#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5S007	uniprotkb:P10636-8	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8804229|imex:IM-21733-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 2C|comment:Tau = 2N4R|kinetic_conditions:"The Km of WT and G2019S LRRK2 for the Tau-A peptide was determined to be ~170 μM.  The V max of tau phosphorylation by G2019S LRRK2  was ~threefold greater than that of WT LRRK2 (10738 and 3739 relative values)."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	intact-crc:39EFD693915203AF|rigid:jCHXFf3snLxcZC3dq9OqSliNWPo	false	glutathione s tranferase tag:?-?|mutation increasing interaction rate:2019-2019|sufficient binding region:970-2527	mutation disrupting interaction rate:149-149|mutation decreasing interaction rate:153-153|sufficient binding region:140-163	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P10636-8	uniprotkb:Q5S007	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8803909|imex:IM-21733-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 1A/B,  Supp fig 1.|comment:Tau = 2N4R|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:A0CA1BB83F04071B|rigid:jCHXFf3snLxcZC3dq9OqSliNWPo	false	-	glutathione s tranferase tag:?-?|sufficient binding region:970-2527|mutation disrupting interaction rate:1994-1994|mutation increasing interaction rate:2019-2019	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	-	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	-	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8803935|imex:IM-21733-2	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig 1A/B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2016/07/07	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	intact-crc:3E2979237BB41FC2	false	sufficient binding region:970-2527|glutathione s tranferase tag:?-?|mutation disrupting interaction rate:1994-1994|mutation increasing interaction rate:2019-2019	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:P10636-8	uniprotkb:Q5S007	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8804184|imex:IM-21733-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 2Bi|comment:Tau = 2N4R|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:ACFDED5761ECA975|rigid:jCHXFf3snLxcZC3dq9OqSliNWPo	false	mutation disrupting interaction rate:149-149|sufficient binding region:140-163|mutation decreasing interaction rate:153-153	glutathione s tranferase tag:?-?|mutation:2019-2019|sufficient binding region:970-2527	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P10636-2	uniprotkb:Q5S007	intact:EBI-7796412|ensembl:ENSP00000334886|ensembl:ENSP00000487570|ensembl:ENSP00000488245|intact:MINT-134452	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:p10636-2(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:0N3R(isoform synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8803978|imex:IM-21733-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENSG00000277956(gene)|ensembl:ENST00000334239(transcript)|ensembl:ENST00000628393(transcript)|ensembl:ENST00000633047(transcript)|intact:EBI-366182(isoform-parent)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	comment:mint	-	figure legend:Fig 1B,  Supp Fig 1.|comment:Tau = 0N3R|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:mdF/ejZEUkoIGs1MGVC70Xyi4Yk9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:DB6150EDCDD2A478|rigid:xZZtX0t5437dblGo+7c8vxHiDSo	false	-	sufficient binding region:970-2527|glutathione s tranferase tag:?-?|mutation:2019-2019	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	uniprotkb:P10636-4	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-8804019|ensembl:ENSP00000443028	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:p10636-4(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:1N3R(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8804004|imex:IM-21733-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	ensembl:ENSG00000186868(gene)|ensembl:ENST00000535772(transcript)|intact:EBI-366182(isoform-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 1B-2,  Supp fig 1.|comment:Tau = 1N3R|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:+uAM16ezyl7CSf9reK+sD4UNItE9606	intact-crc:DD42D91619637F3C|rigid:NEQXEklP1v3BsnUCUPu4+MURf+I	false	glutathione s tranferase tag:?-?|mutation:2019-2019|sufficient binding region:970-2527	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P10636-8	uniprotkb:Q5S007	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8804207|imex:IM-21733-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 2Bii.