(regulation of cell adhesion)|evidence ontology:"ECO:0005547"|complex portal:CPX-1770(complex-primary)	-	-	complex-properties:"Complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end."|curated-complex:Major component of basment membranes which binds to cells via a high affinity, cell-surface receptor.  Role in the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Found in the subendothelium of vascular vessels and mediates platelet adhesion under static and shear conditions.|complex-assembly:Heterotrimer.	figure legend:Table 4 Kinetics and affinity of PCPE-1 interactions|kinetics:Two-state model|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:58.8x10^-12 ~1.8(molar)|kon:52800.0x10^3(per mole per second)|kon:5.42x10^-3(second -1)|koff:39.9x10^-3(second -1)|koff:0.411x10^-3(second -1)	2013/11/20	2016/06/28	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	-	intact-crc:9F534710FEAE3A81	false	-	-	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P07996	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9082590|imex:IM-21580-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	-	-	-	figure legend:Table 4 Kinetics and affinity of PCPE-1 interactions|kinetics:Heterogeneous ligand|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:19.9x10^-12(molar)|kd:14.5x10^-9(molar)|kon:22.8x10^3(per mole per second)|kon:397.0x10^3(per mole per second)|koff:4.53x10^-7(second -1)|koff:5.75x10^-3(second -1)	2013/11/20	2014/10/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	intact-crc:9670F1E202D74BE1|rigid:j3PjzLuCt9KhVcHV+oVDHd539IE	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P05067-PRO_0000000092	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-821758	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9082720|imex:IM-21580-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Table 4 Kinetics and affinity of PCPE-1 interactions|kinetics:"1:1 model"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1000.0x10^-9(molar)	2013/11/20	2017/03/06	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	intact-crc:4E88B21DC4D14215|rigid:+6epkRBBWpXm3EUtWU6AFYZTxlw	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61769	uniprotkb:Q15113	intact:EBI-714718|uniprotkb:P01884|uniprotkb:Q9UDF4|uniprotkb:Q540F8|uniprotkb:Q6IAT8|uniprotkb:Q9UCK0|uniprotkb:Q9UD48|ensembl:ENSP00000453191|ensembl:ENSP00000453350|ensembl:ENSP00000481426|ensembl:ENSP00000488321|ensembl:ENSP00000488548|ensembl:ENSP00000497910	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:b2mg_human(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Salza et al. (2014)	pubmed:24117177|imex:IM-21580	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-9082737|imex:IM-21580-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:5KNM|rcsb pdb:5L2J|rcsb pdb:5L2K|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:5N1Y|rcsb pdb:5N6B|rcsb pdb:5NHT|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:5NQ1|rcsb pdb:5NQ3|rcsb pdb:5NQK|rcsb pdb:5OPI|rcsb pdb:5SWQ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:5T6Y|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TEZ|rcsb pdb:5HYJ|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5IEK|rcsb pdb:5IM7|rcsb pdb:5TRZ|rcsb pdb:5TS1|rcsb pdb:5INC|rcsb pdb:5TXS|rcsb pdb:5IND|rcsb pdb:5IRO|rcsb pdb:5ISZ|rcsb pdb:5IUE|rcsb pdb:5J1A|rcsb pdb:5U16|rcsb pdb:5JHD|rcsb pdb:5JZI|rcsb pdb:5U17|rcsb pdb:5U1R|rcsb pdb:5U2V|rcsb pdb:5U6Q|rcsb pdb:5U72|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:5VVP|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5W1V|rcsb pdb:5W1W|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:5WER|rcsb pdb:5WHK|rcsb pdb:5WJL|rcsb pdb:5WJN|rcsb pdb:5WKE|rcsb pdb:5WKF|rcsb pdb:5WKG|rcsb pdb:5WKH|rcsb pdb:5WKI|rcsb pdb:5WL1|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5WSH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5XOV|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6AEE|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|rcsb pdb:6AT5|rcsb pdb:6AT9|rcsb