|comment:Tau = 2N4R|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:8EA1CCA931E4EF5F|rigid:jCHXFf3snLxcZC3dq9OqSliNWPo	false	sufficient binding region:221-243|mutation decreasing interaction rate:231-231	sufficient binding region:970-2527|mutation:2019-2019|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5S007	uniprotkb:P10636-7	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	intact:EBI-6926270|ensembl:ENSP00000413056|ensembl:ENSP00000478602|ensembl:ENSP00000483784|ensembl:ENSP00000487837|ensembl:ENSP00000505258|intact:EBI-7416105|intact:MINT-1915830|intact:EBI-7416343|intact:EBI-7416191|intact:EBI-7416026|intact:EBI-7416148|intact:EBI-7416263|intact:EBI-7416419|intact:EBI-7416286	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:p10636-7(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:1N4R(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8804033|imex:IM-21733-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENSG00000277956(gene)|ensembl:ENST00000420682(transcript)|ensembl:ENST00000612872(transcript)|ensembl:ENST00000613360(transcript)|ensembl:ENST00000632500(transcript)|ensembl:ENST00000680542(transcript)|intact:EBI-366182(isoform-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 1B-3,  Supp Fig 1.|comment:Tau = 1N4R|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rogid:oJJZkJXdq50wtdSgmN48BzG9Swc9606	intact-crc:A7A1786DAEAD877B|rigid:p4PfW5ptanW9CRbHhPHHmYcj2Ew	false	glutathione s tranferase tag:?-?|mutation:2019-2019|sufficient binding region:970-2527	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P10636-2	uniprotkb:Q5S007	intact:EBI-7796412|ensembl:ENSP00000334886|ensembl:ENSP00000487570|ensembl:ENSP00000488245|intact:MINT-134452	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:p10636-2(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:0N3R(isoform synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8804144|imex:IM-21733-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENSG00000277956(gene)|ensembl:ENST00000334239(transcript)|ensembl:ENST00000628393(transcript)|ensembl:ENST00000633047(transcript)|intact:EBI-366182(isoform-parent)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	comment:mint	-	figure legend:Fig 2A,  Supp. Table 1 and 2.|comment:Tau = 0N3R|resulting-ptm:T149, T153, T169, T205, T263 and T231 were identified as the major phosphorylation sites.|resulting-ptm:P10636-2 thr-149 O-phospho-L-threonine;  P10636-2 thr-153 O-phospho-L-threonine;  P10636-2 thr-169 O-phospho-L-threonine;  P10636-2 thr-205 O-phospho-L-threonine;  P10636-2 thr-263 O-phospho-L-threonine;  P10636-2 thr-231 O-phospho-L-threonine;|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:mdF/ejZEUkoIGs1MGVC70Xyi4Yk9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:ABF85553D9FC7C44|rigid:xZZtX0t5437dblGo+7c8vxHiDSo	false	-	sufficient binding region:970-2527|glutathione s tranferase tag:?-?|mutation:2019-2019|mutation disrupting interaction rate:1994-1994	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P10636-2	uniprotkb:Q5S007	intact:EBI-7796412|ensembl:ENSP00000334886|ensembl:ENSP00000487570|ensembl:ENSP00000488245|intact:MINT-134452	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:p10636-2(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:0N3R(isoform synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bailey et al. (2013)	pubmed:24113872|imex:IM-21733	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8804288|imex:IM-21733-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENSG00000277956(gene)|ensembl:ENST00000334239(transcript)|ensembl:ENST00000628393(transcript)|ensembl:ENST00000633047(transcript)|intact:EBI-366182(isoform-parent)	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	comment:mint	-	figure legend:Fig 3B|comment:Tau = 0N3R|resulting-ptm:Tau was phosphorylated by LRRK2 at T149 and T153 by G2019S  LRRK2 but not by the KD form.|resulting-ptm:"P10636-2  thr149  O-phospho-L-threonine:  P10636-2  thr153  O-phospho-L-threonine:"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/21	2014/10/16	rogid:mdF/ejZEUkoIGs1MGVC70Xyi4Yk9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	intact-crc:544565DC424586FD|rigid:xZZtX0t5437dblGo+7c8vxHiDSo	false	-	glutathione s tranferase tag:?-?|mutation:2019-2019|sufficient binding region:970-2527|mutation disrupting interaction rate:1994-1994	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)