pdb:6AVF|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6C09|rcsb pdb:6CUG|rcsb pdb:6D29|rcsb pdb:6C15|rcsb pdb:6C97|rcsb pdb:6D2B|rcsb pdb:6C98|rcsb pdb:6C99|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6D64|rcsb pdb:6D78|rcsb pdb:6DKP|rcsb pdb:6EI2|rcsb pdb:6ENY|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6FGB|rcsb pdb:6G3J|rcsb pdb:6G3K|rcsb pdb:6GGM|rcsb pdb:6GH1|rcsb pdb:6GH4|rcsb pdb:6GHN|rcsb pdb:6GK3|rcsb pdb:6GL1|rcsb pdb:6ID4|rcsb pdb:6IEX|rcsb pdb:6ILM|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6J29|rcsb pdb:6J2A|rcsb pdb:6J2E|rcsb pdb:6J2G|rcsb pdb:6J2H|rcsb pdb:6J2I|rcsb pdb:6J2J|rcsb pdb:6JOZ|rcsb pdb:6JP3|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6K60|rcsb pdb:6K7T|rcsb pdb:6LA6|rcsb pdb:6LA7|rcsb pdb:6M1B|rcsb pdb:6M24|rcsb pdb:6M2J|rcsb pdb:6M2K|rcsb pdb:6MPP|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|rcsb pdb:6MTL|rcsb pdb:6MTM|rcsb pdb:6MWR|rcsb pdb:6NCA|rcsb pdb:6NHA|rcsb pdb:6NPR|rcsb pdb:6NUX|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6P2S|rcsb pdb:6P64|rcsb pdb:6PA1|rcsb pdb:6PAG|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6PBH|rcsb pdb:6PTB|rcsb pdb:6OPD|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6PTE|rcsb pdb:6P2F|rcsb pdb:6PUC|rcsb pdb:6PUD|rcsb pdb:6PUE|rcsb pdb:6PUF|rcsb pdb:6PUG|rcsb pdb:6PUH|rcsb pdb:6PUI|rcsb pdb:6PUJ|rcsb pdb:6PUK|rcsb pdb:6PUL|rcsb pdb:6PUM|rcsb pdb:6PVC|rcsb pdb:6PVD|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6Q3K|rcsb pdb:6Q3S|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R2L|rcsb pdb:6RP9|rcsb pdb:6RPA|rcsb pdb:6RPB|rcsb pdb:6RSY|rcsb pdb:6SS7|rcsb pdb:6SS8|rcsb pdb:6SS9|rcsb pdb:6SSA|rcsb pdb:6TDO|rcsb pdb:6TDP|rcsb pdb:6TDQ|rcsb pdb:6TDR|rcsb pdb:6TDS|rcsb pdb:6TMO|rcsb pdb:6TRN|rcsb pdb:6TRO|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6UJO|rcsb pdb:6UJQ|rcsb pdb:6UK2|rcsb pdb:6UK4|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6UZ1|rcsb pdb:6UZM|rcsb pdb:6UZN|rcsb pdb:6UZO|rcsb pdb:6UZP|rcsb pdb:6UZQ|rcsb pdb:6UZS|rcsb pdb:6V2O|rcsb pdb:6V2P|rcsb pdb:6V2Q|rcsb pdb:6V3J|rcsb pdb:6V7Y|rcsb pdb:6V7Z|rcsb pdb:6V80|rcsb pdb:6VB0|rcsb pdb:6VB1|rcsb pdb:6VB2|rcsb pdb:6VB3|rcsb pdb:6VB5|rcsb pdb:6VB6|rcsb pdb:6VB7|rcsb pdb:6VIU|rcsb pdb:6VM7|rcsb pdb:6VM8|rcsb pdb:6VM9|rcsb pdb:6VB4|rcsb pdb:6VMA|rcsb pdb:6VMC|rcsb pdb:6VMX|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQO|rcsb pdb:6VQY|rcsb pdb:6VQZ|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6W9U|rcsb pdb:6W9V|rcsb pdb:6WZY|rcsb pdb:6X00|rcsb pdb:6XQA|rcsb pdb:6XQP|rcsb pdb:6Y26|rcsb pdb:6Y27|rcsb pdb:6Y28|rcsb pdb:6Y29|rcsb pdb:6Y2A|rcsb pdb:6Y2B|rcsb pdb:6Z9V|rcsb pdb:6Z9W|rcsb pdb:6Z9X|rcsb pdb:7AFV|rcsb pdb:7ALO|rcsb pdb:7C9V|rcsb pdb:7JYU|rcsb pdb:7JYV|rcsb pdb:7JYW|rcsb pdb:7JYX|rcsb pdb:7K80|rcsb pdb:7K81|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:7KOZ|rcsb pdb:7KP0|rcsb pdb:7KP1|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LG2|rcsb pdb:7LG3|rcsb pdb:7LGD|rcsb pdb:7LGT|rcsb pdb:7M8S|rcsb pdb:7M8T|rcsb pdb:7M8U|rcsb pdb:7MKB|rcsb pdb:7NUI|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-9637628|reactome:R-HSA-977225|reactome:R-HSA-983170|ensembl:ENSG00000166710(gene)|ensembl:ENSG00000273686(gene)|ensembl:ENST00000559916(transcript)|ensembl:ENST00000561424(transcript)|ensembl:ENST00000617605(transcript)|ensembl:ENST00000631573(transcript)|ensembl:ENST00000631728(transcript)|ensembl:ENST00000648006(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005925"(focal adhesion)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007611"(learning or memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031905"(early endosome lumen)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042493"|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071283"("cellular response to iron(III) ion")|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1904434"(positive regulation of ferrous iron binding)|go:"GO:1904437"(positive regulation of transferrin receptor binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2000978"(negative regulation of forebrain neuron differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015707(Beta-2-Microglobulin)|interpro:IPR036179|mint:P61769|rcsb pdb:1A1M|rcsb pdb:1A1N|rcsb pdb:1A1O|rcsb pdb:1A6Z|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1C16|rcsb pdb:1CE6|rcsb pdb:1CG9|rcsb pdb:1DE4|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1EFX|rcsb pdb:1EXU|rcsb pdb:1GZP|rcsb pdb:1GZQ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1HSA|rcsb pdb:1HSB|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1IM9|rcsb pdb:1JF1|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1JHT|rcsb pdb:1JNJ|rcsb pdb:1K5N|rcsb pdb:1KPR|rcsb pdb:1KTL|rcsb pdb:1LDS|rcsb pdb:1LP9|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MHE|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGA|rcsb pdb:1OGT|rcsb pdb:1ONQ|rcsb pdb:1P7Q|rcsb pdb:1PY4|rcsb pdb:1Q94|rcsb pdb:1QEW|rcsb pdb:1QLF|rcsb pdb:1QQD|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1T20|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1QVO|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1R3H|rcsb pdb:1S8D|rcsb pdb:1TMC|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UQS|rcsb pdb:1UR7|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1VGK|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1W72|rcsb pdb:1X7Q|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1XZ0|rcsb pdb:1YDP|rcsb pdb:1YPZ|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1ZHK|rcsb pdb:1T1W|rcsb pdb:1ZHL|rcsb pdb:1ZS8|rcsb pdb:1ZSD|rcsb pdb:1ZT4|rcsb pdb:1ZVS|rcsb pdb:2A83|rcsb pdb:2AK4|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2AXF|rcsb pdb:2AXG|rcsb pdb:2BCK|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:1T1X|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:1T1Y|rcsb pdb:2C7U|rcsb pdb:2CII|rcsb pdb:1T1Z|rcsb pdb:2CIK|rcsb pdb:2CLR|rcsb pdb:2D31|rcsb pdb:2D4D|rcsb pdb:2D4F|rcsb pdb:2DYP|rcsb pdb:2E8D|rcsb pdb:2ESV|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2F74|rcsb pdb:2F8O|rcsb pdb:2FYY|rcsb pdb:2FZ3|rcsb pdb:2GIT|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:2GUO|rcsb pdb:2H26|rcsb pdb:2H6P|rcsb pdb:2HJK|rcsb pdb:2HJL|rcsb pdb:2HLA|rcsb pdb:2HN7|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2NW3|rcsb pdb:2NX5|refseq:NP_004039.1|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PO6|rcsb pdb:2PYE|rcsb pdb:2RFX|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VB5|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:2X89|rcsb pdb:2XKS|rcsb pdb:2XKU|rcsb pdb:2XPG|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:2YXF|rcsb pdb:2Z9T|rcsb pdb:3AM8|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3BO8|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BVN|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3BXN|rcsb pdb:3BZE|rcsb pdb:3BZF|rcsb pdb:3C9N|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3CIQ|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3D25|rcsb pdb:3D2U|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3DBX|rcsb pdb:3DHJ|rcsb pdb:3DHM|rcsb pdb:3DTX|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3EKC|rcsb pdb:3FFC|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HCV|rcsb pdb:3HG1|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3HUJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3I6L|rcsb pdb:3IB4|rcsb pdb:3IXA|rcsb pdb:3JTS|rcsb pdb:3KLA|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3KPO|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3LN5|rcsb pdb:3LOW|rcsb pdb:3LOZ|rcsb pdb:3LV3|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3M17|rcsb pdb:3M1B|rcsb pdb:3MGO|rcsb pdb:3MGT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MV7|rcsb pdb:3KXF|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3MYJ|rcsb pdb:3MYZ|rcsb pdb:3MZT|rcsb pdb:3KYN|rcsb pdb:3NA4|rcsb pdb:3NFN|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3OV6|rcsb pdb:3OX8|rcsb pdb:3OXR|rcsb pdb:3OXS|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDA|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:3QFD|rcsb pdb:3QFJ|rcsb pdb:3QZW|rcsb pdb:3REW|rcsb pdb:3KYO|rcsb pdb:3L3D|rcsb pdb:3RL1|rcsb pdb:3RL2|rcsb pdb:3RWJ|rcsb pdb:3S6C|rcsb pdb:3SDX|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3TID|rcsb pdb:3TIE|rcsb pdb:3TLR|rcsb pdb:3TM6|rcsb pdb:3TO2|rcsb pdb:3TZV|rcsb pdb:3U0P|rcsb pdb:3UPR|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:3VCL|rcsb pdb:3VFM|rcsb pdb:3VFN|rcsb pdb:3VFO|rcsb pdb:3VFP|rcsb pdb:3VFR|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:3VWJ|rcsb pdb:3VWK|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3W39|rcsb pdb:3WL9|rcsb pdb:3WLB|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4E0K|rcsb pdb:4E0L|rcsb pdb:4E5X|rcsb pdb:4EN3|rcsb pdb:4EUP|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|rcsb pdb:4FTV|rcsb pdb:4FXL|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4GKN|rcsb pdb:4GKS|rcsb pdb:4GUP|rcsb pdb:4HKJ|rcsb pdb:4HWZ|rcsb pdb:4HX1|rcsb pdb:4I48|rcsb pdb:4I4W|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|rcsb pdb:4JQV|rcsb pdb:3T8X|rcsb pdb:4JQX|rcsb pdb:4JRX|rcsb pdb:4JRY|rcsb pdb:4K71|rcsb pdb:4K7F|rcsb pdb:4KDT|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:4L4T|rcsb pdb:4L4V|rcsb pdb:4LCW|rcsb pdb:4L3E|rcsb pdb:4LCY|rcsb pdb:4LHU|rcsb pdb:4LNR|rcsb pdb:4M8V|rcsb pdb:4MJ5|rcsb pdb:4MJ6|rcsb pdb:4MJI|rcsb pdb:4MNQ|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4N8V|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4NO3|rcsb pdb:4NO5|rcsb pdb:4NQC|rcsb pdb:4NQD|rcsb pdb:4NQE|rcsb pdb:4NQV|rcsb pdb:4NQX|rcsb pdb:4NT6|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4ONO|rcsb pdb:4PJ5|rcsb pdb:4PJ7|rcsb pdb:4PJ8|rcsb pdb:4PJ9|rcsb pdb:4PJA|rcsb pdb:4PJB|rcsb pdb:4PJC|rcsb pdb:4PJD|rcsb pdb:4PJE|rcsb pdb:4PJF|rcsb pdb:4PJG|rcsb pdb:4PJH|rcsb pdb:4PJI|rcsb pdb:4PJX|rcsb pdb:4PR5|rcsb pdb:4PRA|rcsb pdb:4PRB|rcsb pdb:4PRD|rcsb pdb:4PRE|rcsb pdb:4PRH|rcsb pdb:4PRI|rcsb pdb:4PRN|rcsb pdb:4PRP|rcsb pdb:4QOK|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4R9H|rcsb pdb:4RA3|rcsb pdb:4RAH|rcsb pdb:4RMQ|rcsb pdb:4RMR|rcsb pdb:4RMS|rcsb pdb:4RMT|rcsb pdb:4RMU|rcsb pdb:4RMV|rcsb pdb:4RMW|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4U6X|rcsb pdb:4U6Y|rcsb pdb:4UQ2|rcsb pdb:4UQ3|rcsb pdb:4WC8|rcsb pdb:4WDI|rcsb pdb:4WJ5|rcsb pdb:4WO4|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:4WUU|rcsb pdb:4WW2|rcsb pdb:4WWK|rcsb pdb:4X0S|rcsb pdb:4X6C|rcsb pdb:4X6D|rcsb pdb:4X6E|rcsb pdb:4X6F|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:4XXC|rcsb pdb:5BJT|rcsb pdb:5BRZ|rcsb pdb:5BS0|rcsb pdb:5BXF|rcsb pdb:5C07|rcsb pdb:5C08|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5C0C|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5C9J|rcsb pdb:5CFH|rcsb pdb:5CKA|rcsb pdb:5CKG|rcsb pdb:5CS7|rcsb pdb:5CSB|rcsb pdb:5CSG|rcsb pdb:5D2L|rcsb pdb:5D2N|rcsb pdb:5D5M|rcsb pdb:5D7I|rcsb pdb:5D7J|rcsb pdb:5D7L|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5E00|rcsb pdb:5E6I|rcsb pdb:5E9D|rcsb pdb:5ENW|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5EOT|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:5EUO|rcsb pdb:5F1I|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5GR7|rcsb pdb:5GRD|rcsb pdb:5GRG|rcsb pdb:5GSB|rcsb pdb:5GSD|rcsb pdb:5GSR|rcsb pdb:5GSV|rcsb pdb:5GSX|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5HHM|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|dip:DIP-6055N	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Table 4 Kinetics and affinity of PCPE-1 interactions|kinetics:Two-state model|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3800.0x10^-9 ~300.0(molar)|kon:6.04x10^3(per mole per second)|kon:3.46x10^-3(second -1)|koff:95.6x10^-3(second -1)|koff:9.21x10^-4(second -1)	2013/11/20	2014/10/16	rogid:P08CZT3zl5vRrh+ELuLhkCM7jR89606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	intact-crc:666E2742682CEA54|rigid:eEHXsHugJIkOjerZ54PDe4qSovg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)